aspirin has been researched along with Acute Lung Injury in 26 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of aspirin in preventing the occurrence of acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) among adult patients are controversial." | 8.98 | The effect of aspirin in preventing the acute respiratory distress syndrome/acute lung injury: A meta-analysis. ( Liang, BM; Liang, ZA; Ni, YN; Wang, Y; Yu, H, 2018) |
| "In the present study, we aimed to evaluate the role of aspirin-triggered resolvin D1 (AT-RvD1) in paraquat (PQ)-induced acute lung injury (ALI) in mice." | 7.91 | Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice. ( Hu, X; Shen, H; Wang, Y; Zhang, L; Zhao, M, 2019) |
| "Aspirin has been found to improve outcomes in an animal model of transfusion-related acute lung injury." | 7.78 | The effect of aspirin in transfusion-related acute lung injury in critically ill patients. ( Binnenkade, JM; Juffermans, NP; Tuinman, PR; Vlaar, AP, 2012) |
| "To establish a model of acute lung injury induced by paraquat poisoning and to observe the effects of anticoagulant therapy on acute lung injury induced by paraquat poisoning." | 7.78 | [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. ( Bi, YQ; Jian, XD; Jiang, J; Liu, F; Liu, HM; Niu, YY; Shang, B; Tian, D; Zhang, W; Zhang, ZC; Zhou, Q, 2012) |
| " A multivariable analysis including age, gender, current tobacco use, prehospital aspirin use, race, and Acute Physiology and Chronic Health Evaluation II score revealed that patients on statin therapy before hospitalization were less likely to have or develop severe sepsis (odds ratio 0." | 7.77 | Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. ( Bernard, GR; Curtis, BR; Fremont, RD; Koehler, EA; Koyama, T; May, AK; O'Neal, HR; Siew, E; Ware, LB, 2011) |
| "To evaluate the association between prehospitalization aspirin therapy and incident acute lung injury in a heterogeneous cohort of at-risk medical patients." | 7.77 | Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients. ( Carter, RE; Erlich, J; Gajic, O; Gong, MN; Kor, DJ; Malinchoc, M; Talmor, DS, 2011) |
| "Because aspirin-triggered 15-epi-lipoxin A(4) (15-epi-LXA(4)) modulates Mac-1 expression, we investigated the impact of 15-epi-LXA(4) on MPO suppression of neutrophil apoptosis and MPO-mediated neutrophil-dependent acute lung injury." | 7.75 | 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. ( El Kebir, D; Filep, JG; József, L; Pan, W; Petasis, NA; Serhan, CN; Wang, L, 2009) |
| "To investigate the possible effects of nuclear factor-KappaB (NF-KappaB) activation on the expression of intercellular adhesion molecular-1 (ICAM-1) and P-selectin in murine acute lung injury (ALI) and assess the potential beneficial effects and mechanism of low molecular weight heparin (LMWH) and aspirin (ASA)." | 7.73 | [Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat]. ( Luan, ZG; Ma, XC; Nala, P; Zhang, ZD, 2006) |
