aspartic acid has been researched along with Spinal Cord Injuries in 24 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "More specifically, the presence of neuropathic pain after spinal cord injury is associated with significant reductions in thalamic N-acetylaspartate, gamma amino butyric acid content, and blood flow in the region of the thalamic reticular nucleus." | 1.40 | Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury. ( Edden, RAE; Gustin, SM; Henderson, LA; McIndoe, L; Rae, CD; Siddall, PJ; Wilcox, SL; Wrigley, PJ; Youssef, AM, 2014) |
| "CNS damage in pure adrenomyeloneuropathy is not confined exclusively to spinal cord and seems to primarily involve the brain." | 1.34 | Prominent brain axonal damage and functional reorganization in "pure" adrenomyeloneuropathy. ( Bramanti, P; De Luca, M; De Stefano, N; Dotti, MT; Federico, A; Formichi, P; Galluzzi, P; Marino, S; Mondelli, M; Stromillo, ML, 2007) |
| "After spinal cord transections at 30% BL, rhythmic burst activity usually was no longer generated by rostral hemi-spinal cords." | 1.33 | Disruption of left-right reciprocal coupling in the spinal cord of larval lamprey abolishes brain-initiated locomotor activity. ( Boyd, MR; Horinek, DF; Jackson, AW; McClellan, AD, 2005) |
| "Hypoxic-hypoglycemic treatment (in vitro ischemia) elicited a rapid release of the excitatory amino acids from cultured spinal cord neurons and glial cells, but the release was greater from glial cells than from neurons." | 1.29 | Role of aspartate in ischemic spinal cord damage. ( Kataoka, K; Nakamura, Y; Ogata, T; Okumura, H; Shibata, T; Tsuji, K, 1996) |
| "Acute spinal cord trauma may initiate a cascade of hemodynamic and biochemical events characterized by direct mechanical destruction of neurons, hemorrhages and significant increases in active substances (glutamate, prostaglandins (PGs), ets." | 1.29 | [Excitatory amino acids and prostanoids release in spinal cord injury]. ( Ishikawa, T; Marsala, M, 1996) |
| "To determine whether spinal cord trauma alters the concentrations of extracellular amino acids, microdialysis was conducted in spinal cord during and after administration of impact trauma." | 1.28 | Alteration in extracellular amino acids after traumatic spinal cord injury. ( Faden, AI; Panter, SS; Yum, SW, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, JK | 1 |
| Vallesi, V | 1 |
| Zölch, N | 1 |
| Chan, KL | 1 |
| Hunkeler, N | 1 |
| Abramovic, M | 1 |
| Hashagen, C | 1 |
| Christiaanse, E | 1 |
| Shetty, G | 1 |
| Verma, RK | 1 |
| Berger, MF | 1 |
| Frotzler, A | 1 |
| Eisenlohr, H | 1 |
| Eriks Hoogland, I | 1 |
| Scheel-Sailer, A | 1 |
| Wyss, PO | 1 |
| Gustin, SM | 1 |
| Wrigley, PJ | 1 |
| Youssef, AM | 1 |
| McIndoe, L | 1 |
| Wilcox, SL | 1 |
| Rae, CD | 1 |
| Edden, RAE | 1 |
| Siddall, PJ | 1 |
| Henderson, LA | 1 |
| Denic, A | 1 |
| Bieber, A | 1 |
| Warrington, A | 1 |
| Mishra, PK | 1 |
| Macura, S | 1 |
| Rodriguez, M | 1 |
| Qian, J | 1 |
| Herrera, JJ | 1 |
| Narayana, PA | 2 |
| Liu, YP | 1 |
| Yang, CS | 1 |
| Chen, MC | 1 |
| Sun, SH | 1 |
| Tzeng, SF | 1 |
| Ahmed, Z | 1 |
| Wieraszko, A | 1 |
| Jackson, AW | 1 |
| Horinek, DF | 1 |
| Boyd, MR | 1 |
| McClellan, AD | 1 |
| Diaz-Ruiz, A | 1 |
| Salgado-Ceballos, H | 1 |
| Montes, S | 1 |
| Maldonado, V | 1 |
| Tristan, L | 1 |
| Alcaraz-Zubeldia, M | 1 |
| Ríos, C | 1 |
| Marino, S | 1 |
| De Luca, M | 1 |
| Dotti, MT | 1 |
| Stromillo, ML | 1 |
| Formichi, P | 1 |
| Galluzzi, P | 1 |
| Mondelli, M | 1 |
| Bramanti, P | 1 |
| Federico, A | 1 |
| De Stefano, N | 1 |
| Likavcanová, K | 1 |
| Urdzíková, L | 1 |
| Hájek, M | 1 |
| Syková, E | 1 |
| Falconer, JC | 1 |
| Liu, SJ | 1 |
| Abbe, RA | 1 |
| Ogata, T | 1 |
| Nakamura, Y | 1 |
| Tsuji, K | 1 |
| Okumura, H | 1 |
| Kataoka, K | 1 |
| Shibata, T | 1 |
| Ishikawa, T | 1 |
| Marsala, M | 1 |
| Craenen, G | 1 |
| Jeftinija, S | 1 |
| Grants, I | 1 |
| Lucas, JH | 1 |
| Watanabe, M | 1 |
| Fujimura, Y | 1 |
| Nakamura, M | 1 |
| Yato, Y | 1 |
| Ohta, K | 1 |
| Okai, H | 1 |
| Ogawa, Y | 1 |
| Puri, BK | 1 |
| Smith, HC | 1 |
| Cox, IJ | 1 |
| Sargentoni, J | 1 |
| Savic, G | 1 |
| Maskill, DW | 1 |
| Frankel, HL | 1 |
| Ellaway, PH | 1 |
| Davey, NJ | 1 |
| Liu, D | 1 |
| Xu, GY | 3 |
| Pan, E | 1 |
| McAdoo, DJ | 3 |
| Robak, G | 1 |
| Hughes, MG | 1 |
| Mills, CD | 1 |
| Hulsebosch, CE | 1 |
| Panter, SS | 1 |
| Yum, SW | 1 |
| Faden, AI | 4 |
| Demediuk, P | 1 |
| Daly, MP | 1 |
| Simon, RP | 2 |
| Lemke, M | 1 |
| Noble, LJ | 1 |
| Potashner, SJ | 1 |
| Tran, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mapping the Natural History of Traumatic Spinal Cord Injury in the Sensorimotor Cortex Using Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging[NCT00790361] | 20 participants (Actual) | Observational | 2009-06-18 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for aspartic acid and Spinal Cord Injuries
| Article | Year |
|---|---|
Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study.
