aspartic acid has been researched along with Seizures in 196 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 7.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "The relation between changes in the concentrations of some of the neuroactive extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid, glycine and taurine) and epileptic seizures has been tested in a new experimental model of seizures induced by picrotoxin microdialysis in chronic freely moving rats." | 7.70 | Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. ( Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD, 1998) |
| "Our previous studies have shown a local decrease in glutamate and aspartate levels during seizures, induced by picrotoxin microdialysis in the hippocampus of chronic freely moving rats." | 7.70 | Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats. ( Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD, 2000) |
| "Using a newly developed technique, based on microdialysis, which allows cellular uptake of glutamate and aspartate to be studied in awake animals, we investigated uptake of glutamate and aspartate in the hippocampal formation of rats during limbic seizures induced by systemical administration of kainic acid (KA)." | 7.69 | Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion' method. ( Bruhn, T; Christensen, T; Diemer, NH, 1997) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 7.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| " Metabolic changes associated with kainic acid seizures predominate in the hippocampus, where there are decreases in aspartate (-26%), glutamate (-45%), taurine (-20%), and glutamine (-32%) concentrations and an increase in gamma-aminobutyric acid (GABA) concentration (+ 26%)." | 7.67 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| " tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg)." | 7.67 | The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( Halsey, MJ; Meldrum, BS; Wardley-Smith, B, 1984) |
| "Seizures produced by pilocarpine given i." | 7.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "The prepiriform cortex (PPCx) shows high sensitivity to the epileptogenic action of chemo-convulsants and to the protective action of the NMDA receptor antagonist, 2-amino-7-phosphono-heptanoate (APH) against pilocarpine-induced (motor) limbic seizures in rats." | 7.67 | The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 7.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "Aspartic acid concentration in CSF was markedly elevated in a newborn infant with severe, intractable seizures." | 7.66 | A possible role for aspartic acid in neonatal seizures. ( Amir, J; Merlob, P; Reisner, SH; Weitz, R, 1981) |
| "It was noted that hypoglycemic seizures were generated less frequently, and had less impact on synaptic transmission in hippocmpi from PD 22-24 as compared to hippocampi from mice PD 15-19 or PD 8-13." | 5.35 | Factors which abolish hypoglycemic seizures do not increase cerebral glycogen content in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Weisspapir, M, 2008) |
| "Both of these compounds elicited clonic seizures, though by different mechanisms." | 5.28 | Antagonism between intracerebroventricularly administered N-methyl-D-aspartate and bicuculline methiodide in induction of clonic seizures in mice. ( Gennings, C; Kapetanovic, IM; Kupferberg, HJ; Torchin, CD, 1990) |
| "2APH, 0." | 5.26 | Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. ( Czuczwar, SJ; Meldrum, B, 1982) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Relative to wild-type (WT) mice, the tremor mice presented: increased tremors and bradykinesia associated with postural instability, decreased range of motion, and difficulty in initiating voluntary movements directly proportional to age; reduced step length for right and left hindlimbs; reduced cortical GABA, glutamate and, aspartate levels, the DOPAC/DA and ratio and increased the NOR levels; in the striatum, the levels of glycine and aspartate were reduced while the HVA levels, the HVA/DA and 5HIAA/5-HT ratios increased; in the cerebellum the glycine, NOR and 5-HIAA levels increased." | 4.31 | Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction. ( Alexandre-Ribeiro, SR; Bernardi, MM; Bondan, EF; Coque, AC; Flório, JC; Garcia-Gomes, MSA; Gonçalves, FB; Kirsten, TB; Lebrun, I; Massironi, SMG; Mori, CMC; Sandini, TM; Silva-Sampaio, AC, 2023) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 3.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "The relation between changes in the concentrations of some of the neuroactive extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid, glycine and taurine) and epileptic seizures has been tested in a new experimental model of seizures induced by picrotoxin microdialysis in chronic freely moving rats." | 3.70 | Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. ( Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD, 1998) |
| "Our previous studies have shown a local decrease in glutamate and aspartate levels during seizures, induced by picrotoxin microdialysis in the hippocampus of chronic freely moving rats." | 3.70 | Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats. ( Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD, 2000) |
| "The effects of some neurosteroids on N-methyl-D-aspartic acid (NMDA)-induced seizures were examined in mice." | 3.70 | Protective effects of neurosteroids against NMDA-induced seizures and lethality in mice. ( Budziszewska, B; Jaworska-Feil, L; Lasoń, W; Leśkiewicz, M; Siwanowicz, J, 1998) |
| "Using a newly developed technique, based on microdialysis, which allows cellular uptake of glutamate and aspartate to be studied in awake animals, we investigated uptake of glutamate and aspartate in the hippocampal formation of rats during limbic seizures induced by systemical administration of kainic acid (KA)." | 3.69 | Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion' method. ( Bruhn, T; Christensen, T; Diemer, NH, 1997) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 3.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| " The purpose of this study was to test the hypothesis that a short period of hypoxia would affect release of excitatory and inhibitory amino acids during subsequent bicuculline-induced seizure." | 3.68 | Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit. ( Aquila, WJ; During, MJ; Ley, E; Tendler, D; Young, RS, 1992) |
| " In mice, (+)-HA-966 antagonized sound and N-methyl-DL-aspartic acid (NMDLA)-induced seizures with ED50 values of 52." | 3.68 | Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. ( Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L, 1990) |
| "The prepiriform cortex (PPCx) shows high sensitivity to the epileptogenic action of chemo-convulsants and to the protective action of the NMDA receptor antagonist, 2-amino-7-phosphono-heptanoate (APH) against pilocarpine-induced (motor) limbic seizures in rats." | 3.67 | The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "The participation of excitatory neurotransmitter systems in the basal ganglia in the initiation and propagation of limbic seizures induced by pilocarpine has been investigated in the rat." | 3.67 | Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats. ( De Sarro, GB; Meldrum, BS; Patel, S, 1988) |
