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aspartic acid and Sarcoma

aspartic acid has been researched along with Sarcoma in 11 studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Research Excerpts

ExcerptRelevanceReference
"A total of 21 patients with advanced soft tissue sarcoma enrolled in a phase II trial of 3."6.67A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma. ( Baselga, J; Casper, ES; Magill, GB; Markman, M; Ranhosky, A; Smart, TB, 1991)
"A total of 21 patients with advanced soft tissue sarcoma enrolled in a phase II trial of 3."2.67A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma. ( Baselga, J; Casper, ES; Magill, GB; Markman, M; Ranhosky, A; Smart, TB, 1991)
"5-Fluorouracil (FUra) is a clinically useful antineoplastic agent."1.27Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. ( Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW, 1983)
"One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen."1.26Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982)
"It was found that SV40-induced hamster tumors, BHK21/cl 13 cells in culture, certain carcinogen-induced tumors in the Ehrlich ascites tumor, and a number of human carcinomas and adenocarcinomas contained a distinct increase (3- to 20-fold) in the percentage of a late-eluting aspartyl-tRNA over that found in nonmalignant tissues, other animal tumors, and in human melanomas and sarcomas."1.25The distribution and properties of aspartyl transfer RNA in human and animal tumors. ( Bowen, JM; Briscoe, WT; Griffin, AC; McBride, C, 1975)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199010 (90.91)18.7374
1990's1 (9.09)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MCCOY, TA2
ORR, G1
PATTERSON, MK2
ORR, GR1
Bramwell, V1
Van Oosterom, A1
Mouridsen, HT1
Cheix, F1
Somers, R1
Thomas, D1
Rozencweig, M1
Presant, CA1
Ardalan, B1
Multhauf, P1
Chan, C1
Staples, R1
Green, L1
Browning, S1
Carr, BI1
Chang, FF1
Thayer, W1
Kurzrock, R1
Yap, BS1
Plager, C1
Papdopoulos, N1
Benjamin, RS1
Valdivieso, M1
Bodey, GP1
Casper, ES2
Vale, K1
Williams, LJ1
Martin, DS1
Young, CW1
Erlichman, C1
Donehower, RC1
Speyer, JL1
Klecker, R1
Chabner, BA1
Weiss, GR1
Ervin, TJ1
Meshad, MW1
Kufe, DW1
Briscoe, WT1
Griffin, AC1
McBride, C1
Bowen, JM1
Baselga, J1
Smart, TB1
Magill, GB1
Markman, M1
Ranhosky, A1
Fischer, W1
Müller, E1

Trials

1 trial available for aspartic acid and Sarcoma

ArticleYear
A phase II trial of PALA + dipyridamole in patients with advanced soft-tissue sarcoma.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Dipyridamole; Drug Evaluation; Drug Therapy, Comb

1991

Other Studies

10 other studies available for aspartic acid and Sarcoma

ArticleYear
CARBON DIOXIDE FIXATION IN THE JA-1 SARCOMA IN VITRO.
    Cancer research, 1963, Volume: 23

    Topics: Alanine; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Fumarates; Glutamat

1963
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
    Analytical biochemistry, 1963, Volume: 6

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins;

1963
N-(phosphonacetyl)-L-aspartate (PALA) in advanced soft tissue sarcoma: a phase II trial of the EORTC soft tissue sarcoma group.
    European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Digestive System; Drug Erup

1982
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial.
    Medical and pediatric oncology, 1983, Volume: 11, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptio

1983
Phase II evaluation of PALA in patients with refractory metastatic sarcomas.
    American journal of clinical oncology, 1984, Volume: 7, Issue:4

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Bone Neoplasms; Diarrhea; Drug Evaluati

1984
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.
    Cancer research, 1983, Volume: 43, Issue:5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Admin

1983
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection.
    Journal of the National Cancer Institute, 1982, Volume: 68, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule;

1982
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.
    Cancer treatment reports, 1982, Volume: 66, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Th

1982
The distribution and properties of aspartyl transfer RNA in human and animal tumors.
    Cancer research, 1975, Volume: 35, Issue:9

    Topics: Adenocarcinoma; Animals; Aspartic Acid; Carcinoma; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricet

1975
[Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1972, Volume: 115, Issue:1

    Topics: Adenoma; Aspartate Aminotransferases; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Craniopha

1972