| "Systematic inflammation has been reported to contribute to cancer progression through various mechanisms; however, the exact mechanism is still the subject of research." | 5.91 | Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration. ( Fukuda, K; Hirahashi, J; Kawakubo, H; Kitagawa, Y; Kobayashi, R; Matsuda, S; Matsui, K; Nakamura, R; Nishimura, E; Okubo, K; Takeuchi, M, 2023) |
| "Aspirin (ASA) treatment significantly reduced lung platelet sequestration and activation, NPA formation, and lung injury." | 5.40 | Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. ( Bins, A; Headley, M; Krummel, MF; Looney, MR; Mallavia, B; Ortiz-Muñoz, G, 2014) |
| "The effects of aspirin in preventing the occurrence of acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) among adult patients are controversial." | 4.98 | The effect of aspirin in preventing the acute respiratory distress syndrome/acute lung injury: A meta-analysis. ( Liang, BM; Liang, ZA; Ni, YN; Wang, Y; Yu, H, 2018) |
| "In the present study, we aimed to evaluate the role of aspirin-triggered resolvin D1 (AT-RvD1) in paraquat (PQ)-induced acute lung injury (ALI) in mice." | 3.91 | Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice. ( Hu, X; Shen, H; Wang, Y; Zhang, L; Zhao, M, 2019) |
| "Aspirin may prevent organ dysfunction in critically ill patients and mitigate transfusion associated acute lung injury." | 3.83 | Impact of aspirin use on morbidity and mortality in massively transfused cardiac surgery patients: a propensity score matched cohort study. ( Galvagno, S; Gammie, JS; Mazzeffi, M; Tanaka, K, 2016) |
| "Use of aspirin (acetylsalicylic acid [ASA]) was found to improve outcome in animal models of acute lung injury (ALI) or its more severe form, acute respiratory distress syndrome." | 3.79 | High-dose acetylsalicylic acid is superior to low-dose as well as to clopidogrel in preventing lipopolysaccharide-induced lung injury in mice. ( Hegeman, MA; Jongsma, G; Juffermans, NP; Müller, MC; Tuinman, PR, 2013) |
| "Aspirin has been found to improve outcomes in an animal model of transfusion-related acute lung injury." | 3.78 | The effect of aspirin in transfusion-related acute lung injury in critically ill patients. ( Binnenkade, JM; Juffermans, NP; Tuinman, PR; Vlaar, AP, 2012) |
| "To establish a model of acute lung injury induced by paraquat poisoning and to observe the effects of anticoagulant therapy on acute lung injury induced by paraquat poisoning." | 3.78 | [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. ( Bi, YQ; Jian, XD; Jiang, J; Liu, F; Liu, HM; Niu, YY; Shang, B; Tian, D; Zhang, W; Zhang, ZC; Zhou, Q, 2012) |
| " A multivariable analysis including age, gender, current tobacco use, prehospital aspirin use, race, and Acute Physiology and Chronic Health Evaluation II score revealed that patients on statin therapy before hospitalization were less likely to have or develop severe sepsis (odds ratio 0." | 3.77 | Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. ( Bernard, GR; Curtis, BR; Fremont, RD; Koehler, EA; Koyama, T; May, AK; O'Neal, HR; Siew, E; Ware, LB, 2011) |
| "To evaluate the association between prehospitalization aspirin therapy and incident acute lung injury in a heterogeneous cohort of at-risk medical patients." | 3.77 | Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients. ( Carter, RE; Erlich, J; Gajic, O; Gong, MN; Kor, DJ; Malinchoc, M; Talmor, DS, 2011) |
