aspirin has been researched along with Adjuvant Arthritis in 70 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combined effect of acetylsalicylic acid (ASA) and misoprostol (MISO) on adjuvant arthritis was investigated on rats." | 7.68 | Acetylsalicylic acid and misoprostol combination in adjuvant arthritis of rats. ( Dizbay-Sak, S; Melli, M; Saray, A; Taşcilar, O, 1993) |
| "The effect of combination NSAID therapy of tilomisole with aspirin or naproxen was studied in rats with carrageenan-induced paw edema and established adjuvant arthritis." | 7.68 | Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat. ( Calhoun, W; Carlson, RP; Copenhaver, TW; Datko, LJ; Gilman, SC, 1992) |
| "The effect of treatment with the new anti-inflammatory drug etodolac on the articular and bone pathology associated with adjuvant arthritis in rats has been compared to the effects produced by aspirin and naproxen." | 7.67 | Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen. ( Klicius, J; Martel, RR; Metcalf, G, 1984) |
| "We studied the effects of two non-steroidal anti-inflammatory analgesics (NSAIAs), acetylsalicylic acid (ASA) and acetaminophen, on sleep patterns in rats with adjuvant-induced arthritis." | 7.67 | Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989) |
| "Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms." | 5.40 | Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014) |
| "Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals." | 5.31 | A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Adjuvant arthritis was induced in rats with and without prophylactic losartan (AT1R antagonist) treatment." | 3.79 | Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis. ( Dunning, L; Ferrell, WR; Lockhart, JC; Mackenzie, A, 2013) |
| "Phospho-aspirin, phospho-ibuprofen and phospho-sulindac were safer than their parent NSAIDs, were highly effective in rat adjuvant arthritis and inhibited many key mediators in the pathophysiology of RA." | 3.77 | The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. ( Huang, L; Johnson, F; Komninou, D; Mackenzie, G; Ouyang, N; Rigas, B; Sun, Y; Xie, G, 2011) |
| "The present study was undertaken to assess the activity/anti-inflammatory potential of Linum usitatissimum fixed oil against castor oil-induced diarrhoea, turpentine oil-induced joint oedema, formaldehyde and Complete Freund's Adjuvant (CFA)-induced arthritis in Wistar albino rats." | 3.76 | Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats. ( Kaithwas, G; Majumdar, DK, 2010) |
| " Furthermore bukittinggine could significantly reduce fever in yeast-induced hyperthermic rats and possessed analgesic activity comparable to that of acetylsalicylic acid when tested in acetic acid-induced writhing response in mice." | 3.70 | Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum. ( Arbain, D; Kanjanapothi, D; Panthong, A; Taesotikul, T; Thitiponpunt, Y, 1998) |
| "A series of 2-substituted- and 2,3-disubstituted-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1H- pyrroles was synthesized and found to be active in the rat adjuvant arthritis model of inflammation." | 3.69 | Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR. ( Galbraith, W; Gans-Brangs, K; Grubb, M; Hewes, WE; Jaffee, B; Kenney, JP; Kerr, J; Wilkerson, WW; Wong, N, 1994) |
| " Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan-induced edema and acetic acid-induced writhing assays, respectively." | 3.69 | Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4-[1-oxo-(3-substituted aryl)-2-propenyl]-3-phenylsydnones and of 3-[4-[3-(substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones. ( Rao, MN; Satyanarayana, K, 1995) |
