aspartic acid has been researched along with Oligodendroglioma in 24 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Oligodendroglioma: A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diffusion tensor imaging (DTI) and MR spectroscopy are noninvasive, quantitative tools for the preoperative assessment of gliomas with which the quantitative parameter fractional anisotropy (FA) and the concentration of neurometabolites N-acetylaspartate (NAA), choline (Cho), creatine (Cr) of the brain can be determined." | 3.73 | Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. ( Ding, XQ; Fiehler, J; Goebell, E; Hagel, C; Heese, O; Kucinski, T; Nietz, S; Paustenbach, S; Westphal, M; Zeumer, H, 2006) |
| " Oligodendrogliomas had higher choline levels than astrocytomas." | 3.68 | [1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia]. ( Felber, SR, 1993) |
| "Linear regression analyses between seizure duration and NAA/Cr decrease was not significant." | 2.69 | Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy. ( Andermann, F; Arnold, DL; Cendes, F; Dubeau, F; Li, LM; Miller, SP; Tasch, E, 2000) |
| " Therefore, this study highlights a potential role for nuclear ASPA expression in GSC malignancy and suggests that the use of NAA or NAAG is not an appropriate therapeutic approach to increase acetate bioavailability in glioma." | 1.39 | N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. ( Jaworski, DM; Lawler, SE; Long, PM; Moffett, JR; Namboodiri, AMA; Viapiano, MS, 2013) |
| "The histological diagnosis was anaplastic oligodendroglioma (WHO grade III)." | 1.37 | [Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma]. ( Akutsu, H; Anno, I; Isobe, T; Masumoto, T; Matsumura, A; Nakai, K; Shiigai, M; Takano, S; Yamamoto, T, 2011) |
| "Ten patients with untreated gliomas were examined on a 1." | 1.32 | Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas. ( Buslei, R; Fahlbusch, R; Ganslandt, O; Gruber, S; Moser, E; Nimsky, C; Stadlbauer, A, 2004) |
| "We examined 120 patients with brain tumors using a 1." | 1.31 | In vivo proton magnetic resonance spectroscopy of brain tumors. ( Fountas, KN; Gotsis, SD; Johnston, KW; Kapsalaki, EZ; Kapsalakis, JZ; Papadakis, N; Robinson, JS; Smisson , HF, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruber, S | 3 |
| Heckova, E | 1 |
| Strasser, B | 1 |
| Považan, M | 1 |
| Hangel, GJ | 1 |
| Minarikova, L | 1 |
| Trattnig, S | 1 |
| Bogner, W | 1 |
| Long, PM | 1 |
| Moffett, JR | 1 |
| Namboodiri, AMA | 1 |
| Viapiano, MS | 1 |
| Lawler, SE | 1 |
| Jaworski, DM | 1 |
| Bourdillon, P | 1 |
| Hlaihel, C | 1 |
| Guyotat, J | 1 |
| Guillotton, L | 1 |
| Honnorat, J | 1 |
| Ducray, F | 1 |
| Cotton, F | 1 |
| Isobe, T | 1 |
| Akutsu, H | 1 |
| Yamamoto, T | 1 |
| Shiigai, M | 1 |
| Masumoto, T | 1 |
| Nakai, K | 1 |
| Takano, S | 1 |
| Anno, I | 1 |
| Matsumura, A | 1 |
| Bianchi, MG | 1 |
| Franchi-Gazzola, R | 1 |
| Reia, L | 1 |
| Allegri, M | 1 |
| Uggeri, J | 1 |
| Chiu, M | 1 |
| Sala, R | 1 |
| Bussolati, O | 1 |
| Rijpkema, M | 1 |
| Schuuring, J | 1 |
| van der Meulen, Y | 1 |
| van der Graaf, M | 1 |
| Bernsen, H | 1 |
| Boerman, R | 1 |
| van der Kogel, A | 1 |
| Heerschap, A | 1 |
| Vuori, K | 1 |
| Kankaanranta, L | 1 |
| Häkkinen, AM | 2 |
| Gaily, E | 1 |
| Valanne, L | 1 |
| Granström, ML | 1 |
| Joensuu, H | 1 |
| Blomstedt, G | 1 |
| Paetau, A | 2 |
| Lundbom, N | 2 |
| Stadlbauer, A | 2 |
| Moser, E | 2 |
| Buslei, R | 1 |
| Nimsky, C | 2 |
| Fahlbusch, R | 1 |
| Ganslandt, O | 2 |
| Magalhaes, A | 1 |
| Godfrey, W | 1 |
| Shen, Y | 1 |
| Hu, J | 1 |
| Smith, W | 1 |
| Pulkkinen, J | 1 |
| Kauppinen, RA | 1 |
| Hiltunen, Y | 1 |
| Lichy, MP | 1 |
| Bachert, P | 1 |
| Hamprecht, F | 1 |
| Weber, MA | 1 |
| Debus, J | 1 |
| Schulz-Ertner, D | 1 |
| Schlemmer, HP | 1 |
| Kauczor, HU | 1 |
| Goebell, E | 1 |
| Fiehler, J | 1 |
| Ding, XQ | 1 |
| Paustenbach, S | 1 |
| Nietz, S | 1 |
| Heese, O | 1 |
| Kucinski, T | 1 |
| Hagel, C | 1 |
| Westphal, M | 1 |
| Zeumer, H | 1 |
| Hammen, T | 1 |
| Engelhorn, T | 1 |
| Buchfelder, M | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| Felber, SR | 1 |
| Adalsteinsson, E | 1 |
| Spielman, DM | 1 |
| Wright, GA | 1 |
| Pauly, JM | 1 |
| Meyer, CH | 1 |
| Macovski, A | 1 |
| Gutowski, NJ | 1 |
| Gómez-Ansón, B | 1 |
| Torpey, N | 1 |
| Revesz, T | 1 |
| Miller, D | 1 |
| Rudge, P | 1 |
| Miller, SP | 1 |
| Li, LM | 1 |
| Cendes, F | 1 |
| Tasch, E | 1 |
| Andermann, F | 1 |
| Dubeau, F | 1 |
