aspirin has been researched along with Acidosis in 49 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topically applied acetylsalicylic acid (ASA), salicylic acid (SA) and indomethacin were tested in an experimental pain model that provides direct nociceptor excitation through cutaneous tissue acidosis." | 9.08 | Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin. ( Kreysel, HW; Reeh, PW; Steen, KH, 1995) |
| "Diaspirin cross-linked hemoglobin (DCLHb) is a vasoactive hemoglobin-based oxygen carrier or "blood substitute" that has been shown to improve base deficit in several experimental studies of hemorrhagic shock." | 7.70 | The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned rats. ( Hansbrough, JF; Soltero, RG, 1999) |
| "Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses." | 7.67 | Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. ( Baird, IM; Cowan, RA; Hartnell, GG; Leak, AM; Lowdell, CP, 1984) |
| "Topically applied acetylsalicylic acid (ASA), salicylic acid (SA) and indomethacin were tested in an experimental pain model that provides direct nociceptor excitation through cutaneous tissue acidosis." | 5.08 | Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin. ( Kreysel, HW; Reeh, PW; Steen, KH, 1995) |
| "In the final regression model, VFD was associated with maternal consumption of aspirin during the current pregnancy, recurring/persistent acidemia during the first 3 postnatal days, cerebral ventriculomegaly seen on neonatal ultrasound, prethreshold retinopathy of prematurity (ROP), and supplemental oxygen and ventilator dependence at 36 weeks post-menstrual age." | 3.81 | Antecedents and correlates of visual field deficits in children born extremely preterm. ( Allred, E; Dammann, O; Holm, M; Leviton, A; Msall, ME; Skranes, J, 2015) |
| "Diaspirin cross-linked hemoglobin (DCLHb) is a vasoactive hemoglobin-based oxygen carrier or "blood substitute" that has been shown to improve base deficit in several experimental studies of hemorrhagic shock." | 3.70 | The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned rats. ( Hansbrough, JF; Soltero, RG, 1999) |
| "Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses." | 3.67 | Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. ( Baird, IM; Cowan, RA; Hartnell, GG; Leak, AM; Lowdell, CP, 1984) |
| " Veverimer is not systemically absorbed, so potential drug-drug interactions (DDIs) are limited to effects on the absorption of other oral drugs through binding to veverimer in the gastrointestinal tract or increases in gastric pH caused by veverimer binding to hydrochloric acid." | 3.01 | Assessment of the Potential for Veverimer Drug-Drug Interactions. ( Biyani, K; Guttendorf, R; Klaerner, G; Lee, A; Li, E; Mathur, V; Parsell, D; Shao, J; Stasiv, Y; Tabakman, S; Tsao, L; Wu, YS, 2021) |
| "The principal toxic manifestations of respiratory alkalosis and metabolic acidosis, altered glucose availability and depletion, fluid and electrolyte losses, and hypermetabolism result in serious morbidity and are potentially fatal." | 2.36 | Pathophysiology of aspirin overdosage toxicity, with implications for management. ( Temple, AR, 1978) |
