aspirin has been researched along with Achlorhydria in 13 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of aspirin (acetylsalicylic acid) ingestion on occult gastrointestinal blood loss has been studied in patients with treated Addisonian pernicious anaemia and proved achlorhydria and in control patients able to secrete hydrochloric acid." | 7.65 | Influence of achlorhydria on aspirin-induced occult gastrointestinal blood loss: studies in Addisonian pernicious anaemia. ( John, DJ; McDermott, FT, 1970) |
| "Benign gastric ulceration occurred in a patient with pernicious anemia in association with aspirin therapy." | 3.66 | Benign gastric ulceration in pernicious anemia. ( Heading, RC; Holt, S; Reid, J; Taylor, TV, 1980) |
| "Recurrent gastrojejunal ulceration is reported in three patients with histamine-fast achlorhydria." | 3.65 | Marginal ulcer in achlorhydric patients. ( Hirschowitz, BI; Tauxe, RV; Wright, LF, 1975) |
| "The effect of aspirin (acetylsalicylic acid) ingestion on occult gastrointestinal blood loss has been studied in patients with treated Addisonian pernicious anaemia and proved achlorhydria and in control patients able to secrete hydrochloric acid." | 3.65 | Influence of achlorhydria on aspirin-induced occult gastrointestinal blood loss: studies in Addisonian pernicious anaemia. ( John, DJ; McDermott, FT, 1970) |
| "Dipyridamole (DP) is an antiplatelet agent that shows decreased oral bioavailability with increased gastric pH that occurs with commonly prescribed antacids." | 2.71 | Dipyridamole bioavailability in subjects with reduced gastric acidity. ( Brickl, RS; Derendorf, H; Eisert, W; MacGregor, TR; VanderMaelen, CP, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GASPARDY, G | 1 |
| VIDA, M | 1 |
| BANYAI, B | 1 |
| Derendorf, H | 1 |
| VanderMaelen, CP | 1 |
| Brickl, RS | 1 |
| MacGregor, TR | 1 |
| Eisert, W | 1 |
| Reid, J | 1 |
| Taylor, TV | 1 |
| Holt, S | 1 |
| Heading, RC | 1 |
| Wald, A | 1 |
| Tauxe, RV | 1 |
| Wright, LF | 1 |
| Hirschowitz, BI | 1 |
| Rafoth, RJ | 1 |
| Silvis, SE | 1 |
| Pottage, A | 1 |
| Nimmo, J | 1 |
| Prescott, LF | 1 |
| Thompson, CE | 1 |
| Ashurst, PM | 1 |
| Butler, TJ | 1 |
| John, DJ | 1 |
| McDermott, FT | 2 |
| Saint John, DJ | 1 |
| Jabbari, M | 1 |
| Valberg, LS | 1 |
| Russell, RI | 1 |
| Goldberg, A | 1 |
| Gottschalk, AM | 1 |
| Menguy, R | 1 |
1 trial available for aspirin and Achlorhydria
| Article | Year |
|---|---|
Dipyridamole bioavailability in subjects with reduced gastric acidity.
Topics: Achlorhydria; Adult; Aspirin; Biological Availability; Cross-Over Studies; Dipyridamole; Drug Combin | 2005 |
12 other studies available for aspirin and Achlorhydria
| Article | Year |
|---|---|
[New considerations on the treatment of gastric disorders produced by salicylate].
Topics: Achlorhydria; Arthritis; Arthritis, Rheumatoid; Aspirin; Gastric Juice; Salicylates; Stomach Disease | 1962 |
Benign gastric ulceration in pernicious anemia.
Topics: Achlorhydria; Aged; Anemia, Pernicious; Aspirin; Female; Humans; Stomach Ulcer | 1980 |
Aspirin and prepyloric ulcer.
Topics: Achlorhydria; Aspirin; Humans; Male; Stomach Ulcer | 1976 |
Marginal ulcer in achlorhydric patients.
Topics: Achlorhydria; Aged; Alcoholism; Aspirin; Gastrectomy; Gastric Acidity Determination; Gastric Juice; | 1975 |
Gastric ulceration associated with aspirin ingestion in an achlorhydric patient: a case report.
Topics: Achlorhydria; Arthritis, Rheumatoid; Aspirin; Gastric Mucosa; Gastroscopy; Humans; Male; Middle Aged | 1976 |
The absorption of aspirin and paracetamol in patients with achlorhydria.
Topics: Acetaminophen; Achlorhydria; Administration, Oral; Aspirin; Female; Humans; Hydrogen-Ion Concentrati | 1974 |
Survey of haemorrhagic erosive gastritis.
Topics: ABO Blood-Group System; Achlorhydria; Acute Disease; Adult; Aged; Aspirin; Autoantibodies; Female; F | 1968 |
Influence of achlorhydria on aspirin-induced occult gastrointestinal blood loss: studies in Addisonian pernicious anaemia.
Topics: Achlorhydria; Adult; Aged; Anemia, Pernicious; Aspirin; Bone Marrow Examination; Female; Fluorescent | 1970 |
Effect of aspirin upon gastrointestinal blood loss in pernicious anaemia.
Topics: Achlorhydria; Anemia, Pernicious; Aspirin; Chromium Isotopes; Gastric Juice; Gastrointestinal Hemorr | 1969 |
Role of acid secretion in aspirin-induced gastric mucosal injury.
Topics: Achlorhydria; Adult; Aged; Aspirin; Biopsy; Blood Coagulation Tests; Female; Gastric Juice; Gastric | 1970 |
The effect of buffered and unbuffered aspirin on gastric pH measured by a pH-sensitive telemetering capsule.
Topics: Achlorhydria; Aspirin; Buffers; Gastric Acidity Determination; Gastric Juice; Humans; Hydrogen-Ion C | 1970 |
Influence of gastric atrophy on the susceptibility of the gastric mucosa to injury by aspirin.
Topics: Achlorhydria; Animals; Aspirin; Atrophy; Gastric Acidity Determination; Gastric Juice; Gastric Mucos | 1970 |