| "Seizures produced by pilocarpine given i." | 3.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "Strychnine poisoning leads to seizures that have traditionally been attributed to competitive antagonism of glycine receptors in the spinal cord." | 3.67 | Glycine potentiates strychnine-induced convulsions: role of NMDA receptors. ( Beitz, AJ; Larson, AA, 1988) |
| " tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg)." | 3.67 | The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( Halsey, MJ; Meldrum, BS; Wardley-Smith, B, 1984) |
| " Metabolic changes associated with kainic acid seizures predominate in the hippocampus, where there are decreases in aspartate (-26%), glutamate (-45%), taurine (-20%), and glutamine (-32%) concentrations and an increase in gamma-aminobutyric acid (GABA) concentration (+ 26%)." | 3.67 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| "An effect of the beta-stereoisomer of kainic acid on seizures produced by intracerebroventricular injections of excitatory amino acids was tested in mice." | 3.67 | Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist? ( Collins, JF; Meldrum, BS; Turski, L, 1985) |
| " The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively." | 3.67 | A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties. ( Balm, M; Coyle, JT; Markl, A; Zaczek, R, 1986) |
| "Previous studies in our laboratory have shown that bilateral motor seizures can be elicited from a discrete site within the deep prepiriform cortex (DPC) after a single, unilateral microinjection of picomole amounts of bicuculline, carbachol or kainic acid." | 3.67 | Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex. ( Gale, K; Piredda, S, 1986) |
| "Aspartic acid concentration in CSF was markedly elevated in a newborn infant with severe, intractable seizures." | 3.66 | A possible role for aspartic acid in neonatal seizures. ( Amir, J; Merlob, P; Reisner, SH; Weitz, R, 1981) |
| "Ten analogues of valproic acid (substituted butyric, pentanoic and hexanoic acids) were tested for anticonvulsant activity against audiogenic seizures in DBA/2 mice." | 3.66 | Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content. ( Chapman, AG; Meldrum, BS; Mendes, E, 1983) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 3.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "Linear regression analyses between seizure duration and NAA/Cr decrease was not significant." | 2.69 | Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy. ( Andermann, F; Arnold, DL; Cendes, F; Dubeau, F; Li, LM; Miller, SP; Tasch, E, 2000) |
| "Epilepsy is too complex to be considered as a disease; it is more of a syndrome, characterized by seizures, which can be caused by a diverse array of afflictions." | 2.55 | Control of seizures by ketogenic diet-induced modulation of metabolic pathways. ( Akabani, G; Aramayo, R; Clanton, RM; Wu, G, 2017) |
| "He was admitted due to recurrent convulsions experienced over the past two years." | 1.91 | Hypomagnesemia with Secondary Hypocalcemia (HSH): a Case Report. ( Jiang, Z; Lin, Y; Zhao, C, 2023) |
| "Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood." | 1.62 | Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas. ( Abe, M; Hirose, Y; Inamasu, J; Kumon, M; Kuwahara, K; Murayama, K; Nakae, S; Ohba, S; Sasaki, H; Yamada, S, 2021) |
| "These 2 patients presented with seizures." | 1.46 | Magnetic Resonance Spectroscopy Findings in Patients with Dural Arteriovenous Fistulas: Three Case Reports. ( Fujita, A; Hosoda, K; Kohmura, E; Kohta, M; Nagashima, H; Sasayama, T; Tanaka, J; Tanaka, K, 2017) |
| "At examination, five patients were seizure free." | 1.46 | Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism. ( Bisulli, F; Ferri, L; Gramegna, LL; Licchetta, L; Lodi, R; Naldi, I; Rizzo, G; Testa, C; Tinuper, P; Tonon, C, 2017) |
| "We predict the seizure-like discharges under the dysfunction of AG degradation duration." | 1.43 | Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation. ( Du, M; Li, J; Ma, J; Tang, J; Wang, R; Wu, Y, 2016) |
| "We conclude that reactive astrocytosis and activation of glutamate release from astrocyte processes might contribute, together with increased reactive oxygen species production, to the vulnerability to kainate excitotoxicity in Dach-SMO mice." | 1.43 | Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. ( Berretta, N; Cecconi, F; Cervelli, M; Cervetto, C; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Mercuri, N; Passalacqua, M; Ragazzoni, M; Venturini, A; Vergani, L; Voci, A, 2016) |
| "Pilomotor seizure (PS) is a rare subtype of simple and complex partial seizures, often related to temporal lobe epilepsy and occasionally linked to alterations of amygdala." | 1.36 | Dissociation between neurovegetative signs and subjective symptoms in a case of idiopathic pilomotor seizures. ( Balestrieri, A; Barberini, L; Bortolato, M; Genugu, F; Gioi, G; Marrosu, F; Puligheddu, M, 2010) |
| "It was noted that hypoglycemic seizures were generated less frequently, and had less impact on synaptic transmission in hippocmpi from PD 22-24 as compared to hippocampi from mice PD 15-19 or PD 8-13." | 1.35 | Factors which abolish hypoglycemic seizures do not increase cerebral glycogen content in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Weisspapir, M, 2008) |
| "These data argue that within the seizure onset zone, the tight correlation between total power and NAA/Cr suggests that total electrical output is powered by available mitochondrial function." | 1.35 | Intracranial EEG power and metabolism in human epilepsy. ( Hetherington, HP; Pan, JW; Spencer, DD; Spencer, SS; Zaveri, HP, 2009) |
| "Duration of the seizures in the controls and Mg-deficient rats were 64." | 1.35 | [The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment]. ( Iezhitsa, IN; Kharitonova, MV; Kravchenko, MS; Spasov, AA, 2008) |
| "Duration of seizure symptoms associated with increased Cr peaks probably reflects increased gliosis." | 1.34 | 1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG. ( Doelken, M; Doerfler, A; Engelhorn, T; Ganslandt, O; Hammen, T; Kerling, F; Nimsky, C; Schwarz, M; Stadlbauer, A; Stefan, H, 2007) |
| "Our results demonstrate effects of seizures on the hippocampi in neocortical epilepsy and the relation between SGTCS and NAA/Cr of the contralateral hippocampus in mTLE." | 1.33 | Effect of seizure on hippocampus in mesial temporal lobe epilepsy and neocortical epilepsy: an MRS study. ( Chang, KH; Chung, CK; Kim, DW; Kim, KK; Lee, SK; Song, IC, 2005) |
| "Canavan disease is an early onset leukodystrophy associated with psychomotor retardation, seizures, and premature death." | 1.33 | Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease. ( During, MJ; Klugmann, M; Leichtlein, CB; Serikawa, T; Symes, CW; Young, D, 2005) |
| "These four children all had seizure activity and abnormal initial neurological examinations and required admission to the PICU." | 1.33 | Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. ( Ball, WS; Care, M; Cecil, KM; Makoroff, KL, 2005) |
