aspartic acid has been researched along with Substance Withdrawal Syndrome in 25 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A body of evidence supports that excitatory amino acid systems, particularly glutamatergic one, participate in morphine dependence and naloxone-precipitated withdrawal." | 8.81 | [Involvement of glial glutamate transporters in morphine dependence and naloxone-precipitated withdrawal]. ( Nakagawa, T, 2001) |
| "A body of evidence supports that excitatory amino acid systems, particularly glutamatergic one, participate in morphine dependence and naloxone-precipitated withdrawal." | 4.81 | [Involvement of glial glutamate transporters in morphine dependence and naloxone-precipitated withdrawal]. ( Nakagawa, T, 2001) |
| " Previous studies have demonstrated that mivazerol prevents hemodynamic instability during emergence from halothane anesthesia in rats (3)." | 3.70 | Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats. ( Hanin, I; Kindel, G; Wülfert, E; Zhang, X, 1998) |
| " After long-term use it is often difficult to discontinue benzodiazepines due to psychological and physiological dependence." | 2.58 | Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users. ( Baandrup, L; Ebdrup, BH; Glenthøj, BY; Gluud, C; Lindschou, J; Rasmussen, JØ, 2018) |
| "Tizanidine (TIZ) has long been known to be an alpha 2-adrenoceptor agonist and inhibitor of ASP and GLU release." | 1.28 | Effects of tizanidine on morphine physical dependence: attenuation and intensification. ( Ariciŏglu, F; Dizdar, Y; Esin, Y; Koyuncuŏglu, H; Uresin, Y, 1992) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| "Aspartic acid was found to prevent or antagonize the behavioural signs and the changes in the free amino acid levels in the brain." | 1.26 | The antagonizing effect of aspartic acid on morphine withdrawal and levallorphan-precipitated abstinence syndrome signs and on associated changes in brain levels of free amino acids in the rat. ( Eroğlu, L; Güngör, M; Koyuncuoğlu, H; Sağduyu, H, 1979) |
| "When nalorphine (20mg/kg) was administered to rats previously treated with morphine three times daily for 2 weeks, there was an increase in brain glucose (100%), lactate (23%), pyruvate (18%) and citrate (10%) concentrations." | 1.25 | The effects of acute and chronic morphine treatment and of morphine withdrawal on rat brain in vivo. ( Harris, RL; Hawkins, RA; Miller, AL; Veech, RL, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baandrup, L | 1 |
| Ebdrup, BH | 1 |
| Rasmussen, JØ | 1 |
| Lindschou, J | 1 |
| Gluud, C | 1 |
| Glenthøj, BY | 1 |
| Fischer, KD | 1 |
| Houston, AC | 1 |
| Rebec, GV | 1 |
| Seidemann, T | 1 |
| Spies, C | 1 |
| Morgenstern, R | 1 |
| Wernecke, KD | 1 |
| Netzhammer, N | 1 |
| Frischknecht, U | 1 |
| Hermann, D | 1 |
| Tunc-Skarka, N | 1 |
| Wang, GY | 1 |
| Sack, M | 1 |
| van Eijk, J | 1 |
| Demirakca, T | 1 |
| Falfan-Melgoza, C | 1 |
| Krumm, B | 1 |
| Dieter, S | 1 |
| Spanagel, R | 1 |
| Kiefer, F | 1 |
| Mann, KF | 1 |
| Sommer, WH | 1 |
| Ende, G | 1 |
| Weber-Fahr, W | 1 |
| Nordahl, TE | 2 |
| Salo, R | 2 |
| Possin, K | 1 |
| Gibson, DR | 1 |
| Flynn, N | 1 |
| Leamon, M | 1 |
| Galloway, GP | 2 |
| Pfefferbaum, A | 1 |
| Spielman, DM | 1 |
| Adalsteinsson, E | 1 |
| Sullivan, EV | 1 |
| Sekiya, Y | 1 |
| Nakagawa, T | 2 |
| Ozawa, T | 1 |
| Minami, M | 1 |
| Satoh, M | 1 |
| Wong, SME | 1 |
| Sweitzer, SM | 1 |
| Peters, MC | 1 |
| Kendig, JJ | 1 |
| Natsuaki, Y | 1 |
| Waters, C | 1 |
| Moore, CD | 1 |
| Kile, S | 1 |
| Buonocore, MH | 1 |
| Aghajanian, GK | 1 |
| Kogan, JH | 1 |
| Moghaddam, B | 1 |
| Zhang, T | 1 |
| Feng, Y | 1 |
| Rockhold, RW | 1 |
| Ho, IK | 2 |
| Hoshi, K | 1 |
| Ma, T | 1 |
| Sepulveda, MJ | 1 |
| Hernandez, L | 1 |
| Rada, P | 1 |
| Tucci, S | 1 |
| Contreras, E | 1 |
| Tsai, GE | 1 |
| Ragan, P | 1 |
| Chang, R | 1 |
| Chen, S | 1 |
| Linnoila, VM | 1 |
| Coyle, JT | 1 |
| Zhang, X | 1 |
| Kindel, G | 1 |
| Wülfert, E | 1 |
| Hanin, I | 1 |
| Chen, JC | 1 |
| Liang, KW | 1 |
| Huang, YK | 1 |
| Liang, CS | 1 |
| Chiang, YC | 1 |
| Favalli, L | 1 |
| Rozza, A | 1 |
| Frattini, P | 1 |
| Masoero, E | 1 |
| Scelsi, R | 1 |
| Pascale, A | 1 |
| Govoni, S | 1 |
| Koyuncuoğlu, H | 4 |
| Güngör, M | 2 |
| Eroğlu, L | 1 |
| Sağduyu, H | 2 |
| Ariciŏglu, F | 2 |
| Uresin, Y | 1 |
| Dizdar, Y | 1 |
| Esin, Y | 1 |
| Little, HJ | 1 |
| McCaslin, PP | 2 |
| Morgan, WW | 2 |
| Sener, AI | 1 |
| Ceylan, ME | 1 |
| Miller, AL | 1 |
| Hawkins, RA | 1 |
| Harris, RL | 1 |
| Veech, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploring the Utility and Safety of Benzodiazepine Prescribing Among People Receiving Opiate Replacement Therapy in Scotland (the BENZORT Study).[NCT04622995] | 46,899 participants (Actual) | Observational | 2021-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aspartic acid and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users.
