aspirin has been researched along with Acute Brain Injuries in 31 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The potential neuroprotective effects of the novel nitro-derivate of aspirin (NCX4016) on permanent focal cerebral ischemia in spontaneously hypertensive rats (SHRs) was investigated." | 7.71 | Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat. ( Ambrosini, MV; Del Soldato, P; Fredduzzi, S; Mariucci, G; Tantucci, M, 2001) |
| " The aim of this study was to evaluate the protective potential of implanted human umbilical cord mesenchymal stem (hUCMs) cells with/without aspirin (ASA) against focal cerebral ischemia." | 3.81 | Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats. ( Eslaminejad, T; Esmaeilpour, K; Nematollahi-Mahani, SN; Shams ara, A; Sheibani, V, 2015) |
| "The potential neuroprotective effects of the novel nitro-derivate of aspirin (NCX4016) on permanent focal cerebral ischemia in spontaneously hypertensive rats (SHRs) was investigated." | 3.71 | Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat. ( Ambrosini, MV; Del Soldato, P; Fredduzzi, S; Mariucci, G; Tantucci, M, 2001) |
| "Anesthetized swine were randomized to receive SPR, diaspirin cross-linked hemoglobin, or DR after cryogenic brain injury and uncontrolled hemorrhagic shock and studied for 70 minutes after the combined insults." | 3.70 | Comparison of standard and alternative prehospital resuscitation in uncontrolled hemorrhagic shock and head injury. ( Bourguignon, P; Buckingham, S; Nichols, P; Novak, L; Osler, T; Sartorelli, K; Shackford, SR, 1999) |
| "The effects of aminazin and aspirin on brain injuries in animals with immunological hypersensitivity of the body were studied." | 3.66 | [Nerve tissue ultrastructure in experimental brain injuries in animals with increased immunobiologic reactivity following treatment with certain desensitizing drugs]. ( Sukhorukova, LI, 1981) |
| "Key secondary endpoints include rate of intracranial hemorrhage progression, and intensive care unit- and hospital-free days." | 1.91 | The impact of low-dose aspirin in the Brain Injury Guidelines on outcomes in traumatic brain injury: A retrospective cohort study. ( Barton, CA; Gibson, E; Knapp, C; Munger, DN; Oetken, HJ; Plott, AJ; Schreiber, M; Webb, AJ, 2023) |
| "Aspirin and/or CLOP treatment prior to TBI is a double-edged sword that exerts a dual effect post-injury." | 1.72 | The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model. ( Dakroub, F; Dalloul, Z; Darwish, H; El-Achkar, GA; Habib, A; Hamade, E; Kobeissy, F; Mallah, K; Mallah, Z; Mohamed, W; Mondello, S; Nasrallah, L; Nasser, M; Ramadan, N; Zibara, K, 2022) |
| "A total of 144 patients who had intracranial hemorrhage on initial CT scan (ASA group: 72; No-ASA group: 72) were enrolled." | 1.40 | Low-dose aspirin therapy is not a reason for repeating head computed tomographic scans in traumatic brain injury: a prospective study. ( Aziz, H; Friese, RS; Hashmi, A; Joseph, B; Kulvatunyou, N; O'Keeffe, T; Pandit, V; Rhee, P; Tang, A; Vercruysse, G; Wynne, J, 2014) |
| "All patients with intracranial hemorrhage on initial CT with prehospital CAP therapy were included." | 1.40 | Repeat head computed tomography in anticoagulated traumatic brain injury patients: still warranted. ( Aziz, H; Friese, RS; Joseph, B; Kulvatunyou, N; O'Keeffe, T; Pandit, V; Rhee, P; Sadoun, M; Tang, A; Wynne, JL, 2014) |