| "Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging." | 1.31 | Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome. ( Barker, PB; Beauchamp, NJ; Eichler, FS; Wang, P; Wityk, RJ, 2002) |
| "Kainic acid (KA)-induced seizures lead to histopathologic changes in rat brain." | 1.30 | MRS metabolic markers of seizures and seizure-induced neuronal damage. ( Comair, YG; Lüders, HO; Najm, IM; Ng, TC; Shedid, D; Wang, Y, 1998) |
| "The anti-seizure activity of DCG-IV was fully inhibited in the presence of the group II metabotropic glutamate receptor antagonist (2S,1'S, 2'S)-2-methyl-2-(carboxycyclopropyl)glycine (MCCG; 40 nmol), while MCCG alone showed no significant inhibitory effect on seizure activity." | 1.30 | Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV). ( Attwell, PJ; Bradford, HF; Croucher, MJ; Jane, DE; Singh Kent, N, 1998) |
| "All animals were tested three times for seizure threshold, and were then decapitated and the brains removed for analysis of the amino acids." | 1.30 | Effects of ammonia on pentylenetetrazole-induced seizure threshold. ( Arikan, K; Coskun, T; Guvener, B; Oran, O, 1999) |
| "Dexmedetomidine and the lower dose of atipamezole (0." | 1.29 | Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. ( Haapalinna, A; Halonen, T; Riekkinen, P; Valtonen, P, 1995) |
| "1." | 1.29 | Brain amino acid levels are related to seizure propensity in the gerbil (Meriones unguiculatus). ( Blumsom, NL; Gardiner, KA; Laming, PR, 1993) |
| "The separation in potencies in the MES seizure and motor toxicity tests of PCA and PM-THIQ contrasts with PCP which was equally potent in both tests." | 1.28 | Anticonvulsant activities of 1-phenylcyclohexylamine and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline. ( Jacobson, AE; Mattson, MV; Rice, KC; Rogawski, MA; Thurkauf, A; Yamaguchi, S, 1989) |
| "Rb1 mice were clonictonic seizure-prone, Rb2 mice were clonic seizure-prone and Rb3 mice were seizure resistant." | 1.28 | Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures. ( Ciesielski, L; Clement, J; Mandel, P; Simler, S, 1990) |
| "Limbic seizure-activity was induced by injecting kainic acid into the amygdala of rats." | 1.28 | Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats. ( Berg, M; Bruhn, T; Cobo, M; Diemer, NH, 1992) |
| "Both of these compounds elicited clonic seizures, though by different mechanisms." | 1.28 | Antagonism between intracerebroventricularly administered N-methyl-D-aspartate and bicuculline methiodide in induction of clonic seizures in mice. ( Gennings, C; Kapetanovic, IM; Kupferberg, HJ; Torchin, CD, 1990) |
| "1." | 1.28 | Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants. ( Moreau, JL; Pieri, L; Prud'hon, B, 1989) |
| "The patient developed a series of partial seizures during an 8 min period." | 1.28 | Seizure related elevations of extracellular amino acids in human focal epilepsy. ( Carlson, H; Hillered, L; Ronne-Engström, E; Ungerstedt, U, 1992) |
| "NPC 12626 failed to inhibit the specific binding of RS-[3H] amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid or [3H] kainic acid to brain membranes in vitro but displaced both agonist and antagonist binding to N-methyl-D-aspartic acid (NMDA) receptors." | 1.28 | Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist. ( Borosky, S; Ellenberger, SR; Ferkany, JW; Guzewska, ME; Jones, SM; Kyle, DJ; Rzeszotarski, WJ; Sacaan, AI; Snell, LD; Willets, J, 1989) |
| "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures." | 1.28 | NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. ( Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA, 1989) |
| "Before seizure, glutamate and aspartate concentration showed no significant changes in the S4 and S6 group compared with the Sh group." | 1.28 | [Sequential changes in content of excitatory amino acids in the epileptic focus during seizure]. ( Eguchi, T; Hirabayashi, H; Morimoto, T; Nakase, H; Sakaki, T; Tada, T, 1991) |
| "AP7, 0." | 1.28 | Homocysteic acid: convulsant action of stereoisomers in mice. ( Turski, WA, 1989) |
| "To clarify the biochemical mechanism of convulsions from a view point of the amino acid metabolism, the free amino acid patterns in brains of El mice were investigated." | 1.27 | Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure. ( Honda, T, 1984) |
| "Clonic seizures were induced in Swiss or DBA/2 mice by methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), 0." | 1.27 | Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents. ( Chapman, AG; Cheetham, SC; Hart, GP; Meldrum, BS; Westerberg, E, 1985) |
| "Audiogenic convulsions in DBA/2 mice were blocked by CPP (ED50 = 1." | 1.27 | CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo. ( Bennett, DA; Bernard, P; Boehm, C; Lehmann, J; McPherson, S; Murphy, DE; Pastor, G; Schneider, J; Steel, DJ; Tsai, C, 1987) |
| "Using a model in which seizure activity was elicited electrically from the inferior colliculus, the influence of both inhibitory and excitatory putative neurotransmitter amino acids on this seizure activity was assessed by manipulating neurotransmitter amino acid function." | 1.27 | Amino acid influences on seizures elicited within the inferior colliculus. ( Breese, GR; Givens, BS; McCown, TJ, 1987) |
| "CGS 19755 inhibited convulsions elicited by maximal electroshock in rat (ED50 = 3." | 1.27 | CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. ( Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M, 1988) |
| "In contrast, the severity of seizures produced by N-methyl-dl-aspartate (NMA) was increased by nitrendipine." | 1.27 | Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. ( Dolin, SJ; Halsey, MJ; Hunter, AB; Little, HJ, 1988) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| "In the NMDA-induced convulsion test in mice, ketamine and dexoxadrol blocked convulsant activity only at doses that also induced nonspecific effects of PCP-like behaviors, thereby confounding the interpretation of results." | 1.27 | A comparison of PCP-like compounds for NMDA antagonism in two in vivo models. ( Amrick, CL; Bennett, DA; Bernard, PS, 1988) |
| "The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs." | 1.27 | Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A, 1987) |
| "Tiletamine-induced convulsions were antagonized by the broad spectrum excitatory amino acid antagonist, gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS), and were potentiated by the competitive NMDA antagonist, 2-amino-7-phosphonohepatanoate (AP7)." | 1.27 | Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine. ( Klockgether, T; Lehmann, J; Schwarz, M; Sontag, KH; Turski, L, 1988) |
| "Quisqualate induces myoclonic seizures in mice after intracerebroventricular application and increases muscle tone in genetically spastic rats following intrathecal injection." | 1.27 | Unusual interactions of excitatory amino acid receptor agonists: alpha- and beta-kainate antagonize motor responses to N-methyl-D-aspartate in rodents. ( Klockgether, T; Meldrum, BS; Schwarz, M; Sontag, KH; Turski, L, 1987) |
