aspirin has been researched along with Alzheimer Disease in 75 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized controlled trial in Alzheimer's disease (AD), we found a higher number of intracerebral hemorrhages (ICHs) in patients randomized to aspirin treatment." | 10.24 | Aspirin in Alzheimer's disease: increased risk of intracerebral hemorrhage: cause for concern? ( Bentham, P; De Haan, RJ; Gray, R; Nederkoorn, PJ; Richard, E; Thoonsen, H; van Geloven, N; Van Gool, WA, 2010) |
| "To evaluate the effectiveness and adverse effects of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for the primary or secondary prevention of dementia." | 9.05 | Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia. ( Devane, D; Jordan, F; Kelly, JP; McGuinness, B; Murphy, K; Passmore, P; Quinn, TJ; Tudur Smith, C, 2020) |
| "In a randomized controlled trial in Alzheimer's disease (AD), we found a higher number of intracerebral hemorrhages (ICHs) in patients randomized to aspirin treatment." | 6.24 | Aspirin in Alzheimer's disease: increased risk of intracerebral hemorrhage: cause for concern? ( Bentham, P; De Haan, RJ; Gray, R; Nederkoorn, PJ; Richard, E; Thoonsen, H; van Geloven, N; Van Gool, WA, 2010) |
| "CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease." | 5.43 | Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging. ( Hachinski, V; Oveisgharan, S, 2016) |
| "Findings from this MR analysis suggest a genetic protective effect of aspirin use on AD, possibly influenced by coronary heart disease, blood pressure, and lipid levels." | 5.41 | Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study. ( Ding, P; Gorenflo, MP; Xu, R; Zhu, X, 2023) |
| " The authors--in view of the increased neuroinflammatory reaction frequently observed during normal brain ageing--suggest the long-term use of "fatty aspirin", an association of DHA and/or NPD1 and aspirin (or nitroaspirin), to postpone, or prevent, the structural neurodegeneration of the brain." | 5.35 | Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? ( Bria, P; Di Gioia, A; Pomponi, M; Pomponi, MF, 2008) |
| "To evaluate the effectiveness and adverse effects of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for the primary or secondary prevention of dementia." | 5.05 | Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia. ( Devane, D; Jordan, F; Kelly, JP; McGuinness, B; Murphy, K; Passmore, P; Quinn, TJ; Tudur Smith, C, 2020) |
| " Similar but weaker trends were present among pairs discordant for history of arthritis or for prior daily use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin." | 3.69 | Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. ( Anthony, JC; Breitner, JC; Gau, BA; Helms, MJ; McDonald, WM; Plassman, BL; Welsh, KA, 1994) |
| "However, unlike stroke, treatment of hyperlipidemia with statin class drugs or treatment of blood clotting abnormalities with acetylsalicylic acid do not appear to have an effect on VaD incidence or progression." | 2.48 | Pharmacological prevention and treatment of vascular dementia: approaches and perspectives. ( Baskys, A; Cheng, JX, 2012) |
| " The appropriate dosage and duration of drug use and the ratios of risk to benefit are still unclear." | 2.42 | Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. ( Etminan, M; Gill, S; Samii, A, 2003) |
