aspirin and Aging studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
"A total of 973 patients aged≥75 years with atrial fibrillation were recruited from primary care and randomly assigned to warfarin (n=488; target international normalized ratio, 2-3) or aspirin (n=485; 75 mg/d)."	9.19	Warfarin versus aspirin for prevention of cognitive decline in atrial fibrillation: randomized controlled trial (Birmingham Atrial Fibrillation Treatment of the Aged Study). ( Fitzmaurice, D; Fletcher, K; Hobbs, FD; Lip, GY; Mant, J; Mavaddat, N; Roalfe, A, 2014)
"This paper describes the rationale and design of the ENVIS-ion Study, which aims to determine whether low-dose aspirin reduces the development of white matter hyper-intense (WMH) lesions and silent brain infarction (SBI)."	9.16	Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). ( Abhayaratna, WP; Budge, MM; Essex, R; Janke, A; Kam, A; Reid, CM; Storey, E; Tonkin, A; Wang, JJ; Wong, TY; Woods, R, 2012)
"There was no difference between the beta carotene and placebo groups in the overall incidence of cataract (998 cases vs 1017 cases; relative risk [RR], 1."	9.10	A randomized trial of beta carotene and age-related cataract in US physicians. ( Buring, JE; Christen, WG; Gaziano, JM; Glynn, RJ; Hennekens, CH; Manson, JE; Sperduto, RD, 2003)
"Aspirin is one of the most commonly consumed cyclooxygenase (COX)-inhibitors and anti-inflammatory drugs and has been shown to block COX-produced regulators of inflammation and aging skeletal muscle size."	8.31	Influence of aspirin on aging skeletal muscle: Insights from a cross-sectional cohort of septuagenarians. ( Claiborne, A; Finch, WH; Fountain, WA; Naruse, M; Trappe, SW; Trappe, TA, 2023)
" We investigated the time-dependent methylation drift in aspirin users and nonusers using multivariable regression and related the modulatory effect of aspirin to colonic epigenome-aging and CC."	7.96	Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging. ( Chaber-Ciopinska, A; Noreen, F; Regula, J; Schär, P; Truninger, K, 2020)
" The most common adverse effects that occurred were related to the gastrointestinal tract, nervous system, skin, and special senses."	6.67	Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. ( Fleischmann, RM, 1992)
"CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease."	5.43	Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging. ( Hachinski, V; Oveisgharan, S, 2016)
"Aspirin treatment decreased 8-OHdG levels (P < 0."	5.35	Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging. ( Boulanger, E; Bulckaen, H; Corman, B; Creusy, C; Garçon, G; Gaxatte, C; Gosset, P; Prévost, G; Puisieux, F; Robitaille, G; Roquet, V; Shirali, P, 2008)
"In the PRODIGY trial, prolonging clopidogrel-based DAPT beyond six months in elderly patients increased the risk of bleeding, without affording a significant prevention of ischaemic events."	5.24	Ischaemic and bleeding outcomes in elderly patients undergoing a prolonged versus shortened duration of dual antiplatelet therapy after percutaneous coronary intervention: insights from the PRODIGY randomised trial. ( Ariotti, S; Franzone, A; Gargiulo, G; Heg, D; Magnani, G; Marino, M; Piccolo, R; Santucci, A; Tebaldi, M; Valgimigli, M; Windecker, S, 2017)
"A total of 973 patients aged≥75 years with atrial fibrillation were recruited from primary care and randomly assigned to warfarin (n=488; target international normalized ratio, 2-3) or aspirin (n=485; 75 mg/d)."	5.19	Warfarin versus aspirin for prevention of cognitive decline in atrial fibrillation: randomized controlled trial (Birmingham Atrial Fibrillation Treatment of the Aged Study). ( Fitzmaurice, D; Fletcher, K; Hobbs, FD; Lip, GY; Mant, J; Mavaddat, N; Roalfe, A, 2014)
"This paper describes the rationale and design of the ENVIS-ion Study, which aims to determine whether low-dose aspirin reduces the development of white matter hyper-intense (WMH) lesions and silent brain infarction (SBI)."	5.16	Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). ( Abhayaratna, WP; Budge, MM; Essex, R; Janke, A; Kam, A; Reid, CM; Storey, E; Tonkin, A; Wang, JJ; Wong, TY; Woods, R, 2012)
"There was no difference between the beta carotene and placebo groups in the overall incidence of cataract (998 cases vs 1017 cases; relative risk [RR], 1."	5.10	A randomized trial of beta carotene and age-related cataract in US physicians. ( Buring, JE; Christen, WG; Gaziano, JM; Glynn, RJ; Hennekens, CH; Manson, JE; Sperduto, RD, 2003)
"Color vision function was measured at baseline in 2,701 patients enrolled in the Early Treatment Diabetic Retinopathy Study, a randomized trial investigating photocoagulation and aspirin in the treatment of diabetic retinopathy."	5.09	Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 15. ( Barton, FB; Bresnick, GH; Fong, DS, 1999)
"This review examines ulcers and gastrointestinal bleeding with low-dose aspirin, focusing on randomized placebo-controlled trials."	4.83	Review article: gastrointestinal bleeding with low-dose aspirin - what's the risk? ( Laine, L, 2006)
"Nonopioid analgesics, which include acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2)-specific inhibitors (coxibs), are frequently used for the relief of mild-to-moderate pain."	4.83	Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. ( Whelton, A, 2006)
" It is unclear whether low-dose aspirin reduces this burden in aging populations."	4.02	Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. ( Ernst, ME; Espinoza, S; Fitzgerald, SM; Lockery, JE; McNeil, JJ; Murray, AM; Nelson, MR; Newman, AB; Orchard, SG; Reid, CM; Ryan, J; Shah, RC; Stocks, NP; Storey, E; Thao, LTP; Trevaks, RE; Ward, SA; Williamson, JD; Wolfe, R; Woods, RL, 2021)
" We investigated the time-dependent methylation drift in aspirin users and nonusers using multivariable regression and related the modulatory effect of aspirin to colonic epigenome-aging and CC."	3.96	Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging. ( Chaber-Ciopinska, A; Noreen, F; Regula, J; Schär, P; Truninger, K, 2020)
" In diabetic patients treated with DAPT (ASA + clopidogrel or ticagrelor) platelet reactivity was assessed at 30-90 days post-discharge for an acute coronary syndrome or elective PCI."	3.91	Impact of aging on platelet reactivity in diabetic patients receiving dual antiplatelet therapy. ( Carriero, A; De Luca, G; Kedhi, E; Nardin, M; Pergolini, P; Rolla, R; Suryapranata, H; Tonon, F; Verdoia, M, 2019)
" Data were analysed from three community-dwelling populations of older persons (>50 years) in central Scotland: the Aspirin for Asymptomatic Atherosclerosis (AAA) Trial (n = 2,091), the Edinburgh Type 2 Diabetes Study (ET2DS, n = 1,066), and the Lothian Birth Cohort 1936 (LBC1936, n = 1,091)."	3.77	Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts. ( Deary, IJ; Fowkes, FG; Gow, AJ; Harris, SE; Houlihan, LM; Lowe, GD; Luciano, M; Marioni, RE; Murray, GD; Price, JF; Rumley, A; Stewart, MC; Strachan, MW, 2011)
"In our present study we investigated the association between platelet aggregation in patients treated with the most widely used antiplatelet agents (100 and 300-325 mg acetylsalicylic acid (ASA), 75 mg clopidogrel, 500 mg ticlopidine and the combination of 100 mg aspirin and 75 mg clopidogrel), fibrinogen levels and aging."	3.74	Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. ( Alexy, T; Feher, G; Horvath, B; Kenyeres, P; Kesmarky, G; Koltai, K; Lenart, I; Marton, Z; Toth, K, 2008)
