aspartic acid has been researched along with Psychotic Disorders in 42 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
Excerpt | Relevance | Reference |
---|---|---|
"Schizophrenia is a complex mental disorder whose course varies with periods of deterioration and symptomatic improvement without diagnosis and treatment specific for the disease." | 1.56 | The Relationship between the Level of Anterior Cingulate Cortex Metabolites, Brain-Periphery Redox Imbalance, and the Clinical State of Patients with Schizophrenia and Personality Disorders. ( Bryll, A; Karcz, P; Kozicz, T; Krzyściak, W; Pilecki, M; Popiela, TJ; Skrzypek, J; Śmierciak, N; Szwajca, M, 2020) |
"Choline was significantly elevated in FEP compared to HC." | 1.48 | Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients. ( Gonzales, SS; Kraguljac, NV; Lahti, AC; Morgan, CJ; Sivaraman, S; White, DM, 2018) |
"Schizophrenia is a genetically complex syndrome with substantial inter-subject variability in multiple domains." | 1.43 | Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity. ( Antonius, D; Berns, A; Chao, MV; Goetz, R; Gonen, O; Harroch, S; Hasan, S; Heguy, A; Kranz, TM; Lazar, M; Malaspina, D; Mazgaj, R; Rothman, K, 2016) |
" Chronic use has been suggested to lead to persistent schizophrenia-like neurobiological changes." | 1.40 | Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users. ( Fam, J; Furby, H; Howes, OD; Hughes, E; Morgan, C; Pepper, F; Stone, JM, 2014) |
"Schizophrenia is associated with significant brain abnormalities, including changes in brain metabolites as measured by proton magnetic resonance spectroscopy (MRS)." | 1.35 | A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis. ( Berger, GE; McConchie, M; McGorry, PD; Pantelis, C; Proffitt, T; Velakoulis, D; Wellard, RM; Wood, SJ, 2008) |
"A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy." | 1.33 | Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis. ( Erfurth, A; Lüdemann, P; Michael, N; Möller, HE; Schuierer, G, 2005) |
"Following the chronic use of methamphetamine, some individuals experience psychosis and anxiety." | 1.31 | Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study. ( Ashby, CR; Isoda, H; Iyo, M; Kawai, M; Minabe, Y; Mori, N; Sakahara, H; Sekine, Y; Suzuki, K; Takei, N, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (4.76) | 18.7374 |
1990's | 1 (2.38) | 18.2507 |
2000's | 10 (23.81) | 29.6817 |
2010's | 20 (47.62) | 24.3611 |
2020's | 9 (21.43) | 2.80 |
Authors | Studies |
---|---|
Chen, X | 3 |
Fan, X | 2 |
Song, X | 1 |
Gardner, M | 1 |
Du, F | 4 |
Öngür, D | 4 |
Bissonnette, JN | 1 |
Francis, AM | 1 |
MacNeil, S | 1 |
Crocker, CE | 2 |
Tibbo, PG | 2 |
Fisher, DJ | 1 |
Li, W | 1 |
