aspartic acid has been researched along with Spinocerebellar Ataxias in 16 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Spinocerebellar Ataxias: A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autosomal dominant ataxia type 14 (SCA14) is a rare usually adult-onset progressive disorder with cerebellar neurodegeneration caused by mutations in protein kinase C gamma." | 1.42 | Cerebellar neurochemical alterations in spinocerebellar ataxia type 14 appear to include glutathione deficiency. ( Brandt, AU; Doss, S; Endres, M; Klockgether, T; Lux, S; Maul, S; Minnerop, M; Papazoglou, S; Paul, F; Rinnenthal, JL; Schmitz-Hübsch, T; Würfel, J, 2015) |
| "Autosomal-dominant spinocerebellar ataxia type 1 (SCA1) is an adult-onset progressive disorder with well-characterized neurodegeneration in the cerebellum and brainstem." | 1.40 | Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1. ( Brandt, AU; Doss, S; Endres, M; Oberwahrenbrock, T; Paul, F; Rinnenthal, JL, 2014) |
| "We reported a Japanese case of spinocerebellar ataxia type 6 (SCA6) with episodic ataxia type 2 (EA2) phenotype." | 1.33 | [A case of spinocerebellar ataxia type 6 with its initial symptom of episodic ataxia-like phenotype]. ( Ishikawa, K; Nakano, I; Nakao, K; Shimazaki, H; Takiyama, Y, 2006) |
| "Spinocerebellar ataxia type 14 (SCA14) is a rare form of autosomal dominant cerebellar ataxias caused by mutations in the protein kinase Cgamma gene (PRKCG)." | 1.33 | A Japanese case of SCA14 with the Gly128Asp mutation. ( Ikeda, SI; Morita, H; Suzuki, K; Yoshida, K, 2006) |
| "Compared with control subjects, the SCA1 and SCA2 patients showed a decrease (P < 0." | 1.32 | Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study. ( Belli, G; Cosottini, M; De Grandis, D; Della Nave, R; Filla, A; Foresti, S; Ginestroni, A; Guerrini, L; Lolli, F; Mascalchi, M; Piacentini, S; Plasmati, R; Salvi, F; Siciliano, G; Tessa, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joers, JM | 1 |
| Deelchand, DK | 2 |
| Lyu, T | 1 |
| Emir, UE | 2 |
| Hutter, D | 2 |
| Gomez, CM | 2 |
| Bushara, KO | 2 |
| Eberly, LE | 4 |
| Öz, G | 4 |
| Sen, NE | 1 |
| Canet-Pons, J | 1 |
| Halbach, MV | 1 |
| Arsovic, A | 1 |
| Pilatus, U | 1 |
| Chae, WH | 1 |
| Kaya, ZE | 1 |
| Seidel, K | 1 |
| Rollmann, E | 1 |
| Mittelbronn, M | 1 |
| Meierhofer, D | 1 |
| De Zeeuw, CI | 1 |
| Bosman, LWJ | 1 |
| Gispert, S | 1 |
| Auburger, G | 1 |
| Doss, S | 2 |
| Brandt, AU | 2 |
| Oberwahrenbrock, T | 1 |
| Endres, M | 2 |
| Paul, F | 2 |
| Rinnenthal, JL | 2 |
| Kittelson, E | 1 |
| Demirgöz, D | 1 |
| Rainwater, O | 1 |
| Orr, HT | 2 |
| Clark, HB | 2 |
| Adanyeguh, IM | 1 |
| Henry, PG | 1 |
| Nguyen, TM | 1 |
| Rinaldi, D | 1 |
| Jauffret, C | 1 |
| Valabregue, R | 1 |
| Brice, A | 1 |
| Durr, A | 1 |
| Mochel, F | 1 |
| Schmitz-Hübsch, T | 1 |
| Papazoglou, S | 1 |
| Lux, S | 1 |
| Maul, S | 1 |
| Würfel, J | 1 |
| Klockgether, T | 1 |
| Minnerop, M | 1 |
| Tkác, I | 1 |
| Gross, MD | 1 |
| Jiang, H | 1 |
| Duvick, L | 1 |
| Barnes, J | 1 |
| Ebner, B | 1 |
| Agrawal, S | 1 |
| Andresen, M | 1 |
| Lim, J | 1 |
| Giesler, GJ | 1 |
| Zoghbi, HY | 1 |
| Wang, PS | 1 |
| Chen, HC | 1 |
| Wu, HM | 1 |
| Lirng, JF | 1 |
| Wu, YT | 1 |
| Soong, BW | 1 |
| Guerrini, L | 1 |
| Lolli, F | 1 |
| Ginestroni, A | 1 |
| Belli, G | 1 |
| Della Nave, R | 1 |
| Tessa, C | 1 |
| Foresti, S | 1 |
| Cosottini, M | 1 |
| Piacentini, S | 1 |
| Salvi, F | 1 |
| Plasmati, R | 1 |
| De Grandis, D | 1 |
| Siciliano, G | 1 |
| Filla, A | 1 |
| Mascalchi, M | 1 |
| Harno, H | 1 |
| Heikkinen, S | 1 |
| Kaunisto, MA | 1 |
| Kallela, M | 1 |
| Häkkinen, AM | 1 |
| Wessman, M | 1 |
| Färkkilä, M | 1 |
| Lundbom, N | 1 |
| Shimazaki, H | 1 |
| Nakao, K | 1 |
| Ishikawa, K | 1 |
| Takiyama, Y | 1 |
| Nakano, I | 1 |
| Morita, H | 1 |
| Yoshida, K | 1 |