| "The combined effect of acetylsalicylic acid (ASA) and misoprostol (MISO) on adjuvant arthritis was investigated on rats." | 3.68 | Acetylsalicylic acid and misoprostol combination in adjuvant arthritis of rats. ( Dizbay-Sak, S; Melli, M; Saray, A; Taşcilar, O, 1993) |
| "The effect of combination NSAID therapy of tilomisole with aspirin or naproxen was studied in rats with carrageenan-induced paw edema and established adjuvant arthritis." | 3.68 | Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat. ( Calhoun, W; Carlson, RP; Copenhaver, TW; Datko, LJ; Gilman, SC, 1992) |
| " Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model." | 3.67 | Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives. ( Sancilio, LF; Sleevi, MC; Walsh, DA, 1984) |
| "The effect of treatment with the new anti-inflammatory drug etodolac on the articular and bone pathology associated with adjuvant arthritis in rats has been compared to the effects produced by aspirin and naproxen." | 3.67 | Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen. ( Klicius, J; Martel, RR; Metcalf, G, 1984) |
| "We studied the effects of two non-steroidal anti-inflammatory analgesics (NSAIAs), acetylsalicylic acid (ASA) and acetaminophen, on sleep patterns in rats with adjuvant-induced arthritis." | 3.67 | Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989) |
| "Sequential potentiation of antiinflammatory activity of dexamethasone was obtained by co-administration of diclofenac-Na (and indomethacin), but not of phenylbutazone and, apparently, of acetylsalicylic acid (ASA) in the carrageenin rat paw edema." | 3.67 | On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis. ( Bekemeier, H; Hirschelmann, R, 1986) |
| " As a model to explore these questions, the effect of oral administration of aspirin or ethanol on gastric lesion formation was examined in rats with or without established adjuvant-induced polyarthritis." | 3.67 | Altered susceptibility of arthritic rats to the gastric lesion-inducing effects of aspirin or ethanol and the antilesion effect of rioprostil. ( Fuller, BL; Genna, T; Katz, LB; Shriver, DA; Tolman, EL, 1987) |
| "One hundred analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti-inflammatory tests and the 2-phenyl-1,4-benzoquinone writhing and inflamed paw pressure analgesic tests." | 3.65 | Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs. ( Child, RG; Osterberg, AC; Sloboda, AE; Tomcufcik, AS, 1977) |
| "Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms." | 1.40 | Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014) |
| "Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals." | 1.31 | A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "The gastric toxic effects of aspirin (ASA) and NCX-4016, a nitric oxide (NO)-releasing ASA, were compared in normal, cirrhotic, and arthritic rats." | 1.31 | Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis. ( Kato, S; Komoike, Y; Suzuki, K; Takeuchi, K; Ukawa, H, 2001) |
| " It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity." | 1.26 | Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles. ( Ariyan, ZS; Fogt, SW; Heilman, RD; Matthews, RJ; Powers, LJ; Rippin, DJ, 1981) |
| " In addition, dose-response derived potencies show fenbufen more potent than ASA and at least as potent as phenylbutazone in all five tests." | 1.26 | A new non-steroidal anti-inflammatory analgesic: gamma-oxo (1,1'-biphenyl)-4-butanoic acid (fenbufen). Chemistry and activity of analogs. ( Child, RG; Osterberg, AC; Sloboda, AE; Tomcufcik, AS, 1980) |
