aspartic acid has been researched along with Sarcoma in 11 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 21 patients with advanced soft tissue sarcoma enrolled in a phase II trial of 3." | 6.67 | A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma. ( Baselga, J; Casper, ES; Magill, GB; Markman, M; Ranhosky, A; Smart, TB, 1991) |
| "A total of 21 patients with advanced soft tissue sarcoma enrolled in a phase II trial of 3." | 2.67 | A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma. ( Baselga, J; Casper, ES; Magill, GB; Markman, M; Ranhosky, A; Smart, TB, 1991) |
| "5-Fluorouracil (FUra) is a clinically useful antineoplastic agent." | 1.27 | Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. ( Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW, 1983) |
| "One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen." | 1.26 | Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982) |
| "It was found that SV40-induced hamster tumors, BHK21/cl 13 cells in culture, certain carcinogen-induced tumors in the Ehrlich ascites tumor, and a number of human carcinomas and adenocarcinomas contained a distinct increase (3- to 20-fold) in the percentage of a late-eluting aspartyl-tRNA over that found in nonmalignant tissues, other animal tumors, and in human melanomas and sarcomas." | 1.25 | The distribution and properties of aspartyl transfer RNA in human and animal tumors. ( Bowen, JM; Briscoe, WT; Griffin, AC; McBride, C, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MCCOY, TA | 2 |
| ORR, G | 1 |
| PATTERSON, MK | 2 |
| ORR, GR | 1 |
| Bramwell, V | 1 |
| Van Oosterom, A | 1 |
| Mouridsen, HT | 1 |
| Cheix, F | 1 |
| Somers, R | 1 |
| Thomas, D | 1 |
| Rozencweig, M | 1 |
| Presant, CA | 1 |
| Ardalan, B | 1 |
| Multhauf, P | 1 |
| Chan, C | 1 |
| Staples, R | 1 |
| Green, L | 1 |
| Browning, S | 1 |
| Carr, BI | 1 |
| Chang, FF | 1 |
| Thayer, W | 1 |
| Kurzrock, R | 1 |
| Yap, BS | 1 |
| Plager, C | 1 |
| Papdopoulos, N | 1 |
| Benjamin, RS | 1 |
| Valdivieso, M | 1 |
| Bodey, GP | 1 |
| Casper, ES | 2 |
| Vale, K | 1 |
| Williams, LJ | 1 |
| Martin, DS | 1 |
| Young, CW | 1 |
| Erlichman, C | 1 |
| Donehower, RC | 1 |
| Speyer, JL | 1 |
| Klecker, R | 1 |
| Chabner, BA | 1 |
| Weiss, GR | 1 |
| Ervin, TJ | 1 |
| Meshad, MW | 1 |
| Kufe, DW | 1 |
| Briscoe, WT | 1 |
| Griffin, AC | 1 |
| McBride, C | 1 |
| Bowen, JM | 1 |
| Baselga, J | 1 |
| Smart, TB | 1 |
| Magill, GB | 1 |
| Markman, M | 1 |
| Ranhosky, A | 1 |
| Fischer, W | 1 |
| Müller, E | 1 |
1 trial available for aspartic acid and Sarcoma
| Article | Year |
|---|---|
A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Dipyridamole; Drug Evaluation; Drug Therapy, Comb | 1991 |
10 other studies available for aspartic acid and Sarcoma
| Article | Year |
|---|---|
CARBON DIOXIDE FIXATION IN THE JA-1 SARCOMA IN VITRO.
Topics: Alanine; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Fumarates; Glutamat | 1963 |
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins; | 1963 |
N-(phosphonacetyl)-L-aspartate (PALA) in advanced soft tissue sarcoma: a phase II trial of the EORTC soft tissue sarcoma group.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Digestive System; Drug Erup | 1982 |
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial.
Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptio | 1983 |
Phase II evaluation of PALA in patients with refractory metastatic sarcomas.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Bone Neoplasms; Diarrhea; Drug Evaluati | 1984 |
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Admin | 1983 |
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; | 1982 |
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.
Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Th | 1982 |
The distribution and properties of aspartyl transfer RNA in human and animal tumors.
Topics: Adenocarcinoma; Animals; Aspartic Acid; Carcinoma; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricet | 1975 |
[Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors].
Topics: Adenoma; Aspartate Aminotransferases; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Craniopha | 1972 |