aspirin has been researched along with Abnormalities, Drug-Induced in 123 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes." | 8.82 | Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis. ( Boskovic, R; Costei, AM; Koren, G; Kozer, E; Nikfar, S; Nulman, I, 2003) |
| "The purpose of this study was to determine, on the basis of published reports, whether aspirin use during the first trimester of pregnancy is associated with an increased risk of congenital malformations." | 8.81 | Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis. ( Boskovic, R; Costei, A; Koren, G; Kozer, E; Nikfar, S; Nulman, I, 2002) |
| "Recent surveys of prenatal drug consumption indicate that aspirin is the most frequently consumed drug in pregnancy." | 8.75 | Aspirin in pregnancy: maternal and fetal effects. ( Corby, DG, 1978) |
| "It is still controversial whether aspirin use during pregnancy increases the risk of certain congenital abnormalities (in particular, neural tube defects, gastroschisis, and cleft lip +/- palate)." | 7.73 | Aspirin use during early pregnancy and the risk of congenital abnormalities: a population-based case-control study. ( Czeizel, AE; Nørgård, B; Puhó, E; Skriver, MV; Sørensen, HT, 2005) |
| "It has been hypothesized that the ingestion of aspirin by women during pregnancy increases their infants' risk of certain congenital heart defects." | 7.67 | The relation of aspirin use during the first trimester of pregnancy to congenital cardiac defects. ( Mitchell, AA; Shapiro, S; Werler, MM, 1989) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 7.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "Pretreatment with aspirin significantly augmented alcohol-induced resorption, IUGR, cleft palate and digital malformations associated with haematomas." | 5.29 | Aspirin-alcohol interaction in the production of cleft palate and limb malformations in the TO mouse. ( Padmanabhan, R; Pallot, DJ, 1995) |
| "We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes." | 4.82 | Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis. ( Boskovic, R; Costei, AM; Koren, G; Kozer, E; Nikfar, S; Nulman, I, 2003) |
| "NSAIDs or cyclooxygenase inhibitors (COX inhibitors), including aspirin, are widely used to treat pain, fever and the articular symptoms of chronic rheumatic diseases." | 4.82 | Anti-inflammatory pharmacotherapy during pregnancy. ( Skomsvoll, JF; Østensen, ME, 2004) |
| "The purpose of this study was to determine, on the basis of published reports, whether aspirin use during the first trimester of pregnancy is associated with an increased risk of congenital malformations." | 4.81 | Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis. ( Boskovic, R; Costei, A; Koren, G; Kozer, E; Nikfar, S; Nulman, I, 2002) |
| "Recent surveys of prenatal drug consumption indicate that aspirin is the most frequently consumed drug in pregnancy." | 4.75 | Aspirin in pregnancy: maternal and fetal effects. ( Corby, DG, 1978) |
| "The use of low-dose aspirin in pregnancy should remain a highly targeted indication since its long-term safety has not been established and should be restricted to women at high risk of vascular complications." | 3.85 | [For a targeted use of aspirin]. ( Brun, S; Coatleven, F; Gleyze, M; Lecoq, C; Madar, H; Merlot, B; Nithart, A; Sentilhes, L, 2017) |
| " In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis." | 3.80 | Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014) |
| "It is still controversial whether aspirin use during pregnancy increases the risk of certain congenital abnormalities (in particular, neural tube defects, gastroschisis, and cleft lip +/- palate)." | 3.73 | Aspirin use during early pregnancy and the risk of congenital abnormalities: a population-based case-control study. ( Czeizel, AE; Nørgård, B; Puhó, E; Skriver, MV; Sørensen, HT, 2005) |
| "Antenatal intake of low dose aspirin is advised for prevention of pregnancy induced hypertension, intrauterine growth retardation and pre-term labour." | 3.71 | Fetal intracranial hemorrhage due to antenatal low dose aspirin intake. ( Kutty, PM; Sajith, N; Sasidharan, CK, 2001) |
| "A patient with systemic lupus erythematosus and elevated cardiolipin antibody levels was given low-dose aspirin therapy prior to and throughout her third pregnancy to minimize the risk of miscarriage." | 3.68 | Anticardiolipin syndrome, aspirin therapy and fetal malformation. ( Chakravarty, K; Merry, P, 1993) |
| "It has been hypothesized that the ingestion of aspirin by women during pregnancy increases their infants' risk of certain congenital heart defects." | 3.67 | The relation of aspirin use during the first trimester of pregnancy to congenital cardiac defects. ( Mitchell, AA; Shapiro, S; Werler, MM, 1989) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 3.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| ", malformation rates were similar in the children of 35 418 women not exposed to aspirin, 9736 with intermediate exposure, and 5128 women heavily exposed during the first four lunar months of pregnancy." | 3.65 | Aspirin and congenital malformations. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1976) |