Topics: Adult; Antidepressive Agents; Aspartic Acid; Benzodiazepines; Buspirone; Carbamazepine; Ethylamines; | 2018 |
[Involvement of glial glutamate transporters in morphine dependence and naloxone-precipitated withdrawal].
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Excita | 2001 |
Mechanisms that may underlie the behavioural effects of ethanol.
Topics: Alcoholic Intoxication; Animals; Aspartic Acid; Behavior; Behavior, Animal; Calcium; Calcium Channel | 1991 |
1 trial available for aspartic acid and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Comparison of the suppressive effects of L-aspartic acid and chlorpromazine + diazepam treatments on opiate abstinence syndrome signs in men.
Topics: Aspartic Acid; Chlorpromazine; Diazepam; Drug Therapy, Combination; Humans; Male; Opioid-Related Dis | 1986 |
21 other studies available for aspartic acid and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior.
Topics: Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Blotting, Western; Ceftriaxone; Coca | 2013 |
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens in a Rat Model of Alcohol Withdrawal: A Pilot Study.
Topics: Amino Acids; Anesthesia, Inhalation; Animals; Arginine; Aspartic Acid; Desflurane; Disease Models, A | 2017 |
Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats.
Topics: Adult; Alcohol Abstinence; Alcoholism; Animals; Aspartic Acid; Biomarkers; Female; Glutamic Acid; Gr | 2017 |
Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Magnetic resonance spectroscopy.
Topics: Adult; Age Factors; Amphetamine-Related Disorders; Aspartic Acid; Choline; Creatine; Dopamine; Front | 2002 |
Facilitation of morphine withdrawal symptoms and morphine-induced conditioned place preference by a glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate in rats.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Conditioning, Operant; Male; Morphine; Rat | 2004 |
Hyperresponsiveness on washout of volatile anesthetics from isolated spinal cord compared to withdrawal from ethanol.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Bronchial Hyperreactivity; Calcitonin Gene-Related | 2005 |
Methamphetamine users in sustained abstinence: a proton magnetic resonance spectroscopy study.
Topics: Adult; Ambulatory Care; Amphetamine-Related Disorders; Aspartic Acid; Brain; Choline; Creatine; Dopa | 2005 |
Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Drug Implants; Extracellular Space; Glutamates; Glutamic Acid; Locus Coerule | 1994 |
Naloxone-precipitated morphine withdrawal increases pontine glutamate levels in the rat.
Topics: Animals; Aspartic Acid; Dialysis; Drug Interactions; Glutamates; Glutamic Acid; Locus Coeruleus; Mal | 1994 |
Precipitated kappa-opioid receptor agonist withdrawal increase glutamate in rat locus coeruleus.
Topics: Analgesics; Analysis of Variance; Animals; Aspartic Acid; Benzeneacetamides; Butorphanol; Glutamic A | 1996 |
Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens of chronically morphine-treated rats: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Calcium; Extracellular Space; Glutamic Acid; Male; Microdialysis; Morphine; | 1998 |
Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal.
Topics: Adult; Alcoholism; Aspartic Acid; Dipeptides; Ethanol; Excitatory Amino Acids; Female; gamma-Aminobu | 1998 |
Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Anesthetics, Inhalation; Animals; Aspartic Acid; Blood Pressu | 1998 |
Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine.
Topics: Amphetamine; Animals; Aspartic Acid; Behavior, Animal; Central Nervous System Stimulants; Dizocilpin | 2001 |
Ischemia-induced glutamate release in rat frontoparietal cortex after chronic alcohol and withdrawal.
Topics: Alcoholism; Animals; Aspartic Acid; Central Nervous System Depressants; Dialysis Solutions; Ethanol; | 2002 |
The antagonizing effect of aspartic acid on morphine withdrawal and levallorphan-precipitated abstinence syndrome signs and on associated changes in brain levels of free amino acids in the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Body Weight; Brain Chemistry; Humans; Levallorphan; Motor Activ | 1979 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamat | 1992 |
Intensification and attenuation of morphine dependence by D-aspartic acid and PLG.
Topics: Animals; Asparaginase; Aspartic Acid; Brain; Mice; Mice, Inbred BALB C; Morphine Dependence; MSH Rel | 1990 |
Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats.
Topics: Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Dose-Response Relationship, | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
The effects of acute and chronic morphine treatment and of morphine withdrawal on rat brain in vivo.
Topics: Acetazolamide; Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Animals; Arteries; Aspartic A | 1972 |