| "It is mainly the secondary phase of adjuvant arthritis which cannot be inhibited by treatment with several proteins." | 1.26 | The modulation of inflammation by the acute phase reaction in adjuvant arthritis in rats. ( Bekemeier, H; Hirschelmann, R; Schade, R, 1981) |
| "Aspirin treatment prevented thrombocytosis and formation of platelet aggregates." | 1.26 | Thrombocytosis and platelet aggregates in the circulation of adjuvant arthritic rats. ( Görög, P; Kovács, IB, 1978) |
| " These results suggest that Y-8004 may make feasible a reduction in dosage or a withdrawal of the steroid prescription." | 1.26 | [Pharmacological studies of 2-(5H-(1)benzopyrano[2,3-b]pyridin-7-yl)propionic acid (Y-8004). (3) Its interaction with anti-inflammatory agents]. ( Foto, K; Imayoshi, T; Kadobe, Y; Maruyama, Y, 1977) |
| "Butibufen was within the potency range of ibuprofen as an antipyretic and analgesic agent and greater than that of acetylsalicylic acid." | 1.26 | Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. ( Aparicio, L, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (60.00) | 18.7374 |
| 1990's | 13 (18.57) | 18.2507 |
| 2000's | 6 (8.57) | 29.6817 |
| 2010's | 9 (12.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, RL | 1 |
| Pessolano, AA | 1 |
| Witzel, B | 1 |
| Lanza, T | 1 |
| Shen, TY | 1 |
| Van Arman, CG | 1 |
| Risley, EA | 1 |
| Welstead, WJ | 1 |
| Moran, HW | 1 |
| Stauffer, HF | 1 |
| Turnbull, LB | 1 |
| Sancilio, LF | 2 |
| Buckler, RT | 1 |
| Hartzler, HE | 1 |
| Kurchacova, E | 1 |
| Nichols, G | 1 |
| Phillips, BM | 1 |
| O'Rourke, M | 1 |
| Lang, SA | 1 |
| cohen, E | 1 |
| Lazer, ES | 1 |
| Matteo, MR | 1 |
| Possanza, GJ | 1 |
| Sharpe, TR | 1 |
| Cherkofsky, SC | 1 |
| Hewes, WE | 2 |
| Smith, DH | 1 |
| Gregory, WA | 1 |
| Haber, SB | 1 |
| Leadbetter, MR | 1 |
| Whitney, JG | 1 |
| Walsh, DA | 1 |
| Sleevi, MC | 1 |
| Toja, E | 1 |
| Selva, D | 2 |
| Schiatti, P | 2 |
| Powers, LJ | 1 |
| Fogt, SW | 1 |
| Ariyan, ZS | 1 |
| Rippin, DJ | 1 |
| Heilman, RD | 1 |
| Matthews, RJ | 1 |
| Wilkerson, WW | 1 |
| Galbraith, W | 1 |
| Gans-Brangs, K | 1 |
| Grubb, M | 1 |
| Jaffee, B | 1 |
| Kenney, JP | 1 |
| Kerr, J | 1 |
| Wong, N | 1 |
| Shi, JB | 1 |
| Chen, LZ | 1 |
| Wang, BS | 1 |
| Huang, X | 1 |
| Jiao, MM | 1 |
| Liu, MM | 1 |
| Tang, WJ | 1 |
| Liu, XH | 1 |
| Zhang, N | 1 |
| Liu, Z | 1 |
| Luo, H | 1 |
| Wu, W | 1 |
| Nie, K | 1 |
| Cai, L | 1 |
| Tan, S | 1 |
| Chen, X | 1 |
| Huang, Y | 1 |
| Liu, J | 1 |
| Lv, M | 1 |
| Zhang, X | 1 |
| Fan, Y | 1 |
| Lin, Y | 1 |
| Ye, S | 1 |
| Liu, Y | 1 |
| Wu, L | 1 |
| Xu, J | 1 |
| Mackenzie, A | 1 |
| Dunning, L | 1 |
| Ferrell, WR | 1 |
| Lockhart, JC | 1 |
| El-Sayed, RM | 1 |
| Moustafa, YM | 1 |
| El-Azab, MF | 1 |
| Sun, LL | 1 |
| Wu, H | 1 |
| Zhang, YZ | 1 |
| Wang, R | 1 |
| Wang, WY | 1 |
| Wang, W | 1 |
| Li, SP | 1 |
| Dai, L | 1 |
| Zhang, ZR | 1 |
| Kaithwas, G | 1 |
| Majumdar, DK | 1 |
| Conte, FP | 1 |
| Menezes-de-Lima, O | 1 |
| Verri, WA | 1 |
| Cunha, FQ | 1 |
| Penido, C | 1 |
| Henriques, MG | 1 |
| Huang, L | 1 |
| Mackenzie, G | 1 |
| Ouyang, N | 1 |
| Sun, Y | 1 |
| Xie, G | 1 |
| Johnson, F | 1 |
| Komninou, D | 1 |
| Rigas, B | 1 |
| Singh, S | 1 |
| Nair, V | 1 |
| Gupta, YK | 1 |
| Fiorucci, S | 1 |
| Di Lorenzo, A | 1 |
| Renga, B | 1 |
| Farneti, S | 1 |
| Morelli, A | 1 |
| Cirino, G | 1 |
| Whitehouse, MW | 2 |
| Khayyal, MT | 1 |
| El-Ghazaly, MA | 1 |
| Abdallah, DM | 1 |
| Okpanyi, SN | 1 |
| Kelber, O | 1 |
| Weiser, D | 1 |
| Martel, RR | 1 |
| Klicius, J | 1 |
| Metcalf, G | 1 |
| Guilbaud, G | 2 |