| " In the VIGOR gastrointestinal outcomes trial of >8000 patients, naproxen (an NSAID with aspirin-like sustained antiplatelet effects throughout its dosing interval) was associated with a significantly lower risk of CV events than was rofecoxib." | 2.42 | Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program. ( Gertz, BJ; Reicin, A; Sperling, RS; Weir, MR, 2003) |
| "Late-onset sporadic Alzheimer's disease is a heterogeneous disorder." | 2.42 | Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. ( Casserly, I; Topol, E, 2004) |
| "Antiplatelet use on the risk of intracerebral hemorrhage (ICH) in patients with Alzheimer's disease (AD) has not yet been completely elucidated." | 1.56 | The Impact of Antiplatelet Use on the Risk of Intracerebral Hemorrhage in Patients with Alzheimer's Disease: A Nationwide Cohort Study. ( Chang, YM; Chen, CH; Chien, CY; Lee, TL; Lin, SH; Lin, TY; Liu, CH; Sung, PS; Tsai, KJ, 2020) |
| "Aspirin is a widely available pain reliever that is showing promise beyond its known pain-relieving capacity." | 1.51 | Aspirin up-regulates suppressor of cytokine signaling 3 in glial cells via PPARα. ( Chakrabarti, S; Dasarathi, S; Pahan, K; Patel, D; Prorok, T; Roy, A, 2019) |
| "CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease." | 1.43 | Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging. ( Hachinski, V; Oveisgharan, S, 2016) |
| "Our hypothesis -- Alzheimer's disease is brain wound healing gone awry at least in some cases -- could be tested by measuring progression with biomarkers for the four stages of wound healing in humans or appropriate animal models." | 1.43 | A derangement of the brain wound healing process may cause some cases of Alzheimer's disease. ( Lehrer, S; Rheinstein, PH, 2016) |
| " The authors--in view of the increased neuroinflammatory reaction frequently observed during normal brain ageing--suggest the long-term use of "fatty aspirin", an association of DHA and/or NPD1 and aspirin (or nitroaspirin), to postpone, or prevent, the structural neurodegeneration of the brain." | 1.35 | Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? ( Bria, P; Di Gioia, A; Pomponi, M; Pomponi, MF, 2008) |
| "Tau protein pathology in Alzheimer's disease is characterized by the hyperphosphorylation of tau at some specific sites." | 1.33 | Acetylsalicylic acid decreases tau phosphorylation at serine 422. ( Avila, J; Pérez, M; Tortosa, E, 2006) |
| "Aspirin might protect against Alzheimer's disease, but controlled trials are warranted." | 1.32 | Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged > or =80 years. ( Berg, S; Johansson, B; McClearn, G; Melander, A; Nilsson, SE; Takkinen, S; Zarit, S, 2003) |
| " Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin for arthritis decreases the risk of developing Alzheimer's disease (AD) by unknown mechanisms." | 1.31 | Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation. ( Nadackal, TG; Thomas, K; Thomas, T, 2001) |
| "Because brain ischemia has recently been recognized to contribute to the pathogenesis of AD, we studied the effect of focal brain ischemia in 8- and 20-month-old mice overexpressing the 751-amino acid isoform of human APP." | 1.31 | Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. ( Bures, J; Goldsteins, G; Higgins, LS; Kauppinen, RA; Keinänen, R; Kettunen, MI; Koistinaho, J; Koistinaho, M; Liu, D; Ort, M; Salminen, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (16.00) | 18.2507 |
| 2000's | 27 (36.00) | 29.6817 |