"The nonsteroidal anti-inflammatory drug aspirin and the spice curcumin retard adenoma formation when administered long-term to Apc(Min/+) mice, a model of human familial adenomatous polyposis coli."	3.72	Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin. ( Clarke, AR; Gescher, A; Perkins, S; Steward, W, 2003)
"These observations indicate that gastric mucosal prostaglandin synthesis decreases with aging in rats and that aged animals are more susceptible to aspirin-induced acute gastric mucosal injury."	3.69	Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats. ( Feldman, M; Lee, M, 1994)
" The steady-state trough MPA to ADP 20 micromol/L during 10-mg maintenance dosing was 30."	2.74	Effect of age on the pharmacokinetics and pharmacodynamics of prasugrel during multiple dosing: an open-label, single-sequence, clinical trial. ( Ernest, CS; Farid, NA; Li, YG; Ni, L; Payne, CD; Salazar, DE; Small, DS; Winters, KJ; Wrishko, RE, 2009)
"Aspirin use was also inversely associated with coronary heart disease mortality (multivariable-adjusted RR = 0."	2.73	Association of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs with cancer incidence and mortality. ( Anderson, K; Bardia, A; Cerhan, JR; Ebbert, JO; Limburg, PJ; Olson, JE; Vachon, CM; Vierkant, RA; Wang, AH, 2007)
" The most common adverse effects that occurred were related to the gastrointestinal tract, nervous system, skin, and special senses."	2.67	Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. ( Fleischmann, RM, 1992)
"Cataract is one such disease and post-translational modifications of proteins in the lens during cataract formation are described as a possible guide to the changes in other age-related conditions."	2.41	Viewing molecular mechanisms of ageing through a lens. ( Harding, JJ, 2002)
" We used femtosecond laser ablation to rupture arterioles in the cortex of both young (2-5 months old) and aged (18-29 months old) mice dosed on aspirin in their drinking water and measured the extent of penetration of both red blood cells and blood plasma into the surrounding tissue."	1.51	Aspirin treatment does not increase microhemorrhage size in young or aged mice. ( Brophy, M; Chan, S; Nishimura, N; Schaffer, CB, 2019)
"Chronic inflammation was detected in intact uninjured old nerves, characterized by increased macrophage infiltration and raised levels of monocyte chemoattractant protein 1 (MCP1) and CC chemokine ligand 11 (CCL11)."	1.48	Inflammaging impairs peripheral nerve maintenance and regeneration. ( Akula, AK; Baader, SL; Bauer, R; Büttner, R; Carlstedt, A; Mindos, T; Morrison, H; Reuter, M; Riecken, LB; Schulz, A, 2018)
"CSHA-1 participants with vascular dementia performed worse in copying pentagons and writing subtests of modified Mini-Mental State Examination test than participants with probable Alzheimer's disease."	1.43	Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging. ( Hachinski, V; Oveisgharan, S, 2016)
"Aspirin treatment is associated with diminished endogenous oxidant stress and enhanced resistance to exogenous peroxide, both likely mediated by activation of antioxidant defenses."	1.39	Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. ( Ayyadevara, S; Bharill, P; Dandapat, A; Hu, C; Khaidakov, M; Mehta, JL; Mitra, S; Shmookler Reis, RJ, 2013)
"Aspirin treatment decreased 8-OHdG levels (P < 0."	1.35	Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging. ( Boulanger, E; Bulckaen, H; Corman, B; Creusy, C; Garçon, G; Gaxatte, C; Gosset, P; Prévost, G; Puisieux, F; Robitaille, G; Roquet, V; Shirali, P, 2008)
" Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons."	1.35	Anti-inflammatory agents and cognitive decline in a bi-racial population. ( Bennett, DA; Bienias, JL; Evans, DA; Grodstein, F; Skarupski, KA; Wilson, RS, 2008)
"One hundred forty-one prostate cancer cases diagnosed between 1980 and May 2004 were confirmed by medical record review."	1.33	Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. ( Carter, HB; Corrada, MM; De Marzo, AM; Landis, PK; Metter, EJ; Pearson, JD; Platz, EA; Rohrmann, S; Watson, DJ, 2005)
" Dose-response curves were compared by analysis of the area under the curve (AUC) using independent samples t test."	1.31	Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. ( MacAllister, RJ; Prasad, S; Singer, DR; Singh, N, 2002)
"Pregnancy was authorized if disease was inactive on 20 mg/day prednisone or less for at least 1 yr."	1.30	Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies. ( Blétry, O; Darbois, Y; Godeau, P; Lê Huong, D; Lefèbvre, G; Piette, JC; Seebacher, J; Vauthier-Brouzes, D; Wechsler, B, 1997)
"Hydroxyurea was given to patients with ET with a positive history for major vascular complications or with an extreme thrombocytosis."	1.30	Acute coronary disease in essential thrombocythemia and polycythemia vera. ( Girolami, A; Randi, ML; Rinaldi, V; Rossi, C; Zerbinati, P, 1998)
"Treatment with aspirin led to a significant decrease in membrane fluidity in both patients and old controls, but had no apparent effect on the platelet membrane fluidity of younger controls."	1.29	Aspirin-induced conformational changes in platelet membrane in subjects with stroke. ( Hasan, M; Jackson, SK; Sinclair, AJ, 1995)
"Aspirin was less likely to be prescribed to older patients at discharge (79%, 82%, 70%, and 62%, P < ."	1.29	Age-related differences in the utilization of therapies post acute myocardial infarction. ( Battiola, RJ; Goodwin, JS; Malone, ML; Nachodsky, JP; Sial, SH; Solomon, DJ, 1995)
" Predicted plasma salicylate concentration-time curves were constructed for various aspirin dosage regimens."	1.29	Plasma salicylate concentrations in immature dogs following aspirin administration: comparison with adult dogs. ( Bill, RL; Bowers, LD; Caywood, DD; Cipolle, RJ; Waters, DJ, 1993)
" A dose-response relation was found between level of anger and overall CHD risk (P for trend, ."	1.29	A prospective study of anger and coronary heart disease. The Normative Aging Study. ( Kawachi, I; Sparrow, D; Spiro, A; Vokonas, P; Weiss, ST, 1996)
" At the same time, the effects of oral dosage with aspirin, and the exchange of stimulated and non-stimulated plasma were investigated."	1.28	Dietary polyenoic fatty acids change the response of cat blood platelets to inductions of aggregation by ADP. ( Davidson, BC; Haggan, J, 1990)
"Aspirin damage was dose-related and more severe in the stomach than in the duodenum."	1.28	Age does not influence acute aspirin-induced gastric mucosal damage. ( Avots-Avotins, A; Bjorkman, DJ; Mitchell, MD; Moore, JG, 1991)
"Osteoarthritis is one of the oldest and most common forms of arthritis afflicting human beings."	1.27	Osteoarthritis. ( Brandt, KD; Eyanson, S, 1984)
" Most of the pharmacokinetic parameters derived from these profiles were not significantly different between young subjects, elderly subjects and subjects with alcoholic liver disease."	1.27	Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease. ( Brooks, PM; Roberts, MS; Rumble, RH; Thomas, D; Wanwimolruk, S, 1983)
" There was no difference with either drug between the two age-groups in the mean absorption rate constant and the time at which maximum concentration in the plasma occurred."	1.26	The effect of ageing on drug absorption from the gut. ( Castleden, CM; Raymond, K; Volans, CN, 1977)
"Aspirin was discontinued and ibuprofen, 600 mg four times daily, begun."	1.26	Aspirin hepatotoxicity. ( Hindin, BI; Kanada, SA; Kolling, WM, 1978)

