aspartic acid has been researched along with von Willebrand Diseases in 2 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
von Willebrand Diseases: Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In type 2N von Willebrand disease (vWD), von Willebrand factor (vWF) is characterized by normal multimeric pattern, normal platelet-dependent function, but a markedly decreased affinity for factor VIII (FVIII)." | 1.30 | A novel mutation in the D3 domain of von Willebrand factor markedly decreases its ability to bind factor VIII and affects its multimerization. ( Gaucher, C; Goudemand, J; Jorieux, S; Mazurier, C, 1998) |
| "Type IIB von Willebrand disease is characterized by increased affinity of mutant von Willebrand factor (vWF) for platelet glycoprotein Ib." | 1.29 | Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib. ( Rabinowitz, I; Randi, AM; Rustagi, PK; Sadler, JE; Shindler, KS; Tuley, EA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabinowitz, I | 1 |
| Randi, AM | 1 |
| Shindler, KS | 1 |
| Tuley, EA | 1 |
| Rustagi, PK | 1 |
| Sadler, JE | 1 |
| Jorieux, S | 1 |
| Gaucher, C | 1 |
| Goudemand, J | 1 |
| Mazurier, C | 1 |
2 other studies available for aspartic acid and von Willebrand Diseases
| Article | Year |
|---|---|
Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.
Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Blood Platelets; Crotalid | 1993 |
A novel mutation in the D3 domain of von Willebrand factor markedly decreases its ability to bind factor VIII and affects its multimerization.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Base Sequence; DNA Mutational Analysis; Electrop | 1998 |