| "The data suggest that NMDLA-induced convulsions can be blocked effectively by direct antagonism of NMDLA-produced excitation, enhancement of GABA-mediated inhibition, and activation of central alpha 2-adrenoceptors." | 1.27 | Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents. ( Czuczwar, SJ; Frey, HH; Löscher, W, 1985) |
| "In Swiss S mice suppression of seizure activity induced by i." | 1.27 | Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity. ( Chapman, AG; Hart, GP; Meldrum, BS; Turski, L; Watkins, JC, 1985) |
| "Both seizures and encephalopathy began after the second dose of PALA or later." | 1.26 | Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate. ( Casper, ES; Gralla, RJ; Kemeny, N; Wiley, RG, 1982) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "2APH, 0." | 1.26 | Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. ( Czuczwar, SJ; Meldrum, B, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 110 (56.12) | 18.7374 |
| 1990's | 39 (19.90) | 18.2507 |
| 2000's | 25 (12.76) | 29.6817 |
| 2010's | 17 (8.67) | 24.3611 |
| 2020's | 5 (2.55) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, X | 1 |
| Liu, L | 1 |
| Wang, W | 1 |
| Tan, Q | 1 |
| Su, X | 1 |
| Zhang, S | 1 |
| Yang, X | 1 |
| Yue, Q | 1 |
| Gong, Q | 1 |
| Gonçalves, FB | 1 |
| Garcia-Gomes, MSA | 1 |
| Silva-Sampaio, AC | 1 |
| Kirsten, TB | 1 |
| Bondan, EF | 1 |
| Sandini, TM | 1 |
| Flório, JC | 1 |
| Lebrun, I | 1 |
| Coque, AC | 1 |
| Alexandre-Ribeiro, SR | 1 |
| Massironi, SMG | 1 |
| Mori, CMC | 1 |
| Bernardi, MM | 1 |
| Zhao, C | 1 |
| Lin, Y | 1 |
| Jiang, Z | 1 |
| Vidya Shankar, R | 1 |
| Hu, HH | 1 |
| Bikkamane Jayadev, N | 1 |
| Chang, JC | 1 |
| Kodibagkar, VD | 1 |
| Simani, L | 1 |
| Raminfard, S | 1 |
| Asadollahi, M | 1 |
| Roozbeh, M | 1 |
| Ryan, F | 1 |
| Rostami, M | 1 |
| Nakae, S | 1 |
| Kumon, M | 1 |
| Murayama, K | 1 |
| Ohba, S | 1 |
| Sasaki, H | 1 |
| Inamasu, J | 1 |
| Kuwahara, K | 1 |
| Yamada, S | 1 |
| Abe, M | 1 |
| Hirose, Y | 1 |
| Nagashima, H | 1 |
| Fujita, A | 1 |
| Tanaka, J | 1 |
| Kohta, M | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Hosoda, K | 1 |
| Kohmura, E | 1 |
| Naldi, I | 1 |
| Bisulli, F | 1 |
| Testa, C | 1 |
| Rizzo, G | 1 |
| Ferri, L | 1 |
| Gramegna, LL | 1 |
| Licchetta, L | 1 |
| Lodi, R | 1 |
| Tonon, C | 1 |
| Tinuper, P | 1 |
| Meller, S | 1 |
| Brandt, C | 1 |
| Theilmann, W | 1 |
| Klein, J | 1 |
| Löscher, W | 3 |
| Xiang, J | 1 |
| Jiang, Y | 1 |
| Dahlberg, D | 1 |
| Ivanovic, J | 1 |
| Hassel, B | 1 |
| Sierra-Paredes, G | 3 |
| Loureiro, AI | 1 |
| Wright, LC | 1 |
| Sierra-Marcuño, G | 3 |
| Soares-da-Silva, P | 1 |
| Lin, YJ | 1 |
| Ho, CS | 1 |
| Chiu, NC | 1 |
| Tseng, HS | 1 |
| Hsu, CH | 1 |
| Huang, JK | 1 |
| Cervetto, C | 1 |
| Vergani, L | 1 |
| Passalacqua, M | 1 |
| Ragazzoni, M | 1 |
| Venturini, A | 1 |
| Cecconi, F | 1 |
| Berretta, N | 1 |
| Mercuri, N | 1 |
| D'Amelio, M | 1 |
| Maura, G | 1 |
| Mariottini, P | 1 |
| Voci, A | 1 |
| Marcoli, M | 1 |
| Cervelli, M | 1 |
| Li, J | 1 |
| Tang, J | 1 |
| Ma, J | 1 |
| Du, M | 1 |
| Wang, R | 1 |
| Wu, Y | 1 |
| Clanton, RM | 1 |
| Wu, G | 1 |
| Akabani, G | 1 |
| Aramayo, R | 1 |
| Fadaie, F | 1 |
| Mobarakeh, NM | 1 |
| Fesharaki, SS | 1 |
| Harirchian, MH | 1 |
| Kharazi, HH | 1 |
| Rad, HS | 1 |
| Habibabadi, JM | 1 |
| Choudhary, AK | 1 |
| Lee, YY | 1 |
| Simister, RJ | 1 |
| McLean, MA | 1 |
| Salmenpera, TM | 1 |
| Barker, GJ | 1 |
| Duncan, JS | 1 |
| Spasov, AA | 3 |
| Iezhitsa, IN | 3 |
| Kravchenko, MS | 3 |
| Kharitonova, MV | 3 |
| Alfaro-Sáez, A | 1 |
| Bernabéu, A | 1 |
| Pan, JW | 1 |
| Zaveri, HP | 1 |
| Spencer, DD | 1 |
| Hetherington, HP | 1 |
| Spencer, SS | 1 |
| Zahr, NM | 1 |
| Crawford, EL | 1 |
| Hsu, O | 1 |
| Vinco, S | 1 |
| Mayer, D | 1 |
| Rohlfing, T | 1 |
| Sullivan, EV | 1 |
| Pfefferbaum, A | 1 |
| Filosa, A | 1 |
| Paixão, S | 1 |
| Honsek, SD | 1 |
| Carmona, MA | 1 |
| Becker, L | 1 |
| Feddersen, B | 1 |
| Gaitanos, L | 1 |
| Rudhard, Y | 1 |
| Schoepfer, R | 1 |
| Klopstock, T | 1 |
| Kullander, K | 1 |
| Rose, CR | 1 |
| Pasquale, EB | 1 |
| Klein, R | 1 |
| de Freitas, RM | 1 |
| de Oliveira Silva, F | 1 |
| Saldanha, GB | 1 |
| Jordán, J | 1 |
| González-Ramírez, M | 1 |
| Razo-Juárez, LI | 1 |
| Sauer-Ramírez, JL | 1 |
| González-Trujano, ME | 1 |
| Salgado-Ceballos, H | 1 |
| Orozco-Suarez, S | 1 |
| Puligheddu, M | 1 |
| Bortolato, M | 1 |
| Barberini, L | 1 |
| Genugu, F | 1 |
| Gioi, G | 1 |
| Balestrieri, A | 1 |
| Marrosu, F | 1 |
| MacKay, KB | 1 |
| Lowenson, JD | 2 |
| Clarke, SG | 1 |
| Hájek, M | 1 |
| Dezortová, M | 1 |
| Liscák, R | 1 |
| Vymazal, J | 1 |
| Vladyka, V | 1 |
| WEBER, B | 2 |
| LABORIT, H | 2 |
| WOOD, JD | 2 |
| WATSON, WJ | 2 |
| CRAWFORD, JM | 1 |
| MASSIEU, GH | 2 |
| TAPIA, R | 2 |
| PASANTES, H | 2 |
| ORTEGA, BG | 2 |
| CITTADINI, D | 2 |
| CIMINO, F | 2 |
| CARACCIOLI, MD | 1 |
| SALVATORE, F | 1 |
| ROA, PD | 1 |
| TEWS, JK | 2 |
| STONE, WE | 3 |
| CREMER, JE | 1 |
| Demarque, M | 1 |
| Villeneuve, N | 1 |
| Manent, JB | 1 |
| Becq, H | 1 |
| Represa, A | 1 |
| Ben-Ari, Y | 1 |
| Aniksztejn, L | 1 |
| Makoroff, KL | 1 |
| Cecil, KM | 1 |
| Care, M | 1 |
| Ball, WS | 1 |
| Klugmann, M | 1 |
| Leichtlein, CB | 1 |
| Symes, CW | 1 |
| Serikawa, T | 2 |
| Young, D | 1 |
| During, MJ | 3 |
| Brissaud, O | 1 |
| Chateil, JF | 1 |
| Bordessoules, M | 1 |
| Brun, M | 1 |
| Lee, SK | 1 |
| Kim, DW | 1 |
| Kim, KK | 1 |
| Chung, CK | 1 |
| Song, IC | 1 |
| Chang, KH | 1 |
| Hammen, T | 1 |
| Schwarz, M | 3 |
| Doelken, M | 1 |
| Kerling, F | 1 |
| Engelhorn, T | 1 |
| Stadlbauer, A | 1 |
| Ganslandt, O | 1 |
| Nimsky, C | 1 |
| Doerfler, A | 1 |
| Stefan, H | 1 |
| Abdelmalik, PA | 1 |
| Liang, P | 1 |
| Weisspapir, M | 1 |
| Samoilova, M | 1 |
| Burnham, WM | 1 |
| Carlen, PL | 1 |
| Riederer, F | 1 |
| Bittsanský, M | 1 |
| Lehner-Baumgartner, E | 1 |
| Baumgartner, C | 1 |
| Mlynárik, V | 1 |
| Gruber, S | 1 |
| Moser, E | 1 |
| Kaya, M | 1 |
| Serles, W | 1 |
| Narita, S | 1 |
| Pérez de la Mora, M | 1 |
| Nitsch, C | 1 |
| Schmude, B | 1 |
| Haug, P | 1 |
| Donzanti, BA | 1 |
| Uretsky, NJ | 1 |
| Meldrum, BS | 18 |
| Croucher, MJ | 4 |
| Czuczwar, SJ | 4 |
| Collins, JF | 3 |
| Curry, K | 1 |
| Joseph, M | 1 |
| Stone, TW | 3 |
| Chapman, AG | 8 |
| Westerberg, E | 2 |
| Premachandra, M | 1 |
| Jones, AW | 1 |
| Watkins, JC | 2 |
| Craig, CR | 1 |
| Wardley-Smith, B | 3 |
| Halsey, MJ | 4 |
| Hammond, EJ | 1 |
| Wilder, BJ | 1 |
| Bruni, J | 1 |
| Meldrum, B | 2 |
| Perkins, MN | 1 |
| Mendes, E | 1 |
| Honda, T | 1 |
| Wiley, RG | 1 |
| Gralla, RJ | 2 |
| Casper, ES | 2 |
| Kemeny, N | 1 |
| Weitz, R | 1 |
| Merlob, P | 1 |
| Amir, J | 1 |
| Reisner, SH | 1 |
| Coutinho-Netto, J | 1 |
| Abdul-Ghani, AS | 1 |
| Bradford, HF | 3 |
| Natale, RB | 1 |
| Yagoda, A | 1 |
| Young, CW | 1 |
| Nakase, H | 3 |
| Tada, T | 3 |
| Hashimoto, H | 1 |
| Kurokawa, S | 1 |
| Hirabayashi, H | 3 |
| Hoshida, T | 1 |
| Sakaki, T | 3 |
| Ohnishi, H | 1 |
| Kaura, S | 1 |
| Young, AM | 1 |
| Hughes, PD | 1 |
| Gardiner, KA | 1 |
| Laming, PR | 1 |
| Blumsom, NL | 1 |
| Mori, N | 1 |
| Flavin, HJ | 1 |
| Seyfried, TN | 1 |
| Biggs, CS | 1 |
| Pearce, BR | 1 |
| Fowler, LJ | 1 |