| "Acute metabolic acidosis is rarely associated with a reduced or negative anion gap (AG), but several case reports have described such an abnormality occurring in the setting of acute salicylate intoxication." | 1.48 | Spurious Hyperchloremia in the Presence of Elevated Plasma Salicylate: A Cohort Study. ( Kashani, KB; Qian, Q; Steuernagle Iv, JH, 2018) |
| "Recognizing SIDS as part of the diagnostic criteria for BrS would help us identifying a significant number of families susceptible to develop SCD (as well as SIDS)." | 1.40 | EKG pattern of Brugada syndrome and sudden infant death syndrome--is it time to review the diagnostic criteria? Case report and review of literature. ( Dias, A; Franco, E; Hebert, K; Teresa, D, 2014) |
| "She was treated with acetazolamide for simple glaucoma and since 14 days with ASA for acute pericarditis." | 1.30 | [Salicylism and glaucoma: reciprocal augmentation of the toxicity of acetazolamide and acetylsalicylic acid]. ( De Toffol, MC; Grimbert, M; Hazouard, E; Jonville-Berra, AP; Legras, A, 1999) |
| "Ketosis was present with a moderate metabolic acidosis and primary respiratory alkalosis." | 1.26 | Salicylate-induced hypoglycemia and ketoacidosis in a nondiabetic adult. ( Arena, FP; Dugowson, C; Saudek, CD, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (51.02) | 18.7374 |
| 1990's | 8 (16.33) | 18.2507 |
| 2000's | 3 (6.12) | 29.6817 |
| 2010's | 10 (20.41) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, TE | 1 |
| Liu, SY | 1 |
| Wiederkehr, MR | 1 |
| Benevides, R | 1 |
| Santa Ana, CA | 1 |
| Emmett, M | 2 |
| Parsell, D | 1 |
| Shao, J | 1 |
| Guttendorf, R | 1 |
| Mathur, V | 1 |
| Li, E | 1 |
| Wu, YS | 1 |
| Tsao, L | 1 |
| Tabakman, S | 1 |
| Stasiv, Y | 1 |
| Lee, A | 1 |
| Biyani, K | 1 |
| Klaerner, G | 1 |
| Kashani, KB | 1 |
| Steuernagle Iv, JH | 1 |
| Qian, Q | 1 |
| Sepúlveda, RA | 1 |
| Ortega, M | 1 |
| Donoso, N | 1 |
| Jara, A | 1 |
| Lapponi, MJ | 1 |
| Carestia, A | 1 |
| Landoni, VI | 1 |
| Rivadeneyra, L | 1 |
| Etulain, J | 1 |
| Negrotto, S | 1 |
| Pozner, RG | 1 |
| Schattner, M | 1 |
| Aggarwal, N | 1 |
| Kupfer, Y | 1 |
| Chawla, K | 1 |
| Tessler, S | 1 |
| Franco, E | 1 |
| Dias, A | 1 |
| Teresa, D | 1 |
| Hebert, K | 1 |
| Holm, M | 1 |
| Msall, ME | 1 |
| Skranes, J | 1 |
| Dammann, O | 1 |
| Allred, E | 1 |
| Leviton, A | 1 |
| Vázquez Martinez, JL | 1 |
| Stanescu, S | 1 |
| Castrillo Bustamante, S | 1 |
| Del Rey Sanchez, JM | 1 |
| Pérez-Caballero Macarrón, C | 1 |
| Coca Pérez, A | 1 |
| Sakai, N | 1 |
| Hirose, Y | 1 |
| Sato, N | 1 |
| Kondo, D | 1 |
| Shimada, Y | 1 |
| Hori, Y | 1 |
| Wang, W | 1 |
| Ye, SD | 1 |
| Zhou, KQ | 1 |
| Wu, LM | 1 |
| Huang, YN | 1 |
| Borisevich, N | 1 |
| Loznikova, S | 1 |
| Sukhodola, A | 1 |
| Halets, I | 1 |
| Bryszewska, M | 1 |
| Shcharbin, D | 1 |
| BARNESS, LA | 2 |
| YOUNG, LN | 2 |
| FENNELLY, JJ | 1 |
| LASKER, N | 1 |
| MITSUSE, J | 1 |
| MORIYAMA, K | 1 |
| GHOSE, RR | 1 |
| JOEKES, AM | 1 |
| RAMSAY, AG | 1 |
| WHITE, DF | 1 |
| Müller, GJ | 1 |
| Becker, CE | 1 |
| Cowan, RA | 1 |
| Hartnell, GG | 1 |
| Lowdell, CP | 1 |
| Baird, IM | 1 |
| Leak, AM | 1 |
| Khan, MI | 1 |
| Miller, MT | 1 |
| Bartlett, M | 1 |