Topics: Aspartic Acid; Cerebellum; Choline; Creatine; Humans; Metabolome; Pons; Proton Magnetic Resonance Sp | 2023 |
Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury.
Topics: Adult; Aged; Aspartic Acid; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Mag | 2014 |
Brainstem 1H nuclear magnetic resonance (NMR) spectroscopy: marker of demyelination and repair in spinal cord.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Stem; Demyelinating Diseases; Friend murine leukemia virus | 2009 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Imm | 2010 |
Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Benzoxazoles; Calcium; | 2010 |
Trans-spinal direct current enhances corticospinal output and stimulation-evoked release of glutamate analog, D-2,3-³H-aspartic acid.
Topics: Animals; Aspartic Acid; Behavior, Animal; Calcium; Cerebral Cortex; Disease Models, Animal; Electric | 2012 |
Disruption of left-right reciprocal coupling in the spinal cord of larval lamprey abolishes brain-initiated locomotor activity.
Topics: Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Brain; Electromyography; Escape Reac | 2005 |
Acute alterations of glutamate, glutamine, GABA, and other amino acids after spinal cord contusion in rats.
Topics: Animals; Aspartic Acid; Citrulline; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glyci | 2007 |
Prominent brain axonal damage and functional reorganization in "pure" adrenomyeloneuropathy.
Topics: Adolescent; Adrenoleukodystrophy; Adult; Aged; Aspartic Acid; Axons; Brain; Cerebral Cortex; Choline | 2007 |
Metabolic changes in the thalamus after spinal cord injury followed by proton MR spectroscopy.
Topics: Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Glutamic Acid; Hindlimb; Hot Temper | 2008 |
Time dependence of N-acetyl-aspartate, lactate, and pyruvate concentrations following spinal cord injury.
Topics: Animals; Aspartic Acid; Gas Chromatography-Mass Spectrometry; Lactates; Osmolar Concentration; Pyruv | 1996 |
Role of aspartate in ischemic spinal cord damage.
Topics: Animals; Aspartic Acid; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acids; | 1996 |
[Excitatory amino acids and prostanoids release in spinal cord injury].
Topics: Animals; Aspartic Acid; Dinoprostone; Excitatory Amino Acids; Glutamates; Male; Microdialysis; Rats; | 1996 |
The role of excitatory amino acids in hypothermic injury to mammalian spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Deat | 1996 |
Changes of amino acid levels and aspartate distribution in the cervical spinal cord after traumatic spinal cord injury.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Hemorrhage; Chromatography, High Pressure Liquid; Fema | 1998 |
The human motor cortex after incomplete spinal cord injury: an investigation using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Creatinine; Electromyography; Evoked Potentials, Motor; Humans; Injury S | 1998 |
Neurotoxicity of glutamate at the concentration released upon spinal cord injury.
Topics: Animals; Aspartic Acid; Contusions; Glutamic Acid; Male; Microdialysis; Nerve Degeneration; Neurotox | 1999 |
Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Citrulline; Glutamic Acid; Glycine; Male; Microdialys | 1999 |
Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Ami | 2001 |
Alteration in extracellular amino acids after traumatic spinal cord injury.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glycine; Male; Rabbits; Sp | 1990 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Gluta | 1989 |
A potential role for excitotoxins in the pathophysiology of spinal cord injury.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine M | 1988 |
N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies.
Topics: Animals; Aspartic Acid; Blood Pressure; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Rel | 1988 |
Decreased uptake and release of D-aspartate in the guinea pig spinal cord after partial cordotomy.
Topics: Animals; Aspartic Acid; Biological Transport; gamma-Aminobutyric Acid; Guinea Pigs; Nerve Degenerati | 1985 |