aspirin has been researched along with ALS - Amyotrophic Lateral Sclerosis in 6 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The association of aspirin use and nonsteroid anti-inflammatory drug (NSAID) use with amyotrophic lateral sclerosis (ALS) risk is unclear." | 7.81 | Aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study. ( Lee, CT; Lee, JK; Lin, FC; Tsai, CP, 2015) |
| "We have studied the effect of lysine acetylsalicylate (LAS; Aspegic), a soluble salt of aspirin, on motor deficits in transgenic mice expressing a human superoxide dismutase SOD1 mutation (Gly-93 --> Ala), an animal model of familial amyotrophic lateral sclerosis (FALS)." | 7.70 | Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis. ( Barnéoud, P; Curet, O, 1999) |
| "The association of aspirin use and nonsteroid anti-inflammatory drug (NSAID) use with amyotrophic lateral sclerosis (ALS) risk is unclear." | 3.81 | Aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study. ( Lee, CT; Lee, JK; Lin, FC; Tsai, CP, 2015) |
| "We have studied the effect of lysine acetylsalicylate (LAS; Aspegic), a soluble salt of aspirin, on motor deficits in transgenic mice expressing a human superoxide dismutase SOD1 mutation (Gly-93 --> Ala), an animal model of familial amyotrophic lateral sclerosis (FALS)." | 3.70 | Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis. ( Barnéoud, P; Curet, O, 1999) |
| " We examined the possibility that concurrent blockade of free radicals and prostaglandin E(2) (PGE(2))-mediated inflammation might constitute a safe and effective therapeutic approach to ALS." | 1.38 | Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. ( Cho, W; Gwag, BJ; Im, DS; Lee, JH; Lee, JK; Lee, YA; Lee, YB; Shin, JH; Springer, JE; Yun, BS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsai, CP | 1 |
| Lin, FC | 1 |
| Lee, JK | 2 |
| Lee, CT | 1 |
| Abdolvahabi, A | 1 |
| Shi, Y | 1 |
| Rhodes, NR | 1 |
| Cook, NP | 1 |
| Martí, AA | 1 |
| Shaw, BF | 1 |
| Qureshi, M | 1 |
| Shui, A | 1 |
| Dibernardo, AB | 1 |
| Brown, RH | 1 |
| Schoenfeld, DA | 1 |
| Cudkowicz, ME | 1 |
| Shin, JH | 1 |
| Lee, YA | 1 |
| Lee, YB | 1 |
| Cho, W | 1 |
| Im, DS | 1 |
| Lee, JH | 1 |
| Yun, BS | 1 |
| Springer, JE | 1 |
| Gwag, BJ | 1 |
| Mohr, JP | 1 |
| Barnéoud, P | 1 |
| Curet, O | 1 |
2 reviews available for aspirin and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Medications and laboratory parameters as prognostic factors in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspirin; Clinical Laboratory Techniques; Female; Fructos | 2008 |
ALS lessons learned from other neurological diseases. Stroke.
Topics: Amyotrophic Lateral Sclerosis; Anticoagulants; Aspirin; Humans; Intracranial Arteriovenous Malformat | 2004 |
4 other studies available for aspirin and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study.
Topics: Adolescent; Adult; Amyotrophic Lateral Sclerosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2015 |
Arresting amyloid with coulomb's law: acetylation of ALS-linked SOD1 by aspirin impedes aggregation.
Topics: Acetylation; Amino Acid Sequence; Amyloid; Amyotrophic Lateral Sclerosis; Aspirin; Humans; Molecular | 2015 |
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Infl | 2012 |
Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weigh | 1999 |