aspirin has been researched along with Alkaptonuria in 4 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Alkaptonuria: An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gentisic acid (GA), a metabolite of acetylsalicylic acid (ASA), and homogentisic acid (HGA), which is excreted at high levels in alkaptonuria, are divalent phenolic acids with very similar structures." | 3.96 | Novel absorbance peak of gentisic acid following the oxidation reaction. ( Ejima, Y; Hirakawa, E; Hosokawa, S; Morinishi, T; Ohsaki, H; Shimosawa, T; Shukuya, K; Sogabe, K; Tokuhara, Y, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hosokawa, S | 1 |
| Shukuya, K | 1 |
| Sogabe, K | 1 |
| Ejima, Y | 1 |
| Morinishi, T | 1 |
| Hirakawa, E | 1 |
| Ohsaki, H | 1 |
| Shimosawa, T | 1 |
| Tokuhara, Y | 1 |
| Frohlich, J | 1 |
| Price, GE | 1 |
| Campbell, DJ | 1 |
| Feldman, JM | 2 |
| Butler, SS | 1 |
| Chapman, BA | 1 |
| Kelley, WN | 1 |
| Lebovitz, HE | 1 |
4 other studies available for aspirin and Alkaptonuria
| Article | Year |
|---|---|
Novel absorbance peak of gentisic acid following the oxidation reaction.
Topics: Alkaptonuria; Aspirin; Chromatography, Liquid; Gentisates; Homogentisic Acid; Humans; Mass Spectrome | 2020 |
Problems in the laboratory diagnosis of alcaptonuria.
Topics: Alkaptonuria; Arthritis, Rheumatoid; Aspirin; Cerumen; Child, Preschool; Chromatography, Paper; Colo | 1973 |
Interference with measurement of 3-methoxy-4-hydroxymandelic acid and 5-hydroxyindoleacetic acid by reducing metabolites.
Topics: Aged; Alkaptonuria; Aspirin; Carcinoid Tumor; Dihydroxyphenylalanine; Female; Humans; Indoleacetic A | 1974 |
Inhibition of glucose oxidase paper tests by reducing metabolites.
Topics: Adult; Alkaptonuria; Aspirin; Diabetes Complications; Diabetes Mellitus; Dihydroxyphenylalanine; Fal | 1970 |