| Whitton, PS | 1 |
| Hörstermann, D | 1 |
| Hönack, D | 1 |
| Rundfeldt, C | 1 |
| Wahnschaffe, U | 1 |
| Valtonen, P | 1 |
| Haapalinna, A | 1 |
| Riekkinen, P | 1 |
| Halonen, T | 1 |
| Tan, WK | 1 |
| Williams, CE | 1 |
| Mallard, CE | 1 |
| Gunning, MI | 1 |
| Gunn, AJ | 1 |
| Gluckman, PD | 1 |
| Reznik-Wolf, H | 1 |
| Treves, TA | 1 |
| Davidson, M | 1 |
| Aharon-Peretz, J | 1 |
| St George Hyslop, PH | 1 |
| Chapman, J | 1 |
| Korczyn, AD | 1 |
| Goldman, B | 1 |
| Friedman, E | 1 |
| Najm, IM | 2 |
| Wang, Y | 2 |
| Hong, SC | 1 |
| Lüders, HO | 2 |
| Ng, TC | 2 |
| Comair, YG | 2 |
| Smolders, I | 1 |
| Van Belle, K | 1 |
| Ebinger, G | 1 |
| Michotte, Y | 1 |
| Bruhn, T | 2 |
| Christensen, T | 1 |
| Diemer, NH | 2 |
| Sejima, H | 1 |
| Ito, M | 1 |
| Kishi, K | 1 |
| Tsuda, H | 1 |
| Shiraishi, H | 1 |
| Kim, E | 1 |
| MacLaren, DC | 1 |
| Clarke, S | 1 |
| Young, SG | 1 |
| Dorandeu, F | 1 |
| Wetherell, J | 1 |
| Pernot-Marino, I | 1 |
| Tattersall, JE | 1 |
| Fosbraey, P | 2 |
| Lallement, G | 1 |
| Budziszewska, B | 1 |
| Siwanowicz, J | 1 |
| Leśkiewicz, M | 1 |
| Jaworska-Feil, L | 1 |
| Lasoń, W | 1 |
| Shedid, D | 1 |
| Galán-Valiente, J | 2 |
| Vazquez-Illanes, MD | 2 |
| Aguilar-Veiga, E | 2 |
| Soto-Otero, R | 1 |
| Mendez-Alvarez, E | 1 |
| Attwell, PJ | 1 |
| Singh Kent, N | 1 |
| Jane, DE | 1 |
| Miller, SP | 1 |
| Li, LM | 1 |
| Cendes, F | 1 |
| Tasch, E | 1 |
| Andermann, F | 1 |
| Dubeau, F | 1 |
| Arnold, DL | 1 |
| Stork, O | 1 |
| Ji, FY | 1 |
| Kaneko, K | 1 |
| Stork, S | 1 |
| Yoshinobu, Y | 1 |
| Moriya, T | 1 |
| Shibata, S | 1 |
| Obata, K | 1 |
| Kitada, K | 1 |
| Akimitsu, T | 1 |
| Shigematsu, Y | 1 |
| Kondo, A | 1 |
| Maihara, T | 1 |
| Yokoi, N | 1 |
| Kuramoto, T | 1 |
| Sasa, M | 1 |
| Arikan, K | 1 |
| Coskun, T | 1 |
| Guvener, B | 1 |
| Oran, O | 1 |
| Bourne, JA | 1 |
| Halliday, J | 1 |
| Kaku, T | 1 |
| Jiang, MH | 1 |
| Hada, J | 1 |
| Morimoto, K | 1 |
| Hayashi, Y | 1 |
| el-Yamany, NA | 1 |
| Horn, E | 1 |
| Eichler, FS | 1 |
| Wang, P | 1 |
| Wityk, RJ | 1 |
| Beauchamp, NJ | 1 |
| Barker, PB | 1 |
| Collins, RC | 1 |
| Mehta, S | 1 |
| Schechter, PJ | 1 |
| Tranier, Y | 1 |
| Grove, J | 1 |
| Battistin, L | 2 |
| Varotto, M | 1 |
| Lorenzi, AD | 1 |
| Young, RS | 1 |
| Aquila, WJ | 1 |
| Tendler, D | 1 |
| Ley, E | 1 |
| Meyerhoff, JL | 1 |
| Robinson, MB | 1 |
| Koller, KJ | 1 |
| Bixler, MA | 1 |
| Coyle, JT | 2 |
| Cobo, M | 1 |
| Berg, M | 1 |
| Carlson, H | 1 |
| Ronne-Engström, E | 1 |
| Ungerstedt, U | 2 |
| Hillered, L | 1 |
| Eguchi, T | 2 |
| Morimoto, T | 2 |
| Singh, L | 6 |
| Oles, RJ | 3 |
| Tricklebank, MD | 4 |
| Simler, S | 1 |
| Ciesielski, L | 1 |
| Clement, J | 1 |
| Mandel, P | 1 |
| Higashihara, Y | 1 |
| Hiramatsu, M | 1 |
| Mori, A | 1 |
| Brancati, A | 2 |
| D'Arcangelo, P | 2 |
| Donald, AE | 1 |
| Foster, AC | 1 |
| Hutson, PH | 1 |
| Iversen, LL | 1 |
| Iversen, SD | 2 |
| Kemp, JA | 1 |
| Leeson, PD | 1 |
| Marshall, GR | 1 |
| Koek, W | 1 |
| Colpaert, FC | 1 |
| Wong, EH | 2 |
| Kesingland, AC | 1 |
| Oles, R | 1 |
| Woodruff, G | 1 |
| McDonald, JW | 2 |
| Silverstein, FS | 2 |
| Johnston, MV | 2 |
| Haack, JA | 1 |
| Rivier, J | 1 |
| Parks, TN | 1 |
| Mena, EE | 1 |
| Cruz, LJ | 1 |
| Olivera, BM | 1 |
| Kapetanovic, IM | 1 |
| Gennings, C | 1 |
| Torchin, CD | 1 |
| Kupferberg, HJ | 1 |
| Kulkarni, SK | 1 |
| Mehta, AK | 1 |
| Ticku, MK | 1 |
| Dolin, SJ | 1 |
| Hunter, AB | 1 |
| Little, HJ | 1 |
| Price, GW | 1 |
| Ahier, RG | 1 |
| Middlemiss, DN | 1 |
| Ferkany, JW | 2 |
| Kyle, DJ | 1 |
| Willets, J | 1 |
| Rzeszotarski, WJ | 1 |
| Guzewska, ME | 1 |
| Ellenberger, SR | 1 |
| Jones, SM | 1 |
| Sacaan, AI | 1 |
| Snell, LD | 1 |
| Borosky, S | 1 |
| Preston, C | 1 |
| Sonnenberg, JL | 1 |
| Mitchelmore, C | 1 |
| Macgregor-Leon, PF | 1 |
| Hempstead, J | 1 |
| Morgan, JI | 1 |
| Curran, T | 1 |
| Millan, MH | 3 |
| Feigenbaum, JJ | 1 |
| Bergmann, F | 1 |
| Richmond, SA | 1 |
| Mechoulam, R | 1 |
| Nadler, V | 1 |
| Kloog, Y | 1 |
| Sokolovsky, M | 1 |
| Sheardown, MJ | 1 |
| Drejer, J | 1 |
| Jensen, LH | 1 |
| Stidsen, CE | 1 |
| Honoré, T | 1 |
| Pierson, MG | 1 |
| Smith, KL | 1 |
| Swann, JW | 1 |
| Stasheff, SF | 1 |
| Anderson, WW | 1 |
| Clark, S | 1 |
| Wilson, WA | 1 |
| Moreau, JL | 1 |
| Pieri, L | 1 |
| Prud'hon, B | 1 |
| Turski, WA | 2 |
| Rogawski, MA | 1 |
| Thurkauf, A | 1 |
| Yamaguchi, S | 1 |
| Rice, KC | 1 |
| Jacobson, AE | 1 |
| Mattson, MV | 1 |
| McCaslin, PP | 1 |
| Morgan, WW | 1 |
| Bennett, DA | 2 |
| Bernard, PS | 1 |
| Amrick, CL | 1 |
| Burton, NR | 1 |
| Janusz, W | 1 |
| Wamil, A | 1 |
| Kleinrok, Z | 1 |
| Klockgether, T | 2 |
| Turski, L | 6 |
| Sontag, KH | 2 |
| Lehmann, J | 4 |
| Hutchison, A | 1 |
| Tsai, C | 3 |
| Wood, PL | 1 |
| Patel, S | 2 |
| Cheetham, SC | 1 |
| Hart, GP | 3 |
| Schwarcz, R | 2 |
| Goldberg, O | 1 |
| Teichberg, VI | 2 |
| Ryzhov, IV | 1 |
| Slepokurov, MV | 1 |
| Lapin, IP | 1 |
| Mandel'shtam, IuE | 1 |
| Aleksandrov, VG | 1 |
| Frenk, H | 1 |
| Liban, A | 1 |
| Urca, G | 1 |
| Piredda, S | 1 |
| Gale, K | 1 |
| Sloviter, RS | 1 |
| Yamazaki, M | 1 |
| Suzuki, S | 1 |
| Schneider, J | 1 |
| McPherson, S | 1 |
| Murphy, DE | 2 |
| Bernard, P | 1 |
| Pastor, G | 1 |
| Steel, DJ | 2 |
| Boehm, C | 1 |
| McCown, TJ | 1 |
| Givens, BS | 1 |
| Breese, GR | 1 |
| Wong, BY | 1 |
| Coulter, DA | 1 |
| Choi, DW | 1 |
| Prince, DA | 1 |
| Hutchison, AJ | 1 |
| McPherson, SE | 1 |
| Mondadori, C | 1 |
| Schmutz, M | 1 |
| Sinton, CM | 1 |
| Williams, M | 1 |
| Larson, AA | 1 |
| Beitz, AJ | 1 |
| Cavalheiro, EA | 2 |
| Borosky, SA | 1 |
| Clissold, DB | 1 |
| Pontecorvo, MJ | 1 |
| De Sarro, GB | 1 |
| Vezzani, A | 1 |
| French, ED | 1 |
| Engelsen, B | 1 |
| Faingold, CL | 1 |
| Silver, JM | 1 |
| Bonhaus, DW | 1 |
| McNamara, JO | 1 |
| Zaczek, R | 1 |
| Markl, A | 1 |
| Balm, M | 1 |
| Frey, HH | 1 |
| Cooney, DA | 1 |
| Yavelow, J | 1 |
| Zlotoff, R | 1 |
| Bergenstal, R | 1 |
| Burg, A | 1 |
| Morrison, R | 1 |
| Fleischman, R | 1 |
| Sacktor, B | 1 |
| Wilson, JE | 1 |
| Tiekert, CG | 1 |
| Okudera, N | 1 |
| Nordmann, R | 1 |
| Petit, MA | 1 |
| Nordmann, J | 1 |
| Brown, DJ | 2 |
| Reynolds, AP | 1 |
| Gallagher, BB | 1 |
| King, LJ | 1 |
| Carl, JL | 1 |
| Lao, L | 1 |
| Whisler, KE | 1 |
| Wiechert, P | 4 |
| Knaape, HH | 1 |
| Dobkin, J | 1 |
| Mushahwar, IK | 1 |
| Koeppe, RE | 1 |
| Yoshino, Y | 3 |
| Elliott, KA | 3 |
| Kita, T | 1 |
| Hata, T | 1 |
| Murakami, T | 1 |
| Saradzhishvili, PM | 1 |
| Vetgoron, FG | 1 |
| Okudzhava, VM | 1 |
| Lino, A | 1 |
| Pacchieri, V | 1 |
| Patel, A | 1 |
| Koenig, H | 1 |
| Pasquini, JM | 1 |
| Salomone, JR | 1 |
| Gómez, CJ | 1 |
| Baumgartner, R | 1 |
| Scheidegger, S | 1 |
| Stalder, G | 1 |
| Hottinger, A | 1 |
| Göllnitz, G | 3 |
| Minard, FN | 1 |
| Richter, D | 1 |
| Cheema, PS | 1 |
| Malathi, K | 1 |
| Padmanaban, G | 1 |
| Sarma, PS | 1 |
| Pandolfo, I | 1 |
| Macaione, S | 1 |
| Palma, MM | 1 |
| Fleming, MC | 1 |
| Lowry, OH | 1 |
| De Cristofaro, D | 1 |
| Balestrieri, C | 1 |
7 reviews available for aspartic acid and Seizures
| Article | Year |
|---|---|
Control of seizures by ketogenic diet-induced modulation of metabolic pathways.