Xu, J | 1 |
Xiang, Q | 1 |
Zhuo, K | 1 |
Zhang, Y | 1 |
Liu, D | 1 |
Li, Y | 1 |
Wang, M | 1 |
Barker, PB | 3 |
Cascella, NG | 1 |
Coughlin, JM | 2 |
Nestadt, G | 2 |
Nucifora, FC | 2 |
Sedlak, TW | 2 |
Kelly, A | 1 |
Younes, L | 1 |
Geman, D | 1 |
Palaniyappan, L | 1 |
Sawa, A | 2 |
Yang, K | 1 |
Romeo, B | 1 |
Petillion, A | 1 |
Martelli, C | 1 |
Benyamina, A | 1 |
Bryll, A | 1 |
Krzyściak, W | 1 |
Karcz, P | 1 |
Śmierciak, N | 1 |
Kozicz, T | 1 |
Skrzypek, J | 1 |
Szwajca, M | 1 |
Pilecki, M | 1 |
Popiela, TJ | 1 |
Whitehurst, TS | 1 |
Osugo, M | 1 |
Townsend, L | 1 |
Shatalina, E | 1 |
Vava, R | 1 |
Onwordi, EC | 1 |
Howes, O | 1 |
Malaspina, D | 2 |
Lotan, E | 1 |
Rusinek, H | 1 |
Perez, SA | 1 |
Walsh-Messinger, J | 1 |
Kranz, TM | 2 |
Gonen, O | 2 |
Kuan, E | 1 |
de la Fuente-Sandoval, C | 2 |
Reyes-Madrigal, F | 2 |
Mao, X | 1 |
León-Ortiz, P | 2 |
Rodríguez-Mayoral, O | 1 |
Jung-Cook, H | 1 |
Solís-Vivanco, R | 1 |
Graff-Guerrero, A | 2 |
Shungu, DC | 1 |
Reid, MA | 2 |
Salibi, N | 1 |
White, DM | 3 |
Gawne, TJ | 1 |
Denney, TS | 1 |
Lahti, AC | 3 |
Li, C | 1 |
Wang, A | 1 |
Wang, C | 1 |
Ramamurthy, J | 1 |
Zhang, E | 1 |
Guadagno, E | 1 |
Trakadis, Y | 1 |
Sivaraman, S | 1 |
Kraguljac, NV | 2 |
Morgan, CJ | 1 |
Gonzales, SS | 1 |
Wang, AM | 1 |
Pradhan, S | 2 |
Trivedi, A | 1 |
DuBois, SL | 1 |
Crawford, JL | 1 |
Nucifora, LG | 1 |
Schretlen, DJ | 1 |
Lewandowski, KE | 2 |
Huynh, P | 1 |
Natsubori, T | 1 |
Inoue, H | 1 |
Abe, O | 1 |
Takano, Y | 1 |
Iwashiro, N | 1 |
Aoki, Y | 1 |
Koike, S | 1 |
Yahata, N | 1 |
Katsura, M | 1 |
Gonoi, W | 1 |
Sasaki, H | 1 |
Takao, H | 1 |
Kasai, K | 1 |
Yamasue, H | 1 |
Stone, JM | 1 |
Pepper, F | 1 |
Fam, J | 1 |
Furby, H | 1 |
Hughes, E | 1 |
Morgan, C | 1 |
Howes, OD | 1 |
Howells, FM | 1 |
Uhlmann, A | 1 |
Temmingh, H | 1 |
Sinclair, H | 1 |
Meintjes, E | 1 |
Wilson, D | 1 |
Stein, DJ | 1 |
Bernier, DC | 1 |
Hanstock, CC | 1 |
Lakusta, B | 1 |
Purdon, SE | 1 |
Seres, P | 1 |
Sperry, SH | 1 |
Cohen, BM | 2 |
Sehovic, S | 1 |
Goldbach, JR | 1 |
Shendyapina, MV | 1 |
Omelchenko, MA | 1 |
Lebedeva, IS | 1 |
Kanonovich, PS | 1 |
Semenova, NA | 1 |
Ublinsky, MV | 1 |
Dmitrienko, DM | 1 |
Akhadov, TA | 1 |
Simonova, OA | 1 |
Kaleda, VG | 1 |
Nenadic, I | 1 |
Maitra, R | 1 |
Basu, S | 1 |
Dietzek, M | 1 |
Schönfeld, N | 1 |
Lorenz, C | 1 |
Gussew, A | 1 |
Amminger, GP | 1 |
McGorry, P | 1 |
Reichenbach, JR | 1 |
Sauer, H | 1 |
Gaser, C | 1 |
Smesny, S | 1 |
Plitman, E | 1 |
Chavez, S | 1 |
Gómez-Cruz, G | 1 |
Liemburg, E | 1 |
Sibeijn-Kuiper, A | 2 |
Bais, L | 2 |
Pijnenborg, G | 1 |
Knegtering, H | 2 |
van der Velde, J | 1 |
Opmeer, E | 1 |
de Vos, A | 1 |
Dlabac-De Lange, J | 1 |
Wunderink, L | 1 |
Aleman, A | 2 |