| "Aspirin has potential risks." | 2.44 | Aspirin and reproductive outcomes. ( Brancazio, LR; James, AH; Price, T, 2008) |
| "Recently, the thrombophilias have been revealed as risk factors for severe preeclampsia, abruptio placentae, fetal growth retardation, abortion and still birth as well." | 2.42 | [Anticoagulation and antiaggregation during pregnancy]. ( Biasiutti, FD; Strebel, JK, 2003) |
| "Migraine is a typical "women's disease": the fluctuations of sex hormones, in particular estrogens, during woman's reproductive life show a direct and major influence on migraine course." | 2.42 | [Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies]. ( Airola, G; Allais, G; Benedetto, C; Bosio, A; Ciochetto, D; De Lorenzo, C; Mana, O; Quirico, PE; Terzi, MG, 2003) |
| "Placental infarction due to thrombosis seems to be the most consistent event." | 2.40 | Fertility, pregnancy and the management of myeloproliferative disorders. ( Bergmann, L; Griesshammer, M; Pearson, T, 1998) |
| "Placental infarction due to thrombosis seems to be the most consistent pathological event as far as the fetus is concerned." | 2.39 | Essential thrombocythemia and pregnancy. ( Griesshammer, M; Heimpel, H; Pearson, TC, 1996) |
| "These defects have been labeled fetal alcohol syndrome or, in a milder form, fetal alcohol effects." | 2.37 | Alcohol, pregnancy, and prostaglandins. ( Anton, RF; Becker, HC; Randall, CL, 1987) |
| "Drugs were separately, orally once daily dosed to pregnant rats from day 8 to 21 (GD1=plug day)." | 1.33 | Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study. ( Burdan, F, 2005) |
| "The fetal body weight was significantly lower in COX-exposed group of fetuses when compared with untreated control." | 1.33 | Celosomy is associated with prenatal exposure to cyclooxygenase inhibitors. ( Burdan, F; Dudka, J; Klepacz, R; Korobowicz, A; Szumilo, J, 2006) |
| " The objectives of the current study were to comprehensively define the developmental toxicology profile of ASA in rabbits by using a dosing paradigm encompassing the period of organogenesis and to test the hypothesis that maternal gastrointestinal toxicity after repeated dose administrations hampers the detection of low-incidence malformations with ASA in rabbits by limiting ASA administration to sensitive windows for cardiovascular development and midline closure." | 1.32 | Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development. ( Cappon, GD; Cook, JC; Gupta, U; Hurtt, ME; Tassinari, MS, 2003) |
| " There are no published ASA studies using the multiple dosing paradigm of GDs 6 to 17." | 1.32 | Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms. ( Cook, JC; Gupta, U; Hurtt, ME; Tassinari, MS, 2003) |
| "Pretreatment with aspirin significantly augmented alcohol-induced resorption, IUGR, cleft palate and digital malformations associated with haematomas." | 1.29 | Aspirin-alcohol interaction in the production of cleft palate and limb malformations in the TO mouse. ( Padmanabhan, R; Pallot, DJ, 1995) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| "Aspirin was administered by oral gavage to 25 gravid Sprague-Dawley rats on gestation day 10, as a single dose of 500 mg/kg, in a concentration of 50 mg/ml." | 1.27 | Novel accessory skull bone in fetal rats after exposure to aspirin. ( Boardman, JP; Carrano, RA; Iuliucci, JD; Mitala, JJ, 1984) |
| " These same dosage levels also caused a severe maternal hemolytic anemia following a dramatic decrease in erythrocyte ATP levels." | 1.27 | Diflunisal-induced maternal anemia as a cause of teratogenicity in rabbits. ( Allen, HL; Bokelman, DL; Clark, RL; Cohen, SM; James, ML; Minsker, DH; Robertson, RT; Tocco, DJ, 1984) |
| " A similar study was conducted with Dutch-Belted rabbits dosed po daily at 3, 10, 30, or 100 mg of o-toluenediamine/kg body wt/day from Days 6 through 18 of gestation." | 1.27 | Teratogenesis study of o-toluenediamine in rats and rabbits. ( Barbee, SJ; Becci, PJ; Knickerbocker, MJ; Reagan, EL; Wedig, JH, 1983) |
| "EGTA-treated rat serum was added to the culture medium and tested the toxic effect of EGTA on development of embryo using 11." | 1.27 | Embryotoxic effects of EGTA-induced hypocalcemic condition on cultured rat embryos. ( Eto, K; Igarashi, T; Kitagawa, H; Ueno, K; Yokoyama, A, 1985) |
| "Trimethyl phosphite (TMP) is an organophosphorus alkylating agent used primarily in the synthesis of organophosphate compounds." | 1.27 | Teratological evaluation of trimethyl phosphite in the rat. ( Craig, PH; Gallo, MA; Mehlman, MA, 1984) |
| " Previous studies have indicated that pregnant animals treated acutely with toxic levels of a variety of pharmacologically unrelated chemicals produced litters without a recognizable syndrome of defects, except for an increased incidence of supernumerary ribs (SNR)." | 1.27 | The potential relationship of maternal toxicity, general stress, and fetal outcome. ( Beyer, PE; Chernoff, N; Kavlock, RJ; Miller, D, 1987) |