| 2010's | 24 (32.00) | 24.3611 |
| 2020's | 12 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gökhan-Kelekçi, N | 1 |
| Yabanoğlu, S | 1 |
| Küpeli, E | 1 |
| Salgin, U | 1 |
| Ozgen, O | 1 |
| Uçar, G | 1 |
| Yeşilada, E | 1 |
| Kendi, E | 1 |
| Yeşilada, A | 1 |
| Bilgin, AA | 1 |
| Cao, Z | 1 |
| Song, Q | 1 |
| Yu, G | 1 |
| Liu, Z | 1 |
| Cong, S | 1 |
| Tan, Z | 1 |
| Deng, Y | 1 |
| Gorenflo, MP | 3 |
| Davis, PB | 2 |
| Kendall, EK | 2 |
| Olaker, VR | 2 |
| Kaelber, DC | 2 |
| Xu, R | 3 |
| Ding, P | 1 |
| Zhu, X | 1 |
| Zhou, Z | 1 |
| Ryan, J | 1 |
| Tonkin, AM | 1 |
| Zoungas, S | 1 |
| Lacaze, P | 1 |
| Wolfe, R | 1 |
| Orchard, SG | 1 |
| Murray, AM | 1 |
| McNeil, JJ | 1 |
| Yu, C | 1 |
| Watts, GF | 1 |
| Hussain, SM | 1 |
| Beilin, LJ | 1 |
| Ernst, ME | 1 |
| Stocks, N | 1 |
| Woods, RL | 1 |
| Zhu, C | 1 |
| Reid, CM | 1 |
| Shah, RC | 1 |
| Chong, TT | 1 |
| Sood, A | 1 |
| Sheets, KM | 1 |
| Nelson, MR | 1 |
| Gholami, M | 1 |
| Sadegh, M | 1 |
| Koroush-Arami, M | 1 |
| Norouzi, S | 1 |
| Arismani, RJ | 1 |
| Asadi, E | 1 |
| Amini, M | 1 |
| Khodayari, N | 1 |
| Lee, TL | 1 |
| Liu, CH | 1 |
| Chang, YM | 1 |
| Lin, TY | 1 |
| Chien, CY | 1 |
| Chen, CH | 1 |
| Tsai, KJ | 1 |
| Lin, SH | 1 |
| Sung, PS | 1 |
| Patel, D | 2 |
| Roy, A | 2 |
| Pahan, K | 3 |
| Jordan, F | 1 |
| Quinn, TJ | 1 |
| McGuinness, B | 1 |
| Passmore, P | 1 |
| Kelly, JP | 1 |
| Tudur Smith, C | 1 |
| Murphy, K | 1 |
| Devane, D | 1 |
| Davis, KAS | 1 |
| Bishara, D | 1 |
| Molokhia, M | 1 |
| Mueller, C | 1 |
| Perera, G | 1 |
| Stewart, RJ | 1 |
| Steele, D | 1 |
| James, K | 1 |
| Cadet, M | 1 |
| Ferreira, TR | 1 |
| Lopes, LC | 1 |
| Motter, FR | 1 |
| de Cássia Bergamaschi, C | 1 |
| Weng, J | 1 |
| Zhao, G | 1 |
| Weng, L | 1 |
| Guan, J | 1 |
| Ferrari, C | 1 |
| Lombardi, G | 1 |
| Polito, C | 1 |
| Lucidi, G | 1 |
| Bagnoli, S | 1 |
| Piaceri, I | 1 |
| Nacmias, B | 1 |
| Berti, V | 1 |
| Rizzuto, D | 1 |
| Fratiglioni, L | 1 |
| Sorbi, S | 1 |
| Fink, HA | 1 |
| Jutkowitz, E | 1 |
| McCarten, JR | 1 |
| Hemmy, LS | 1 |
| Butler, M | 1 |
| Davila, H | 1 |
| Ratner, E | 1 |
| Calvert, C | 1 |
| Barclay, TR | 1 |
| Brasure, M | 1 |
| Nelson, VA | 1 |
| Kane, RL | 1 |
| Chandra, S | 1 |
| Jana, M | 1 |
| Melo, HM | 1 |
| Anastasio, TJ | 1 |
| Chakrabarti, S | 1 |
| Prorok, T | 1 |
| Dasarathi, S | 1 |
| Medeiros, R | 1 |
| Kitazawa, M | 1 |
| Passos, GF | 1 |
| Baglietto-Vargas, D | 1 |
| Cheng, D | 1 |
| Cribbs, DH | 1 |
| LaFerla, FM | 1 |
| Pomponi, M | 5 |
| Pomponi, MF | 3 |
| Drochioiu, G | 1 |
| Tudorachi, L | 1 |
| Murariu, M | 1 |
| Lee, M | 1 |
| Wathier, M | 1 |
| Love, JA | 1 |
| McGeer, E | 1 |
| McGeer, PL | 1 |
| Assad, M | 1 |
| Coffin-Pichonnet, S | 1 |
| Billotte, C | 1 |
| Denion, É | 1 |
| Oveisgharan, S | 1 |
| Hachinski, V | 2 |
| Lehrer, S | 1 |
| Rheinstein, PH | 1 |
| Chang, CW | 1 |
| Horng, JT | 1 |
| Hsu, CC | 1 |
| Chen, JM | 1 |
| Szekely, CA | 1 |
| Green, RC | 1 |
| Breitner, JC | 5 |
| Østbye, T | 1 |
| Beiser, AS | 1 |
| Corrada, MM | 1 |
| Dodge, HH | 1 |
| Ganguli, M | 1 |
| Kawas, CH | 1 |
| Kuller, LH | 1 |
| Psaty, BM | 1 |
| Resnick, SM | 1 |
| Wolf, PA | 1 |
| Zonderman, AB | 1 |
| Welsh-Bohmer, KA | 1 |
| Zandi, PP | 3 |
| Di Gioia, A | 2 |
| Bria, P | 2 |
| Richard, E | 2 |
| Kuiper, R | 1 |
| Dijkgraaf, MG | 1 |
| Van Gool, WA | 2 |
| Hartung, B | 1 |
| Grass, H | 1 |
| Montine, TJ | 1 |
| Sonnen, JA | 1 |
| Milne, G | 1 |