Brandt, AS | 1 |
Unschuld, PG | 1 |
Lim, IA | 1 |
Churchill, G | 1 |
Harris, AD | 1 |
Hua, J | 1 |
Ross, CA | 1 |
van Zijl, PC | 1 |
Edden, RA | 1 |
Margolis, RL | 1 |
Heguy, A | 1 |
Harroch, S | 1 |
Mazgaj, R | 1 |
Rothman, K | 1 |
Berns, A | 1 |
Hasan, S | 1 |
Antonius, D | 1 |
Goetz, R | 1 |
Lazar, M | 1 |
Chao, MV | 1 |
Larabi, DI | 1 |
Liemburg, EJ | 1 |
Pijnenborg, GH | 1 |
de Vos, AE | 1 |
Ćurčić-Blake, B | 1 |
Hermens, DF | 1 |
Lagopoulos, J | 1 |
Naismith, SL | 1 |
Tobias-Webb, J | 1 |
Hickie, IB | 1 |
Sekine, Y | 1 |
Minabe, Y | 1 |
Kawai, M | 1 |
Suzuki, K | 1 |
Iyo, M | 1 |
Isoda, H | 1 |
Sakahara, H | 1 |
Ashby, CR | 1 |
Takei, N | 1 |
Mori, N | 1 |
Bertolino, A | 1 |
Sciota, D | 1 |
Brudaglio, F | 1 |
Altamura, M | 1 |
Blasi, G | 1 |
Bellomo, A | 1 |
Antonucci, N | 1 |
Callicott, JH | 1 |
Goldberg, TE | 1 |
Scarabino, T | 1 |
Weinberger, DR | 1 |
Nardini, M | 1 |
BARUK, H | 1 |
FABIANI, P | 1 |
Heresco-Levy, U | 1 |
Wood, SJ | 3 |
Berger, G | 1 |
Velakoulis, D | 3 |
Phillips, LJ | 1 |
McGorry, PD | 3 |
Yung, AR | 1 |
Desmond, P | 2 |
Pantelis, C | 3 |
Reynolds, LM | 1 |
Cochran, SM | 1 |
Morris, BJ | 1 |
Pratt, JA | 1 |
Reynolds, GP | 1 |
Michael, N | 1 |
Erfurth, A | 1 |
Lüdemann, P | 1 |
Schuierer, G | 1 |
Möller, HE | 1 |
Berger, GE | 2 |
Lambert, M | 1 |
Conus, P | 1 |
Stuart, GW | 1 |
Zabala, A | 1 |
Sánchez-González, J | 1 |
Parellada, M | 1 |
Moreno, DM | 1 |
Reig, S | 1 |
Burdalo, MT | 1 |
Robles, O | 1 |
Desco, M | 1 |
Arango, C | 1 |
Wellard, RM | 1 |
Proffitt, T | 1 |
McConchie, M | 1 |
Renshaw, PF | 1 |
Yurgelun-Todd, DA | 1 |
Tohen, M | 1 |
Gruber, S | 1 |
Maier, M | 1 |
Mellers, J | 1 |
Toone, B | 1 |
Trimble, M | 1 |
Ron, MA | 1 |
Demisch, L | 1 |
Gebhart, P | 1 |
Bochnik, HJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Evaluation of Schemes of Administration of Intravenous Ketamine in Treatment-resistant Depression: Clinical-neuroimaging Correlation[NCT03742557] | Phase 3 | 30 participants (Anticipated) | Interventional | 2018-10-01 | Recruiting | ||
Glutamate, Brain Connectivity and Duration of Untreated Psychosis[NCT02034253] | 134 participants (Actual) | Observational | 2014-01-31 | Completed | |||
The Relationship Between the Efficacy of Lumateperone and Central Glutamate and Dopaminergic Metabolism: A Comparison With Risperidone in First Episode Psychosis[NCT05890768] | Phase 4 | 35 participants (Anticipated) | Interventional | 2023-05-11 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 reviews available for aspartic acid and Psychotic Disorders
Article | Year |
---|---|
Glutamate and N-Acetylaspartate Alterations Observed in Early Phase Psychosis: A Systematic Review of Proton Magnetic Resonance Spectroscopy Studies.