| "Toluene was found to potentiate the toxic effect of ASA and to increase both maternal and embryonic toxicity." | 1.27 | Combined embryotoxic action of toluene, a widely used industrial chemical, and acetylsalicylic acid (aspirin). ( Barcza, G; Lõrincz, M; Tátrai, E; Ungváry, G, 1983) |
| "Human fetal alcohol syndrome characteristics have been seen in the mouse fetus by several investigators who dosed the dam with only one or two doses of alcohol." | 1.27 | Teratogenic effects on the CD-1 mouse embryo exposed to concurrent doses of ethanol and aspirin. ( Guy, JF; Sucheston, ME, 1986) |
| "Aspirin-treated embryos removed on day 12 exhibited a unique pattern of preaxial mesodermal cell death in the hindlimb buds." | 1.26 | Aspirin-induced teratogenesis: a unique pattern of cell death and subsequent polydactyly in the rat. ( Klein, KL; Scott, WJ; Wilson, JG, 1981) |
| "Aspirin was administered in single oral doses of 500 and 625 mg/kg on d 10; hydroxyurea was injected ip at 500 mg/kg on d 11." | 1.26 | Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains. ( DePass, LR; Weaver, EV, 1982) |
| "Beagle bitches were administered aspirin at either 100 or 400 mg/kg/day between Days 15 and 22 or Days 23 and 30 postmating, and corresponding control groups were dosed with vehicle during one of these same time periods." | 1.26 | Aspirin: teratogenic evaluation in the dog. ( Allen, HL; Bokelman, DL; Robertson, RT, 1979) |
| " During the dosing period, females received 300mg/kg of M73101 showed pronounced body weight depression and decrease in food and water intake." | 1.26 | [Reproduction study of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) in rabbits. Administration of M73101 during the period of major organogenesis (author's transl)]. ( Kosazuma, T; Obori, R; Tanaka, H; Tanigawa, H; Yoshida, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (70.73) | 18.7374 |
| 1990's | 14 (11.38) | 18.2507 |
| 2000's | 19 (15.45) | 29.6817 |
| 2010's | 3 (2.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madar, H | 1 |
| Brun, S | 1 |
| Coatleven, F | 1 |
| Nithart, A | 1 |
| Lecoq, C | 1 |
| Gleyze, M | 1 |
| Merlot, B | 1 |
| Sentilhes, L | 1 |
| Mazaud-Guittot, S | 1 |
| Nicolas Nicolaz, C | 1 |
| Desdoits-Lethimonier, C | 1 |
| Coiffec, I | 1 |
| Ben Maamar, M | 1 |
| Balaguer, P | 1 |
| Kristensen, DM | 1 |
| Chevrier, C | 1 |
| Lavoué, V | 1 |
| Poulain, P | 1 |
| Dejucq-Rainsford, N | 1 |
| Jégou, B | 1 |
| Dodo, T | 1 |
| Fukuta, T | 1 |
| Uchida, K | 1 |
| Mineshima, H | 1 |
| Okuda, Y | 1 |
| Okada, F | 1 |
| Katsutani, N | 1 |
| Hirano, K | 1 |
| Aoki, T | 1 |
| Zhu, JJ | 1 |
| Xu, YQ | 1 |
| He, JH | 1 |
| Yu, HP | 1 |
| Huang, CJ | 1 |
| Gao, JM | 1 |
| Dong, QX | 1 |
| Xuan, YX | 1 |
| Li, CQ | 1 |
| Kozer, E | 2 |
| Nikfar, S | 2 |
| Costei, A | 1 |
| Boskovic, R | 2 |
| Nulman, I | 2 |
| Koren, G | 2 |
| Biasiutti, FD | 1 |
| Strebel, JK | 1 |
| Gupta, U | 2 |
| Cook, JC | 2 |
| Tassinari, MS | 2 |
| Hurtt, ME | 2 |
| Cappon, GD | 1 |
| Costei, AM | 1 |
| OBBINK, HJ | 1 |
| DALDERUP, LM | 1 |
| EARLEY, PA | 1 |
| HAYDEN, J | 1 |
| HARLEY, JD | 1 |
| BROWN, RA | 1 |
| WEST, GB | 1 |
| LARSSON, KS | 1 |
| BOSTROEM, H | 1 |
| TRASLER, DG | 1 |
| MCCOLL, JD | 4 |
| GLOBUS, M | 2 |
| ROBINSON, S | 2 |
| Østensen, ME | 1 |
| Skomsvoll, JF | 1 |
| Allais, G | 1 |
| Bosio, A | 1 |
| Mana, O | 1 |
| Airola, G | 1 |
| Ciochetto, D | 1 |
| Terzi, MG | 1 |
| De Lorenzo, C | 1 |
| Quirico, PE | 1 |
| Benedetto, C | 2 |
| Nørgård, B | 1 |
| Puhó, E | 1 |
| Czeizel, AE | 1 |
| Skriver, MV | 1 |
| Sørensen, HT | 1 |
| Burdan, F | 3 |
| Szumilo, J | 1 |
| Dudka, J | 1 |
| Korobowicz, A | 1 |
| Klepacz, R | 1 |
| Marinho, SA | 1 |
| Sala, MA | 1 |
| Lopes, RA | 1 |
| de Moraes Grisi, MF | 1 |
| Novaes, AB | 1 |
| de Souza, SL | 1 |
| Taba, M | 1 |
| Aguilera, C | 1 |
| Agustí, A | 1 |
| James, AH | 1 |
| Brancazio, LR | 1 |
| Price, T | 1 |
| Reid, JD | 1 |
| Fahrländer, H | 1 |
| Chen, LJ | 1 |
| Wang, MY | 1 |
| Sun, WK | 1 |
| Liu, MZ | 1 |
| Syrop, CH | 1 |
| Varner, MW | 1 |
| Mitala, JJ | 1 |
| Boardman, JP | 1 |
| Carrano, RA | 1 |
| Iuliucci, JD | 1 |
| Yokoyama, A | 4 |
| Takakubo, F | 1 |
| Eto, K | 2 |
| Ueno, K | 4 |
| Igarashi, T | 2 |
| Satoh, T | 1 |
| Kitagawa, H | 4 |
| Clark, RL | 2 |
| Robertson, RT | 2 |
| Minsker, DH | 1 |
| Cohen, SM | 1 |
| Tocco, DJ | 1 |
| Allen, HL | 2 |
| James, ML | 1 |
| Bokelman, DL | 2 |
| Todorov, S | 1 |
| Becci, PJ | 1 |
| Reagan, EL | 1 |
| Knickerbocker, MJ | 1 |
| Barbee, SJ | 1 |
| Wedig, JH | 1 |
| Mehlman, MA | 1 |
| Craig, PH | 1 |
| Gallo, MA | 1 |
| Tamura, T | 2 |
| Shimoto, Y | 1 |
| Takeno, S | 2 |
| Sakai, T | 2 |
| Saito, H | 2 |
| Ungváry, G | 2 |
| Tátrai, E | 1 |
| Lõrincz, M | 1 |
| Barcza, G | 1 |
| Itami, T | 1 |
| Kanoh, S | 1 |
| DePass, LR | 1 |
| Weaver, EV | 1 |
| Greenaway, JC | 1 |
| Shepard, TH | 2 |
| Fantel, AG | 1 |
| Juchau, MR | 1 |
| Masumura, H | 1 |
| Klein, KL | 1 |
| Scott, WJ | 1 |
| Wilson, JG | 4 |
| Rudolph, AM | 1 |