| "Because aspirin-triggered 15-epi-lipoxin A(4) (15-epi-LXA(4)) modulates Mac-1 expression, we investigated the impact of 15-epi-LXA(4) on MPO suppression of neutrophil apoptosis and MPO-mediated neutrophil-dependent acute lung injury." | 3.75 | 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. ( El Kebir, D; Filep, JG; József, L; Pan, W; Petasis, NA; Serhan, CN; Wang, L, 2009) |
| "To investigate the possible effects of nuclear factor-KappaB (NF-KappaB) activation on the expression of intercellular adhesion molecular-1 (ICAM-1) and P-selectin in murine acute lung injury (ALI) and assess the potential beneficial effects and mechanism of low molecular weight heparin (LMWH) and aspirin (ASA)." | 3.73 | [Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat]. ( Luan, ZG; Ma, XC; Nala, P; Zhang, ZD, 2006) |
| "Systematic inflammation has been reported to contribute to cancer progression through various mechanisms; however, the exact mechanism is still the subject of research." | 1.91 | Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration. ( Fukuda, K; Hirahashi, J; Kawakubo, H; Kitagawa, Y; Kobayashi, R; Matsuda, S; Matsui, K; Nakamura, R; Nishimura, E; Okubo, K; Takeuchi, M, 2023) |
| "Acute lung injury is a life-threatening condition caused by disruption of the alveolar-capillary barrier leading to edema, influx of inflammatory leukocytes, and impaired gas exchange." | 1.43 | Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. ( Abdulnour, RE; Colas, RA; Colby, JK; Cui, Y; Dalli, J; El-Chemaly, S; Hellmann, J; Levy, BD; Petasis, NA; Serhan, CN; Sham, HP; Spite, M; Winkler, JW; Wong, B, 2016) |
| "Aspirin (ASA) treatment significantly reduced lung platelet sequestration and activation, NPA formation, and lung injury." | 1.40 | Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. ( Bins, A; Headley, M; Krummel, MF; Looney, MR; Mallavia, B; Ortiz-Muñoz, G, 2014) |
| "We sought to determine the prevalence of acute respiratory distress syndrome after intracerebral hemorrhage, characterize risk factors for its development, and assess its impact on patient outcomes." | 1.39 | Acute respiratory distress syndrome after spontaneous intracerebral hemorrhage*. ( Avery, L; Bajwa, E; Camargo, CA; Chang, Y; Duran-Mendicuti, MA; Elmer, J; Goldstein, JN; Greenberg, SM; Hess, DR; Hou, P; Okechukwu, I; Pallin, DJ; Pontes-Neto, O; Rosand, J; Schreiber, H; Wilcox, SR, 2013) |
| "Aspirin treatment of hPLTs in vitro abolished hPLT accumulation in the lung and protected mice from lung injury." | 1.38 | Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury. ( Chi, X; Gelderman, MP; Vostal, JG; Zhi, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 22 (84.62) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, Q | 1 |
| Zhang, ZD | 2 |
| Qin, Z | 1 |
| Liu, XW | 1 |
| Li, SH | 1 |
| Bai, LX | 1 |
| Ge, WB | 1 |
| Li, JY | 1 |
| Yang, YJ | 1 |
| Nishimura, E | 1 |
| Fukuda, K | 1 |
| Matsuda, S | 1 |
| Kobayashi, R | 1 |
| Matsui, K | 1 |
| Takeuchi, M | 1 |
| Okubo, K | 1 |