Topics: Amino Acids, Essential; Aspartic Acid; Demyelinating Diseases; Diet, Ketogenic; Epilepsy; Fatty Acid | 2017 |
Neurophysiological symptoms and aspartame: What is the connection?
Topics: Affect; Animals; Aspartame; Aspartic Acid; Brain; Cognitive Dysfunction; Disease Models, Animal; Dop | 2018 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
Roles of excitatory amino acids in expression of secondarily generalized limbic seizures: observations in the kindling model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dimethyl Sulfoxide; Electric Stimulation; Gluta | 1993 |
NMDA receptors and ligands in the vertebrate CNS.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Binding, Competitive; Cent | 1988 |
Anticonvulsant drug action and regional neurotransmitter amino acid changes.
Topics: Acetamides; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Neuro | 1988 |
More meditations of MSG.
Topics: Age Factors; Amino Acids; Animals; Aspartic Acid; Brain; Chickens; Food Additives; Glutamates; Gluta | 1973 |
1 trial available for aspartic acid and Seizures
| Article | Year |
|---|---|
Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy.
Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain Neoplasms; Child; C | 2000 |
188 other studies available for aspartic acid and Seizures
| Article | Year |
|---|---|
1H-MRS reveals metabolic alterations in generalized tonic-clonic seizures before and after treatment.
Topics: Aspartic Acid; Creatine; Dorsolateral Prefrontal Cortex; Humans; Magnetic Resonance Spectroscopy; Pr | 2022 |
Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; | 2023 |
Hypomagnesemia with Secondary Hypocalcemia (HSH): a Case Report.
Topics: Aspartic Acid; Calcitriol; Calcium; Calcium Carbonate; Child; Cholecalciferol; Humans; Hypocalcemia; | 2023 |
2-D magnetic resonance spectroscopic imaging of the pediatric brain using compressed sensing.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Co | 2019 |
Neurochemicals of limbic system and thalamofrontal cortical network: Are they different between patients with idiopathic generalized epilepsy and psychogenic nonepileptic seizure?
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsy, Generalized; Humans; Magnetic Resonance Spectrosc | 2020 |
Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytes; Brain Neoplasms; Female; Glioma; Glutamic | 2021 |
Magnetic Resonance Spectroscopy Findings in Patients with Dural Arteriovenous Fistulas: Three Case Reports.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Central Nervous System Vascular Malformations; Cerebral Angi | 2017 |
Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Epilepsy; Female; Gyrus Cinguli; Humans; Magne | 2017 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain.
Topics: Alkaloids; Animals; Anticonvulsants; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate Decarb | 2013 |
High extracellular concentration of excitatory amino acids glutamate and aspartate in human brain abscess.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Abscess; Child; Child, Preschool; E | 2014 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Hete | 2014 |
The Reversible Corpus Callosum Splenium Lesion in A Neonate with Hypoglycemia and Seizure.
Topics: Aspartic Acid; Corpus Callosum; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Ma | 2015 |
Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.
Topics: Animals; Aspartic Acid; Astrocytes; Benzodiazepines; Biogenic Polyamines; Calcium; Cerebral Cortex; | 2016 |
Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation.
Topics: Aspartic Acid; Astrocytes; Glutamic Acid; Hippocampus; Humans; Neuroglia; Neurons; Receptors, N-Meth | 2016 |
1H-MRS metabolite's ratios show temporal alternation in temporal lobe seizure: Comparison between interictal and postictal phases.
Topics: Adult; Aspartic Acid; Choline; Creatinine; Drug Resistant Epilepsy; Electroencephalography; Epilepsy | 2016 |
The effect of epileptic seizures on proton MRS visible neurochemical concentrations.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Data Interpretation, Statistical; Dipeptid | 2008 |
[The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment].
Topics: Animals; Aspartic Acid; Cations, Divalent; Diet; Magnesium; Magnesium Chloride; Magnesium Deficiency | 2008 |
[In vivo magnetic resonance spectroscopy in the measurement of mesial temporal sclerosis].
Topics: Aspartic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Sclerosis; Seizures; Sensitivity and S | 2009 |
Features of central neurotransmission in animals in conditions of dietary magnesium deficiency and after its correction.
Topics: Animals; Aspartic Acid; Cations, Divalent; Diet; Magnesium; Magnesium Chloride; Magnesium Deficiency | 2009 |
Intracranial EEG power and metabolism in human epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Creatine; Electrodes, Implanted; Electroencephalography; En | 2009 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image | 2009 |
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biophysics; Disease Models, Animal; Electric Stimulation; | 2009 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressu | 2010 |
Dissociation between neurovegetative signs and subjective symptoms in a case of idiopathic pilomotor seizures.
Topics: Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Electroencephalography; Epilepsy, Complex | 2010 |
Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.
Topics: Administration, Oral; Androstadienes; Animals; Asparagine; Aspartic Acid; Brain; Female; Insulin; In | 2012 |
1H MR spectroscopy of mesial temporal lobe epilepsies treated with Gamma knife.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Fo | 2003 |
[Protection of rats against isoniazid-induced convulsions by the potassium and magnesium salts of DL-aspartic acid].
Topics: Animals; Aspartic Acid; Isoniazid; Magnesium; Potassium; Rats; Salts; Seizures | 1959 |
GAMMA-AMINOBUTYRIC ACID LEVELS IN THE BRAIN OF RATS EXPOSED TO OXYGEN AT HIGH PRESSURES.
Topics: Aminobutyrates; Aspartic Acid; Atmospheric Pressure; Brain; gamma-Aminobutyric Acid; Glutamates; Met | 1963 |
THE EFFECT UPON MICE OF INTRAVENTRICULAR INJECTION OF EXCITANT AND DEPRESSANT AMINO ACIDS.
Topics: Amino Acids; Aminobutyrates; Aspartic Acid; Cerebral Ventricles; Glutamates; Hypnotics and Sedatives | 1963 |
CONVULSANT EFFECT OF L-GLUTAMIC ACID-GAMMA-HYDRAZIDE BY SIMULTANEOUS TREATMENT WITH PYRIDOXAL PHOSPHATE.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carboxy-Lyases; Convulsants; Glutamates; Glu | 1964 |
ON THE MECHANISM OF AMMONIA DETOXICATION BY L-ORNITHINE AND L-ASPARTATE.
Topics: Ammonia; Aspartic Acid; Blood Chemical Analysis; Enzyme Inhibitors; Ligases; Liver; Ornithine; Pharm | 1964 |
A NEUROCHEMICAL STUDY OF THIOSEMICARBAZIDE SEIZURES AND THEIR INHIBITION BY AMINO-OXYACETIC ACID.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Azides; Brain; Dogs | 1964 |
AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.
Topics: Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamates; Gl | 1964 |
MOLECULAR STRUCTURE-ACTIVITY RELATIONSHIPS OF COMPOUNDS PROTECTING RATS AGAINST OXYGEN POISONING.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Antidotes; Arginine; Aspartic Acid; Blood-Brain Barr | 1964 |
[Protective effect of potassium and magnesium salts of DL-aspartic acid against convulsions caused by isoniazid and ammonium chloride in the rat].