| Padmanabhan, R | 1 |
| Pallot, DJ | 1 |
| Parazzini, F | 1 |
| Bortolus, R | 1 |
| Chatenoud, L | 1 |
| Restelli, S | 1 |
| Kotwani, A | 1 |
| Mehta, VL | 1 |
| Iyengar, B | 1 |
| Hamed, MR | 1 |
| al-Assy, YS | 1 |
| Ezzeldin, E | 1 |
| Ginsberg, JS | 1 |
| Barron, WM | 1 |
| Chakravarty, K | 1 |
| Merry, P | 1 |
| Lou, YJ | 1 |
| Ding, GS | 1 |
| Tu, ZH | 1 |
| Griesshammer, M | 2 |
| Heimpel, H | 1 |
| Pearson, TC | 1 |
| Bergmann, L | 1 |
| Pearson, T | 1 |
| Karabulut, AK | 1 |
| Ulger, H | 1 |
| Pratten, MK | 1 |
| Colomina, MT | 1 |
| Albina, ML | 1 |
| Sanchez, DJ | 1 |
| Domingo, JL | 1 |
| Sasidharan, CK | 1 |
| Kutty, PM | 1 |
| Sajith, N | 1 |
| Pauzner, R | 1 |
| Dulitzki, M | 1 |
| Langevitz, P | 1 |
| Livneh, A | 1 |
| Kenett, R | 1 |
| Many, A | 1 |
| Slone, D | 1 |
| Siskind, V | 1 |
| Heinonen, OP | 1 |
| Monson, RR | 1 |
| Kaufman, DW | 1 |
| Shapiro, S | 2 |
| Tanigawa, H | 2 |
| Obori, R | 2 |
| Tanaka, H | 2 |
| Yoshida, J | 2 |
| Kosazuma, T | 2 |
| Whitehouse, MW | 1 |
| Rainsford, KD | 1 |
| Corby, DG | 1 |
| Gutová, M | 1 |
| Ishikawa, S | 1 |
| Cheung, MO | 1 |
| Gilbert, EF | 1 |
| Bruyère, HJ | 1 |
| Woo, DC | 1 |
| McClain, RM | 1 |
| Hoar, RM | 1 |
| Palm, PE | 1 |
| Arnold, EP | 1 |
| Rachwall, PC | 1 |
| Leyczek, JC | 1 |
| Teague, KW | 1 |
| Kensler, CJ | 1 |
| Yaffe, SJ | 2 |
| Beall, JR | 1 |
| Klein, MF | 1 |
| Fritz, H | 1 |
| Khera, KS | 1 |
| Nanda, R | 1 |
| Wise, LD | 1 |
| Vetter, CM | 1 |
| Anderson, CA | 1 |
| Antonello, JM | 1 |
| Randall, CL | 4 |
| Anton, RF | 4 |
| Becker, HC | 4 |
| Hale, RL | 1 |
| Ekblad, U | 1 |
| Correy, JF | 1 |
| Newman, NM | 1 |
| Collins, JA | 1 |
| Burrows, EA | 1 |
| Burrows, RF | 1 |
| Curran, JT | 1 |
| Hertz-Picciotto, I | 1 |
| Hopenhayn-Rich, C | 1 |
| Golub, M | 1 |
| Hooper, K | 1 |
| Wells, PG | 2 |
| Zubovits, JT | 1 |
| Wong, ST | 1 |
| Molinari, LM | 1 |
| Ali, S | 1 |
| Werler, MM | 1 |
| Mitchell, AA | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
| White, NM | 1 |
| Chernoff, N | 1 |
| Kavlock, RJ | 1 |
| Beyer, PE | 1 |
| Miller, D | 1 |
| Neubert, D | 1 |
| Stahlmann, R | 1 |
| Guy, JF | 1 |
| Sucheston, ME | 1 |
| Agapitos, M | 1 |
| Georgiou-Theodoropoulou, M | 1 |
| Koutselinis, A | 1 |
| Papacharalampus, N | 1 |
| Courtney, KD | 1 |
| Valerio, DA | 1 |
| Gavan, JA | 1 |
| Tubaro, E | 1 |
| Bulgini, MJ | 1 |
| Del Grande, P | 1 |
| Monai, A | 1 |
| Nelson, MM | 1 |
| Forfar, JO | 1 |
| Eriksson, M | 1 |
| Brown, AK | 1 |
| Palmer, AK | 2 |
| Butcher, RE | 1 |
| Vorhees, CV | 1 |
| Kimmel, CA | 2 |
| Eyring, EJ | 1 |
| Grosfeld, JL | 1 |
| Connelly, PA | 1 |
| Fishbein, L | 1 |
| Flamm, WG | 1 |
| Kreithen, H | 1 |
| Tanimura, T | 1 |
| Koshakji, RP | 1 |
| Schulert, AR | 1 |
| Lambelin, G | 1 |
| Roba, J | 1 |
| Gillet, C | 1 |
| Gautier, M | 1 |
| Buu-Hoï, NP | 1 |
| Frohberg, H | 1 |
| Joshi, PN | 1 |
| Mulherkar, L | 1 |
| Crombie, DL | 1 |
| Pinsent, RJ | 1 |
| Slater, BC | 1 |
| Fleming, D | 1 |
| Cross, KW | 1 |
| Warkany, J | 2 |
| Schumacher, HJ | 1 |
| Mandelcorn, MS | 1 |
| Merin, S | 1 |
| Cardarelli, J | 1 |
| Pap, AG | 1 |
| Tarakhovskiĭ, ML | 1 |
| Uhlenbroock, K | 1 |
| von Freier, G | 1 |
| Takacs, E | 1 |
| Schardein, JL | 1 |
| Blatz, AT | 1 |
| Woosley, ET | 1 |
| Kaump, DH | 1 |
| Baba, T | 1 |
| Nagahama, M | 1 |
| Akiyama, N | 1 |
| Miki, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension: A Pilot Study[NCT04908982] | Phase 4 | 60 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | ||
| Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
| Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649] | Phase 4 | 62 participants (Actual) | Interventional | 2020-02-10 | Completed | ||
| Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728] | Phase 3 | 19 participants (Actual) | Interventional | 2013-01-01 | Completed | ||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 189 |
| Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1078 |
| Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 78 |
| Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 303 |
| Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 134 |
| Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 141 |
| Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 42 |
| Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 352 |
| Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 264 |
| Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 668 |
| Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1506 |
| Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 214 |
| Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 26 |
| Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 54 |
| Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 9 |
| Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 23 |
| Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 290 |
| Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 8 |
| Placebo Arm | 21 |
(NCT03951649)
Timeframe: 7 days
| Intervention | days (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 1 |