| "Of the 500,000 brain injuries in the United States annually, 80% are considered mild (mild traumatic brain injury)." | 1.38 | Impact of age and anticoagulation: need for neurosurgical intervention in trauma patients with mild traumatic brain injury. ( Badellino, M; Moore, MM; Pasquale, MD, 2012) |
| " Initial responders to transfusion received a greater volume of platelets, suggesting a dose-response relationship." | 1.37 | Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury. ( Bachelani, AM; Bautz, JT; Billiar, TR; Corcos, A; Marshall, GT; Peitzman, AB; Sperry, JL; Zenati, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.13) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, D | 1 |
| Chen, D | 1 |
| Chen, T | 1 |
| Sun, X | 1 |
| Kobeissy, F | 1 |
| Mallah, K | 1 |
| Zibara, K | 1 |
| Dakroub, F | 1 |
| Dalloul, Z | 1 |
| Nasser, M | 1 |
| Nasrallah, L | 1 |
| Mallah, Z | 1 |
| El-Achkar, GA | 1 |
| Ramadan, N | 1 |
| Mohamed, W | 1 |
| Mondello, S | 1 |
| Darwish, H | 1 |
| Hamade, E | 1 |
| Habib, A | 1 |
| Webb, AJ | 1 |
| Oetken, HJ | 1 |
| Plott, AJ | 1 |
| Knapp, C | 1 |
| Munger, DN | 1 |
| Gibson, E | 1 |
| Schreiber, M | 1 |
| Barton, CA | 1 |
| Probst, MA | 1 |
| Gupta, M | 1 |
| Hendey, GW | 1 |
| Rodriguez, RM | 1 |
| Winkel, G | 1 |
| Loo, GT | 1 |
| Mower, WR | 1 |
| Holzmacher, JL | 1 |
| Reynolds, C | 1 |
| Patel, M | 1 |
| Maluso, P | 1 |
| Holland, S | 1 |
| Gamsky, N | 1 |
| Moore, H | 1 |
| Acquista, E | 1 |
| Carrick, M | 1 |
| Amdur, R | 1 |
| Hancock, H | 1 |
| Metzler, M | 1 |
| Dunn, J | 1 |
| Sarani, B | 1 |
| Joseph, B | 3 |
| Aziz, H | 2 |
| Pandit, V | 3 |
| Kulvatunyou, N | 3 |
| O'Keeffe, T | 3 |
| Tang, A | 3 |
| Wynne, J | 1 |
| Hashmi, A | 1 |
| Vercruysse, G | 1 |
| Friese, RS | 3 |
| Rhee, P | 3 |
| Sadoun, M | 1 |
| Wynne, JL | 1 |
| Meyer, D | 1 |
| Butvidas, L | 1 |
| Khalil, M | 1 |
| Zangbar, B | 1 |
| Gries, L | 1 |
| Grandhi, R | 1 |
| Harrison, G | 1 |
| Voronovich, Z | 1 |
| Bauer, J | 1 |
| Chen, SH | 1 |
| Nicholas, D | 1 |
| Alarcon, LH | 1 |
| Okonkwo, DO | 1 |
| Shams ara, A | 1 |
| Sheibani, V | 1 |
| Esmaeilpour, K | 1 |
| Eslaminejad, T | 1 |
| Nematollahi-Mahani, SN | 1 |
| Bartels, A | 1 |
| Sarpong, Y | 1 |
| Coberly, J | 1 |
| Hughes, N | 1 |
| Litt, J | 1 |
| Quick, J | 1 |
| Kessel, J | 1 |
| Nelson, C | 1 |
| Coughenour, J | 1 |
| Barnes, SL | 1 |
| Litofsky, NS | 1 |
| Hammer, RD | 1 |
| Ahmad, S | 1 |
| Prinz, V | 1 |
| Finger, T | 1 |
| Bayerl, S | 1 |
| Rosenthal, C | 1 |
| Wolf, S | 1 |
| Liman, T | 1 |
| Vajkoczy, P | 1 |
| Ivascu, FA | 1 |
| Howells, GA | 1 |
| Junn, FS | 1 |
| Bair, HA | 1 |
| Bendick, PJ | 1 |
| Janczyk, RJ | 1 |
| Wong, DK | 1 |
| Lurie, F | 1 |
| Wong, LL | 1 |
| Nadarajah, M | 1 |
| Power, M | 1 |
| Barry, B | 1 |
| Wenderoth, J | 1 |
| Bachelani, AM | 1 |
| Bautz, JT | 1 |
| Sperry, JL | 1 |
| Corcos, A | 1 |
| Zenati, M | 1 |
| Billiar, TR | 1 |
| Peitzman, AB | 1 |
| Marshall, GT | 1 |
| Moore, MM | 1 |
| Pasquale, MD | 1 |
| Badellino, M | 1 |
| Spektor, S | 1 |
| Agus, S | 1 |
| Merkin, V | 1 |
| Constantini, S | 1 |
| Malhotra, AK | 1 |
| Schweitzer, JB | 2 |
| Fox, JL | 1 |
| Fabian, TC | 2 |
| Proctor, KG | 2 |
| Sukhorukova, LI | 1 |
| Cole, DJ | 1 |
| Schell, RM | 1 |
| Drummond, JC | 1 |
| Reynolds, L | 1 |
| Chappell, JE | 1 |
| McBride, WJ | 1 |
| Shackford, SR | 3 |
| Piper, IR | 1 |
| Garrioch, MA | 1 |
| Souter, MJ | 1 |
| Andrews, PJ | 1 |
| Thomson, D | 1 |
| Novak, L | 1 |
| Bourguignon, P | 1 |
| Nichols, P | 1 |
| Buckingham, S | 1 |
| Osler, T | 1 |
| Sartorelli, K | 1 |
