aspartic acid has been researched along with Ovarian Neoplasms in 17 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we show that ovarian cancer cells become addicted to extracellular glutamine when silenced for glutamine synthetase (GS), similar to naturally occurring GS-low, glutaminolysis-high ovarian cancer cells." | 1.62 | N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages. ( Campanella, A; Canton, M; Carrà, G; Castegna, A; Cormio, G; De Grassi, A; Favia, M; Gerbino, A; Gissi, R; Laera, L; Loizzi, V; Mazzone, M; Menga, A; Pierri, CL; Spera, I; Vegliante, MC, 2021) |
| " Here, the natural product betulinic acid (BA) and chemical drug lonidamine (LN) were used as chemosensitizers in combination with doxorubicin (DOX) for ovarian cancer treatment." | 1.51 | Doxorubicin combined with betulinic acid or lonidamine in RGD ligand-targeted pH-sensitive micellar system for ovarian cancer treatment. ( Jin, X; Lv, H; Zhang, Z; Zhou, J, 2019) |
| "In high-grade serous ovarian cancer (HGSOC) samples (n = 101), over 170 metabolites were profiled and compared with normal ovarian tissues (n = 15)." | 1.43 | Role of Increased n-acetylaspartate Levels in Cancer. ( Achreja, A; Armaiz-Pena, G; Baddour, J; Baggerly, KA; Bhattacharya, PK; Dalton, HJ; Davies, MA; Eli, MB; Gharpure, KM; Guindani, M; Hu, W; Ivan, C; Liu, J; Lopez-Berestein, G; Lutgendorf, SK; Mangala, LS; McCullough, CR; Mitamura, T; Nagaraja, AS; Nagrath, D; Nick, AM; Pecot, CV; Pradeep, S; Previs, RA; Rodriguez-Aguayo, C; Rupaimoole, R; Shoshan, E; Sood, AK; Wang, Y; Wu, SY; Yang, L; Zacharias, NM; Zand, B, 2016) |
| "Ovarian teratoma was detected and resected in only one case of initial episode." | 1.42 | [Clinical analysis of relapsing anti-N-methyl-D-aspartate receptor encephalitis]. ( Bin, P; Dawei, S; Haitao, R; Hang, S; Hongzhi, G; Liying, C; Qiang, L; Qing, L; Weize, K; Yan, H; Yicheng, Z; Yuan, J, 2015) |
| "Gossypol treatment resulted in cell death through oxidative stress." | 1.39 | Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. ( Chen, Y; Deng, H; Ge, R; Jin, L; Li, X; Lian, Q; Wang, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, X | 1 |
| Zhou, J | 1 |
| Zhang, Z | 1 |
| Lv, H | 1 |
| Menga, A | 1 |
| Favia, M | 1 |
| Spera, I | 1 |
| Vegliante, MC | 1 |
| Gissi, R | 1 |
| De Grassi, A | 1 |
| Laera, L | 1 |
| Campanella, A | 1 |
| Gerbino, A | 1 |
| Carrà, G | 1 |
| Canton, M | 1 |
| Loizzi, V | 1 |
| Pierri, CL | 1 |
| Cormio, G | 1 |
| Mazzone, M | 1 |
| Castegna, A | 1 |
| Wang, J | 1 |
| Jin, L | 1 |
| Li, X | 1 |
| Deng, H | 2 |
| Chen, Y | 1 |
| Lian, Q | 1 |
| Ge, R | 1 |
| Hongzhi, G | 1 |
| Weize, K | 1 |
| Bin, P | 1 |
| Yan, H | 1 |
| Qiang, L | 1 |
| Yuan, J | 1 |
| Qing, L | 1 |
| Hang, S | 1 |
| Haitao, R | 1 |
| Yicheng, Z | 1 |
| Dawei, S | 1 |
| Liying, C | 1 |
| Zand, B | 1 |
| Previs, RA | 1 |
| Zacharias, NM | 1 |
| Rupaimoole, R | 1 |
| Mitamura, T | 1 |
| Nagaraja, AS | 1 |
| Guindani, M | 1 |
| Dalton, HJ | 1 |
| Yang, L | 1 |
| Baddour, J | 1 |
| Achreja, A | 1 |
| Hu, W | 2 |
| Pecot, CV | 1 |
| Ivan, C | 1 |
| Wu, SY | 1 |
| McCullough, CR | 1 |
| Gharpure, KM | 1 |
| Shoshan, E | 1 |
| Pradeep, S | 1 |
| Mangala, LS | 1 |
| Rodriguez-Aguayo, C | 1 |
| Wang, Y | 1 |
| Nick, AM | 1 |
| Davies, MA | 1 |
| Armaiz-Pena, G | 1 |
| Liu, J | 1 |
| Lutgendorf, SK | 1 |
| Baggerly, KA | 1 |
| Eli, MB | 1 |
| Lopez-Berestein, G | 1 |
| Nagrath, D | 1 |
| Bhattacharya, PK | 1 |
| Sood, AK | 1 |
| Zheng, H | 1 |
| Yu, D | 1 |
| Shen, DY | 1 |
| Fu, S | 1 |
| Kavanagh, JJ | 1 |
| Wei, IC | 1 |
| Yang, DJ | 1 |
| Kolwijck, E | 2 |
| Engelke, UF | 3 |
| van der Graaf, M | 1 |
| Heerschap, A | 1 |
| Blom, HJ | 2 |
| Hadfoune, M | 1 |
| Buurman, WA | 1 |
| Massuger, LF | 3 |
| Wevers, RA | 3 |
| Woudenberg, J | 1 |
| Bulten, J | 1 |
| Stehman, FB | 2 |