Topics: Ammonium Chloride; Animals; Aspartic Acid; Isoniazid; Magnesium; Potassium; Rats; Salts; Seizures | 1959 |
Glutamate transporters prevent the generation of seizures in the developing rat neocortex.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Biological Clocks; Calci | 2004 |
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Topics: Aspartic Acid; Brain Chemistry; Brain Injuries; Critical Care; Female; Fractures, Bone; Frontal Lobe | 2005 |
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.
Topics: Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Dependovirus; Dise | 2005 |
Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates.
Topics: Apgar Score; Aspartic Acid; Asphyxia Neonatorum; Brain; Choline; Creatine; Electroencephalography; F | 2005 |
Effect of seizure on hippocampus in mesial temporal lobe epilepsy and neocortical epilepsy: an MRS study.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Epilepsy, Temporal Lobe; Female; Hippocampus; H | 2005 |
1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG.
Topics: Adult; Aspartic Acid; Biomarkers; Brain Mapping; Choline; Creatine; Dipeptides; Electroencephalograp | 2007 |
Factors which abolish hypoglycemic seizures do not increase cerebral glycogen content in vitro.
Topics: Age Factors; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Aspartic Acid; Cer | 2008 |
Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Drug Resistance; Epilepsy, Temporal Lobe | 2007 |
Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency.
Topics: Animals; Anticonvulsants; Aspartic Acid; Magnesium Chloride; Magnesium Deficiency; Male; Pentylenete | 2007 |
[Behavioral and electrographic changes during hippocampal--seizure induced by N-mechyl aspartic acid in cats].
Topics: Animals; Aspartic Acid; Behavior, Animal; Cats; Electroencephalography; Hippocampus; Seizures | 1966 |
Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Carboxy-Lyases; Glutamates; Glutam | 1967 |
Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glut | 1983 |
Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Ka | 1983 |
A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic A | 1983 |
Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid.
Topics: Allylglycine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Brain; gamma-Aminobutyric Acid; Glut | 1984 |
Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic A | 1984 |
Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Aspartic Acid; Brain; Choline O-Acetyltransferase; Dis | 1984 |
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Brain; Fasti | 1984 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kain | 1982 |
On the interaction of 2-amino-7-phosphono-heptanoic acid and quinolinic acid in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Iontophoresis; | 1983 |
Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Brain; Dose-Response Relationship, Dr | 1983 |
Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Cystathionine; gamma-Aminobutyric Acid; Glutami | 1984 |
Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Brain Diseases; Disease Models | 1982 |
A possible role for aspartic acid in neonatal seizures.
Topics: Animals; Aspartic Acid; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mice; Rats; Seiz | 1981 |
Is glutamate a trigger factor in epileptic hyperactivity?
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Epilep | 1981 |
Phase I trial of PALA.
Topics: Antineoplastic Agents; Aspartic Acid; Brain Diseases; Diarrhea; Dose-Response Relationship, Drug; Ga | 1980 |
Experimental study of the mechanism of seizure induction: changes in the concentrations of excitatory amino acids in the epileptic focus of the cat amygdaloid kindling model.
Topics: Amygdala; Animals; Aspartic Acid; Cats; Excitatory Amino Acids; Glutamic Acid; Seizures | 1994 |
Effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex: in vivo and in vitro studies.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Cerebral Cortex; Dialysis; Electric Stimulation; Glut | 1995 |
Brain amino acid levels are related to seizure propensity in the gerbil (Meriones unguiculatus).
Topics: Amino Acids; Analysis of Variance; Animals; Arginine; Aspartic Acid; Behavior, Animal; Brain; Citrul | 1993 |
Enhanced aspartate release related to epilepsy in (EL) mice.
Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippoca | 1994 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Gl | 1994 |
Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Electric | 1993 |
Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1995 |
Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep.
Topics: Animals; Aspartic Acid; Brain Edema; Brain Ischemia; Cytotoxins; Electroencephalography; Extracellul | 1996 |
A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis.
Topics: Alzheimer Disease; Aspartic Acid; Electrophoresis, Polyacrylamide Gel; Exons; Female; Glutamic Acid; | 1996 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; | 1997 |
Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Carbamazepine; Cerebellum; gamma-Aminobutyric Acid; Glutamic Ac | 1997 |
Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion' method.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Glutamic Acid; Hippocampus; Kainic Acid; Male; Micro | 1997 |
Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; | 1997 |
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.
Topics: Animals; Asparagine; Aspartic Acid; Body Weight; Death, Sudden; DNA Primers; Female; Growth Disorder | 1997 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; | 1997 |
Protective effects of neurosteroids against NMDA-induced seizures and lethality in mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Hippocampus; In Vitro Techniques; Lethal Dose 50; Male; Mic | 1998 |
MRS metabolic markers of seizures and seizure-induced neuronal damage.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Cell Count; Choline; Creatine; Cycloheximide; Hippocampus | 1998 |
Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Electroencephalography; Extracellular Space; gamma-Aminobutyric | 1998 |
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cyclopropanes; Glutamic Acid; Gl | 1998 |
Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.
Topics: Age Factors; Aggression; Animals; Anxiety; Aspartic Acid; Brain; Brain Chemistry; Circadian Rhythm; | 2000 |
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
Topics: Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Blotting, Southern; Central Nervous System; | 2000 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-A | 1999 |
Changes in striatal electroencephalography and neurochemistry induced by kainic acid seizures are modified by dopamine receptor antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Benzazepines; Corpus Striatum; Dopamine; Dop | 2001 |
Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus.
Topics: Adenosine; Animals; Aspartic Acid; Chelating Agents; Dithiothreitol; Ditiocarb; Hippocampus; Male; N | 2001 |
Time courses of aspartate and glutamate concentrations in the focus area during penicillin induced epileptiform activity in awake rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Glutamic Acid; Male; Microdialysis; | 2002 |
Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
Topics: Adult; Aspartic Acid; Brain Diseases; Choline; Confusion; Creatine; Female; Headache; Humans; Magnet | 2002 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity.
Topics: Animals; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Noise; Seizure | 1978 |
Cerebral permeability phenomena in epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cell Membrane Permeability; Disease Models, Animal; Extr | 1976 |
Amino acid uptake in vivo by the mouse brain and by various regions of the rabbit brain after drug-induced convulsions.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Blood-Brain Barrier; Bra | 1975 |
Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit.
Topics: Animals; Aspartic Acid; Bicuculline; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Aci | 1992 |
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Brain Mapping; Dipeptidases; Dipeptides; Disease Models, An | 1992 |
Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain Mapping; Chromatography, High Pressure Liquid; | 1992 |
Seizure related elevations of extracellular amino acids in human focal epilepsy.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cerebral Cortex; Dialysis; Electroencephalography; Epilepsie | 1992 |
[Sequential changes in content of excitatory amino acids in the epileptic focus during seizure].
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Cats; Dialysis; Epilepsies, Partial; Extracellular Sp | 1991 |
Sequential changes in content of excitatory amino acids in the focus of epilepsy in seizure induction.
Topics: Amygdala; Animals; Aspartic Acid; Cats; Chromatography, High Pressure Liquid; Electroencephalography | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |
Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures.
Topics: Acoustic Stimulation; Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate | 1990 |
Aspartic acid release from cerebral cortical slices of E1 mice with high seizure susceptibility.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Mice; Mice, | 1990 |
Effects evoked by pentamethylenetetrazol-induced seizures upon N-acetylaspartate and N-acetylaspartylglutamate levels in different regions of the rat neuraxis.
Topics: Animals; Aspartic Acid; Brain; Brain Stem; Dipeptides; Male; Pentylenetetrazole; Rats; Rats, Inbred | 1991 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dop | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male | 1990 |
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047).
Topics: Animals; Aspartic Acid; Binding, Competitive; Dibenzocycloheptenes; Discrimination, Psychological; D | 1990 |
In vivo interaction of a polyamine with the NMDA receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventricul | 1990 |
Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Dose-Response Relationship, Drug; Magnesium; Microin | 1990 |
Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity.
Topics: 1-Carboxyglutamic Acid; Amino Acid Sequence; Animals; Aspartic Acid; Benzofurans; Calcium; Cerebellu | 1990 |
Antagonism between intracerebroventricularly administered N-methyl-D-aspartate and bicuculline methiodide in induction of clonic seizures in mice.
Topics: Animals; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Injections | 1990 |
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; | 1990 |
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
In vivo labelling of the NMDA receptor channel complex by [3H]MK-801.
Topics: Affinity Labels; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Binding, Competitive; Diben | 1988 |
Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Brain Ischemia; C | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptene | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA- | 1989 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; G | 1989 |
Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Dronabinol; Heart Rate; Mice; Mice, Inbred C | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gam | 1989 |
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Coll | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease | 1989 |
Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Binding, Competitive; | 1989 |
Homocysteic acid: convulsant action of stereoisomers in mice.
