aspartic acid has been researched along with Phenylketonurias in 21 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Phenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six adults heterozygous for phenylketonuria (PKU) ingested eight successive servings of unsweetened and aspartame (APM)-sweetened beverage at 1-hour intervals in a randomized, balanced, crossover design." | 2.67 | Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria. ( Bell, EF; Filer, LJ; Krause, WL; Stegink, LD; Tephly, TR; Ziegler, EE, 1990) |
| "This report examines the safety issues related to the nutritive sweetener aspartame, including possible toxic effects of aspartame's component amino acids, aspartic acid and phenylalanine, and its major decomposition products, methanol and diketopiperazine, and the potential synergistic effect of aspartame and dietary carbohydrate on brain neurochemicals." | 1.27 | Aspartame. Review of safety issues. Council on Scientific Affairs. ( , 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (66.67) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| TSUKADA, Y | 2 |
| Sijens, PE | 1 |
| Oudkerk, M | 1 |
| Reijngoud, DJ | 1 |
| Leenders, KL | 1 |
| de Valk, HW | 1 |
| van Spronsen, FJ | 1 |
| Stegink, LD | 6 |
| Koch, R | 2 |
| Blaskovics, ME | 1 |
| Filer, LJ | 6 |
| Baker, GL | 3 |
| McDonnell, JE | 3 |
| Johannik, K | 1 |
| Van Hecke, P | 1 |
| François, B | 1 |
| Marchal, G | 1 |
| Smet, MH | 1 |
| Jaeken, J | 1 |
| Breysem, L | 1 |
| Wilms, G | 1 |
| Baert, AL | 1 |
| Hájek, M | 1 |
| Hejcmanová, L | 1 |
| Prádný, J | 1 |
| Knappskog, PM | 2 |
| Eiken, HG | 1 |
| Martínez, A | 2 |
| Bruland, O | 1 |
| Apold, J | 1 |
| Flatmark, T | 1 |
| Waters, PI | 1 |
| Hewson, AS | 1 |
| Scriver, CR | 1 |
| Treacy, EP | 1 |
| Parniak, MA | 1 |
| Burlina, AB | 1 |
| Bonafé, L | 1 |
| Ferrari, V | 1 |
| Suppiej, A | 1 |
| Zacchello, F | 1 |
| Burlina, AP | 1 |
| Bhagavan, NV | 1 |
| Bell, EF | 2 |
| Ziegler, EE | 2 |
| Tephly, TR | 1 |
| Krause, WL | 2 |
| Wolf-Novak, LC | 1 |
| Brummel, MC | 1 |
| Galewicz, A | 1 |
| Gorska, D | 1 |
| Rodo, M | 1 |
| Zaremba, J | 1 |
| Jenner, FA | 1 |
| Levy, HL | 1 |
| Barkin, E | 1 |
2 trials available for aspartic acid and Phenylketonurias
| Article | Year |
|---|---|
Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria.
Topics: Adult; Amino Acids; Aspartame; Aspartic Acid; Beverages; Female; Heterozygote; Humans; Male; Methano | 1990 |
Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria.
Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Biological Transport; Dipeptide | 1987 |
19 other studies available for aspartic acid and Phenylketonurias
| Article | Year |
|---|---|
[AMINO ACID METABOLISM IN THE BRAIN AND BEHAVIORAL CHANGES].
Topics: Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Behavior, Animal; Brain; Carbon Isotop | 1964 |
[BIOCHEMICAL STUDIES ON EXPERIMENTAL PHENYLKETONURIA].
Topics: Amino Acids; Animals; Aspartic Acid; Diet; Discrimination Learning; Glutamine; Haplorhini; Phenylala | 1964 |
1H MR chemical shift imaging detection of phenylalanine in patients suffering from phenylketonuria (PKU).
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Cerebral Ventricles; Choline; Creatine; Female; H | 2004 |
Plasma phenylalanine levels in phenylketonuric heterozygous and normal adults administered aspartame at 34 mg/kg body weight.
Topics: Adult; Aspartame; Aspartic Acid; Dipeptides; Female; Heterozygote; Humans; Male; Phenylalanine; Phen | 1981 |
Effect of an abuse dose of aspartame upon plasma and erythrocyte levels of amino acids in phenylketonuric heterozygous and normal adults.
Topics: Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Dose-Response Relationship, Drug; Erythrocytes; F | 1980 |
Localized brain proton NMR spectroscopy in young adult phenylketonuria patients.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Reson | 1994 |
Proton in vivo spectroscopy of patients with hyperphenylalaninaemia.
Topics: Adult; Aspartic Acid; Biopterins; Brain; Brain Chemistry; Brain Diseases; Child; Choline; Creatine; | 1993 |
PKU mutation (D143G) associated with an apparent high residual enzyme activity: expression of a kinetic variant form of phenylalanine hydroxylase in three different systems.
Topics: Aspartic Acid; Cell Line; Cloning, Molecular; Escherichia coli; Exons; Genetic Variation; Glycine; H | 1996 |
Comparative analysis of phenylalanine hydroxylase A104D mutant, associated with variant phenylketonuria, and wild-type enzyme.
Topics: Alanine; Aspartic Acid; Chromatography, Affinity; Chromatography, Gel; Humans; Kinetics; Phenylalani | 1997 |
Measurement of neurotransmitter metabolites in the cerebrospinal fluid of phenylketonuric patients under dietary treatment.
Topics: Adolescent; Adult; Aspartic Acid; Child; Dipeptides; Dopamine; Female; Homovanillic Acid; Humans; Hy | 2000 |
Effect of aspartame loading upon plasma and erythrocyte amino acid levels in phenylketonuric heterozygotes and normal adult subjects.
Topics: Adult; Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Erythrocytes; Female; Heterozygote; Humans | 1979 |
Letter: Hazards in indiscriminate use of sweeteners containing phenylalanine.
Topics: Aspartic Acid; Diet; Dipeptides; Female; Fetus; Heterozygote; Homozygote; Humans; Phenylalanine; Phe | 1975 |
Letter: Safety of aspartame as a sweetener.
Topics: Aspartic Acid; Dipeptides; Female; Humans; Phenylalanine; Phenylketonurias; Pregnancy; Sweetening Ag | 1975 |
Synthetic sweetners: cyclamates, saccharin, aspartame.
Topics: Animals; Aspartame; Aspartic Acid; Beverages; Cyclamates; Cyclohexylamines; Diet, Reducing; Dipeptid | 1975 |
Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects.
Topics: Adult; Aspartame; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Erythrocytes; | 1989 |
Aspartame. Review of safety issues. Council on Scientific Affairs.
Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplas | 1985 |
A search for aspartylglycosaminuria in Poland.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Child, Institutionalized; Chromatography, Paper | 1974 |
Medical research council unit for metabolic studies in psychiatry, Sheffield.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Bipolar Disorder; Catatonia; Circadian Rhythm; | 1973 |
Comparison of amino acid concentrations between plasma and erythrocytes. Studies in normal human subjects and those with metabolic disorders.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Aspartic Acid; Biological Transp | 1971 |