| Ehrlich, CE | 1 |
| Muss, HB | 1 |
| Slavik, M | 1 |
| Bundy, B | 1 |
| Creasman, WT | 1 |
| Erlichman, C | 1 |
| Donehower, RC | 1 |
| Speyer, JL | 1 |
| Klecker, R | 1 |
| Chabner, BA | 1 |
| Sharma, A | 1 |
| Straubinger, NL | 1 |
| Straubinger, RM | 1 |
| Yang, JL | 1 |
| Fernandes, DJ | 1 |
| Wheeler, KT | 1 |
| Capizzi, RL | 1 |
| Cleaveland, ES | 1 |
| Zaharevitz, DW | 1 |
| Kelley, JA | 1 |
| Paull, K | 1 |
| Cooney, DA | 1 |
| Ford, H | 1 |
| Boss, EA | 1 |
| Moolenaar, SH | 1 |
| Boonstra, H | 1 |
| de Jong, JG | 1 |
| Chan, TC | 1 |
| Howell, SB | 1 |
| Kronberger, L | 1 |
| Fink, E | 1 |
17 other studies available for aspartic acid and Ovarian Neoplasms
| Article | Year |
|---|---|
Doxorubicin combined with betulinic acid or lonidamine in RGD ligand-targeted pH-sensitive micellar system for ovarian cancer treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arginine; Aspartic Acid; Betulinic Acid; Ce | 2019 |
N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages.
Topics: Aspartic Acid; Cell Line, Tumor; Female; Humans; Macrophages; Ovarian Neoplasms; Tumor Microenvironm | 2021 |
Gossypol induces apoptosis in ovarian cancer cells through oxidative stress.
Topics: Apoptosis; Aspartic Acid; Carrier Proteins; Cell Line, Tumor; Chaperonin 60; Contraceptive Agents, M | 2013 |
[Clinical analysis of relapsing anti-N-methyl-D-aspartate receptor encephalitis].
Topics: Adolescent; Adult; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Aspartic Acid; Autoantibodies; B | 2015 |
Role of Increased n-acetylaspartate Levels in Cancer.
Topics: Acetyltransferases; Animals; Apoptosis; Aspartic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cell Pro | 2016 |
Diammine dicarboxylic acid platinum enhances cytotoxicity in platinum-resistant ovarian cancer cells through induction of apoptosis and S-phase cell arrest.
Topics: Antineoplastic Agents; Apoptosis; Aspartic Acid; Cell Proliferation; Chondroitin; Cisplatin; Cyclin | 2008 |
N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumors.
Topics: Adult; Aged; Aspartic Acid; Cyst Fluid; Female; Humans; Magnetic Resonance Spectroscopy; Middle Aged | 2009 |
Ovarian cyst fluid of serous ovarian tumors contains large quantities of the brain amino acid N-acetylaspartate.
Topics: Aspartic Acid; Cyst Fluid; Epithelial Cells; Female; Gas Chromatography-Mass Spectrometry; Humans; N | 2010 |
Peritoneo-cystic shunt for malignant ascites.
Topics: Ascites; Aspartic Acid; Combined Modality Therapy; Female; Fluorouracil; Humans; Middle Aged; Ovaria | 1984 |
A phase II study of PALA (NSC 224131) in patients with advanced ovarian carcinoma. A Gynecologic Oncology Group study.
Topics: Adult; Aged; Aspartic Acid; Blood Cell Count; Drug Evaluation; Female; Humans; Middle Aged; Neoplasm | 1984 |
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; | 1982 |
Modulation of human ovarian tumor cell sensitivity to N-(phosphonacetyl)-L-aspartate (PALA) by liposome drug carriers.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Division; Drug Carriers; Drug Compounding; Female; Humans | 1993 |
PALA enhancement of bromodeoxyuridine incorporation into DNA increases radiation cytotoxicity to human ovarian adenocarcinoma cells.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Aspartic Acid; Bromodeoxyuridine; Cell Division; DN | 1996 |
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, N | 1996 |
High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid.
Topics: Adult; Amino Acids; Aspartic Acid; Blood Glucose; Body Fluids; Cyst Fluid; Cystadenoma, Serous; Fema | 2000 |
Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Line; Dip | 1985 |
[Potassium-magnesium-aspartate therapy in operated cancer patients].
Topics: Adult; Aged; Anemia, Hypochromic; Aspartic Acid; Body Weight; Breast Neoplasms; Female; Hemoglobinom | 1971 |