(NCT03951649)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 9 |
| Oral Acetaminophen/Caffeine Group | 4 |
(NCT03951649)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 7 |
| Oral Acetaminophen/Caffeine Group | 2 |
Other: Pain at injection site (NCT03951649)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 0 |
| Oral Acetaminophen/Caffeine Group | 2 |
(NCT03951649)
Timeframe: 7 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 0 |
| Oral Acetaminophen/Caffeine Group | 0 |
(NCT03951649)
Timeframe: 4 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 9 |
| Oral Acetaminophen/Caffeine Group | 14 |
(NCT03951649)
Timeframe: 5 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 4 |
| Oral Acetaminophen/Caffeine Group | 2 |
Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 5 |
| Oral Acetaminophen/Caffeine Group | 1 |
(NCT03951649)
Timeframe: 120 min
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 5 |
| Oral Acetaminophen/Caffeine Group | 5 |
Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 20 |
| Oral Acetaminophen/Caffeine Group | 16 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 3 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 180min
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 4 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 2 hrs
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6.0 |
| Oral Acetaminophen/Caffeine Group | 6.5 |
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
20 reviews available for aspirin and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis.
Topics: Abnormalities, Drug-Induced; Aspirin; Case-Control Studies; Cohort Studies; Congenital Abnormalities | 2002 |
Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis.
Topics: Abnormalities, Drug-Induced; Aspirin; Case-Control Studies; Cohort Studies; Congenital Abnormalities | 2002 |
Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis.
Topics: Abnormalities, Drug-Induced; Aspirin; Case-Control Studies; Cohort Studies; Congenital Abnormalities | 2002 |
Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis.
Topics: Abnormalities, Drug-Induced; Aspirin; Case-Control Studies; Cohort Studies; Congenital Abnormalities | 2002 |
[Anticoagulation and antiaggregation during pregnancy].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Abruptio Placentae; Administration, Oral; Adult; | 2003 |
Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Weight; | 2003 |
Anti-inflammatory pharmacotherapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthr | 2004 |
[Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acupuncture Points; Acupuncture Therapy; Adult; Analgesi | 2003 |
Aspirin and reproductive outcomes.
Topics: Abnormalities, Drug-Induced; Antibodies, Antiphospholipid; Aspirin; Cyclooxygenase Inhibitors; Dose- | 2008 |
Systemic lupus erythematosus.
Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Adrenal Cortex Hormones; Aspirin; Azathioprine; | 1983 |
Essential thrombocythemia and pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Aspirin; Busulfan; Combined Modality Therapy; Di | 1996 |
Fertility, pregnancy and the management of myeloproliferative disorders.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Alkylating Agents; Animals; Aspirin; Bone Marrow | 1998 |
[Prenatal effects of acetylsalicylic acid].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Huma | 2001 |
Side-effects of anti-inflammatory drugs: are they essential or can they be circumvented?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents; Aspirin; Drug Evaluation, Preclinica | 1977 |
Aspirin in pregnancy: maternal and fetal effects.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Birth Weight; Cleft Lip; Cleft Palate; Female; Fetal | 1978 |
[Clinical pharmacology of acetylsalicylic acid].
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Asthma; Female; Humans; Hydrolysis; Intestinal Absorp | 1979 |
The risks and benefits of taking aspirin during pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Fetus; Hemorrhage; Humans; Infant, Newborn; P | 1990 |
[Drug prescriptions in pregnancy. Current status].
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Humans; Pregnancy; Pregnancy Complications; R | 1988 |
Alcohol, pregnancy, and prostaglandins.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Brain; Chick Embryo; Cricetinae; Dinoprost; Embryonic | 1987 |
Potential environmental chemical hazards. I. Drugs.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Analgesics; Animals; Aspirin; Carcinogens; Drug-Rela | 1972 |
Present status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; | 1973 |
Allergy in adverse drug reactions.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Aged; Anemia, Aplastic; Anemia, Hemolytic; Anemia, | 1973 |
[Present position of the toxicology of drugs].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo | 1970 |
2 trials available for aspirin and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Follow-up of children in the Italian Study of Aspirin in Pregnancy.