| Benoist, JM | 1 |
| Gautron, M | 1 |
| Kayser, V | 1 |
| Sofia, RD | 3 |
| Child, RG | 2 |
| Osterberg, AC | 2 |
| Sloboda, AE | 2 |
| Tomcufcik, AS | 2 |
| Görög, P | 2 |
| Kovács, IB | 2 |
| Sugishita, E | 1 |
| Amagaya, S | 1 |
| Ogihara, Y | 1 |
| Hirschelmann, R | 2 |
| Schade, R | 1 |
| Bekemeier, H | 2 |
| Isakson, P | 1 |
| Seibert, K | 1 |
| Masferrer, J | 1 |
| Salvemini, D | 1 |
| Lee, L | 1 |
| Needleman, P | 1 |
| Satyanarayana, K | 1 |
| Rao, MN | 1 |
| Franch, A | 1 |
| Castellote, C | 1 |
| Castell, M | 1 |
| Dauksas, V | 1 |
| Gaidelis, P | 1 |
| Udrènaitè, E | 1 |
| Kuliesius, V | 1 |
| Labanauskas, L | 1 |
| Abbadie, C | 1 |
| Besson, JM | 1 |
| Taşcilar, O | 1 |
| Saray, A | 1 |
| Dizbay-Sak, S | 1 |
| Melli, M | 1 |
| Panthong, A | 1 |
| Kanjanapothi, D | 1 |
| Thitiponpunt, Y | 1 |
| Taesotikul, T | 1 |
| Arbain, D | 1 |
| Hung, DY | 1 |
| Mellick, GD | 1 |
| Masci, PP | 1 |
| Whitaker, AN | 1 |
| Roberts, MS | 1 |
| Okuyama, K | 1 |
| Jinbo, M | 1 |
| Saito, N | 1 |
| Igarashi, S | 1 |
| Narita, H | 1 |
| Kinoshita, M | 1 |
| LaBuda, CJ | 1 |
| Fuchs, PN | 1 |
| Kato, S | 1 |
| Suzuki, K | 1 |
| Ukawa, H | 1 |
| Komoike, Y | 1 |
| Takeuchi, K | 1 |
| Diamantis, W | 1 |
| Ludwig, BJ | 1 |
| Phillips, NC | 1 |
| Page-Thomas, DP | 1 |
| Rosenbaum, ES | 1 |
| Barbieri, EJ | 1 |
| Tarzia, G | 1 |
| Panzone, G | 1 |
| Maruyama, Y | 1 |
| Imayoshi, T | 1 |
| Foto, K | 1 |
| Kadobe, Y | 1 |
| Rainsford, KD | 1 |
| Sofia, DR | 1 |
| Knobloch, LC | 1 |
| Douglas, JF | 1 |
| Aparicio, L | 1 |
| Shriver, DA | 2 |
| Dove, PA | 1 |
| White, CB | 1 |
| Sandor, A | 1 |
| Rosenthale, ME | 1 |
| DiPasquale, G | 1 |
| Rassaert, C | 1 |
| Welaj, P | 1 |
| Tripp, L | 1 |
| Calhoun, W | 1 |
| Gilman, SC | 2 |
| Datko, LJ | 1 |
| Copenhaver, TW | 1 |
| Carlson, RP | 2 |
| Kishore, V | 2 |
| McQueen, DS | 1 |
| Iggo, A | 2 |
| Birrell, GJ | 1 |
| Grubb, BD | 1 |
| Ray, SM | 1 |
| Roy, A | 1 |
| Lahiri, SC | 1 |
| Landis, CA | 1 |
| Robinson, CR | 1 |
| Helms, C | 1 |
| Levine, JD | 1 |
| De Castro-Costa, M | 1 |
| Gybels, J | 1 |
| Kupers, R | 1 |
| Van Hees, J | 1 |
| Katz, LB | 1 |
| Genna, T | 1 |
| Fuller, BL | 1 |
| Tolman, EL | 1 |
| Seiffge, D | 1 |
| Kremer, E | 1 |
| Fujiyoshi, T | 1 |
| Iida, H | 1 |
| Saito, M | 1 |
| Ikeda, K | 1 |
| Yamaura, T | 1 |
| Uematsu, T | 1 |
| Braga, PC | 1 |
| Biella, G | 1 |
| Tiengo, M | 1 |
| Fraschini, F | 1 |
| Larsen, JJ | 1 |
| Arnt, J | 1 |
| Puig Parellada, P | 1 |
| Chang, J | 1 |
| Lewis, AJ | 1 |
| Connolly, K | 1 |
| Stecher, VJ | 1 |
| Kaplan, JE | 1 |
| Mielens, Z | 1 |
| Rostami, HJ | 1 |
| Saelens, JK | 1 |
1 review available for aspirin and Adjuvant Arthritis
| Article | Year |
|---|---|
Discovery of a better aspirin.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Carra | 1995 |
69 other studies available for aspirin and Adjuvant Arthritis
| Article | Year |
|---|---|
2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1978 |
Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzophenones; Biotransformation; Female | 1979 |
Synthesis and antiinflammatory activity of some 1,2,3- and 1,2,4-triazolepropionic acids.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Male; Pleural Effusion; Propionates; Rat | 1978 |
3-Aryl-as-triazines as potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Edema; Rats; Triazines | 1977 |
Benzimidazole derivatives with atypical antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Benzimidazoles | 1987 |
Preparation and antiarthritic and analgesic activity of 4,5-diaryl-2-(substituted thio)-1H-imidazoles and their sulfoxides and sulfones.