| Hirahashi, J | 1 |
| Nakamura, R | 1 |
| Kawakubo, H | 1 |
| Kitagawa, Y | 1 |
| Du, F | 1 |
| Jiang, P | 1 |
| He, S | 1 |
| Song, D | 1 |
| Xu, F | 1 |
| Yu, H | 1 |
| Ni, YN | 1 |
| Liang, ZA | 1 |
| Liang, BM | 1 |
| Wang, Y | 2 |
| Hu, X | 1 |
| Shen, H | 1 |
| Zhang, L | 1 |
| Zhao, M | 1 |
| Elmer, J | 1 |
| Hou, P | 1 |
| Wilcox, SR | 1 |
| Chang, Y | 1 |
| Schreiber, H | 1 |
| Okechukwu, I | 1 |
| Pontes-Neto, O | 1 |
| Bajwa, E | 1 |
| Hess, DR | 1 |
| Avery, L | 1 |
| Duran-Mendicuti, MA | 1 |
| Camargo, CA | 1 |
| Greenberg, SM | 1 |
| Rosand, J | 1 |
| Pallin, DJ | 1 |
| Goldstein, JN | 1 |
| Tuinman, PR | 2 |
| Müller, MC | 1 |
| Jongsma, G | 1 |
| Hegeman, MA | 1 |
| Juffermans, NP | 2 |
| Ortiz-Muñoz, G | 1 |
| Mallavia, B | 1 |
| Bins, A | 1 |
| Headley, M | 1 |
| Krummel, MF | 1 |
| Looney, MR | 3 |
| Tang, H | 1 |
| Liu, Y | 1 |
| Yan, C | 1 |
| Petasis, NA | 3 |
| Serhan, CN | 3 |
| Gao, H | 1 |
| Zimring, JC | 1 |
| Cox, R | 1 |
| Phillips, O | 1 |
| Fukumoto, J | 1 |
| Fukumoto, I | 1 |
| Parthasarathy, PT | 1 |
| Arias, S | 1 |
| Cho, Y | 1 |
| Lockey, RF | 1 |
| Kolliputi, N | 1 |
| Colby, JK | 1 |
| Abdulnour, RE | 1 |
| Sham, HP | 1 |
| Dalli, J | 1 |
| Colas, RA | 1 |
| Winkler, JW | 1 |
| Hellmann, J | 1 |
| Wong, B | 1 |
| Cui, Y | 1 |
| El-Chemaly, S | 1 |
| Spite, M | 1 |
| Levy, BD | 2 |
| Mazzeffi, M | 1 |
| Galvagno, S | 1 |
| Gammie, JS | 1 |
| Tanaka, K | 1 |
| El Kebir, D | 1 |
| József, L | 1 |
| Pan, W | 1 |
| Wang, L | 1 |
| Filep, JG | 1 |
| O'Neal, HR | 1 |
| Koyama, T | 1 |
| Koehler, EA | 1 |
| Siew, E | 1 |
| Curtis, BR | 1 |
| Fremont, RD | 1 |
| May, AK | 1 |
| Bernard, GR | 1 |
| Ware, LB | 1 |
| Somma, MM | 1 |
| Weinstock, PJ | 1 |
| Kor, DJ | 1 |
| Erlich, J | 1 |
| Gong, MN | 1 |
| Malinchoc, M | 1 |
| Carter, RE | 1 |
| Gajic, O | 1 |
| Talmor, DS | 1 |
| Weinbroum, AA | 1 |
| Vlaar, AP | 1 |
| Binnenkade, JM | 1 |
| Caudrillier, A | 2 |
| Kessenbrock, K | 1 |
| Gilliss, BM | 1 |
| Nguyen, JX | 1 |
| Marques, MB | 1 |
| Monestier, M | 1 |
| Toy, P | 1 |
| Werb, Z | 1 |
| Levitt, JE | 1 |
| Matthay, MA | 1 |
| Eickmeier, O | 1 |
| Seki, H | 1 |
| Haworth, O | 1 |
| Hilberath, JN | 1 |
| Gao, F | 1 |
| Uddin, M | 1 |
| Croze, RH | 1 |
| Carlo, T | 1 |
| Pfeffer, MA | 1 |
| Liu, F | 1 |
| Jian, XD | 1 |
| Zhang, ZC | 1 |
| Liu, HM | 1 |
| Zhou, Q | 1 |
| Zhang, W | 1 |
| Shang, B | 1 |
| Tian, D | 1 |
| Niu, YY | 1 |
| Bi, YQ | 1 |
| Jiang, J | 1 |
| Chi, X | 1 |
| Zhi, L | 1 |
| Gelderman, MP | 1 |
| Vostal, JG | 1 |
| Luan, ZG | 1 |
| Nala, P | 1 |
| Ma, XC | 1 |
4 reviews available for aspirin and Acute Lung Injury
| Article | Year |
|---|---|
Antiplatelet Therapy for Critically Ill Patients: A Pairwise and Bayesian Network Meta-Analysis.
Topics: Acute Lung Injury; Aspirin; Critical Illness; Hospital Mortality; Humans; Incidence; Network Meta-An | 2018 |
The effect of aspirin in preventing the acute respiratory distress syndrome/acute lung injury: A meta-analysis.
Topics: Acute Lung Injury; Aspirin; Humans; Randomized Controlled Trials as Topic; Respiratory Distress Synd | 2018 |
Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury.