Topics: Abnormalities, Drug-Induced; Aspirin; Developmental Disabilities; Female; Follow-Up Studies; Humans; | 1994 |
Low molecular weight heparin and warfarin in the treatment of patients with antiphospholipid syndrome during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune D | 2001 |
101 other studies available for aspirin and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
[For a targeted use of aspirin].
Topics: Abnormalities, Drug-Induced; Antiphospholipid Syndrome; Aspirin; Female; Humans; Pre-Eclampsia; Preg | 2017 |
Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Acetaminophen; Analgesics, Non-Narcotic; Androgens; | 2013 |
A comparative investigation of fetal skeletal anomalies in rats induced by acetylsalicylic acid with single- and double-staining techniques.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone and Bon | 2009 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease | 2014 |
Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weight; | 2003 |
Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weight; | 2003 |
EFFECT OF ACETYLSALICYLIC ACID ON FOETAL MICE AND RATS.
Topics: Abnormalities, Drug-Induced; Animals, Newborn; Aspirin; Fetus; Mice; Pregnancy; Pregnancy, Animal; R | 1964 |
EFFECT OF ACETYLSALICYLIC ACID ON FOETAL RABBITS.
Topics: Abnormalities, Drug-Induced; Aspirin; Female; Fetal Death; Fetus; Humans; Maternal-Fetal Exchange; P | 1964 |
GROSS CONGENITAL MALFORMATIONS IN SIBLINGS OF CHILDREN WITH GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES.
Topics: Abnormalities, Drug-Induced; Aspirin; Congenital Abnormalities; Erythrocytes; Glucosephosphate Dehyd | 1964 |
EFFECT OF ACETYLSALICYLIC ACID ON FOETAL RATS.
Topics: Abnormalities, Drug-Induced; Aspirin; Caseins; Fetus; Pharmacology; Pregnancy; Rats; Research; Reser | 1964 |
TERATOGENIC ACTION OF SALICYLATES RELATED TO THE INHIBITION OF MUCOPOLYSACCHARIDE SYNTHESIS.
Topics: Abnormalities, Drug-Induced; Aspirin; Blood Vessels; Carbohydrate Metabolism; Glycosaminoglycans; Mi | 1965 |
ASPIRIN-INDUCED CLEFT LIP AND OTHER MALFORMATIONS IN MICE.
Topics: Abnormalities, Drug-Induced; Aspirin; Cleft Lip; Genetics; Mice; Pregnancy; Pregnancy, Animal; Resea | 1965 |
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS.
Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female; | 1965 |
Aspirin use during early pregnancy and the risk of congenital abnormalities: a population-based case-control study.
Topics: Abnormalities, Drug-Induced; Aspirin; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Fetus; | 2005 |
Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study.
Topics: Abdominal Wall; Abnormalities, Drug-Induced; Alanine Transaminase; Animals; Aspartate Aminotransfera | 2005 |
Celosomy is associated with prenatal exposure to cyclooxygenase inhibitors.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cyclooxygenase Inhibitors; Female; Fetal Weight; Fetu | 2006 |
Teratogenic effects of the interaction acetylsalicylic acid (ASA) and ethanol: morphologic and morphometric evaluation of the lingual epithelium in rat fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Respons | 2007 |
[Low dose of aspirin during pregnancy].
Topics: Abnormalities, Drug-Induced; Abortion, Habitual; Abortion, Spontaneous; Adult; Animals; Anti-Inflamm | 2007 |
Effect of some therapeutic agents on the rabbit fetus.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Dimenhydrinate; Female; Fetus; Glut | 1967 |
Effects of selected OTC medications on the unborn and newborn.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Aspirin; Female; Fetus; Histamine H1 Antagonists; Humans | 1983 |
[Azulfidine/Salazopyrin therapy during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Colitis, Ulcerative; Crohn Disease; Female; Humans; I | 1981 |
[Embryotoxicity and teratogenicity studies on artemether in mice, rats and rabbits].
Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Artemether; Artemisinins; Aspirin; Embryo, Mamm | 1984 |
Novel accessory skull bone in fetal rats after exposure to aspirin.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Gestational Age; Pregnancy; Rats; Rats, Inbre | 1984 |
Teratogenicity of aspirin and its metabolite, salicylic acid, in cultured rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Embryo, Mammalian; Female; Organ Culture Techniques; | 1984 |
Diflunisal-induced maternal anemia as a cause of teratogenicity in rabbits.
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Anemia, Hemolytic; Animals; Antioxidants; Aspir | 1984 |
[Relationship between the placental-fetal index (PFI) and the toxic and teratogenic effect in the fetuses of mothers treated with sedalgin during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Codeine; Drug Combinations; Female; Fetus; | 1983 |
Teratogenesis study of o-toluenediamine in rats and rabbits.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Aspirin; Bone and Bones; Dose-Response Re | 1983 |
Teratological evaluation of trimethyl phosphite in the rat.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Aspirin; Dose-Response Relationship, Drug; | 1984 |
[Aspirin-induced abnormality, liver damage induced by antibiotics, fatal drug reaction, and observation of the teeth].
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Aspirin; Aurothioglucose; Chemical and Dr | 1980 |
Alleviation of acetylsalicylic acid-induced fetal toxicity by calcium.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Calcium; Calcium Chloride; Drug Antagoni | 1983 |
Combined embryotoxic action of toluene, a widely used industrial chemical, and acetylsalicylic acid (aspirin).
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Animals; Aspirin; Drug Interactions; Embryo, Mammalian; | 1983 |
[Studies on the pharmacological bases of fetal toxicity of drugs. (I). Relation of fetal toxicity and tissue concentration of acetylsalicylic acid with pyrogen in pregnant rats].