| Brimioulle, S | 2 |
| Lejeune, P | 2 |
| Vachiéry, JL | 1 |
| Delcroix, M | 1 |
| Hallemans, R | 2 |
| Leeman, M | 2 |
| Naeije, R | 2 |
| Steen, KH | 1 |
| Reeh, PW | 1 |
| Kreysel, HW | 1 |
| Chabali, R | 1 |
| Matfin, G | 1 |
| Durand, D | 1 |
| Christopher, KR | 1 |
| Adelman, HM | 1 |
| Soltero, RG | 1 |
| Hansbrough, JF | 1 |
| Hazouard, E | 1 |
| Grimbert, M | 1 |
| Jonville-Berra, AP | 1 |
| De Toffol, MC | 1 |
| Legras, A | 1 |
| Sunela, K | 1 |
| Mathew, TH | 1 |
| Bulugahapitiya, DT | 1 |
| Hebron, B | 1 |
| Beck, PR | 1 |
| Temple, AR | 2 |
| Narins, RG | 1 |
| Arena, FP | 1 |
| Dugowson, C | 1 |
| Saudek, CD | 1 |
| Onstad, GR | 1 |
| Gustafson, A | 1 |
| Gustafsson, B | 1 |
| Demanet, JC | 1 |
| Buchanan, N | 1 |
| Good, AE | 1 |
| Welch, MH | 1 |
| Thibault, GE | 1 |
| Melot, C | 1 |
| de Groen, PC | 1 |
| Bergentz, SE | 1 |
| Done, AK | 1 |
| Hosková, A | 1 |
| Matthew, H | 1 |
| Wright, N | 1 |
| Gietko, M | 1 |
| Ilowiecka, K | 1 |
| Worowska, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Analysis Between Ringer's Lactate vs Acetate Containing Balanced Crystalloid Solution (Plasma Lyte-A) as Cardiopulmonary Bypass Prime[NCT03043131] | Phase 3 | 60 participants (Anticipated) | Interventional | 2017-02-10 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for aspirin and Acidosis
| Article | Year |
|---|---|
[Physiopathology and management of acetylsalicylic acid intoxication].
Topics: Acidosis; Aspirin; Drug Overdose; Fibrinolytic Agents; Humans; Hypoglycemia; Hypotension; Mitochondr | 2018 |
[Metabolic acidosis].
Topics: Acid-Base Equilibrium; Acidosis; Aspirin; Bicarbonates; Humans; Hydrogen-Ion Concentration; Hypoxia; | 2006 |
Pathophysiology of aspirin overdosage toxicity, with implications for management.
Topics: Acidosis; Alkalosis, Respiratory; Aspirin; Fever; Fluid Therapy; Glucose; Humans; Water-Electrolyte | 1978 |
Septic shock and disturbances in coagulation.
Topics: Acidosis; Acute Kidney Injury; Aminocaproates; Aspirin; Blood Coagulation Disorders; Blood Coagulati | 1974 |
Treatment of salicylate poisoning.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin | 1971 |
2 trials available for aspirin and Acidosis
| Article | Year |
|---|---|
Assessment of the Potential for Veverimer Drug-Drug Interactions.
Topics: Absorption, Physicochemical; Acidosis; Administration, Oral; Adolescent; Adult; Aspirin; Cross-Over | 2021 |
Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin.
Topics: Acidosis; Administration, Topical; Adult; Aspirin; Cross-Over Studies; Double-Blind Method; Female; | 1995 |
42 other studies available for aspirin and Acidosis
| Article | Year |
|---|---|
Severe Metabolic Acidosis and Hyperammonemia Induced by the Concomitant Use of Acetazolamide and Aspirin in a Patient With Impaired Renal Function.
Topics: Acetazolamide; Acidosis; Aspirin; Humans; Hyperammonemia; Kidney; Male; Middle Aged; Renal Dialysis | 2021 |
Pseudohyperchloremia and Negative Anion Gap - Think Salicylate!
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Artifacts; Aspirin; Chlorides; Equipment Failu | 2021 |
Spurious Hyperchloremia in the Presence of Elevated Plasma Salicylate: A Cohort Study.