Topics: Acute Lung Injury; Animals; Aspirin; Blood Platelets; Blood Transfusion; Drug Delivery Systems; Hemo | 2012 |
Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure.
Topics: Acute Lung Injury; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Anti-Inflammatory A | 2012 |
22 other studies available for aspirin and Acute Lung Injury
| Article | Year |
|---|---|
Aspirin eugenol ester alleviates lipopolysaccharide-induced acute lung injury in rats while stabilizing serum metabolites levels.
Topics: A549 Cells; Acute Lung Injury; Animals; Antioxidants; Aspirin; Eugenol; Humans; Interleukin-6; Lipop | 2022 |
Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration.
Topics: Acute Lung Injury; Animals; Aspirin; Humans; Inflammation; Lung; Lung Neoplasms; Mice; Neutrophil In | 2023 |
Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cytokines; Docosahexae | 2019 |
Acute respiratory distress syndrome after spontaneous intracerebral hemorrhage*.
Topics: Acute Lung Injury; Aged; Aspirin; Cerebral Hemorrhage; Cohort Studies; Erythrocyte Transfusion; Fema | 2013 |
High-dose acetylsalicylic acid is superior to low-dose as well as to clopidogrel in preventing lipopolysaccharide-induced lung injury in mice.
Topics: Acute Lung Injury; Animals; Aspirin; Blood Platelets; Bronchoalveolar Lavage Fluid; Clopidogrel; Lip | 2013 |
Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Bronc | 2014 |
Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Antibody Complex; Aspir | 2014 |
The fat and the skinny on acute lung injury.
Topics: Acute Lung Injury; Animals; Aspirin; Lipoxins; Male; Neutrophils; Platelet Aggregation | 2014 |
Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.
Topics: Acute Lung Injury; Airway Resistance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; A | 2015 |
Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.
Topics: Acute Lung Injury; Animals; Aspirin; Blotting, Western; Disease Models, Animal; Fatty Acids, Unsatur | 2016 |
Impact of aspirin use on morbidity and mortality in massively transfused cardiac surgery patients: a propensity score matched cohort study.
Topics: Acute Lung Injury; Aged; Aspirin; Blood Transfusion; Cardiac Surgical Procedures; Cohort Studies; Cr | 2016 |
15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Bronchoalve | 2009 |
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.
Topics: Acute Lung Injury; Aged; Aspirin; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hydroxyme | 2011 |
Statins and sepsis: a magic bullet or just shooting blanks?
Topics: Acute Lung Injury; Aspirin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggrega | 2011 |
Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients.
Topics: Acute Lung Injury; Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Comorbidity; Elective Surgi | 2011 |
Preventing acute lung injury and acute respiratory distress syndrome: back to square one.
Topics: Acute Lung Injury; Aspirin; Elective Surgical Procedures; Emergency Service, Hospital; Female; Human | 2011 |
The effect of aspirin in transfusion-related acute lung injury in critically ill patients.
Topics: Acute Lung Injury; Adult; Aged; APACHE; Aspirin; Case-Control Studies; Cohort Studies; Critical Care | 2012 |
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.
Topics: Acute Lung Injury; Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cell Aggregation; Cell | 2012 |
Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury.
Topics: Acute Lung Injury; Adaptor Proteins, Signal Transducing; Airway Resistance; Animals; Anti-Inflammato | 2013 |
[Experimental anticoagulant therapy of acute lung injury induced by paraquat].
Topics: Acute Lung Injury; Animals; Anticoagulants; Aspirin; Disease Models, Animal; Drug Therapy, Combinati | 2012 |
Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.
Topics: Acute Lung Injury; Animals; Aspirin; Blood Platelets; Disease Models, Animal; Female; Humans; Lipopo | 2012 |
[Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat].
Topics: Acute Lung Injury; Animals; Aspirin; Disease Models, Animal; Heparin, Low-Molecular-Weight; Intercel | 2006 |