| Baker, LD | 1 |
| Cordonnier, C | 1 |
| Hiramatsu, M | 1 |
| Takiguchi, O | 1 |
| Nishiyama, A | 1 |
| Mori, H | 1 |
| Gambassi, G | 1 |
| Masullo, C | 1 |
| Thoonsen, H | 1 |
| Bentham, P | 2 |
| Gray, R | 2 |
| van Geloven, N | 1 |
| De Haan, RJ | 1 |
| Nederkoorn, PJ | 1 |
| Jaturapatporn, D | 1 |
| Isaac, MG | 1 |
| McCleery, J | 1 |
| Tabet, N | 1 |
| Sakurai, H | 1 |
| Hanyu, H | 1 |
| Sato, T | 1 |
| Kume, K | 1 |
| Hirao, K | 1 |
| Kanetaka, H | 1 |
| Iwamoto, T | 1 |
| Mizushima, T | 1 |
| Baskys, A | 1 |
| Cheng, JX | 1 |
| Peters, O | 1 |
| Anthony, JC | 3 |
| Hayden, KM | 1 |
| Mehta, K | 1 |
| Mayer, L | 1 |
| Harris, JR | 1 |
| Relkin, NR | 1 |
| Reichman, WE | 1 |
| Orazem, J | 1 |
| McRae, T | 1 |
| in 't Veld, BA | 1 |
| Launer, LJ | 1 |
| Breteler, MM | 1 |
| Hofman, A | 1 |
| Stricker, BH | 1 |
| Nilsson, SE | 1 |
| Johansson, B | 1 |
| Takkinen, S | 1 |
| Berg, S | 1 |
| Zarit, S | 1 |
| McClearn, G | 1 |
| Melander, A | 1 |
| Etminan, M | 1 |
| Gill, S | 1 |
| Samii, A | 1 |
| Weir, MR | 1 |
| Sperling, RS | 1 |
| Reicin, A | 1 |
| Gertz, BJ | 1 |
| Morgan, G | 2 |
| Rollet, J | 1 |
| Casserly, I | 1 |
| Topol, E | 1 |
| Koistinaho, M | 2 |
| Koistinaho, J | 2 |
| Tortosa, E | 1 |
| Avila, J | 1 |
| Pérez, M | 1 |
| Ciabattoni, G | 1 |
| Porreca, E | 1 |
| Di Febbo, C | 1 |
| Di Iorio, A | 1 |
| Paganelli, R | 1 |
| Bucciarelli, T | 1 |
| Pescara, L | 1 |
| Del Re, L | 1 |
| Giusti, C | 1 |
| Falco, A | 1 |
| Sau, A | 1 |
| Patrono, C | 1 |
| Davì, G | 1 |
| Aisen, PS | 1 |
| Sellwood, E | 1 |
| Hills, R | 1 |
| Crome, P | 1 |
| Raftery, J | 1 |
| Gau, BA | 1 |
| Welsh, KA | 1 |
| Plassman, BL | 1 |
| McDonald, WM | 1 |
| Helms, MJ | 1 |
| Harding, JJ | 1 |
| Doraiswamy, PM | 1 |
| Krishen, A | 1 |
| Stallone, F | 1 |
| Martin, WL | 1 |
| Potts, NL | 1 |
| Metz, A | 1 |
| MRCPsych, AM | 1 |
| DeVeaugh-Geiss, J | 1 |
| Gidal, BE | 1 |
| Crismon, ML | 1 |
| Wagner, ML | 1 |
| Fagan, SC | 1 |
| Privitera, MD | 1 |
| Dalmady-Israel, C | 1 |
| Graves, NM | 1 |
| Rockwood, K | 1 |
| Ebly, E | 1 |
| Hogan, D | 1 |
| Stewart, WF | 1 |
| Kawas, C | 1 |
| Corrada, M | 1 |
| Metter, EJ | 1 |
| Vainio, H | 1 |
| Vanchieri, C | 1 |
| Moreno González, A | 1 |
| Pennisi, E | 1 |
| Meyer, MR | 1 |
| Jurasova, I | 1 |
| Norton, MC | 1 |
| Stone, SV | 1 |
| Asanuma, M | 1 |
| Nishibayashi-Asanuma, S | 1 |
| Miyazaki, I | 1 |
| Kohno, M | 1 |
| Ogawa, N | 1 |
| Thomas, T | 1 |
| Nadackal, TG | 1 |
| Thomas, K | 1 |
| Scriabine, A | 1 |
| Kettunen, MI | 1 |
| Goldsteins, G | 1 |
| Keinänen, R | 1 |
| Salminen, A | 1 |
| Ort, M | 1 |
| Bures, J | 1 |
| Liu, D | 1 |
| Kauppinen, RA | 1 |
| Higgins, LS | 1 |
| Oken, RJ | 1 |
| Wisniewski, HM | 1 |
| Kieras, FJ | 1 |
| Zebrower, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multidomain Intervention Program for Older People With Dementia: A Pilot Study[NCT04948450] | 60 participants (Anticipated) | Interventional | 2022-11-24 | Active, not recruiting | |||
| Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.[NCT05262257] | Early Phase 1 | 120 participants (Anticipated) | Interventional | 2022-04-01 | Not yet recruiting | ||
| Biomarkers of Nonsteroidal Anti-Inflammatories[NCT00239746] | Phase 1 | 40 participants (Anticipated) | Interventional | 2005-10-31 | Active, not recruiting | ||