Topics: Acidosis; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bromides; Chlor | 2018 |
Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs.
Topics: Acidosis; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Asp | 2013 |
Altered mental status and complete heart block: an unusual presentation of aspirin toxicity.
Topics: Acidosis; Aged; Aspirin; Female; Heart Block; Humans; Mental Disorders; Pacemaker, Artificial | 2013 |
EKG pattern of Brugada syndrome and sudden infant death syndrome--is it time to review the diagnostic criteria? Case report and review of literature.
Topics: Acidosis; Adult; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brugada S | 2014 |
Antecedents and correlates of visual field deficits in children born extremely preterm.
Topics: Acidosis; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebral Ventricles; Child Develo | 2015 |
Unrecognized Transcutaneous Severe Salicylate Intoxication in an Infant.
Topics: Acidosis; Administration, Topical; Alkalosis, Respiratory; Aspirin; Humans; Infant; Male | 2015 |
Late Metabolic Acidosis Caused by Renal Tubular Acidosis in Acute Salicylate Poisoning.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Renal Tubular; Adolescent; Aspirin; Fluid Therapy; Humans | 2016 |
High doses of salicylate and aspirin are inhibitory on acid-sensing ion channels and protective against acidosis-induced neuronal injury in the rat cortical neuron.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroi | 2012 |
Acidosis, magnesium and acetylsalicylic acid: effects on thrombin.
Topics: Acidosis; Aspirin; Humans; Hydrogen-Ion Concentration; Kinetics; Luminescent Measurements; Magnesium | 2013 |
A SIMPLIFIED VIEW OF FLUID THERAPY.
Topics: Acidosis; Adrenal Insufficiency; Aspirin; Calcium; Child; Cystic Fibrosis; Dehydration; Diabetes Mel | 1964 |
ACUTE RENAL FAILURE FOLLOWING ACETOPHENETIDIN INGESTION.
Topics: Acidosis; Acute Kidney Injury; Aspirin; Caffeine; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosi | 1964 |
[PULMONARY ENCEPHALOPATHY].
Topics: Acidosis; Aspirin; Bicarbonates; Brain Diseases; Carbon Dioxide; Coma; Electroencephalography; Human | 1964 |
TREATMENT OF SEVERE ASPIRIN POISONING WITHOUT DIALYSIS.
Topics: Acidosis; Alkalosis; Aspirin; Bicarbonates; Blood Chemical Analysis; Diuretics; Gastric Lavage; Huma | 1964 |
A SIMPLIFIED VIEW OF FLUID THERAPY.
Topics: Acidosis; Adrenal Insufficiency; Anuria; Aspirin; Body Weight; Burns; Calcium; Child; Cystic Fibrosi | 1964 |
PHENACETIN NEPHROPATHY.
Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy | 1965 |
Aspirin, other salicylates and non-steroidal anti-inflammatory agents.
Topics: Acidosis; Adult; Alkalosis, Respiratory; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Charcoal; | 2004 |
The alcoholic patient as a toxic emergency.
Topics: 1-Propanol; Acidosis; Alcoholic Intoxication; Alcoholism; Aspirin; Blood Glucose; Diagnosis, Differe | 1984 |
Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function.
Topics: Acetazolamide; Acidosis; Adult; Arthritis; Aspirin; Carbonic Anhydrase Inhibitors; Child; Dichlorphe | 1984 |
Complete recovery after profound acidosis (pH 6.49).
Topics: Acidosis; Aspirin; Female; Humans; Hydrogen-Ion Concentration; Infant | 1984 |
Stimulus-response curve of hypoxic pulmonary vasoconstriction in intact dogs: effects of ASA.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Aspirin; Blood Gas Analysis; Cardiac Output; Cyclooxygenas | 1994 |
Diagnostic use of anion and osmolal gaps in pediatric emergency medicine.