Research

Studies (134)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Maximum Change in Subject-reported Assessment of Symptom Severity and Frequency (PAC SYM).

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (29.85)	18.7374
1990's	28 (20.90)	18.2507
2000's	33 (24.63)	29.6817
2010's	26 (19.40)	24.3611
2020's	7 (5.22)	2.80

Authors	Studies
Fountain, WA	1
Naruse, M	1
Finch, WH	1
Claiborne, A	1
Trappe, SW	1
Trappe, TA	1
Khezrian, M	1
Waymont, JMJ	1
Myint, PK	1
McNeil, CJ	1
Whalley, LJ	1
Staff, R	1
Murray, AD	1
Woods, RL	3
Polekhina, G	1
Wolfe, R	2
Nelson, MR	3
Ernst, ME	3
Reid, CM	4
Shah, RC	3
Lockery, JE	3
Orchard, SG	3
Murray, AM	3
McNeil, JJ	3
Chan, MV	1
Chen, MH	1
Barwari, T	1
Huffman, JE	1
Armstrong, PC	1
Hwang, SJ	1
Santer, P	1
Wierer, B	1
Mayr, M	1
Kiechl, S	1
Johnson, AD	1
Willeit, J	1
Warner, TD	1
Noreen, F	1
Chaber-Ciopinska, A	1
Regula, J	1
Schär, P	1
Truninger, K	1
Espinoza, S	1
Thao, LTP	1
Ryan, J	1
Ward, SA	1
Storey, E	3
Trevaks, RE	2
Fitzgerald, SM	2
Stocks, NP	1
Williamson, JD	2
Newman, AB	2
Moriarty, F	1
Barry, A	1
Kenny, RA	1
Fahey, T	1
Kirpach, B	1
Wolfe, RS	1
Tonkin, AM	1
Margolis, KL	1
Abhayaratna, WP	2
Stocks, N	1
Beilin, LJ	1
Donnan, GA	1
Gibbs, P	1
Johnston, CI	1
Grimm, RH	1
Chau, SH	1
Sluiter, RL	1
Kievit, W	1
Wensing, M	1
Teichert, M	1
Hugtenburg, JG	1
Büttner, R	1
Schulz, A	1
Reuter, M	1
Akula, AK	1
Mindos, T	1
Carlstedt, A	1
Riecken, LB	1
Baader, SL	1
Bauer, R	1
Morrison, H	1
Chan, S	1
Brophy, M	1
Nishimura, N	1
Schaffer, CB	1
Hillson, O	1
Gonzalez, S	1
Rallis, C	1
Miller, RA	2
Harrison, DE	2
Astle, CM	2
Bogue, MA	1
Brind, J	1
Fernandez, E	1
Flurkey, K	2
Javors, M	1
Ladiges, W	1
Leeuwenburgh, C	2
Macchiarini, F	1
Nelson, J	1
Ryazanov, AG	1
Snyder, J	1
Stearns, TM	1
Vaughan, DE	1
Strong, R	2
Verdoia, M	1
Pergolini, P	1
Nardin, M	1
Rolla, R	1
Tonon, F	1
Kedhi, E	1
Suryapranata, H	1
Carriero, A	1
De Luca, G	1
Narum, S	1
Solhaug, V	1
Myhr, K	1
Brørs, O	1
Kringen, MK	1
Pomponi, M	1
Pomponi, MF	1
Mavaddat, N	1
Roalfe, A	1
Fletcher, K	1
Lip, GY	1
Hobbs, FD	1
Fitzmaurice, D	1
Mant, J	1
Burkewitz, K	1
Zhang, Y	1
Mair, WB	1
Mårtensson, J	1
Bellomo, R	1
Trenson, S	1
de Ceuninck, M	1
Arnardottir, HH	1
Dalli, J	1
Colas, RA	1
Shinohara, M	1
Serhan, CN	1
Blagosklonny, MV	1
Wehbeh, A	1
Tamim, HM	1
Abu Daya, H	1
Abou Mrad, R	1
Badreddine, RJ	1
Eloubeidi, MA	1
Rockey, DC	1
Barada, K	1
Bazhanova, ED	1
Anisimov, VN	1
Sukhanov, DS	1
Teplyĭ, DL	1
Austad, SN	1
Bartke, A	1
Oveisgharan, S	1
Hachinski, V	1
Piccolo, R	1
Magnani, G	1
Ariotti, S	1
Gargiulo, G	1
Marino, M	1
Santucci, A	1
Franzone, A	1
Tebaldi, M	1
Heg, D	1
Windecker, S	1
Valgimigli, M	1
Radovits, T	1
Gerö, D	1
Lin, LN	1
Loganathan, S	1
Hoppe-Tichy, T	1
Szabó, C	1
Karck, M	1
Sakurai, H	1
Szabó, G	1
Koltai, K	1
Feher, G	1
Kenyeres, P	1
Lenart, I	1
Alexy, T	1
Horvath, B	1
Marton, Z	1
Kesmarky, G	1
Toth, K	1
Chiu, PW	1
Ng, EK	1
Small, DS	1
Wrishko, RE	1
Ernest, CS	1
Ni, L	1
Winters, KJ	1
Farid, NA	1
Li, YG	1
Salazar, DE	1
Payne, CD	1
Sostres, C	1
Gargallo, C	1
Lanas, A	1
Marioni, RE	1
Deary, IJ	1
Murray, GD	1
Lowe, GD	1
Strachan, MW	1
Luciano, M	1
Houlihan, LM	1
Gow, AJ	1
Harris, SE	1
Rumley, A	1
Stewart, MC	1
Fowkes, FG	1
Price, JF	1
Feuring, M	1
Wehling, M	1
Ruf, A	1
Burkhardt, H	1
Schultz, A	1
Morgan, GP	1
Wong, TY	1
Woods, R	1
Tonkin, A	1
Wang, JJ	1
Kam, A	1
Janke, A	1
Essex, R	1
Budge, MM	1
Ayyadevara, S	1
Bharill, P	1
Dandapat, A	1
Hu, C	1
Khaidakov, M	1
Mitra, S	1
Shmookler Reis, RJ	1
Mehta, JL	1
Matsumoto, C	1
Matthan, NR	1
Wilk, JB	1
Lichtenstein, AH	1
Michael Gaziano, J	1
Djoussé, L	1
Jourdan, D	1
Pickering, G	1
Marchand, F	1
Gaulier, JM	1
Alliot, J	1
Eschalier, A	1
Christen, WG	2
Manson, JE	2
Glynn, RJ	2
Gaziano, JM	1
Sperduto, RD	1
Buring, JE	2
Hennekens, CH	2
Kang, JH	1
Grodstein, F	2
Perkins, S	1
Clarke, AR	1
Steward, W	1
Gescher, A	1
TRABUCCHI, E	1
CHIESARA, E	1
NUTTALL, FQ	1
DOE, RP	1
Beckman, M	1
Platz, EA	1
Rohrmann, S	1
Pearson, JD	1
Corrada, MM	1
Watson, DJ	1
De Marzo, AM	1
Landis, PK	1
Metter, EJ	1
Carter, HB	1
Easter, MJ	1
Marshall, JM	1
Jung, KJ	1
Kim, JY	1
Zou, Y	1
Kim, YJ	1
Yu, BP	1
Chung, HY	1
Soti, C	1
Csermely, P	1
Whelton, A	1
Laine, L	1
Graham, DY	1
Kang, KB	1
Rajanayagam, MA	1
van der Zypp, A	1
Majewski, H	1
Varma, SD	1
Hegde, KR	1
Pignone, M	1
Anderson, GK	1
Binns, K	1
Tilson, HH	1
Weisman, SM	1
Bardia, A	1
Ebbert, JO	1
Vierkant, RA	1
Limburg, PJ	1
Anderson, K	1
Wang, AH	1
Olson, JE	1
Vachon, CM	1
Cerhan, JR	1
Floyd, RA	1
Hensley, KL	1
Javors, MA	1
Nelson, JF	1
Ongini, E	1
Nadon, NL	1
Warner, HR	1
Matsumoto, T	1
Telman, G	1
Kouperberg, E	1
Sprecher, E	1
Yarnitsky, D	1
Bulckaen, H	1
Prévost, G	1
Boulanger, E	1
Robitaille, G	1
Roquet, V	1
Gaxatte, C	1
Garçon, G	1
Corman, B	1
Gosset, P	1
Shirali, P	1
Creusy, C	1
Puisieux, F	1
Skarupski, KA	1
Bienias, JL	1
Wilson, RS	1
Bennett, DA	1
Evans, DA	1
Harris, R	1
Eyanson, S	1
Brandt, KD	1
Roberts, MS	1
Rumble, RH	1
Wanwimolruk, S	1
Thomas, D	1
Brooks, PM	1
Ek, I	1
Thunell, S	1
Blombäck, M	1
Schmeling, JW	1
Foegh, M	1
Ramey, E	1
Ramwell, PW	1
Johnson, PC	1
Vivian, AS	1
Goldberg, IB	1
Jørgensen, KA	1
Dyerberg, J	1
Olesen, AS	1
Stoffersen, E	1
Cleland, JG	1
Hasan, M	1
Jackson, SK	1
Sinclair, AJ	1
James, MF	1
Heald, G	1
Shorter, JH	1
Turner, RA	1
Malone, ML	1
Sial, SH	1
Battiola, RJ	1
Nachodsky, JP	1
Solomon, DJ	1
Goodwin, JS	1
Barnes, CJ	1
Lee, M	3
Hardman, WE	2
Cameron, IL	1
Twersky, Y	1
Blumstein, M	1
Bank, S	1
Kranz, V	1
Feldman, M	1
Waters, DJ	1
Bowers, LD	1
Cipolle, RJ	1
Caywood, DD	1
Bill, RL	1
Cherian, M	1
Abraham, EC	2
Talley, NJ	1
Weaver, AL	1
Zinsmeister, AR	1
Melton, LJ	1
Malik, NS	1
Meek, KM	1
Kawachi, I	1
Sparrow, D	1
Spiro, A	1
Vokonas, P	1
Weiss, ST	1
Goodfield, M	1
Slattery, ML	1
Schaffer, D	1
Edwards, SL	1
Ma, KN	1
Potter, JD	1
Lê Huong, D	1
Wechsler, B	1
Vauthier-Brouzes, D	1
Seebacher, J	1
Lefèbvre, G	1
Blétry, O	1
Darbois, Y	1
Godeau, P	1
Piette, JC	1
Stickel, F	1
Meydani, M	1
Wu, D	1
Bronson, R	1
Martin, A	1
Smith, D	1
Meydani, SN	1
Russell, RM	1
Cameron, I	1
Rossi, C	1
Randi, ML	1
Zerbinati, P	1
Rinaldi, V	1
Girolami, A	1
Turunen, M	1
Sindelar, P	1
Dallner, G	1
Fong, DS	1
Barton, FB	1
Bresnick, GH	1
Ajani, UA	1
Schaumberg, DA	1
Fleming, DJ	1
Jacques, PF	1
Massaro, JM	1
D'Agostino, RB	1
Wilson, PW	1
Wood, RJ	1
Matz, RL	1
Van Overloop, B	1
Gaubert, E	1
Gairard, A	1
Napoli, C	1
Aldini, G	1
Wallace, JL	1
de Nigris, F	1
Maffei, R	1
Abete, P	1
Bonaduce, D	1
Condorelli, G	1
Rengo, F	1
Sica, V	1
D'Armiento, FP	1
Mignogna, C	1
de Rosa, G	1
Condorelli, M	1
Lerman, LO	1
Ignarro, LJ	1
Singh, N	1
Prasad, S	1
Singer, DR	1
MacAllister, RJ	1
Strain, WD	1
Lye, M	1
Harding, JJ	2
Berkowitz, BA	1
Bienenstock, H	1
Fernando, KR	1
Matsuo, T	2
Ohki, Y	1
Hewitt, WR	1
Wagner, PA	1
Bostwick, EF	1
Hook, JB	1
Kanada, SA	1
Kolling, WM	1
Hindin, BI	1
Burry, A	1
Cross, R	1
Axelsen, R	1
Seixas, FA	1
Karmazyn, M	1
Horrobin, DF	1
Oka, M	1
Manku, MS	1
Ally, AI	1
Karmali, RA	1
Morgan, RO	1
Cunnane, SC	1
Jacobs, JC	1
Sechserová, M	1
Sechser, T	1
Rasková, H	1
Elis, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Aspirin in Reducing Events in the Elderly[NCT01038583]		19,114 participants (Actual)	Observational	2010-01-31	Active, not recruiting
Mesh-Reduced Sling For Treating Stress Urinary Incontinence, Efficacy and Durability Trial[NCT05842005]		15 participants (Anticipated)	Interventional	2023-01-01	Recruiting
A Multi-center Study to Assess the Outcomes of Stapled Trans-Anal Rectal Resection (STARR) in the Treatment of Obstructed Defecation Syndrome (ODS)[NCT00256984]	Phase 4	75 participants (Actual)	Interventional	2005-10-01	Completed
[NCT00000500]	Phase 3	0 participants	Interventional	1981-09-30	Completed
Effects of Anti-IgE Antibody Omalizumab (Xolair) on Patients With Chronic Sinusitis and a Positive Allergen Test[NCT00117611]	Phase 4	14 participants (Actual)	Interventional	2005-07-31	Completed
'The Factors Associated With the Formation of Nasal Polyp'[NCT01278719]		180 participants (Anticipated)	Observational	2010-01-31	Recruiting
Prospective Observational Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab[NCT03369574]		0 participants (Actual)	Observational	2017-11-14	Withdrawn (stopped due to Study personnel diverted to other activities and the study was not commenced)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Assessed as patient-reported assessment of symptom severity and frequency (PAC-SYM)associated with constipation. Patient response options are absent, mild, moderate, severe, and very severe.12 questions relate to severity, 8 questions relate to frequency of symptoms. The lower the score, the less severe the symptoms. Sizing consistent with primary outcome; analysis was per-protocol. (NCT00256984)
Timeframe: Baseline, 6 months