Topics: Analgesia; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chemical Phenomena | 1985 |
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chemical Phenomena; Chemistry | 1984 |
3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclini | 1984 |
Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1981 |
Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; D | 1994 |
Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Crystallography, X-Ray; Dimerization; Di | 2019 |
FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Curcumin; Disease Progression; | 2019 |
Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Arthritis, Experimental; Aspirin; Charyb | 2013 |
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
Topics: Administration, Oral; Angiopoietin-1; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Ex | 2014 |
Design, synthesis and preliminary evaluation of the anti-inflammatory of the specific selective targeting druggable enzymome cyclooxygenase-2 (COX-2) small molecule.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Cyclooxygenase 2 Inhibitors; Dr | 2016 |
Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats.
Topics: Acute Disease; Alanine Transaminase; Albinism; Animals; Arthritis, Experimental; Aspartate Aminotran | 2010 |
Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Endothelin-1; Gene Expre | 2010 |
The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Cell Line; Cytok | 2011 |
Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat.
Topics: Analysis of Variance; Animals; Arthritis, Experimental; Aspirin; Dose-Response Relationship, Drug; F | 2011 |
Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cy | 2004 |
Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 2; Cycloo | 2005 |
Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cy | 2005 |
Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Bone and B | 1984 |
Aspirin clearly depresses responses of ventrobasal thalamus neurons to joint stimuli in arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Depression, Chemical; Dose-Response Relationsh | 1982 |
Effect of glyceryl guaiacolate in animal models of inflammation and pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Guaifenesin; Male; | 1980 |
A new non-steroidal anti-inflammatory analgesic: gamma-oxo (1,1'-biphenyl)-4-butanoic acid (fenbufen). Chemistry and activity of analogs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Biphenyl Compounds; Carrageenan | 1980 |
Impaired red cell deformability in established adjuvant arthritic disease in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Erythrocytes; Hemolysis; Hot Temperature; Hydr | 1980 |
Anti-inflammatory testing methods: comparative evaluation of mice and rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Cyproheptadine; Edema; Female; | 1981 |
The modulation of inflammation by the acute phase reaction in adjuvant arthritis in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Blood Proteins; Blood Sedimentation; Dexametha | 1981 |
Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4-[1-oxo-(3-substituted aryl)-2-propenyl]-3-phenylsydnones and of 3-[4-[3-(substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; As | 1995 |
Effect of acetylsalicylic acid and dexamethasone on antibody production in adjuvant arthritis.
Topics: Analysis of Variance; Animals; Antibodies, Anti-Idiotypic; Antibodies, Bacterial; Antibody Formation | 1994 |
Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-(3-dimethylaminopropionyl)benzenes and their 5-halogeno derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Foot Inju | 1994 |
Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and Fos-like immunoreactivity in rat lumbar spinal cord.
Topics: Acetaminophen; Animals; Arthritis, Experimental; Aspirin; Avidin; Biotin; Freund's Adjuvant; Immunoh | 1994 |
Acetylsalicylic acid and misoprostol combination in adjuvant arthritis of rats.
Topics: Animals; Arthritis, Experimental; Aspirin; Dose-Response Relationship, Drug; Drug Combinations; Fema | 1993 |
Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agen | 1998 |
Focused antithrombotic therapy: novel anti-platelet salicylates with reduced ulcerogenic potential and higher first-pass detoxification than aspirin in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Blood Platelets; Diflunisal; Do | 1998 |
Role of mucus reduction and luminal acid elevation in increased susceptibility of stomach to nonsteroidal antiinflammatory drug-induced injury in arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Dinoprostone; Do | 2000 |
A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis.