| Fredduzzi, S | 1 |
| Mariucci, G | 1 |
| Tantucci, M | 1 |
| Del Soldato, P | 1 |
| Ambrosini, MV | 1 |
| Gibson, JB | 1 |
| Maxwell, RA | 1 |
| McDonald, L | 1 |
| Rosenblum, WI | 2 |
| El-Sabban, F | 2 |
| Koenig, H | 1 |
| Goldstone, AD | 1 |
| Lu, CY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）[NCT05975398] | 450 participants (Anticipated) | Observational [Patient Registry] | 2022-07-01 | Recruiting | |||
| Effect and Safety of Surgical Intervention for Severe Spontaneous Intracerebral Hemorrhage Patients on Long-term Oral Antiplatelet Treatment[NCT05766865] | 450 participants (Actual) | Observational | 2019-07-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
31 other studies available for aspirin and Acute Brain Injuries
| Article | Year |
|---|---|
Aspirin Exerts Neuroprotective Effects by Reversing Lipopolysaccharide-Induced Secondary Brain Injury and Inhibiting Matrix Metalloproteinase-3 Gene Expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Injuries; Gene Expression Regulatio | 2021 |
The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model.
Topics: Animals; Aspirin; Brain Injuries; Brain Injuries, Traumatic; Clopidogrel; Humans; Platelet Aggregati | 2022 |
The impact of low-dose aspirin in the Brain Injury Guidelines on outcomes in traumatic brain injury: A retrospective cohort study.
Topics: Aspirin; Brain Injuries; Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Intracranial Hemorrh | 2023 |
Prevalence of Intracranial Injury in Adult Patients With Blunt Head Trauma With and Without Anticoagulant or Antiplatelet Use.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Female; Head I | 2020 |
Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Injury Severity Score | 2018 |
Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Injury Severity Score | 2018 |
Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Injury Severity Score | 2018 |
Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Injury Severity Score | 2018 |
Low-dose aspirin therapy is not a reason for repeating head computed tomographic scans in traumatic brain injury: a prospective study.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Injuries; Female; Head; Humans; Intracranial Hemorrhages; Ma | 2014 |
Repeat head computed tomography in anticoagulated traumatic brain injury patients: still warranted.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Cohort Studies | 2014 |
The significance of platelet count in traumatic brain injury patients on antiplatelet therapy.
Topics: Aged; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Male; Platelet | 2014 |
Preinjury warfarin, but not antiplatelet medications, increases mortality in elderly traumatic brain injury patients.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; In | 2015 |
Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats.
Topics: Adipogenesis; Analysis of Variance; Animals; Aspirin; Brain Injuries; Brain Ischemia; Cell Different | 2015 |
Failure of the Platelet Function Assay (PFA)-100 to detect antiplatelet agents.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelet Disorders; Brain Injuries; Clopidogrel; False Negat | 2015 |
High prevalence of pharmacologically induced platelet dysfunction in the acute setting of brain injury.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Brain Injuries; Cerebral Hemorrhage; Femal | 2016 |
Predictors of mortality in trauma patients with intracranial hemorrhage on preinjury aspirin or clopidogrel.