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Animals; Aspirin; Body Weight; Drug Synergism; | 1982 |
Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Hydroxyurea; Pregnancy; Rats; Rats, Inbred F3 | 1982 |
Sodium salicylate teratogenicity in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Relationship, Drug; Female; In Vitro Te | 1982 |
Fetal toxicity and hypocalcemia induced by acetylsalicylic acid analogues.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Fetus; Gentisates; Hydroxybenzoates; Hypocalc | 1982 |
Aspirin-induced teratogenesis: a unique pattern of cell death and subsequent polydactyly in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cell Survival; Culture Techniques; Ectoderm; Female; | 1981 |
Effects of aspirin and acetaminophen in pregnancy and in the newborn.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Aspirin; Blood Platelets; Female; Fetus; Humans | 1981 |
Aspirin-alcohol interaction in the production of cleft palate and limb malformations in the TO mouse.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Drug Interactions; Ethanol; Female; Lim | 1995 |
Aspirin by virtue of its acidic property may act as teratogen in early chick embryo.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Blastoderm; Buffers; Chick Embryo; Dose-Response Rela | 1995 |
Influence of protein malnutrition on teratogenicity of acetylsalicylic acid in rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Aspirin; Body Weight; Bone and Bones; Ca | 1994 |
Pregnancy and prosthetic heart valves.
Topics: Abnormalities, Drug-Induced; Aspirin; Bioprosthesis; Embryo, Mammalian; Female; Heart Valve Prosthes | 1994 |
Anticardiolipin syndrome, aspirin therapy and fetal malformation.
Topics: Abnormalities, Drug-Induced; Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Aspirin; | 1993 |
Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Relationship, Drug; Embryo Implantation | 1996 |
Protection by free oxygen radical scavenging enzymes against salicylate-induced embryonic malformations in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Drug Interactions; Embryonic and Fetal Development; F | 2000 |
Interactions in developmental toxicology: combined action of restraint stress, caffeine, and aspirin in pregnant mice.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Embryonic and Fetal Development; Female; Ma | 2001 |
Fetal intracranial hemorrhage due to antenatal low dose aspirin intake.
Topics: Abnormalities, Drug-Induced; Adult; Aspirin; Cesarean Section; Dose-Response Relationship, Drug; Fem | 2001 |
Aspirin and congenital malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aspirin; Birth Weight; Female; Humans; Infant, | 1976 |
[Effects of aspirin on pregnant women and fetus; tetracycline-induced esophageal ulcer; and re-evaluation of sulfa drugs, anti-inflammatory enzymes and vitamins].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anemia; Anti-Inflammatory Agents; Aspirin; Esophagea | 1977 |
[Reproduction study of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) in rats (II). Administration of M73101 during the period of major organogenesis (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Behavior, An | 1979 |
[Reproduction study of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) in rabbits. Administration of M73101 during the period of major organogenesis (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weight; | 1979 |
Acetylsalicylic acid-induced morphological changes in the ductus arteriosus of the chick embryo.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Chick Embryo; Ductus Arteriosus | 1979 |
Aspirin: teratogenic evaluation in the dog.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Dogs; Dose-Response Relationship, Drug; Female; Fetal | 1979 |
Teratogenicity of therapeutic agents.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Anima | 1979 |
Potentiation of methotrexate embryolethality by aspirin in rats.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Drug Synergism; Embryo, Mammalian; Femal | 1978 |
Evaluation of the teratogenic potential of fresh-brewed coffee and caffeine in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Caffeine; Coffee; Cricetinae; Female; Le | 1978 |
Drugs and pregnancy.
Topics: Abnormalities, Drug-Induced; Aspirin; Embryo, Mammalian; Ethanol; Female; Fetus; Humans; Maternal-Fe | 1978 |
Enhancement of aspirin-induced teratogenicity by food restriction in rats.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Female; Food Deprivation; Maternal-Fetal | 1977 |
The effect of cortisone on the teratogenic action of acetylsalicylic acid and diphenylhydantoin in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Cortisone; Drug Administration Schedule | 1976 |
Teratogenicity studies with methotrexate, aminopterin, and acetylsalicylic acid in domestic cats.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Cats; Female; Methotrexate; Teratogens; | 1976 |
Teratogenic effects of environmental agents on embryonic development.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Anticonvulsants; Antide | 1975 |
A clinical look at the problem of drugs in pregnancy and their effect on the fetus.
Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse | 1975 |
Reversible effects of triamcinolone and lack of effects with aspirin or L-656,224 on external genitalia of male Sprague-Dawley rats exposed in utero.
Topics: Abnormalities, Drug-Induced; Animals; Arachidonic Acid; Aspirin; Benzofurans; Female; Fetal Death; G | 1991 |
Aspirin dose-dependently reduces alcohol-induced birth defects and prostaglandin E levels in mice.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Relationship, Drug; Ethanol; Female; Fe | 1991 |
Use of prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Aspirin; Contraceptives, Oral; Dicyclomine; Female; Humans; Infant, New | 1991 |
Effect of ibuprofen on alcohol-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Aspirin; Body Weight; Ethanol; Female; F | 1991 |
Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Biotransformation; Caffeic Acids; Cinnamates; Cyclic | 1989 |
The relation of aspirin use during the first trimester of pregnancy to congenital cardiac defects.
