aspartic acid has been researched along with Status Epilepticus in 17 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 7.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "Amino acid concentrations were measured in specific structures from the brains of rats decapitated before and during the course of status epilepticus induced by lithium and pilocarpine, with the stages of status defined by the electroencephalographic (EEG) pattern displayed." | 7.68 | Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine. ( Gunawan, S; Treiman, DM; Walton, NY, 1990) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 3.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "Kainic acid (KA) has long been used in experimental animals to induce status epilepticus (SE)." | 3.70 | [31P]/[1H] nuclear magnetic resonance study of mitigating effects of GYKI 52466 on kainate-induced metabolic impairment in perfused rat cerebrocortical slices. ( Liachenko, S; Melick, JA; Tang, P; Xu, Y, 1998) |
| "Amino acid concentrations were measured in specific structures from the brains of rats decapitated before and during the course of status epilepticus induced by lithium and pilocarpine, with the stages of status defined by the electroencephalographic (EEG) pattern displayed." | 3.68 | Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine. ( Gunawan, S; Treiman, DM; Walton, NY, 1990) |
| " Although there was no difference in kainate dosing or seizure count between them, the metabolic pattern of injury was different." | 1.43 | Metabolic injury in a variable rat model of post-status epilepticus. ( de Lanerolle, N; Kelly, KM; Pan, JW; Pearce, PS; Rapuano, A; Wu, Y, 2016) |
| "Kainic acid (KA)-induced seizures lead to histopathologic changes in rat brain." | 1.30 | MRS metabolic markers of seizures and seizure-induced neuronal damage. ( Comair, YG; Lüders, HO; Najm, IM; Ng, TC; Shedid, D; Wang, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meller, S | 1 |
| Brandt, C | 1 |
| Theilmann, W | 1 |
| Klein, J | 1 |
| Löscher, W | 1 |
| Wu, Y | 2 |
| Pearce, PS | 2 |
| Rapuano, A | 2 |
| Hitchens, TK | 1 |
| de Lanerolle, NC | 1 |
| Pan, JW | 2 |
| Kelly, KM | 1 |
| de Lanerolle, N | 1 |
| Rabeson, H | 1 |
| Fauvelle, F | 1 |
| Testylier, G | 1 |
| Foquin, A | 1 |
| Carpentier, P | 1 |
| Dorandeu, F | 1 |
| van Ormondt, D | 1 |
| Graveron-Demilly, D | 1 |
| Zahr, NM | 1 |
| Crawford, EL | 1 |
| Hsu, O | 1 |
| Vinco, S | 1 |
| Mayer, D | 1 |
| Rohlfing, T | 1 |
| Sullivan, EV | 1 |
| Pfefferbaum, A | 1 |
| de Freitas, RM | 1 |
| de Oliveira Silva, F | 1 |
| Saldanha, GB | 1 |
| Jordán, J | 1 |
| Deng, Y | 1 |
| Wang, M | 1 |
| Wang, W | 1 |
| Ma, C | 1 |
| He, N | 1 |
| Boltshauser, E | 1 |
| Schmitt, B | 1 |
| Wevers, RA | 1 |
| Engelke, U | 1 |
| Burlina, AB | 1 |
| Burlina, AP | 1 |
| Cendes, F | 1 |
| Andermann, F | 1 |
| Silver, K | 1 |
| Arnold, DL | 1 |
| Ebisu, T | 2 |
| Rooney, WD | 2 |
| Graham, SH | 2 |
| Weiner, MW | 2 |
| Maudsley, AA | 2 |
| Mancuso, A | 1 |
| Najm, IM | 1 |
| Wang, Y | 1 |
| Shedid, D | 1 |
| Lüders, HO | 1 |
| Ng, TC | 1 |
| Comair, YG | 1 |
| Tang, P | 1 |
| Liachenko, S | 1 |
| Melick, JA | 1 |
| Xu, Y | 1 |
| Mueller, SG | 1 |
| Kollias, SS | 1 |
| Trabesinger, AH | 1 |
| Buck, A | 1 |
| Boesiger, P | 1 |
| Wieser, HG | 1 |
| Treiman, DM | 2 |
| Walton, NY | 2 |
| Gunawan, S | 2 |
| Ormandy, GC | 1 |
| Jope, RS | 1 |
| Snead, OC | 1 |
17 other studies available for aspartic acid and Status Epilepticus
| Article | Year |
|---|---|
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats.
Topics: Animals; Antigens, Nuclear; Aspartic Acid; Brain Chemistry; Creatine; Epilepsy, Temporal Lobe; Gluta | 2015 |
Metabolic injury in a variable rat model of post-status epilepticus.
Topics: Animals; Aspartic Acid; Cluster Analysis; Creatine; Disease Models, Animal; Electroencephalography; | 2016 |
Quantitation with QUEST of brain HRMAS-NMR signals: application to metabolic disorders in experimental epileptic seizures.
Topics: Acetates; Alanine; Algorithms; Animals; Aspartic Acid; Brain; Choline; gamma-Aminobutyric Acid; Glut | 2008 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image | 2009 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the hippocampus of PTZ-kindled epileptic and PTZ-induced status epilepticus rats.
Topics: Animals; Aspartic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kin | 2013 |
Follow-up of a child with hypoacetylaspartia.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Brain; Developmental Disabilities; Follow-Up St | 2004 |
Imaging of axonal damage in vivo in Rasmussen's syndrome.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Child; Chronic Disease; Creatine; Disease Progression; E | 1995 |
N-acetylaspartate as an in vivo marker of neuronal viability in kainate-induced status epilepticus: 1H magnetic resonance spectroscopic imaging.
Topics: Animals; Aspartic Acid; Biomarkers; Cell Survival; Kainic Acid; Magnetic Resonance Imaging; Magnetic | 1994 |
MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat.
Topics: Animals; Aspartic Acid; Blood Gas Analysis; Brain; Excitatory Amino Acid Agonists; Hydrogen-Ion Conc | 1996 |
MRS metabolic markers of seizures and seizure-induced neuronal damage.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Cell Count; Choline; Creatine; Cycloheximide; Hippocampus | 1998 |
[31P]/[1H] nuclear magnetic resonance study of mitigating effects of GYKI 52466 on kainate-induced metabolic impairment in perfused rat cerebrocortical slices.
Topics: Adenosine Triphosphate; Animals; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepine | 1998 |
Proton magnetic resonance spectroscopy characteristics of a focal cortical dysgenesis during status epilepticus and in the interictal state.
Topics: Adult; Aspartic Acid; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Protons; Severity of I | 2001 |
Brain amino acid concentrations during specific electroencephalographic stages of status epilepticus in the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; Evoked Potentials; gamma-Aminobu | 1992 |
Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutama | 1990 |
Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; | 1989 |