| Suzuki, K | 1 |
| Ikeda, SI | 1 |
| Boesch, SM | 2 |
| Wolf, C | 1 |
| Seppi, K | 1 |
| Felber, S | 2 |
| Wenning, GK | 1 |
| Schocke, M | 2 |
| Döhlinger, S | 1 |
| Hauser, TK | 1 |
| Borkert, J | 1 |
| Luft, AR | 1 |
| Schulz, JB | 1 |
| Bürk, K | 1 |
| Hollosi, P | 1 |
| Fornai, F | 1 |
| Aichner, FT | 1 |
| Poewe, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identification of Biomarkers in Patients With Autosomal Dominant Cerebellar Ataxia[NCT01470729] | 102 participants (Actual) | Observational | 2011-11-30 | Completed | |||
| Clinical Trial Readiness for SCA1 and SCA3[NCT03487367] | 200 participants (Anticipated) | Observational | 2018-08-16 | Active, not recruiting | |||
| Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2[NCT01543750] | Phase 2 | 0 participants (Actual) | Interventional | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for aspartic acid and Spinocerebellar Ataxias
| Article | Year |
|---|---|
Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Cerebellum; Choline; Creatine; Diagnosis, Differential; Fe | 2007 |
15 other studies available for aspartic acid and Spinocerebellar Ataxias
| Article | Year |
|---|---|
Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.
Topics: Activities of Daily Living; Adult; Aged; Aspartic Acid; Ataxins; Brain; Brain Diseases, Metabolic; C | 2018 |
Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.
Topics: Acetyltransferases; Animals; Aspartic Acid; Ataxin-2; Brain; Female; Gene Knock-In Techniques; Male; | 2019 |
Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Female; | 2014 |
Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology.
Topics: Animals; Area Under Curve; Aspartic Acid; Ataxin-1; Cerebellum; Doxycycline; Gene Expression; Humans | 2015 |
In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7.
Topics: Adult; Aspartic Acid; Ataxins; Cohort Studies; Female; Glutamic Acid; Humans; Machado-Joseph Disease | 2015 |
Cerebellar neurochemical alterations in spinocerebellar ataxia type 14 appear to include glutathione deficiency.
Topics: Adult; Aged; Aspartic Acid; Cerebellum; Cerebral Cortex; Creatine; Female; Glutamic Acid; Glutathion | 2015 |
Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status.
Topics: Analysis of Variance; Aspartic Acid; Brain Chemistry; Case-Control Studies; Female; Functional Later | 2010 |
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Topics: Animals; Aspartic Acid; Ataxin-1; Ataxins; Calbindins; Cerebellum; Dendrites; Disease Models, Animal | 2010 |
Association between proton magnetic resonance spectroscopy measurements and CAG repeat number in patients with spinocerebellar ataxias 2, 3, or 6.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Case-Control Studies; Cerebellum; Creatine; Disease Progre | 2012 |
Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Stem; Cerebellum; Creatine; Female; Humans; Magnetic R | 2004 |
Decreased cerebellar total creatine in episodic ataxia type 2: a 1H MRS study.
Topics: Adolescent; Adult; Aspartic Acid; Calcium Channels; Cerebellum; Child; Choline; Creatine; Dysarthria | 2005 |
[A case of spinocerebellar ataxia type 6 with its initial symptom of episodic ataxia-like phenotype].
Topics: Adult; Aspartic Acid; Brain Chemistry; Creatine; Female; Humans; Magnetic Resonance Imaging; Magneti | 2006 |
A Japanese case of SCA14 with the Gly128Asp mutation.
Topics: Adult; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Base Sequence; Cerebellum; Femal | 2006 |
Magnetic resonance imaging in spinocerebellar ataxias.
Topics: Aspartic Acid; Ataxin-1; Ataxin-3; Ataxins; Atrophy; Brain; Cerebellum; Humans; Magnetic Resonance I | 2008 |
Proton magnetic resonance spectroscopic imaging reveals differences in spinocerebellar ataxia types 2 and 6.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Midd | 2001 |