PAC QOL Patient Assessment of Constipation (Overall)

Intervention	units on a scale (Mean)
Stapled Trans-Anal Rectal Resection (STARR)	1.43

PAC-QOL is Patient Assessment of Constipation, Quality of Life. The instrument consists of 28 questions on a 0-4 scale. A lower score indicates better quality of life. The score is a number without units.Change from baseline in patient assessment of constipation in quality of life as measured by the PAC QOL instrument score. The questions are designed to measure the impact constipation has had on daily life during the week prior to the subject visit. Sizing was consistent with the primary outcome; analysis was per-protocol (NCT00256984)
Timeframe: Baseline, 12 months

Percentage of Change (Reduction) in Total ODS Symptom Composite Score From Baseline to One Year Post Procedure

Intervention	units on a scale (Mean)
Stapled Trans-Anal Rectal Resection (STARR)	0.95

The primary endpoint used to assess effectiveness of STARR for treatment of ODS was the percentage of change in total ODS symptom composite score (0=worst, 24=best) 1 year after completion of the procedure. (NCT00256984)
Timeframe: one year from Baseline

Percentage of Change in ODS Symptom Composite Score From Baseline at 1 Month Post Procedure

Intervention	percentage of change (Mean)
Stapled Trans-Anal Rectal Resection (STARR)	60.8

Percentage of change in Obstructive Defecation Syndrome (ODS) symptom composite score from baseline at 1 month post procedure. This score is based on a series of questions designed to understand the extent ODS effects an individual's daily lifestyle (0 is worst score, 24 is best score). Sizing consistent with primary outcome; analysis was per-protocol. (NCT00256984)
Timeframe: Baseline, 1 month post procedure

Percentage of Change in ODS Symptom Composite Score From Baseline at 6 Months (0 is Worst Score, 24 is Best Score)

Intervention	percentage of change (Mean)
Stapled Trans-Anal Rectal Resection (STARR)	-50.7

SF-12 QOL Change (Mental Component) at 12 Months From Baseline

Intervention	percentage of change (Mean)
Stapled Trans-Anal Rectal Resection (STARR)	-57.0

SF 12 change from baseline, mental component. The SF-12 is a validated 12 question quality-of-life questionnaire. The SF-12 extracts 12 items from the SF-36 questionnaire in two six-item subscales, PCS (physical functioning) and MCS (emotional functioning). The SF-36 scores range from 0 (maximum impairment) to 100 (no impairment), the SF-12 scores range from 10 (maximum impairment) to 70 (no impairment). For this study, the endpoint is the percentage of change from baseline over 12 months post procedure. (NCT00256984)
Timeframe: Baseline, 12 months

SF-12 QOL Change From Baseline (Physical Component)at 12 Months

Intervention	units on a scale (Mean)
Stapled Trans-Anal Rectal Resection (STARR)	4.83

The SF-12 is a validated 12 question quality-of-life questionnaire. The SF-12 extracts 12 items from the SF-36 questionnaire in two six-item subscales, PCS (physical functioning) and MCS (emotional functioning). The SF-12 scores can range from 10 (maximum impairment) to 70 (no impairment). For this study, the endpoint is the percentage of change from baseline over 12 months post procedure. (NCT00256984)
Timeframe: Baseline, 12 Months