| Phase 4 Study of the Effects of Pravastatin on Cholesterol Levels, Inflammation and Cognition in Schizophrenia[NCT01082588] | Phase 4 | 60 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)[NCT00007189] | Phase 3 | 2,625 participants | Interventional | 2001-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/L (Mean) |
|---|---|
| Pravastatin | 0.8063 |
| Placebo | -0.5136 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/dl (Mean) |
|---|---|
| Pravastatin | -25.565 |
| Placebo | -2.913 |
"The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery measures cognitive functioning within 7 domains: speed of processing, attention/vigilance, working memory (non verbal and verbal), verbal learning, visual learning, reasoning and problem solving and social cognition.~The composite score is calculated by the MATRICS computer program, which equally weights each of the 7 domain scores. The range of composite scores is 20-80. Higher scores indicate higher levels or cognitive functioning, while lower scores indicate lower levels of cognitive functioning." (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | 4.0417 |
| Placebo | 4.125 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 15-105. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -5.625 |
| Placebo | -3.76 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -0.83 |
| Placebo | -0.28 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -2.9583 |
| Placebo | -2.44 |
The Positive and Negative Syndrome Scale (PANSS) is a scale used to rate severity of schizophrenia. All items are summed to calculate the total score. The scale range is 30-210. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -9.416 |
| Placebo | -6.48 |
21 reviews available for aspirin and Alzheimer Disease
| Article | Year |
|---|---|
Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study.
Topics: Alzheimer Disease; Aspirin; Coronary Disease; Genome-Wide Association Study; Humans; Mendelian Rando | 2023 |
Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Aspirin; Cyclooxygenase 2; Cytokines; Humans; | 2023 |
PPARα serves as a new receptor of aspirin for neuroprotection.
Topics: Alzheimer Disease; Animals; Aspirin; Brain; Humans; Neuronal Plasticity; Neurons; Neuroprotective Ag | 2020 |
Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Age | 2020 |
Aspirin in people with dementia, long-term benefits, and harms: a systematic review.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardio | 2021 |
Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Cholin | 2018 |
Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Cholin | 2018 |
Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Cholin | 2018 |
Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Cholin | 2018 |
Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Apolipoprot | 2011 |
Aspirin in Alzheimer's disease: increased risk of intracerebral hemorrhage: cause for concern?
Topics: Aged; Alzheimer Disease; Aspirin; Cerebral Hemorrhage; Humans; Incidence; Middle Aged; Platelet Aggr | 2010 |
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2012 |
[Novel pharmacological effects of NSAIDs and their molecular mechanism].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2012 |
Pharmacological prevention and treatment of vascular dementia: approaches and perspectives.
Topics: Alzheimer Disease; Antihypertensive Agents; Aspirin; Cholinesterase Inhibitors; Cognition; Dementia, | 2012 |
[Alzheimer's disease: are non-steroidal anti-inflammatory drugs effective?].