Topics: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Coagulati | 2008 |
The effects of clopidogrel on elderly traumatic brain injured patients.
Topics: Aged; Aspirin; Brain Damage, Chronic; Brain Injuries; Cardiovascular Diseases; Case-Control Studies; | 2008 |
Treatment of a traumatic carotid-cavernous fistula by the sole use of a flow diverting stent.
Topics: Abducens Nerve Diseases; Accidents, Traffic; Angiography, Digital Subtraction; Aspirin; Brain Injuri | 2012 |
Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Injuries; Cohort Studies; Female; Humans; Intracranial Hemor | 2011 |
Impact of age and anticoagulation: need for neurosurgical intervention in trauma patients with mild traumatic brain injury.
Topics: Age Factors; Aged; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Craniotomy; Decompressive C | 2012 |
Low-dose aspirin prophylaxis and risk of intracranial hemorrhage in patients older than 60 years of age with mild or moderate head injury: a prospective study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Injuries; Dose-Resp | 2003 |
Cerebral perfusion pressure elevation with oxygen-carrying pressor after traumatic brain injury and hypotension in Swine.
Topics: Amyloid beta-Protein Precursor; Animals; Aspirin; Blood Pressure; Blood Volume; Brain Chemistry; Bra | 2004 |
[Nerve tissue ultrastructure in experimental brain injuries in animals with increased immunobiologic reactivity following treatment with certain desensitizing drugs].
Topics: Animals; Aspirin; Autoimmune Diseases; Brain; Brain Edema; Brain Injuries; Chinchilla; Chlorpromazin | 1981 |
Focal cerebral ischemia in rats. Effect of hypervolemic hemodilution with diaspirin cross-linked hemoglobin versus albumin on brain injury and edema.
Topics: Albumins; Animals; Aspirin; Brain Edema; Brain Injuries; Brain Ischemia; Cross-Linking Reagents; Hem | 1993 |
Diaspirin cross-linked hemoglobin resuscitation improves cerebral perfusion after head injury and shock.
Topics: Animals; Aspirin; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Fluid Therapy; Hemody | 1996 |
Effect of small-volume resuscitation on intracranial pressure and related cerebral variables.
Topics: Animals; Aspirin; Brain Injuries; Cerebrovascular Circulation; Dextrans; Disease Models, Animal; Dru | 1997 |
Effects of diaspirin cross-linked haemoglobin on post-traumatic cerebral perfusion pressure and blood flow in a rodent model of diffuse brain injury.
Topics: Animals; Aspirin; Blood Pressure; Blood Substitutes; Brain Injuries; Cerebrovascular Circulation; He | 1998 |
Comparison of standard and alternative prehospital resuscitation in uncontrolled hemorrhagic shock and head injury.
Topics: Animals; Aspirin; Blood Substitutes; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Em | 1999 |
Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Astrocytes; Brain; Brain Injur | 2001 |
Resuscitation from severe hemorrhagic shock after traumatic brain injury using saline, shed blood, or a blood substitute.
Topics: Animals; Aspirin; Blood Substitutes; Blood Transfusion; Brain; Brain Injuries; Brain Ischemia; Carbo | 2002 |
Determination of brain death via pulsatile echoencephalography.
Topics: Adult; Aspirin; Brain Death; Brain Diseases; Brain Injuries; Cerebrovascular Circulation; Echoenceph | 1978 |
Effects of brain trauma on undamaged cerebral microvessels.
Topics: Animals; Aspirin; Brain; Brain Injuries; Indomethacin; Mice; Microcirculation; Platelet Aggregation | 1977 |
Platelet aggregation and vasoconstriction in undamaged microvessels on cerebral surface adjacent to brain traumatized by a penetrating needle.
Topics: Animals; Arterioles; Aspirin; Brain Injuries; Dipyridamole; Indomethacin; Male; Mice; Pia Mater; Pla | 1978 |
Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: both are coordinately inhibited by verapamil, dexamethasone, and aspirin.
Topics: Animals; Aspirin; Blood-Brain Barrier; Brain; Brain Injuries; Cold Temperature; Cycloheximide; Dacti | 1989 |