Article	Year
Prospects of Pharmacological Interventions to Organismal Aging. Biomolecular concepts, 2018, Dec-31, Volume: 9, Issue:1 Topics: Aging; Animals; Aspirin; Growth Hormone; Humans; Metformin; Resveratrol; Signal Transduction; TOR Se	2018
AMPK at the nexus of energetics and aging. Cell metabolism, 2014, Jul-01, Volume: 20, Issue:1 Topics: Aging; AMP-Activated Protein Kinases; Animals; Aspirin; Energy Metabolism; Humans; Metabolic Disease	2014
Prevention of renal dysfunction in postoperative elderly patients. Current opinion in critical care, 2014, Volume: 20, Issue:4 Topics: Acute Kidney Injury; Aged; Aging; Aspirin; Humans; Kidney; Postoperative Care; Postoperative Complic	2014
Koschei the immortal and anti-aging drugs. Cell death & disease, 2014, Dec-04, Volume: 5 Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Caloric Restriction; Exercise; Folklore; G	2014
Sex Differences in Longevity and in Responses to Anti-Aging Interventions: A Mini-Review. Gerontology, 2015, Volume: 62, Issue:1 Topics: Acarbose; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Glycoside Hydrol	2015
Predicting poor outcome from acute upper gastrointestinal hemorrhage. Gastroenterology clinics of North America, 2009, Volume: 38, Issue:2 Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endoscopy, Gastrointestinal; Esophageal and	2009
Drug-related damage of the ageing gastrointestinal tract. Best practice & research. Clinical gastroenterology, 2009, Volume: 23, Issue:6 Topics: Age Factors; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-St	2009
Pharmacological modulation of the heat shock response. Handbook of experimental pharmacology, 2006, Issue:172 Topics: Aging; Animals; Aspirin; Cytoprotection; Electromagnetic Fields; Glutamine; Heat-Shock Response; HSP	2006
Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease. The American journal of cardiology, 2006, May-08, Volume: 97, Issue:9A Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir	2006
Review article: gastrointestinal bleeding with low-dose aspirin - what's the risk? Alimentary pharmacology & therapeutics, 2006, Sep-15, Volume: 24, Issue:6 Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Ca	2006
[Unrecognized myocardial infarction]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Sep-28, Volume: Suppl 5 Pt 2 Topics: Adrenergic beta-Antagonists; Aging; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme In	2007
Cardiovascular diseases in the elderly. The Medical clinics of North America, 1983, Volume: 67, Issue:2 Topics: Aged; Aging; Amyloidosis; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Aspirin; Brain Ischemia; Car	1983
ACE inhibitors for the prevention and treatment of heart failure: why are they 'under-used'? Journal of human hypertension, 1995, Volume: 9, Issue:6 Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiac Output, Low; Clinical Trials as To	1995
Optimal management of chronic leg ulcers in the elderly. Drugs & aging, 1997, Volume: 10, Issue:5 Topics: Administration, Oral; Aged; Aging; Arterial Occlusive Diseases; Aspirin; Bandages; Combined Modality	1997
Viewing molecular mechanisms of ageing through a lens. Ageing research reviews, 2002, Volume: 1, Issue:3 Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Cellular Senescence; Cry	2002
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone. Clinical pharmacokinetics, 1976, Volume: 1, Issue:3 Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fem	1976
Arthritis in the elderly. An overview. The Medical clinics of North America, 1976, Volume: 60, Issue:6 Topics: Adolescent; Adult; Aged; Aging; Anti-Inflammatory Agents; Arthritis; Arthritis, Infectious; Arthriti	1976
Analgesic nephropathy and the renal concentrating mechanism. Pathology annual, 1977, Volume: 12 Pt 2 Topics: Aging; Amyloidosis; Analgesics; Anemia, Sickle Cell; Animals; Aspirin; Calcinosis; Dehydration; Diab	1977
[Antithrombotic drugs]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1989, Volume: 26, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Aspirin; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Mi	1989

Article	Year
Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. The journals of gerontology. Series A, Biological sciences and medical sciences, 2017, Oct-12, Volume: 72, Issue:11 Topics: Activities of Daily Living; Administration, Oral; Aged; Aged, 80 and over; Aging; Aspirin; Australia	2017
Warfarin versus aspirin for prevention of cognitive decline in atrial fibrillation: randomized controlled trial (Birmingham Atrial Fibrillation Treatment of the Aged Study). Stroke, 2014, Volume: 45, Issue:5 Topics: Aged; Aged, 80 and over; Aging; Anticoagulants; Aspirin; Atrial Fibrillation; Cognition Disorders; F	2014
Ischaemic and bleeding outcomes in elderly patients undergoing a prolonged versus shortened duration of dual antiplatelet therapy after percutaneous coronary intervention: insights from the PRODIGY randomised trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2017, May-15, Volume: 13, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspirin; Clopidogrel; Drug Therapy, Combination; Female	2017
Effect of age on the pharmacokinetics and pharmacodynamics of prasugrel during multiple dosing: an open-label, single-sequence, clinical trial. Drugs & aging, 2009, Volume: 26, Issue:9 Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aging; Aspirin; Bleeding Time; Body Mass Inde	2009
Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC neurology, 2012, Feb-08, Volume: 12 Topics: Aged; Aging; Aspirin; Australia; Brain Infarction; Cognition; Cognition Disorders; Double-Blind Meth	2012
A randomized trial of beta carotene and age-related cataract in US physicians. Archives of ophthalmology (Chicago, Ill. : 1960), 2003, Volume: 121, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspiri	2003
Association of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs with cancer incidence and mortality. Journal of the National Cancer Institute, 2007, Jun-06, Volume: 99, Issue:11 Topics: Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Cohort Studies; Cyc	2007
Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 15. American journal of ophthalmology, 1999, Volume: 128, Issue:5 Topics: Adolescent; Adult; Aged; Aging; Aspirin; Color; Color Perception; Diabetic Retinopathy; Discriminati	1999
Baseline self-reported cataract and subsequent mortality in Physicians' Health Study I. Ophthalmic epidemiology, 2000, Volume: 7, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Aspirin; Cardiovascular Diseases; Cataract; Cause of Death; H	2000
Hypersensitivity to acetylsalicylic acid (ASA) and tartrazine in patients with asthma. Clinical allergy, 1976, Volume: 6, Issue:2 Topics: Adolescent; Adult; Aged; Aging; Airway Obstruction; Aspirin; Asthma; Azo Compounds; Benzenesulfonate	1976
Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. The Journal of rheumatology. Supplement, 1992, Volume: 36 Topics: Adult; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Butanon	1992
Coronary thrombolysis and aging. Kansas medicine : the journal of the Kansas Medical Society, 1990, Volume: 91, Issue:2 Topics: Aged; Aging; Aspirin; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Fibrinolysis	1990