Topics: Adrenal Cortex Hormones; Aged; Alzheimer Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents | 2012 |
Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antioxidants; A | 2002 |
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Coh | 2003 |
Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood | 2003 |
Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Cholest | 2004 |
Interactions between Alzheimer's disease and cerebral ischemia--focus on inflammation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspirin; Brain Ischemia; Humans; Inflamm | 2005 |
Is Alzheimer's disease a synaptic disorder?
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Docosahexaenoic Acids; Eicosape | 2008 |
Current developments in neurology, Part II: Advances in the pharmacotherapy of Alzheimer disease, Parkinson's disease, and stroke.
Topics: Alzheimer Disease; Anticoagulants; Apomorphine; Aspirin; Cerebrovascular Disorders; Cholinergic Agen | 1996 |
Aspirin for the second hundred years: new uses for an old drug.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular Disea | 1997 |
Aspirin and its friends: an old standby with new prospects.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebrovascular Disorders; Colo | 1999 |
10 trials available for aspirin and Alzheimer Disease
| Article | Year |
|---|---|
Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults: A Prospective Cohort Study.
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Aspirin; Cognition; Cognitive Dysfunction; Female; Human | 2023 |
Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-a randomized clinical trial.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Aspirin; Cerebrovascular Disorders; Cost-Benefi | 2009 |
Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, | 2010 |
Aspirin in Alzheimer's disease: increased risk of intracerebral hemorrhage: cause for concern?
Topics: Aged; Alzheimer Disease; Aspirin; Cerebral Hemorrhage; Humans; Incidence; Middle Aged; Platelet Aggr | 2010 |
Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: a pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspirin; Cerebrovascular Circulati | 2013 |
A large, community-based, open-label trial of donepezil in the treatment of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antidepr | 2003 |
Determinants of platelet activation in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspirin; Body Mass Index; C-Reacti | 2007 |
Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspirin; Female; Fibrinolytic Agents; Humans; Longitudin | 2008 |
NSAIDs and cognition in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cognit | 1996 |
Risk of Alzheimer's disease and duration of NSAID use.
Topics: Acetaminophen; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; | 1997 |
45 other studies available for aspirin and Alzheimer Disease
| Article | Year |
|---|---|
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Hydrogen Bonding; | 2007 |
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; | 2021 |
Association of Aspirin Use with Reduced Risk of Developing Alzheimer's Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study.
Topics: Aged; Alzheimer Disease; Aspirin; Humans; Ischemic Stroke; Retrospective Studies; Risk Factors; Stro | 2023 |
Association of Aspirin Use with Reduced Risk of Developing Alzheimer's Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study.
Topics: Aged; Alzheimer Disease; Aspirin; Humans; Ischemic Stroke; Retrospective Studies; Risk Factors; Stro | 2023 |
Association of Aspirin Use with Reduced Risk of Developing Alzheimer's Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study.
Topics: Aged; Alzheimer Disease; Aspirin; Humans; Ischemic Stroke; Retrospective Studies; Risk Factors; Stro | 2023 |
Association of Aspirin Use with Reduced Risk of Developing Alzheimer's Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study.
Topics: Aged; Alzheimer Disease; Aspirin; Humans; Ischemic Stroke; Retrospective Studies; Risk Factors; Stro | 2023 |
The Impact of Antiplatelet Use on the Risk of Intracerebral Hemorrhage in Patients with Alzheimer's Disease: A Nationwide Cohort Study.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aspirin; Cerebral Hemorrhage; Cohort Studies; Dem | 2020 |
Ineffectiveness and safety concerns of using aspirin and other NSAIDs in preventing dementia.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans | 2022 |
Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspirin; Brazil; Cardiovascular Agents; Central Nervous | 2021 |
Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Cog | 2021 |
Alzheimer's Disease Progression: Factors Influencing Cognitive Decline.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Aspirin; Cognitive Dysfuncti | 2018 |
Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal | 2018 |
Potential Effects of Aspirin on Lysosomal Biogenesis and Amyloid-β Clearance: An Old Drug and Novel Insights in Alzheimer's Disease Therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspirin; Lysosomes; Mice; Plaque, Amyloid; PPAR a | 2019 |
Exploring the Correlation between the Cognitive Benefits of Drug Combinations in a Clinical Database and the Efficacies of the Same Drug Combinations Predicted from a Computational Model.
