aspartic acid has been researched along with Tay-Sachs Disease in 3 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Tay-Sachs Disease: An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lemieux, MJ | 1 |
| Mark, BL | 1 |
| Cherney, MM | 1 |
| Withers, SG | 1 |
| Mahuran, DJ | 2 |
| James, MN | 1 |
| Tse, R | 1 |
| Vavougios, G | 1 |
| Hou, Y | 1 |
| Trop, I | 1 |
| Kaplan, F | 1 |
| Brown, C | 1 |
| Mahuran, D | 1 |
| Hechtman, P | 1 |
3 other studies available for aspartic acid and Tay-Sachs Disease
| Article | Year |
|---|---|
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Topics: Acetylglucosamine; Amino Acid Substitution; Arginine; Aspartic Acid; beta-N-Acetylhexosaminidases; B | 2006 |
Identification of an active acidic residue in the catalytic site of beta-hexosaminidase.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Bacteria; Base Sequence; beta-N-Acetylhexosaminidases; | 1996 |
A glycine250--> aspartate substitution in the alpha-subunit of hexosaminidase A causes juvenile-onset Tay-Sachs disease in a Lebanese-Canadian family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; beta-N-Acetylhexosaminidases; Canada; Ce | 1992 |