Topics: Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Male; Proton Magnetic Resonance Spectroscop | 2022 |
Magnetic resonance spectroscopy studies in subjects with high risk for psychosis: A meta-analysis and review.
Topics: Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Proton Mag | 2020 |
Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis.
Topics: Aspartic Acid; Choline; Humans; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizop | 2020 |
Metabolomics in patients with psychosis: A systematic review.
Topics: 3-Hydroxybutyric Acid; Aspartic Acid; Biomarkers; Bipolar Disorder; Creatine; Female; Glutamic Acid; | 2018 |
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality.
Topics: Animals; Antipsychotic Agents; Aspartic Acid; Glutamic Acid; Glycine; Humans; Nerve Degeneration; Ne | 2003 |
37 other studies available for aspartic acid and Psychotic Disorders
Article | Year |
---|---|
White Matter Metabolite Relaxation and Diffusion Abnormalities in First-Episode Psychosis: A Longitudinal Study.
Topics: Aspartic Acid; Brain; Choline; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Human | 2022 |
Neurometabolic and functional changes of default-mode network relate to clinical recovery in first-episode psychosis patients: A longitudinal
Topics: Antipsychotic Agents; Aspartic Acid; Brain; Brain Mapping; Default Mode Network; gamma-Aminobutyric | 2022 |
Longitudinal changes in brain metabolites in healthy controls and patients with first episode psychosis: a 7-Tesla MRS study.
Topics: Adult; Aspartic Acid; Brain; Glutamic Acid; Glutamine; Glutathione; Gyrus Cinguli; Humans; Psychotic | 2023 |
The Relationship between the Level of Anterior Cingulate Cortex Metabolites, Brain-Periphery Redox Imbalance, and the Clinical State of Patients with Schizophrenia and Personality Disorders.
Topics: Adult; Antioxidants; Aspartic Acid; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance | 2020 |
Preliminary Findings Associate Hippocampal
Topics: Adult; Aspartic Acid; Choline; Female; Hippocampus; Humans; Male; Mania; Middle Aged; Proton Magneti | 2021 |
N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects.
Topics: Aspartic Acid; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Neurons; Psychotic Disord | 2021 |
Prefrontal and Striatal Gamma-Aminobutyric Acid Levels and the Effect of Antipsychotic Treatment in First-Episode Psychosis Patients.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Corpus Striatum; Female; gamma-Aminobutyric | 2018 |
7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia.
Topics: Adult; Aspartic Acid; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus C | 2019 |
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Diseas | 2018 |
Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis.
Topics: Aspartic Acid; Brain; Case-Control Studies; Cross-Sectional Studies; Dipeptides; Female; gamma-Amino | 2019 |
Role of glia in prefrontal white matter abnormalities in first episode psychosis or mania detected by diffusion tensor spectroscopy.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Diffusion Tensor Im | 2019 |
Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Chronic Disease; Disease Progression; Female; Glutamic Acid; Gluta | 2014 |
Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users.