Topics: Abnormalities, Drug-Induced; Aortic Coarctation; Aortic Valve Stenosis; Aspirin; Case-Control Studie | 1989 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |
Role of prostaglandins in alcohol teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Ethanol; Female; Indomethacin; Mice; Mice, Inbred C57 | 1989 |
The potential relationship of maternal toxicity, general stress, and fetal outcome.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Corticosterone; Female; Heat-Shock Proteins; Humans; | 1987 |
Teratogenic effects on the CD-1 mouse embryo exposed to concurrent doses of ethanol and aspirin.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Bone and Bones; Drug Interactions; Ethanol; Female; M | 1986 |
Cyclopia and maternal ingestion of salicylates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aspirin; Brain; Female; Humans; Infant, Newbor | 1986 |
Embryotoxic effects of EGTA-induced hypocalcemic condition on cultured rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Blood; Calcium; Culture Media; Egtazic Acid; Ethylene | 1985 |
The possible contribution of industrial chemicals (organic solvents) to the incidence of congenital defects caused by teratogenic drugs and consumer goods--an experimental study.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Benzene; Drug Synergism; Ethanol; Female; Fetus; Preg | 1985 |
Teratology in the Macaca mulatta.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Clomiphene; Encephalocele; Female; Fetal Death; Haplo | 1968 |
Congenital malformations in nonhuman primates: spontaneous and experimentally induced.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Congenital Abnormalities; Female; Haplor | 1967 |
Some toxicological aspects of a nicotinamide-methylaminopyrazolone (Ra 101).
Topics: Abnormalities, Drug-Induced; Acetylcholine; Aminopyrine; Analgesics; Animals; Aspirin; Blood; Blood | 1970 |
Associations between drugs administered during pregnancy and congenital abnormalities of the fetus.
Topics: Abnormalities, Drug-Induced; Adult; Analgesics; Antacids; Antiemetics; Appetite Depressants; Ascorbi | 1971 |
Salicylate-induced foetal damage late in pregnancy. An experimental study in mice.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Carbon Isotopes; Coumarins; Female; | 1971 |
The susceptibility of the fetus and child to chemical pollutants. Special susceptibility of the fetal and neonatal hematopoietic system to chemical pollutants including drugs administered to the mother.
Topics: Abnormalities, Drug-Induced; Adenosine Diphosphate; Age Factors; Aspirin; Blood Platelets; Environme | 1974 |
Problems associated with the screening of drugs for possible teratogenic activity.
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Rela | 1974 |
Leaning impairment from maternal salicylate treatment in rats.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Embryo, Mammalian; Female; Humans; | 1972 |
Development of aspirin hydrolase in fetal, newborn and adult tissues.
Topics: Abnormalities, Drug-Induced; Adenosine Diphosphate; Age Factors; Animals; Animals, Newborn; Aspirin; | 1973 |
Effects on macaque embryos of drugs reported or suspected to be teratogenic to humans.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Cesarean Section; Embryo, Mammalian; Fem | 1972 |
Biochemical mechanisms of salicylate teratology in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Carbon Isotopes; Edetic Acid; Female; Fetus; Iron; Ir | 1973 |
Sporadic malformations in laboratory animals and their influence on drug testing.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Laboratory; Aspirin; Bone and Bones; Congenital Abnor | 1972 |
Drug toxicity in the animal fetus.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cats; Cricetinae; Dogs; Embryo, Mammalian; Female; Fe | 1967 |
Toxicity studies of 4-allyloxy-3-chlorophenylacetic acid, a new analgesic, antipyretic, and anti-inflammatory agent.
Topics: Abnormalities, Drug-Induced; Aminopyrine; Analgesics; Anemia; Animals; Anti-Inflammatory Agents; Asp | 1970 |
The analgesic powder.
Topics: Abnormalities, Drug-Induced; Anemia; Aspirin; Blood Platelet Disorders; Female; Humans; Infant, Newb | 1971 |
Further observations on the mode of action of chloramphenicol on the chick morphogenesis.
Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Animals; Aspirin; Benzoates; Chick Embryo; Chlora | 1969 |
Salicylates and malformations.
Topics: Abnormalities, Drug-Induced; Aspirin; Central Nervous System; Clubfoot; Digestive System Abnormaliti | 1970 |
Teratogenic drugs--R.C.G.P. survey.
Topics: Abnormalities, Drug-Induced; Aspirin; Barbiturates; Female; Fetal Death; Hormones; Humans; Iron; Pre | 1970 |
Experimental teratology and pediatrics.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Congenital Abnormalities; Female; Fetal Diseases; Mam | 1970 |
Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Benzoates; Biotransformation; Female; Fetal Death; Fe | 1971 |
Goldenhar's syndrome and phocomelia. Case report and etiologic considerations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Threatened; Aspirin; Caffeine; Child | 1971 |
[Effect of several drugs on the fetus].
Topics: Abnormalities, Drug-Induced; Aminopyrine; Animals; Aspirin; Benzimidazoles; Chlorpromazine; Cortison | 1967 |
[On the question of release of fetus toxic effect through mangesium acetylosalicylate].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Female; Fertility; Magnesium; Mice; | 1968 |
Experimental production of congenital cardiovascular malformations in rats by salicylate poisoning.
Topics: Abnormalities, Drug-Induced; Animals; Aorta; Aspirin; Dextrocardia; Female; Fetal Heart; Gestational | 1968 |
Reproduction studies on sodium meclofenamate in comparison to aspirin and phenylbutazone.
Topics: Abnormalities, Drug-Induced; Analgesics; Animals; Animals, Newborn; Anti-Inflammatory Agents; Aspiri | 1969 |
Teratogenicity studies.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Phenobarbital; Rabbits; Rats; Thalidomide | 1966 |
Experimental production of malformations due to acetyl salicylate and phenyl salicylate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Pregnancy; Pregnancy, Animal; Rats; Salicylat | 1966 |