Topics: Alzheimer Disease; Antihypertensive Agents; Aspirin; Cognition; Computer Simulation; Cyclooxygenase | 2019 |
Aspirin up-regulates suppressor of cytokine signaling 3 in glial cells via PPARα.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Male; Mice; Mi | 2019 |
Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspirin; Astrocytes; Brain; Cognition; Lipoxins; | 2013 |
Alzheimer's disease prevention & acetyl salicylic acid: a believable story.
Topics: Aging; Alzheimer Disease; Aspirin; Humans; Synapses | 2014 |
NOSH aspirin may have a protective role in Alzheimer's disease.
Topics: Alzheimer Disease; Aspirin; Disulfides; Encephalitis; Humans; Models, Biological; Nitrates | 2015 |
Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid.
Topics: Alzheimer Disease; Animals; Aspirin; Aurintricarboxylic Acid; Benzhydryl Compounds; Cats; Cells, Cul | 2015 |
[Acute unilateral arteritic anterior ischemic optic neuropathy becoming bilateral despite corticosteroid therapy].
Topics: Acute Disease; Aged; Alzheimer Disease; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Disease P | 2016 |
Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspirin; Canada; Cyclooxygenase Inhibitors; Demen | 2016 |
A derangement of the brain wound healing process may cause some cases of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Aspirin; Brain; Humans; Insulin; Wound Healing | 2016 |
Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer's Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspirin; Databases, Factual; Diabetes Mellitus, Type 2; | 2016 |
No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; | 2008 |
Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type?
Topics: Alzheimer Disease; Animals; Antioxidants; Aspirin; Cognition Disorders; Dementia; Disease Models, An | 2008 |
[Demented patient with strangulation marks. Was it a crime?].
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Asphyxia; Aspirin; Blood Coagulation Tests; Diagn | 2009 |
Brain microbleeds.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Brain; Cerebral | 2010 |
Cilostazol prevents amyloid β peptide(25-35)-induced memory impairment and oxidative stress in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspirin; Avoidance Learning; Cilostazol; Cytokine | 2010 |
Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Sq | 2002 |
In vitro fibrillogenesis of the amyloid beta 1-42 peptide: cholesterol potentiation and aspirin inhibition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspirin; Cholesterol; Copper; Dimerization; Human | 2002 |
Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged > or =80 years.
Topics: Acetaminophen; Aged; Aged, 80 and over; Alzheimer Disease; Analgesics, Non-Narcotic; Analgesics, Opi | 2003 |
Aspirin for everything?
Topics: Adult; Alzheimer Disease; Aspirin; Clinical Trials as Topic; Heart Diseases; Humans; Neoplasms | 2003 |
Should aspirin be used to counteract 'salicylate deficiency'?
Topics: Alzheimer Disease; Aspirin; Cardiovascular Diseases; Chronic Disease; Fruit; Humans; Neoplasms; Publ | 2003 |
The miracle in the cabinet. A look at the future of aspirin.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cycloo | 2004 |
Acetylsalicylic acid decreases tau phosphorylation at serine 422.
Topics: Alzheimer Disease; Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Cel | 2006 |
An aspirin a day for Alzheimer's disease?
Topics: Alzheimer Disease; Aspirin; Cyclooxygenase Inhibitors; Drug Administration Schedule; Humans | 2008 |
Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.
Topics: Age Factors; Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; C | 1994 |
Alzheimer disease (AD), modified proteins, and aspirin.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspirin; Cataract; Humans; Neurofibrillary Tangles | 1993 |
Presence and treatment of vascular risk factors in patients with vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspirin; Cognition Disorders; Dementia; Diabetes Complic | 1997 |
Deciphering aspirin's many modes of action.
Topics: Alzheimer Disease; Aspirin; Cardiovascular Diseases; Colorectal Neoplasms; Humans | 1996 |
[Indications for aspirin on the centennial of its discovery].
Topics: Adult; Aged; Alzheimer Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; A | 1997 |
Building a better aspirin.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspiri | 1998 |
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-C | 2000 |
Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoates; Cell Death; | 2001 |
Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxi | 2001 |
Alzheimer's disease, cancer and the search for a better aspirin. Postgraduate course at Mount Sinai School of Medicine, New York, NY June 22-23, 2001.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cycl | 2001 |
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspirin; Blood Pressure; Brain; Brain Is | 2002 |
Alzheimer disease (AD): aspirin prophylaxis and therapy.
Topics: Alzheimer Disease; Aspirin; Humans | 1992 |