aspartic acid has been researched along with Neuronal Ceroid-Lipofuscinoses in 6 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Neuronal Ceroid-Lipofuscinoses: A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid materials (CEROID; LIPOFUSCIN) in neurons. There are several subtypes based on mutations of the various genes, time of disease onset, and severity of the neurological defects such as progressive DEMENTIA; SEIZURES; and visual failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Late infantile neuronal ceroid lipofuscinosis (LINCL) is associated with progressive degeneration of the brain and retina starting in early childhood." | 1.34 | Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. ( Ballon, D; Crystal, RG; Dyke, JP; Hackett, NR; Heier, L; Hollmann, C; Kaplitt, MG; Kekatpure, MV; Kosofsky, B; Mao, X; Shungu, D; Sondhi, D; Souweidane, MM; Worgall, S, 2007) |
| "Late juvenile neuronal ceroid lipofuscinosis (NCL) is a lysosomal neurodegenerative disorder caused by the accumulation of lipopigment in neurons." | 1.30 | MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis. ( Grodd, W; Klose, U; Nägele, T; Schwab, A; Seeger, U; Seitz, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vanhanen, SL | 1 |
| Puranen, J | 2 |
| Autti, T | 2 |
| Raininko, R | 1 |
| Liewendahl, K | 1 |
| Nikkinen, P | 1 |
| Santavuori, P | 2 |
| Suominen, P | 1 |
| Vuori, K | 1 |
| Häkkinen, AM | 2 |
| Sitter, B | 1 |
| Tyynelä, J | 1 |
| Sonnewald, U | 1 |
| Bathen, TF | 1 |
| Haltia, MJ | 1 |
| Paetau, A | 1 |
| Polvikoski, T | 1 |
| Gribbestad, IS | 1 |
| Pears, MR | 1 |
| Cooper, JD | 1 |
| Mitchison, HM | 1 |
| Mortishire-Smith, RJ | 1 |
| Pearce, DA | 1 |
| Griffin, JL | 1 |
| Worgall, S | 1 |
| Kekatpure, MV | 1 |
| Heier, L | 1 |
| Ballon, D | 1 |
| Dyke, JP | 1 |
| Shungu, D | 1 |
| Mao, X | 1 |
| Kosofsky, B | 1 |
| Kaplitt, MG | 1 |
| Souweidane, MM | 1 |
| Sondhi, D | 1 |
| Hackett, NR | 1 |
| Hollmann, C | 1 |
| Crystal, RG | 1 |
| Brockmann, K | 1 |
| Pouwels, PJ | 1 |
| Christen, HJ | 1 |
| Frahm, J | 1 |
| Hanefeld, F | 1 |
| Seitz, D | 1 |
| Grodd, W | 1 |
| Schwab, A | 1 |
| Seeger, U | 1 |
| Klose, U | 1 |
| Nägele, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Genotype - Phenotype Correlations of Late Infantile Neuronal Ceroid Lipofuscinosis[NCT00151268] | 18 participants (Actual) | Observational | 2004-03-31 | Completed | |||
| Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease[NCT03862274] | 30 participants (Anticipated) | Observational | 2018-12-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for aspartic acid and Neuronal Ceroid-Lipofuscinoses
| Article | Year |
|---|---|
Neuroradiological findings (MRS, MRI, SPECT) in infantile neuronal ceroid-lipofuscinosis (infantile CLN1) at different stages of the disease.
Topics: Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatinine; Humans; Infant; Infant, Newborn; | 2004 |
High-resolution magic angle spinning and 1H magnetic resonance spectroscopy reveal significantly altered neuronal metabolite profiles in CLN1 but not in CLN3.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Child; Child, Presch | 2004 |
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; | 2005 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Age Factors; Age of Onset; Aminopeptidases; Aspartic Acid; Cerebral Cortex; Child; Child | 2007 |
Localized proton magnetic resonance spectroscopy of cerebral metabolic disturbances in children with neuronal ceroid lipofuscinosis.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic; Brain Mapping; Child; Child, Preschool; Choline; Cr | 1996 |
MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis.
Topics: Aspartic Acid; Brain; Brain Diseases; Case-Control Studies; Cerebellum; Cerebral Ventricles; Child; | 1998 |