| Arnold, DL | 1 |
| Fountas, KN | 1 |
| Kapsalaki, EZ | 1 |
| Gotsis, SD | 1 |
| Kapsalakis, JZ | 1 |
| Smisson , HF | 1 |
| Johnston, KW | 1 |
| Robinson, JS | 1 |
| Papadakis, N | 1 |
| Henriksen, O | 1 |
| Wieslander, S | 1 |
| Gjerris, F | 1 |
| Jensen, KM | 1 |
| Erecińska, M | 1 |
| Troeger, MB | 1 |
| Wilson, DF | 1 |
| Silver, IA | 1 |
| Nadler, JV | 1 |
| Cooper, JR | 1 |
| Fischer, W | 1 |
| Müller, E | 1 |
| Bilalov, FI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458] | 50 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for aspartic acid and Oligodendroglioma
| Article | Year |
|---|---|
Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Dipeptides; Female; Glutamic Acid | 2003 |
Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy.
Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain Neoplasms; Child; C | 2000 |
22 other studies available for aspartic acid and Oligodendroglioma
| Article | Year |
|---|---|
Mapping an Extended Neurochemical Profile at 3 and 7 T Using Accelerated High-Resolution Proton Magnetic Resonance Spectroscopic Imaging.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Female; Humans; Magnetic Resonance Spectroscopy; Male; | 2017 |
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.
Topics: Amidohydrolases; Animals; Aspartic Acid; Cell Differentiation; Cell Line, Transformed; Cell Line, Tu | 2013 |
Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Chromosome Deletion; Chromosomes, Human, Pair | 2015 |
[Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma].
Topics: Adult; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; F | 2011 |
Valproic acid induces the glutamate transporter excitatory amino acid transporter-3 in human oligodendroglioma cells.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Anticonvulsants; Aspartic Acid; Cell Line, Tumor; Enzy | 2012 |
Low-grade gliomas and focal cortical developmental malformations: differentiation with proton MR spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Cerebral Cortex; Child; Choline; Creatine; Diagnosis, | 2004 |
Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas.
Topics: Adult; Algorithms; Aspartic Acid; Astrocytoma; Automation; Biopsy; Brain Chemistry; Brain Mapping; B | 2004 |
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin | 2005 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors].
Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined | 2006 |
Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study.
Topics: Adult; Aged; Anisotropy; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Size; Choline; Cre | 2006 |
Changes in fiber integrity, diffusivity, and metabolism of the pyramidal tract adjacent to gliomas: a quantitative diffusion tensor fiber tracking and MR spectroscopic imaging study.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Creatine; Diffusion Magnetic Resonance Ima | 2007 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
[1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Child; Child, Preschool; | 1993 |
Incorporating lactate/lipid discrimination into a spectroscopic imaging sequence.
Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Cerebrovascular Disorders; Humans; Lactates; Lipids | 1993 |
Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Glycine; Humans; Inositol; Magnetic Resonance | 1999 |
In vivo proton magnetic resonance spectroscopy of brain tumors.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Brain; Brain Abscess; Brain Neoplasms; Choline | 2000 |
In vivo 1H-spectroscopy of human intracranial tumors at 1.5 tesla. Preliminary experience at a clinical installation.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactate | 1991 |
The role of glial cells in regulation of neurotransmitter amino acids in the external environment. II. Mechanism of aspartate transport.
Topics: Animals; Aspartic Acid; Astrocytoma; Cell Line; Cell Membrane Permeability; Chlorides; Membrane Pote | 1986 |
N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Cattle; Cerebral Cortex; Craniopharyngioma; Glioblastoma; G | 1972 |
[Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors].
Topics: Adenoma; Aspartate Aminotransferases; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Craniopha | 1972 |
[Various low-molecular nitrogen compounds in experimental brain tumors in white mice].
Topics: Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain; Brain Neoplasms; Glutamates; Mice; Neoplasms | 1970 |