Topics: Animals; Aspartic Acid; Convulsants; Homocysteine; Injections, Intraventricular; Kainic Acid; Male; | 1989 |
Anticonvulsant activities of 1-phenylcyclohexylamine and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Cyclohexylamines; Isoquinolines; Male; Mice; Motor A | 1989 |
Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Body Temperature; F | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
A comparison of PCP-like compounds for NMDA antagonism in two in vivo models.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dioxolanes; Dioxoles; Ketamine; Male; Mice; Motor Activity | 1988 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Di | 1987 |
Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cyclohexanes; Dose-Response Relationship, Drug; Injections, | 1988 |
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic | 1988 |
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Oxadi | 1988 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocyste | 1985 |
Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbolines; Cereb | 1985 |
Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Glutamates; Humans; Hypo | 1985 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Ac | 1985 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug | 1986 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methyl | 1986 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic Syste | 1986 |
On the role of seizure activity and endogenous excitatory amino acids in mediating seizure-associated hippocampal damage.
Topics: Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Survival; Dendrites; Epi | 1986 |
Toxicology of tremorgenic mycotoxins, fumitremorgin A and B.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Chlorpromazine; Dose-Response Relationship, Drug; G | 1986 |
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Glutamic | 1987 |
Amino acid influences on seizures elicited within the inferior colliculus.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1987 |
Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antitussive Agents; Aspartic Acid; Cerebral C | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Comp | 1988 |
Glycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Drug Synergism; Glycine; Injections, Spinal; Mi | 1988 |
Intrastriatal N-methyl-D-aspartate prevents amygdala kindled seizures in rats.
Topics: Amygdala; Animals; Aspartic Acid; Corpus Striatum; Depression, Chemical; Kindling, Neurologic; Male; | 1986 |
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electroencephalog | 1986 |
The effect of two novel dipeptide antagonists of excitatory amino acid neurotransmission on the high pressure neurological syndrome in the rat.
Topics: Animals; Aspartic Acid; Central Nervous System Diseases; Glutamates; Glutamine; High Pressure Neurol | 1987 |
Dextromethorphan inhibits NMDA-induced convulsions.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate | 1988 |
Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.
Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Hippocampus; Microinjections; N-Methylaspartate; Neu | 1988 |
Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats.
Topics: Animals; Aspartic Acid; Corpus Striatum; Globus Pallidus; Kainic Acid; Male; N-Methylaspartate; Pilo | 1988 |
In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Aci | 1985 |
2-Amino-7-phosphonoheptanoic acid inhibits insulin-induced convulsions and striatal aspartate accumulation in rats with frontal cortical ablation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Ce | 1987 |
Induction of audiogenic seizure susceptibility by focal infusion of excitant amino acid or bicuculline into the inferior colliculus of normal rats.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Bicuculline; Inferior Colliculi; Male; Microinjections | 1986 |
Method of lesioning brainstem determines seizure probability.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Stem; Electric Injuries; Hot Temperature; Male; N-Me | 1986 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diaz | 1986 |
Unusual interactions of excitatory amino acid receptor agonists: alpha- and beta-kainate antagonize motor responses to N-methyl-D-aspartate in rodents.
Topics: Animals; Aspartic Acid; Electromyography; Kainic Acid; Male; Mice; Motor Activity; Muscle Spasticity | 1987 |
Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Injections, Intravenous; | 1985 |
Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Glutam | 1985 |
Azotomycin--toxicologic, biochemical and pharmacologic studies in mice.
Topics: Animals; Antibiotics, Antineoplastic; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Ataxia | 1974 |
Regulation of glycolysis in brain, in situ, during convulsions.
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Brain; Brain Chemistry; Central Nervous System Stimulan | 1966 |
[Mutal inhibitory effect between chlorpromazine and several convulsants on convulsion].
Topics: Aminobutyrates; Animals; Aspartic Acid; Central Nervous System Stimulants; Chlorpromazine; Dogs; Dru | 1971 |
[Mechanism of intrahepatic accumulation of dicarboxylic amino acids during ammonia poisoning].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Aspartic Acid; Citrates; Citrulline; Dicarboxylic | 1972 |
Glutamate and aspartate in cortical subarachnoid fluid in relation to convulsive activity.
Topics: Animals; Aspartic Acid; Azoles; Brain; Dogs; Glutamates; Methionine Sulfoximine; Picrotoxin; Seizure | 1973 |
The effect of hexafluorodiethyl ether (flurothyl) on the metabolism of rat brain amino acids labelled by (U-14C)glucose.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Radioisotopes; Chromatog | 1973 |
Brain amino acids during convulsions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Electric Stimulation; Glutamate | 1974 |
Incorporation of carbon from glucose into cerebral amino acids, proteins and lipids, and alterations during recovery from hypoglycaemia.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Blood Glucose; Carbon Isotopes; Cerebr | 1972 |
[Experimental seizures caused by derivatives of glutamic acid].
Topics: Adipates; Amines; Aminocaproates; Animals; Aspartic Acid; Cats; Cysteine; Dogs; Female; Glutamates; | 1972 |
Effects of excitation and anaesthesia on the glutamine content of the rat brain with a reference to the administration of glutamine.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Delirium; Glutamates; Glutamine; Head; Huma | 1972 |
The toxicity of monosodium glutamate in young rats.
Topics: Age Factors; Animals; Aspartic Acid; Brain Chemistry; Glutamates; Glutamine; Glycine; Injections, In | 1971 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; | 1970 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; | 1970 |
[Introduction of mass psychology of animals to pharmacology. IV. Biorhythm in convulsive seizure].
Topics: Animals; Aspartic Acid; Atmospheric Pressure; Biological Clocks; Electroshock; Mice; Psychology; Sei | 1970 |
Protein-bound amide groups in brain.
Topics: Amides; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Glucose; Glut | 1970 |
[Changes in the levels of gamma-aminobutyric, glutamic and aspartic acids and glutamine in primary and reflected foci of epileptic activity].
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Electroencephalography; Epilepsy; Glutamate | 1970 |
[Protective action of N-acetylaspartic acid and N-acetylaspartyl-glutamic acid in convulsive seizures induced with pentamethylene-tetrazole in rats].
Topics: Acetates; Aspartic Acid; Brain; Glutamates; Pentylenetetrazole; Seizures | 1970 |
Some neurochemical aspects of fluorocitrate intoxication.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain | 1971 |
Amino acid changes in the mouse brain during audiogenic seizures and recovery.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Behavior, Animal; Brain; Brain Chemistry; Gluta | 1968 |
[Argininosuccinic aciduria disease of the newborn with lethal course].
Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Anticonvulsants; Aspartic Acid; Brain Diseases; Chromat | 1968 |
[Metabolic investigations of epileptic seizures. The activity of the glutamate decarboxylase prior to and during experimentally produced convulsions].
Topics: Animals; Aspartic Acid; Brain; Carboxy-Lyases; Electroshock; Female; Glutamates; In Vitro Techniques | 1968 |
Electroshock-induced seizures and the turnover of brain protein in the rat.
Topics: Animals; Aspartic Acid; Body Weight; Brain; Carbon Isotopes; Chromatography; Electroshock; Glucose; | 1968 |
[Metabolic investigations of epileptic seizures: the role of aminotransferases and glutamate dehydrogenase in convulsions].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Azoles; Brain; Electrosho | 1969 |
The neurotoxicity of beta-N-oxalyl-L-alphabeta-diaminopropionic acid, the neurotoxin from the pulse Lathyrus sativus.
Topics: Age Factors; Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Glutamates; Glutamine; Injecti | 1969 |
[Metabolic studies of epileptic seizures. The concentration of free amino acids in cerebral tissue prior to and during cerebral seizures].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Centrifugation; Chromatography, | 1969 |
[Action of insulin on the amino acid content and enzymatic activity of the pigeon brain].
Topics: Alanine Transaminase; Aminobutyrates; Animals; Aspartate Aminotransferases; Aspartic Acid; Birds; Br | 1964 |
The measurement of free and N-acetylated aspartic acids in the nervous system.
Topics: Animals; Aspartic Acid; Biological Assay; Brain Chemistry; Fluorometry; Histocytochemistry; In Vitro | 1966 |
Carbamylaspartate, a new agent against acute ammonia intoxication.
Topics: Ammonia; Animals; Aspartic Acid; Carbamates; Male; Mortality; Rats; Seizures | 1966 |