Topics: Animals; Arthritis, Experimental; Aspartame; Aspirin; Behavior, Animal; Carrageenan; Dose-Response R | 2001 |
Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Blood Flow Veloc | 2001 |
Pharmacological properties of 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-one (W-2429. Part 1: Analgesic, antipyretic and antiedema activity.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 1977 |
Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Biphenyl Compoun | 1977 |
Thrombocytosis and platelet aggregates in the circulation of adjuvant arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Blood Cell Count; Blood Platelets; Cell Count; | 1978 |
Monitoring of experimental arthritis in rabbits.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Body Temperature; Hindlimb; Hydrocortisone; Jo | 1979 |
Inhibition by aspirin of gastrointestinal toxicity induced by indomethacin in polyarthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Disease Models, Animal; Dose-Response Relation | 1979 |
Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Female; Indomethacin; Ma | 1979 |
[Pharmacological studies of 2-(5H-(1)benzopyrano[2,3-b]pyridin-7-yl)propionic acid (Y-8004). (3) Its interaction with anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Dose-Response Relationship, Dru | 1977 |
The role of aspirin in gastric ulceration . Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.
Topics: Animals; Arthritis, Experimental; Aspirin; Atropine Derivatives; Bethanechol Compounds; Cold Tempera | 1978 |
Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Blood Sedimentation; Drug Therapy, Combination | 1976 |
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Carrageenan; Chr | 1977 |
Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Gr | 1977 |
A profile of the gastrointestinal toxicity of aspirin, indomethacin, oxaprozin, phenylbutazone, and fentiazac in arthritic and Lewis normal rats.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Body Weigh | 1977 |
Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Body Weight; Dextropropoxyphene | 1976 |
Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Benzimidazoles; | 1992 |
Effects of copper aspirinate and aspirin on tissue copper, zinc, and iron concentrations following chronic oral treatment in the adjuvant arthritic rat.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Aspirin; Body Weight; Copper; Dose-Response | 1990 |
Effects of paracetamol and aspirin on neural activity of joint mechanonociceptors in adjuvant arthritis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; E | 1991 |
Studies on non-steroidal anti-inflammatory and related biological activities of 5-(indan-1'-yl)tetrazoles and their intermediates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Carrageenan; Ede | 1990 |
Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model.
Topics: Acetaminophen; Animals; Arthritis; Arthritis, Experimental; Aspirin; Male; Pain; Rats; Rats, Inbred | 1989 |
On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Dexame | 1986 |
Scratching behaviour in arthritic rats: a sign of chronic pain or itch?
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Astemizole; Behavior, Animal; Benzimidazoles; | 1987 |
Altered susceptibility of arthritic rats to the gastric lesion-inducing effects of aspirin or ethanol and the antilesion effect of rioprostil.
Topics: Animals; Anti-Ulcer Agents; Arthritis; Arthritis, Experimental; Aspirin; Ethanol; Male; Prostaglandi | 1987 |
Antiinflammatory activities of copper-aspirinate and aspirin in adjuvant arthritic rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experi | 1988 |
Effects of propentofylline (HWA 285) on laser-induced thrombus formation in healthy and diseased rat mesenteric arterioles.
Topics: Animals; Arthritis, Experimental; Aspirin; Blood Coagulation; Lasers; Male; Mesenteric Arteries; Pen | 1986 |
[The analgesic and antipyretic effects of a non-steroidal antiinflammatory agent, EB-382, in experimental animals].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Ibuprofen; Indom | 1986 |
Depressant effects of suprofen, a new non-steroidal anti-inflammatory drug on thalamic evoked neuronal firing in arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Aspirin; Depre | 1986 |
Reduction in locomotor activity of arthritic rats as parameter for chronic pain: effect of morphine, acetylsalicylic acid and citalopram.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Chronic Disease; Citalopram; Exploratory Behav | 1985 |
Analgesic, anti-inflammatory and oxy-radical scavenger activity of imidazole and imidazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Gastritis | 1985 |
The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic | 1985 |
The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyarthritis.
Topics: Administration, Topical; Analgesics; Animals; Arthritis; Arthritis, Experimental; Aspirin; Injection | 1985 |
The effect of antiinflammatory drugs on plasma fibronectin.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Fibronectins; Indome | 1985 |