Topics: Adult; Aspartic Acid; Brain; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance | 2014 |
(1)H-magnetic resonance spectroscopy ((1)H-MRS) in methamphetamine dependence and methamphetamine induced psychosis.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamine; Humans; Inositol; Mag | 2014 |
Prefrontal glutamate levels differentiate early phase schizophrenia and methamphetamine addiction: a (1)H MRS study at 3Tesla.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Aspartic Acid; Glutamic Acid; Humans; Prefrontal C | 2014 |
Myelin vs axon abnormalities in white matter in bipolar disorder.
Topics: Adult; Aspartic Acid; Axons; Bipolar Disorder; Diffusion Tensor Imaging; Female; Humans; Magnetic Re | 2015 |
[Information processing and brain metabolic characteristics in patients at ultra-high risk for endogenous psychosis].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Evoked Potentials; Female; Glutamic Acid; Glutamin | 2015 |
Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naïve ultra-high-risk subjects and first-episode schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Female; Frontal Lobe; Glutamic Acid; Gray Matter; H | 2015 |
Elevated Myo-Inositol, Choline, and Glutamate Levels in the Associative Striatum of Antipsychotic-Naive Patients With First-Episode Psychosis: A Proton Magnetic Resonance Spectroscopy Study With Implications for Glial Dysfunction.
Topics: Adult; Aspartic Acid; Choline; Corpus Striatum; Glutamic Acid; Glutamine; Humans; Inositol; Neurogli | 2016 |
A combined diffusion tensor imaging and magnetic resonance spectroscopy study of patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Creatine; Diffusion Tensor Imaging; Female; Glutamic Aci | 2016 |
Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study.
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Disease P | 2016 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin | 2016 |
Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity.
Topics: Adult; Aspartic Acid; Cognition; Female; Humans; Intelligence Tests; Magnetic Resonance Imaging; Mal | 2016 |
Association between prefrontal N-acetylaspartate and insight in psychotic disorders.
Topics: Adult; Aspartic Acid; Awareness; Comprehension; Executive Function; Female; Humans; Male; Metacognit | 2017 |
Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders.
Topics: Adolescent; Adult; Aspartic Acid; Case Management; Combined Modality Therapy; Energy Metabolism; Fem | 2012 |
Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Basal Ganglia; Central Nervous System Stimulants; Cholin | 2002 |
Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder.
Topics: Adult; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; | 2003 |
[Supplementary note on hyperammoniemia in various psychoses (Parelleism of biliary hypertoxicity, hyperammoniemia and increase in the optical density of the bile].
Topics: Aspartic Acid; Bile; Humans; Hyperammonemia; Mental Disorders; Psychotic Disorders | 1963 |
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain Mapping; Choline; Creatine; Depressive Dis | 2003 |
Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.
Topics: Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Dipeptides; Di | 2005 |
Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis.
Topics: Adult; Aspartic Acid; Choline; Electroconvulsive Therapy; Humans; Immunologic Factors; Inositol; Int | 2005 |
Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Follow-Up Studies; Functional Laterality; Hippocamp | 2006 |
Findings of proton magnetic resonance spectometry in the dorsolateral prefrontal cortex in adolescents with first episodes of psychosis.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Cross-Sectional Studies; Female; Follow-Up Stud | 2007 |
A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Female; Frontal Lobe; Functional Late | 2008 |
Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis.
Topics: Adult; Aspartic Acid; Choline; Creatinine; Female; Functional Laterality; Humans; Magnetic Resonance | 1995 |
Schizophrenia, temporal lobe epilepsy and psychosis: an in vivo magnetic resonance spectroscopy and imaging study of the hippocampus/amygdala complex.
Topics: Adult; Amygdala; Aspartic Acid; Case-Control Studies; Epilepsy, Temporal Lobe; Female; Functional La | 2000 |
[On improved prophylaxis of endogenous-phasic psychoses. Influence of L-aspartate on lithium transport (author's transl)].
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Erythrocytes; Humans; In Vitro Techniques; Kidney; Lithi | 1978 |