Topics: Acid-Base Equilibrium; Acidosis; Aspirin; Child, Preschool; Diagnosis, Differential; Emergency Medic | 1997 |
A confused man with rapid respiration.
Topics: Acidosis; Acute Disease; Aged; Alkalosis, Respiratory; Anti-Inflammatory Agents; Aspirin; Confusion; | 1998 |
The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned rats.
Topics: Acidosis; Animals; Aspirin; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therap | 1999 |
[Salicylism and glaucoma: reciprocal augmentation of the toxicity of acetazolamide and acetylsalicylic acid].
Topics: Acetazolamide; Acidosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbonic Anhydrase Inhibi | 1999 |
[A typical alcohol seizure?].
Topics: Acidosis; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Aspirin; Diagnosis, Differential | 2000 |
Analgesic nephropathy.
Topics: Acidosis; Analgesics, Opioid; Aspirin; Australia; Dehydration; Health Education; Humans; Kidney Dise | 1976 |
Salicylate hepatitis with acidosis in an infant.
Topics: Acidosis; Aspirin; Chemical and Drug Induced Liver Injury; Humans; Hydrogen-Ion Concentration; Infan | 1979 |
Clinical use of the anion gap.
Topics: Acid-Base Imbalance; Acidosis; Acidosis, Renal Tubular; Alkalosis; Alkalosis, Respiratory; Aspirin; | 1977 |
Salicylate-induced hypoglycemia and ketoacidosis in a nondiabetic adult.
Topics: Acidosis; Aged; Alkalosis, Respiratory; Aspirin; Female; Glucose; Humans; Hypoglycemia; Infusions, P | 1978 |
Metabolic acidosis but what was the cause?
Topics: Acidosis; Aspirin; Diagnosis, Differential; Female; Humans; Middle Aged | 1978 |
Acute poisoning with dextropropoxyphene. Clinical symptoms and plasma concentrations.
Topics: Acidosis; Acute Disease; Adolescent; Adult; Arrhythmia, Sinus; Aspirin; Barbiturates; Dextropropoxyp | 1976 |
[Serious complications of current treatments].
Topics: Acidosis; Adolescent; Aged; Alcoholism; Antihypertensive Agents; Aspirin; Diuretics; Drug-Related Si | 1975 |
Salicylate intoxication in infancy: a review.
Topics: Acidosis; Alkalosis; Alkalosis, Respiratory; Animals; Aspirin; Child; Child, Preschool; Dehydration; | 1975 |
Hospital-acquired salicylate intoxication. report of a case with psychosis, acidosis, and coma.
Topics: Acidosis; Arthritis, Rheumatoid; Aspirin; Coma; Hospitalization; Humans; Iatrogenic Disease; Male; M | 1975 |
The landlady confirms the diagnosis.
Topics: Acidosis; Adult; Aspirin; Decision Making; Diagnosis, Differential; Drug Overdose; Ethanol; Humans; | 1992 |
Enhancement of hypoxic pulmonary vasoconstriction by metabolic acidosis in dogs.
Topics: Acidosis; Animals; Aspirin; Bicarbonates; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs; Hear | 1990 |
[Chronic poisoning due to salicylic acid compounds: frequently not diagnosed or treated wrong].
Topics: Acidosis; Aged; Aged, 80 and over; Alkalosis, Respiratory; Aspirin; Cognition Disorders; Confusion; | 1989 |
[Acylpyrine hazards in infants and toddlers].
Topics: Acidosis; Age Factors; Aspirin; Child Health Services; Female; Humans; Hyperventilation; Infant; Lip | 1971 |
Aspirin poisoning.
Topics: Acidosis; Acute Disease; Aspirin; Humans; Poisoning; Prognosis; Salicylates | 1971 |
[Severe hypoglycemic coma in a 4-month-old infant during treatment with aspirin].
Topics: Acidosis; Acute Disease; Age Factors; Aspirin; Carbohydrate Metabolism; Coma; Humans; Hypoglycemia; | 1970 |