Article	Year
Influence of aspirin on aging skeletal muscle: Insights from a cross-sectional cohort of septuagenarians. Physiological reports, 2023, Volume: 11, Issue:8 Topics: Aging; Aspirin; Cross-Sectional Studies; Cyclooxygenase Inhibitors; Female; Humans; Male; Muscle, Sk	2023
Aspirin moderates the association between cardiovascular risk, brain white matter hyperintensity total lesion volume and processing speed in normal ageing. Maturitas, 2020, Volume: 133 Topics: Aged; Aging; Aspirin; Cardiovascular Diseases; Cognition; Female; Humans; Magnetic Resonance Imaging	2020
No Modulation of the Effect of Aspirin by Body Weight in Healthy Older Men and Women. Circulation, 2020, 03-31, Volume: 141, Issue:13 Topics: Age Factors; Aging; Aspirin; Body Weight; Female; Humans; Male	2020
Platelet Reactivity in Individuals Over 65 Years Old Is Not Modulated by Age. Circulation research, 2020, 07-17, Volume: 127, Issue:3 Topics: Age Factors; Aged; Aged, 80 and over; Aging; Arterial Occlusive Diseases; Aspirin; Blood Platelets;	2020
Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging. Clinical epigenetics, 2020, 11-03, Volume: 12, Issue:1 Topics: Aged; Aged, 80 and over; Aging; Aspirin; Case-Control Studies; Colon; Colonic Neoplasms; CpG Islands	2020
Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences, 2021, 10-13, Volume: 76, Issue:11 Topics: Activities of Daily Living; Aged; Aging; Aspirin; Disability Evaluation; Disabled Persons; Humans; I	2021
Aspirin prescribing for cardiovascular disease in middle-aged and older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing. Preventive medicine, 2021, Volume: 147 Topics: Aged; Aging; Aspirin; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Ireland; Lon	2021
Cost Effectiveness of Gastroprotection with Proton Pump Inhibitors in Older Low-Dose Acetylsalicylic Acid Users in the Netherlands. Drugs & aging, 2017, Volume: 34, Issue:5 Topics: Aged; Aging; Aspirin; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Gastrointestinal Hemo	2017
Inflammaging impairs peripheral nerve maintenance and regeneration. Aging cell, 2018, Volume: 17, Issue:6 Topics: Aging; Animals; Anti-Inflammatory Agents; Aspirin; Chemokine CCL11; Ganglia, Spinal; Inflammation; M	2018
Aspirin treatment does not increase microhemorrhage size in young or aged mice. PloS one, 2019, Volume: 14, Issue:1 Topics: Age Factors; Aging; Animals; Arterioles; Aspirin; Cerebral Cortex; Cerebral Hemorrhage; Disease Mode	2019
Glycine supplementation extends lifespan of male and female mice. Aging cell, 2019, Volume: 18, Issue:3 Topics: Adenomatosis, Pulmonary; Aging; Animals; Aspirin; Diet; Dietary Supplements; Female; Glycine; Inulin	2019
Impact of aging on platelet reactivity in diabetic patients receiving dual antiplatelet therapy. Journal of thrombosis and thrombolysis, 2019, Volume: 48, Issue:3 Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Aging; Aspirin; Clopidogrel; Diabetes	2019
Characterisation of non-warfarin-associated bleeding events reported to the Norwegian spontaneous reporting system. European journal of clinical pharmacology, 2013, Volume: 69, Issue:7 Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Ag	2013
Alzheimer's disease prevention & acetyl salicylic acid: a believable story. The Indian journal of medical research, 2014, Volume: 139, Issue:1 Topics: Aging; Alzheimer Disease; Aspirin; Humans; Synapses	2014
A calcified left ventricular mass. Acta cardiologica, 2014, Volume: 69, Issue:3 Topics: Aged, 80 and over; Aging; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; At	2014
Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. Journal of immunology (Baltimore, Md. : 1950), 2014, Oct-15, Volume: 193, Issue:8 Topics: Aging; Animals; Aspirin; Autacoids; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Unsat	2014
Aspirin Has a Protective Effect Against Adverse Outcomes in Patients with Nonvariceal Upper Gastrointestinal Bleeding. Digestive diseases and sciences, 2015, Volume: 60, Issue:7 Topics: Adult; Aged; Aging; Aspirin; Cardiovascular Diseases; Diabetes Mellitus; Female; Fibrinolytic Agents	2015
[Comparative experimental study of the influence of drugs that improve brain metabolism (angiogen, cytoflavin) on neuronal apoptosis and function of cerebral cortex during aging]. Eksperimental'naia i klinicheskaia farmakologiia, 2015, Volume: 78, Issue:2 Topics: Aging; Animals; Apoptosis; Aspirin; Behavior, Animal; Caspase 3; Caspase 8; Cerebral Cortex; Cogniti	2015
Simple Neuropsychological Tests May Identify Participants in Whom Aspirin Use Is Associated With Lower Dementia Incidence: The Canadian Study of Health and Aging. American journal of Alzheimer's disease and other dementias, 2016, Volume: 31, Issue:7 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspirin; Canada; Cyclooxygenase Inhibitors; Demen	2016
Improvement of aging-associated cardiovascular dysfunction by the orally administered copper(II)-aspirinate complex. Rejuvenation research, 2008, Volume: 11, Issue:5 Topics: Administration, Oral; Aging; Animals; Antioxidants; Aspirin; Base Sequence; Cardiovascular System; C	2008
Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. Clinical hemorheology and microcirculation, 2008, Volume: 40, Issue:4 Topics: Aged; Aging; Aspirin; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Drug Therapy, C	2008
Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts. Behavior genetics, 2011, Volume: 41, Issue:5 Topics: Aged; Aging; Aspirin; Atherosclerosis; Cognition; Cognition Disorders; Cohort Studies; Cross-Section	2011
Coagulation status in patients with coronary artery disease taking 100 mg aspirin and healthy volunteers using PFA-100® and ROTEM®. International journal of clinical pharmacology and therapeutics, 2011, Volume: 49, Issue:5 Topics: Adult; Aged; Aging; Aspirin; Blood Coagulation; Body Mass Index; Coronary Artery Disease; Female; Hu	2011
On the potential contribution of aspirin to healthy ageing programmes. Age and ageing, 2016, Volume: 45, Issue:2 Topics: Age Factors; Aging; Anticarcinogenic Agents; Aspirin; Cardiovascular Agents; Cardiovascular Diseases	2016
Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxidants & redox signaling, 2013, Feb-10, Volume: 18, Issue:5 Topics: Aging; Animals; Aspirin; Caenorhabditis elegans; Life Expectancy; Locomotion; Microscopy, Fluorescen	2013
Erythrocyte stearidonic acid and other n-3 fatty acids and CHD in the Physicians' Health Study. The British journal of nutrition, 2013, Volume: 109, Issue:11 Topics: Aged; Aging; Aspirin; beta Carotene; Case-Control Studies; Coronary Disease; Double-Blind Method; Er	2013
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat. British journal of pharmacology, 2002, Volume: 137, Issue:6 Topics: Acetaminophen; Aging; Analgesics; Animals; Aspirin; Clomipramine; Dose-Response Relationship, Drug;	2002
Regular use of nonsteroidal anti-inflammatory drugs and cognitive function in aging women. Neurology, 2003, May-27, Volume: 60, Issue:10 Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspir	2003
Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin. British journal of cancer, 2003, May-06, Volume: 88, Issue:9 Topics: Adenoma; Administration, Oral; Aging; Animals; Anticarcinogenic Agents; Aspirin; Curcumin; Female; G	2003
[VARIATIONS IN THE ENZYME ACTIVITY AND PHARMACOLOGIC EFFECTS IN RELATION TO AGE]. Giornale di gerontologia. Supplemento, 1964, Volume: 23 Topics: Aging; Aldosterone; Aspirin; Carisoprodol; Cholesterol; Cholinesterases; Dexamethasone; Meprobamate;	1964
THE ACHILLES REFLEX IN THYROID DISORDERS; A CRITICAL EVALUATION. Annals of internal medicine, 1964, Volume: 61 Topics: Achilles Tendon; Adrenocorticotropic Hormone; Aging; Anemia; Anemia, Pernicious; Aspirin; Cold Tempe	1964
Placing bets. National Institute on Aging committee chooses three compounds for definitive longevity testing. Science of aging knowledge environment : SAGE KE, 2004, Feb-04, Volume: 2004, Issue:5 Topics: Aging; Animals; Aspirin; Flurbiprofen; Longevity; Mice; National Institutes of Health (U.S.); United	2004
Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005, Volume: 14, Issue:2 Topics: Acetaminophen; Aged; Aging; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir	2005
Contribution of prostanoids to endothelium-dependent vasodilatation in the digital circulation of women with primary Raynaud's disease. Clinical science (London, England : 1979), 2005, Volume: 109, Issue:1 Topics: Acetylcholine; Adult; Aging; Analysis of Variance; Aspirin; Case-Control Studies; Cyclooxygenase Inh	2005
Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-kappaB in aged rats. Mechanisms of ageing and development, 2006, Volume: 127, Issue:3 Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gene Expression Regulation; Inflam	2006
Risk of low-dose aspirin: emphasis on outliers undermines the credibility of the conclusions. Alimentary pharmacology & therapeutics, 2007, Feb-01, Volume: 25, Issue:3 Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Ca	2007
A role for cyclooxygenase in aging-related changes of beta-adrenoceptor-mediated relaxation in rat aortas. Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Aging; Animals; Aorta, Thoracic; Aspirin; Immunohistochemistry; Indome	2007
Susceptibility of the ocular lens to nitric oxide: implications in cataractogenesis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:2 Topics: Adenosine Triphosphate; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological	2007
Aspirin use among adults aged 40 and older in the United States: results of a national survey. American journal of preventive medicine, 2007, Volume: 32, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Aging; Aspirin; Cardiovascular Diseases; Female; Health Surveys; Hum	2007
An Aging Interventions Testing Program: study design and interim report. Aging cell, 2007, Volume: 6, Issue:4 Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cyclic N-Oxides; Dru	2007
Distribution of etiologies in patients above and below age 45 with first-ever ischemic stroke. Acta neurologica Scandinavica, 2008, Volume: 117, Issue:5 Topics: Adult; Age Distribution; Aging; Anticoagulants; Aspirin; Atrial Fibrillation; Embolism; Female; Fora	2008
Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4 Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcholine; Age Factors; Aging; Animals; Antioxidants; Aorta; Aspiri	2008
Anti-inflammatory agents and cognitive decline in a bi-racial population. Neuroepidemiology, 2008, Volume: 30, Issue:1 Topics: Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Black People; Chic	2008
Osteoarthritis. Primary care, 1984, Volume: 11, Issue:2 Topics: Adrenal Cortex Hormones; Adult; Aging; Anti-Inflammatory Agents; Arthrodesis; Arthroplasty; Aspirin;	1984
Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease. European journal of clinical pharmacology, 1983, Volume: 25, Issue:2 Topics: Adult; Aged; Aging; Aspirin; Blood Proteins; Humans; Kinetics; Liver Diseases, Alcoholic; Male; Midd	1983
Enhanced in vivo platelet activation in diabetes mellitus. Scandinavian journal of haematology, 1982, Volume: 29, Issue:2 Topics: Adult; Aged; Aging; Aspirin; Blood Platelets; Calcium Channel Blockers; Cardiovascular Diseases; Dia	1982
Reevaluation of sex differences in platelet aggregation in a physiologic system. Progress in lipid research, 1981, Volume: 20 Topics: Adenosine Diphosphate; Adult; Aging; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Female;	1981
Gastrointestinal consequences of treatment with drugs in elderly patients. Journal of the American Geriatrics Society, 1982, Volume: 30, Issue:11 Suppl Topics: Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Digestive System Physiological Phenom	1982
Recognizing chronic salicylate intoxication in the elderly. Geriatrics, 1982, Volume: 37, Issue:11 Topics: Aged; Aging; Analgesics; Aspirin; Humans; Kinetics; Respiration Disorders	1982
Acetylsalicylic acid, bleeding time and age. Thrombosis research, 1980, Sep-15, Volume: 19, Issue:6 Topics: Adolescent; Adult; Aged; Aging; Aspirin; Bleeding Time; Child; Dose-Response Relationship, Drug; Fem	1980
Aspirin-induced conformational changes in platelet membrane in subjects with stroke. Gerontology, 1995, Volume: 41, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Aspirin; Blood Platelets; Case-Control Studies; Cell Membrane	1995
Joint space measurement in hand radiographs using computerized image analysis. Arthritis and rheumatism, 1995, Volume: 38, Issue:7 Topics: Adult; Aged; Aging; Arthritis, Rheumatoid; Aspirin; Female; Fenoprofen; Finger Joint; Hand; Humans;	1995
Age-related differences in the utilization of therapies post acute myocardial infarction. Journal of the American Geriatrics Society, 1995, Volume: 43, Issue:6 Topics: Age Factors; Aged; Aged, 80 and over; Aging; Angioplasty, Balloon; Aspirin; Calcium Channel Blockers	1995
Aspirin, age, and proximity to lymphoid nodules influence cell proliferation parameters in rat colonic crypts. Cell proliferation, 1995, Volume: 28, Issue:2 Topics: Aging; Analysis of Variance; Animals; Aspirin; Cell Communication; Cell Division; Colon; Epithelial	1995
Effect of aging on gastric mucosal proliferation in rats treated with aspirin. Digestive diseases and sciences, 1995, Volume: 40, Issue:3 Topics: Adaptation, Physiological; Aging; Animals; Aspirin; Cell Division; Gastric Mucosa; Rats; Rats, Inbre	1995
Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats. Gastroenterology, 1994, Volume: 107, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Aging; Analysis of Variance; Animals; Aspirin; Dinoprost; Dinoprostone	1994
Plasma salicylate concentrations in immature dogs following aspirin administration: comparison with adult dogs. Journal of veterinary pharmacology and therapeutics, 1993, Volume: 16, Issue:3 Topics: Administration, Oral; Aging; Animals; Aspirin; Dogs; Female; Fluorescence Polarization Immunoassay;	1993
Glycation of human lens crystallins: effect of age and aspirin treatment. Ophthalmic research, 1993, Volume: 25, Issue:6 Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspirin; Child; Child, Preschool; Ch	1993
Functional constipation and outlet delay: a population-based study. Gastroenterology, 1993, Volume: 105, Issue:3 Topics: Adult; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Constipatio	1993
Functional constipation and outlet delay: a population-based study. Gastroenterology, 1993, Volume: 105, Issue:3 Topics: Adult; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Constipatio	1993
Functional constipation and outlet delay: a population-based study. Gastroenterology, 1993, Volume: 105, Issue:3 Topics: Adult; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Constipatio	1993
Functional constipation and outlet delay: a population-based study. Gastroenterology, 1993, Volume: 105, Issue:3 Topics: Adult; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Constipatio	1993
Vitamins and analgesics in the prevention of collagen ageing. Age and ageing, 1996, Volume: 25, Issue:4 Topics: Acetaminophen; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Cellula	1996
A prospective study of anger and coronary heart disease. The Normative Aging Study. Circulation, 1996, Nov-01, Volume: 94, Issue:9 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anger; Angina Pecto	1996
Are dietary factors involved in DNA methylation associated with colon cancer? Nutrition and cancer, 1997, Volume: 28, Issue:1 Topics: Aged; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studie	1997
Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies. British journal of rheumatology, 1997, Volume: 36, Issue:7 Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A	1997
Effect of vitamin E supplementation on prostaglandin concentrations in aspirin-induced acute gastric injury in aged rats. The American journal of clinical nutrition, 1997, Volume: 66, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Aging; Animals; Aspirin; Dinoprostone; Dose-Resp	1997
Age-related changes in gastric mucosal repair and proliferative activities in rats exposed acutely to aspirin. Gerontology, 1998, Volume: 44, Issue:4 Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Gastric Mucosa; Mal	1998
Acute coronary disease in essential thrombocythemia and polycythemia vera. Journal of internal medicine, 1998, Volume: 244, Issue:1 Topics: Adult; Aged; Aging; Antisickling Agents; Aspirin; Female; Follow-Up Studies; Humans; Hydroxyurea; Ma	1998
Induction of endogenous coenzyme Q biosynthesis by administration of peroxisomal inducers. BioFactors (Oxford, England), 1999, Volume: 9, Issue:2-4 Topics: Aging; Animals; Aspirin; Clofibrate; Dehydroepiandrosterone; Diethylhexyl Phthalate; Intracellular M	1999
Aspirin intake and the use of serum ferritin as a measure of iron status. The American journal of clinical nutrition, 2001, Volume: 74, Issue:2 Topics: Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Cy	2001
