aspergillazine-a has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for aspergillazine-a and Neoplasms
| Article | Year |
|---|---|
Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.
The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together with structurally related compounds, trichodermamide A (2) and aspergillazine A (3), were isolated from culture extract of marine-derived Trichoderma lixii. Compounds 1 exhibited potent selective cytotoxic activity against human pancreatic carcinoma PANC-1 cells cultured under glucose-starved conditions with IC Topics: Antineoplastic Agents; Cell Line, Tumor; Dipeptides; Electron Transport; Glucose; Growth Inhibitors; Humans; Mitochondria; Neoplasms; Piperazines; Trichoderma; Tumor Microenvironment | 2020 |