aspartic acid has been researched along with Postoperative Complications in 15 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods." | 1.31 | Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001) |
| "Cerebral ischemia associated with subarachnoid hemorrhage may have severe consequences for neuronal functioning." | 1.29 | Intracerebral microdialysis of glutamate and aspartate in two vascular territories after aneurysmal subarachnoid hemorrhage. ( Boris-Möller, F; Brandt, L; Nilsson, OG; Säveland, H; Wieloch, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hájek, M | 1 |
| Dezortová, M | 1 |
| Liscák, R | 1 |
| Vymazal, J | 1 |
| Vladyka, V | 1 |
| Kimura, T | 1 |
| Sako, K | 1 |
| Tanaka, K | 1 |
| Gotoh, T | 1 |
| Yoshida, H | 1 |
| Aburano, T | 1 |
| Tanaka, T | 1 |
| Arai, H | 1 |
| Nakada, T | 1 |
| Lantz, G | 1 |
| Seeck, M | 1 |
| Lazeyras, F | 1 |
| Erol, DD | 1 |
| Ibis, HA | 1 |
| Gerola, LR | 1 |
| Oliveira, SA | 1 |
| Moreira, LF | 1 |
| Dallan, LA | 1 |
| Delgado, P | 1 |
| da Luz, PL | 1 |
| Jatene, AD | 1 |
| Säveland, H | 1 |
| Nilsson, OG | 1 |
| Boris-Möller, F | 1 |
| Wieloch, T | 1 |
| Brandt, L | 1 |
| Henry, RG | 1 |
| Vigneron, DB | 2 |
| Fischbein, NJ | 1 |
| Grant, PE | 1 |
| Day, MR | 1 |
| Noworolski, SM | 1 |
| Star-Lack, JM | 1 |
| Wald, LL | 1 |
| Dillon, WP | 2 |
| Chang, SM | 1 |
| Nelson, SJ | 2 |
| Park, SW | 1 |
| Chang, KH | 1 |
| Kim, HD | 1 |
| Song, IC | 1 |
| Lee, DS | 1 |
| Lee, SK | 1 |
| Chung, CK | 1 |
| Yu, IK | 1 |
| Han, MH | 1 |
| Park, YH | 1 |
| Graves, EE | 1 |
| Verhey, L | 1 |
| McDermott, M | 1 |
| Larson, D | 1 |
| Chang, S | 1 |
| Prados, MD | 1 |
| Kim, GE | 1 |
| Lee, JH | 1 |
| Cho, YP | 1 |
| Kim, ST | 1 |
| Argyropoulos, G | 1 |
| Clarici, G | 1 |
| Heppner, F | 1 |
| Beyersdorf, F | 1 |
| Kirsh, M | 1 |
| Buckberg, GD | 1 |
| Allen, BS | 1 |
| Gleichmann, U | 1 |
| Fodor, L | 1 |
| Eschner, J | 1 |
| Dick, W | 1 |
| Ahnefeld, FW | 1 |
| Brendel, BS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827] | Phase 3 | 865 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 147 |
| Saline Infusion | 152 |
ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay
| Intervention | hours (Median) |
|---|---|
| Intravenous Glutamate | 21 |
| Saline Infusion | 21 |
(NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 31 |
| Saline Infusion | 25 |
Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 4 |
| Saline Infusion | 6 |
Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 1 |
| Saline Infusion | 5 |
maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days
| Intervention | µmol/L (Mean) |
|---|---|
| Intravenous Glutamate | 106 |
| Saline Infusion | 106 |
Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 3 |
| Saline Infusion | 16 |
p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative
| Intervention | µg/L (Median) | |
|---|---|---|
| CK-MB day 1 | Troponin-T day 3 | |
| Intravenous Glutamate | 14 | 0.27 |
| Saline Infusion | 14 | 0.24 |
Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU
| Intervention | percentage of saturated hemoglobin (Mean) | |
|---|---|---|
| SvO2 at weaning from CPB | SvO2 on arrival to ICU | |
| Intravenous Glutamate | 72.0 | 65.0 |
| Saline Infusion | 72.2 | 64.9 |
2 trials available for aspartic acid and Postoperative Complications
| Article | Year |
|---|---|
Glutamate/aspartate supplementation during cardiopulmonary bypass: effect on postoperative neurocognitive function.
Topics: Aged; Aspartic Acid; Cardiopulmonary Bypass; Cognition; Cognition Disorders; Dietary Supplements; Fe | 2008 |
Blood cardioplegia with warm reperfusion versus intermittent aortic crossclamping in myocardial revascularization. Randomized controlled trial.
Topics: Aorta; Aspartic Acid; Blood; Cardioplegic Solutions; Constriction; Coronary Artery Bypass; Creatine | 1993 |
13 other studies available for aspartic acid and Postoperative Complications
| Article | Year |
|---|---|
1H MR spectroscopy of mesial temporal lobe epilepsies treated with Gamma knife.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Fo | 2003 |
Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TlCl single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Neoplasms; Choline; Contrast Media; Fema | 2004 |
Extent of preoperative abnormalities and focus lateralization predict postoperative normalization of contralateral 1H-magnetic resonance spectroscopy metabolite levels in patients with temporal lobe epilepsy.
Topics: Adult; Aspartic Acid; Atrophy; Choline; Creatine; Dominance, Cerebral; Electroencephalography; Energ | 2006 |
Intracerebral microdialysis of glutamate and aspartate in two vascular territories after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Aspartic Acid; Brain Ischemia; Female; Frontal Lobe; Glutamic Acid; | 1996 |
Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Fema | 2000 |
Lateralizing ability of single-voxel proton mr spectroscopy in hippocampal sclerosis: comparison with mr imaging and positron emission tomography.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Dominance, Cerebral; Energy Metabolism; Epilepsy, Tempora | 2001 |
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies; | 2001 |
Metabolic changes in the ischemic penumbra after carotid endarterectomy in stroke patients by localized in vivo proton magnetic resonance spectroscopy (1H-MRS).
Topics: Aged; Aspartic Acid; Brain Ischemia; Carotid Stenosis; Cerebral Infarction; Choline; Creatine; Endar | 2001 |
[Infusion therapy of pain in a series of neurological-neurosurgical patients].
Topics: Analgesics; Aspartic Acid; Dipyrone; Drug Combinations; Female; Humans; Magnesium; Male; Orphenadrin | 1976 |
Warm glutamate/aspartate-enriched blood cardioplegic solution for perioperative sudden death.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Cardioplegic Solutions; Cardiopulmonary Resuscitation; Coron | 1992 |
[Postoperative electrolyte and water balance after mitral valve replacement].
Topics: Acidosis; Aspartic Acid; Extracorporeal Circulation; Heart; Heart Valve Prosthesis; Humans; Hyperald | 1972 |
[Clinical significance of the zinc deficiency syndrome. Correlation between zinc deficiency and hypoproteinemia].
Topics: Adult; Aspartic Acid; Blood Proteins; Deficiency Diseases; Female; Humans; Hypoproteinemia; Postoper | 1972 |
[Cardiovascular complications in operated patients more than 70 years old suffering from cardiovascular insufficiency].
Topics: Age Factors; Aged; Aminophylline; Anesthesia, General; Aspartic Acid; Cardiac Surgical Procedures; D | 1972 |