Maturation reveals a decrease in endothelium-dependent contraction induced by depolarization in the aorta of spontaneously hypertensive rats. Life sciences, 2001, Aug-31, Volume: 69, Issue:15 Topics: Aging; Animals; Aorta; Aspirin; Biphenyl Compounds; Body Weight; Endothelium, Vascular; Heptanoic Ac	2001
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis. Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-05, Volume: 99, Issue:3 Topics: Aging; Angioplasty, Balloon, Coronary; Animals; Aspirin; Coronary Restenosis; Coronary Vessels; Dise	2002
Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. Clinical science (London, England : 1979), 2002, Volume: 102, Issue:5 Topics: Aged; Aging; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vasc	2002
Chronic pain, bereavement and overdose in a depressed elderly woman. Age and ageing, 2002, Volume: 31, Issue:3 Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Aortic Aneurysm, Thoracic; Aspirin; Back Pain; Bereav	2002
Classification of platelet aggregation patterns with two ADP solutions (the double-ADP method) and its clinical application to diabetes mellitus. Thrombosis research, 1977, Volume: 11, Issue:4 Topics: Adenosine Diphosphate; Adult; Aged; Aging; Aspirin; Blood Glucose; Cholesterol; Diabetes Mellitus; D	1977
Transport ontogeny and selective substrate stimulation as models for identification of multiple renal organic anion transport systems. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:3 Topics: 4-Aminobenzoic Acid; Aging; Animals; Animals, Newborn; Anions; Aspirin; Biological Transport, Active	1977
Aspirin hepatotoxicity. American journal of hospital pharmacy, 1978, Volume: 35, Issue:3 Topics: Adolescent; Adult; Aging; Aspirin; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Li	1978
Drug/alcohol interactions: avert potential dangers. Geriatrics, 1979, Volume: 34, Issue:10 Topics: Aged; Aging; Alcohol Drinking; Alcoholism; Antidepressive Agents, Tricyclic; Aspirin; California; Di	1979
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins. Life sciences, 1979, Dec-03, Volume: 25, Issue:23 Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I	1979
Salicylate treatment of epidemic Kawasaki disease in New York City. Therapeutic drug monitoring, 1979, Volume: 1, Issue:1 Topics: Aging; Aspirin; Child; Child, Preschool; Disease Outbreaks; Feces; Humans; Infant; Lymphatic Disease	1979
Ontogenic drug studies in calves. I. Age dependent salicylate levels and metabolism. Arzneimittel-Forschung, 1979, Volume: 29, Issue:4 Topics: Aging; Animals; Animals, Newborn; Aspirin; Cattle; Salicylates	1979
[Significance of two concentrations of adenosine diphosphate inducing platelet aggregation in patients with diabetes mellitus (author's transl)]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1978, Volume: 15, Issue:6 Topics: Adenosine Diphosphate; Adult; Aged; Aging; Aspirin; Diabetes Mellitus; Diabetic Retinopathy; Female;	1978
Granulocyte adherence in the elderly. American journal of clinical pathology, 1977, Volume: 67, Issue:1 Topics: Adolescent; Adult; Aged; Aging; Aspirin; Black People; Cell Adhesion; Child; Female; Granulocytes; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Nasal polyps in asthma and rhinitis. A review of 6,037 patients. The Journal of allergy and clinical immunology, 1977, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H	1977
Comparable inhibition of aggregation of PRP of neonates and adults by aspirin. Haemostasis, 1977, Volume: 6, Issue:2 Topics: Adenosine Diphosphate; Adult; Aging; Aspirin; Collagen; Dose-Response Relationship, Drug; Epinephrin	1977
The effect of ageing on drug absorption from the gut. Age and ageing, 1977, Volume: 6, Issue:3 Topics: Administration, Oral; Adult; Aged; Aging; Aspirin; Biological Availability; Humans; Intestinal Absor	1977
Dual effects of aspirin in guinea-pig lungs. British journal of pharmacology, 1976, Volume: 57, Issue:4 Topics: Aging; Animals; Aspirin; Bronchi; Constriction, Pathologic; Female; Guinea Pigs; In Vitro Techniques	1976
Mistaken guidelines for thrombolytic therapy of acute myocardial infarction in the elderly. Journal of the American College of Cardiology, 1991, Volume: 17, Issue:5 Topics: Aged; Aging; Aspirin; Drug Therapy, Combination; Humans; Myocardial Infarction; Streptokinase; Survi	1991
Age does not influence acute aspirin-induced gastric mucosal damage. Gastroenterology, 1991, Volume: 100, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aging; Aspirin; Dose-Response Relationship, Drug; Duodenu	1991
Change in formation of gastric lesions by aspirin during aging in rats. Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:8 Topics: Aging; Animals; Aspirin; Biological Assay; Epoprostenol; Gastric Mucosa; Male; Rats; Rats, Inbred St	1990
India-US case-control study of age-related cataracts. Archives of ophthalmology (Chicago, Ill. : 1960), 1990, Volume: 108, Issue:1 Topics: Aging; Aspirin; Case-Control Studies; Cataract; Humans; India; United States	1990
Dietary polyenoic fatty acids change the response of cat blood platelets to inductions of aggregation by ADP. Prostaglandins, leukotrienes, and essential fatty acids, 1990, Volume: 39, Issue:1 Topics: Adenosine Diphosphate; Aging; Animals; Aspirin; Blood Platelets; Cats; Dietary Fats, Unsaturated; Fa	1990
The effects of acetylsalicylic acid on phosphoenolpyruvate carboxykinase activity and acinar heterotopy in livers from juvenile and adult rats. Histochemistry, 1990, Volume: 94, Issue:2 Topics: Aging; Animals; Aspirin; Female; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Sex Fac	1990
Hydroxyurea-induced switching of hemoglobin proportions toward newborn values in normal adult rats is blocked by acetylsalicylic acid. Progress in clinical and biological research, 1989, Volume: 319 Topics: Aging; Anemia; Animals; Animals, Newborn; Aspirin; Fetal Hemoglobin; Hemoglobins; Hydroxyurea; Rats;	1989
Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors. Experientia, 1989, May-15, Volume: 45, Issue:5 Topics: Adult; Aged; Aging; Aspirin; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Female; Histamine; H	1989
Ontogeny of isoproterenol-stimulated renin secretion from sheep renal cortical slices. The American journal of physiology, 1989, Volume: 256, Issue:6 Pt 2 Topics: Aging; Animals; Animals, Newborn; Aspirin; Edetic Acid; Fetus; Gestational Age; Isoproterenol; Kidne	1989
The effect of anti-inflammatory drug administration on the course of retinal dystrophy in RCS rats. Progress in clinical and biological research, 1989, Volume: 314 Topics: Aging; Animals; Aspirin; Female; Male; Phagocytosis; Photoreceptor Cells; Pigment Epithelium of Eye;	1989
The effect of aging on percutaneous absorption in man. Journal of pharmacokinetics and biopharmaceutics, 1989, Volume: 17, Issue:6 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Aspirin; B	1989
Nonenzymatic glycosylation (glycation) of lens crystallins in diabetes and aging. Progress in clinical and biological research, 1989, Volume: 304 Topics: Acetylation; Aging; Animals; Aspirin; Cataract; Crystallins; Diabetes Mellitus, Experimental; Glycos	1989
Management of transient ischemic attacks. Hospital practice (Office ed.), 1987, Mar-15, Volume: 22, Issue:3 Topics: Aged; Aging; Anticoagulants; Aspirin; Cerebrovascular Disorders; Diagnosis, Differential; Humans; Is	1987
Age and the antihypertensive effect of aspirin in rats. British journal of pharmacology, 1988, Volume: 94, Issue:3 Topics: Aging; Animals; Antihypertensive Agents; Aspirin; Dinoprost; Kidney; Male; Rats; Rats, Inbred SHR; R	1988
Renal prostaglandin E2 synthesis and degradation in the developing rat. Biology of the neonate, 1985, Volume: 48, Issue:5 Topics: Aging; Animals; Aspirin; Cytosol; Dinoprostone; Glomerular Filtration Rate; Inulin; Kidney Cortex; K	1985
Pharmacological modification of glutathione and NADP+ reduction. Advances in experimental medicine and biology, 1972, Volume: 27 Topics: Adult; Aging; Aspirin; Binding, Competitive; Chloramphenicol; Erythrocytes; Glucosephosphate Dehydro	1972
Degenerative joint disease (oasteoarthritis). JAMA, 1973, Apr-30, Volume: 224, Issue:5 Suppl Topics: Aged; Aging; Aspirin; Cartilage, Articular; Chondroitin; Female; Finger Joint; Glucocorticoids; Hip	1973
Effect of chronic administration of acetylsalicylic acid on lipid metabolism in growing rats. Experientia, 1968, Sep-15, Volume: 24, Issue:9 Topics: Adrenal Glands; Aging; Animals; Arachidonic Acids; Aspirin; Brain; Fatty Acids; Liver; Male; Palmiti	1968

aspirin and Aging