Page last updated: 2024-10-23

aspirin and Acute Pain

aspirin has been researched along with Acute Pain in 9 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study is to investigate if an orally administered combination of aspirin and ketamine will provide better analgesia than a ketamine alone in adult patients presenting to the Emergency Department (ED) with acute musculoskeletal pain."9.51Oral Aspirin/ketamine versus oral ketamine for emergency department patients with acute musculoskeletal pain. ( Barberan, C; Correa Bravo, S; Davis, A; Drapkin, J; Fassassi, C; Gerges, L; Gohel, A; Hossain, R; Likourezos, A; Motov, S; Niceforo, P; Silver, M, 2022)
"In total, 27 patients with stable cardiovascular, cerebrovascular or peripheral arterial disease and acute or chronic pain were identified and given dipyrone for at least 5 days in combination with low-dose aspirin."9.24Dipyrone (metamizole) markedly interferes with platelet inhibition by aspirin in patients with acute and chronic pain: A case-control study. ( Hohlfeld, T; Kienbaum, P; Pavlaković, G; Romann, L; Schmitz, A; Werdehausen, R, 2017)
"The purpose of this study is to investigate if an orally administered combination of aspirin and ketamine will provide better analgesia than a ketamine alone in adult patients presenting to the Emergency Department (ED) with acute musculoskeletal pain."5.51Oral Aspirin/ketamine versus oral ketamine for emergency department patients with acute musculoskeletal pain. ( Barberan, C; Correa Bravo, S; Davis, A; Drapkin, J; Fassassi, C; Gerges, L; Gohel, A; Hossain, R; Likourezos, A; Motov, S; Niceforo, P; Silver, M, 2022)
"In total, 27 patients with stable cardiovascular, cerebrovascular or peripheral arterial disease and acute or chronic pain were identified and given dipyrone for at least 5 days in combination with low-dose aspirin."5.24Dipyrone (metamizole) markedly interferes with platelet inhibition by aspirin in patients with acute and chronic pain: A case-control study. ( Hohlfeld, T; Kienbaum, P; Pavlaković, G; Romann, L; Schmitz, A; Werdehausen, R, 2017)
"Aspirin has been used in the management of postpartum perineal pain, and its effectiveness and safety should be assessed."2.66Aspirin (single dose) for perineal pain in the early postpartum period. ( Grivell, RM; Shepherd, E, 2020)
"Aspirin has been used in the management of postpartum perineal pain and its effectiveness and safety should be assessed."2.55Aspirin (single dose) for perineal pain in the early postpartum period. ( Grivell, RM; Molakatalla, S; Shepherd, E, 2017)
"Severe acute pain is typically treated with potent opioids."2.49Pharmacologic therapy for acute pain. ( Azadfard, M; Blondell, RD; Wisniewski, AM, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (66.67)24.3611
2020's3 (33.33)2.80

Authors

AuthorsStudies
Davis, A2
Fassassi, C2
Dove, D1
Drapkin, J2
Likourezos, A2
Gohel, A2
Favale, P1
Hossain, R2
Butt, M1
Gerges, L2
Motov, S2
Barberan, C1
Correa Bravo, S1
Silver, M1
Niceforo, P1
Shepherd, E2
Grivell, RM2
Blondell, RD1
Azadfard, M1
Wisniewski, AM1
Kröger, IL1
May, A1
Voelker, M1
Schachtel, BP1
Cooper, SA1
Gatoulis, SC1
Schmitz, A1
Romann, L1
Kienbaum, P1
Pavlaković, G1
Werdehausen, R1
Hohlfeld, T1
Molakatalla, S1
Du, Y1
Ellert, U1
Zhuang, W1
Knopf, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Analgesic Efficacy of Orally Administered VTS-K (Liquid Oral Ketamine Taken Simultaneously With VTS-Aspirin) for Pain Management of Adult ED Patients Presenting to the ED With Acute Musculoskeletal Pain[NCT04702555]25 participants (Actual)Observational2021-01-08Completed
A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone in Adult Patients Presenting to the ED With Acute Musculoskeletal Pain: Prospective, Randomized, Open-Label, Clinical Trial.[NCT04860804]Phase 460 participants (Actual)Interventional2021-04-22Completed
Onset of Action of a Fast Release Aspirin Tablet and Acetaminophen Caplet in Sore Throat Pain[NCT01453400]Phase 3177 participants (Actual)Interventional2011-09-27Completed
Comparative Onset of Action of a Fast Release Aspirin Tablet in a Dental Impaction Pain Model[NCT01420094]Phase 3510 participants (Actual)Interventional2011-06-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Reduction in Pain Score at 60 Minutes

Reduction of pain scores on numeric rating pain scale (NRS) at 60 minutes mark form the baseline. The NRS is an 11 item Likert Scale ranging from 0 (no pain) to 10 (very severe pain) with 5 indicating moderate pain. (NCT04860804)
Timeframe: 60 minutes

Interventionunits on a scale (Mean)
AOK Group2.18
OK Group4.01

Reviews

3 reviews available for aspirin and Acute Pain

ArticleYear
Aspirin (single dose) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2020, 07-24, Volume: 7

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Episiotomy; Female; Humans; Obstetric

2020
Pharmacologic therapy for acute pain.
    American family physician, 2013, Jun-01, Volume: 87, Issue:11

    Topics: Acetaminophen; Acute Pain; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammato

2013
Aspirin (single dose) for perineal pain in the early postpartum period.
    The Cochrane database of systematic reviews, 2017, 02-09, Volume: 2

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Obstetric Labor Compli

2017

Trials

4 trials available for aspirin and Acute Pain

ArticleYear
Oral Aspirin/ketamine versus oral ketamine for emergency department patients with acute musculoskeletal pain.
    The American journal of emergency medicine, 2022, Volume: 58

    Topics: Acute Pain; Adult; Analgesics; Aspirin; Double-Blind Method; Emergency Service, Hospital; Humans; Ke

2022
Central effects of acetylsalicylic acid on trigeminal-nociceptive stimuli.
    The journal of headache and pain, 2014, Sep-09, Volume: 15

    Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Gyrus Cinguli; Humans; Ma

2014
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
    Inflammopharmacology, 2016, Volume: 24, Issue:1

    Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal

2016
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
    Inflammopharmacology, 2016, Volume: 24, Issue:1

    Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal

2016
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
    Inflammopharmacology, 2016, Volume: 24, Issue:1

    Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal

2016
Efficacy of disintegrating aspirin in two different models for acute mild-to-moderate pain: sore throat pain and dental pain.
    Inflammopharmacology, 2016, Volume: 24, Issue:1

    Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Femal

2016
Dipyrone (metamizole) markedly interferes with platelet inhibition by aspirin in patients with acute and chronic pain: A case-control study.
    European journal of anaesthesiology, 2017, Volume: 34, Issue:5

    Topics: Acute Pain; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platele

2017

Other Studies

2 other studies available for aspirin and Acute Pain

ArticleYear
Analgesic Efficacy of Oral Aspirin/Ketamine Combination for Management of Acute Musculoskeletal Pain in the Emergency Department - A Proof of Concept Pilot Study.
    The Journal of emergency medicine, 2022, Volume: 62, Issue:6

    Topics: Acute Pain; Adult; Analgesics; Aspirin; Double-Blind Method; Emergency Service, Hospital; Humans; Ke

2022
Analgesic use in a national community sample of German children and adolescents.
    European journal of pain (London, England), 2012, Volume: 16, Issue:6

    Topics: Acetaminophen; Acute Pain; Adolescent; Analgesics; Aspirin; Child; Child, Preschool; Chronic Pain; F

2012