aspartic acid has been researched along with Neurodegenerative Diseases in 27 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| "Canavan disease is a major point of focus for efforts to define NAA function, with available evidence suggesting NAA serves as an acetyl donor for fatty acid synthesis during myelination." | 1.43 | N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase. ( Bilaniuk, LT; De Vivo, DC; Francis, JS; Gray, SJ; Janson, CG; Leone, P; Markov, V; McCown, TJ; Samulski, RJ; Wang, DJ; Wojtas, I, 2016) |
| "PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 14 (51.85) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, M | 1 |
| Li, M | 1 |
| He, J | 1 |
| He, Y | 1 |
| Yang, J | 1 |
| Sun, Z | 1 |
| Hull, VL | 1 |
| Wang, Y | 1 |
| Burns, T | 1 |
| Sternbach, S | 1 |
| Gong, S | 1 |
| McDonough, J | 1 |
| Guo, F | 1 |
| Borodinsky, LN | 1 |
| Pleasure, D | 1 |
| Zhou, S | 1 |
| Zhou, Y | 1 |
| Zhong, W | 1 |
| Su, Z | 1 |
| Qin, Z | 1 |
| Ren, X | 1 |
| Hinchie, A | 1 |
| Swomley, A | 1 |
| Powell, DK | 1 |
| Butterfield, DA | 1 |
| BoAli, A | 1 |
| Tlili-Graiess, K | 1 |
| AlHashem, A | 1 |
| AlShahwan, S | 1 |
| Zuccoli, G | 1 |
| Tabarki, B | 1 |
| Mishra, PKK | 1 |
| Mahawar, M | 1 |
| Guyenet, SJ | 1 |
| Mookerjee, SS | 1 |
| Lin, A | 1 |
| Custer, SK | 1 |
| Chen, SF | 1 |
| Sopher, BL | 1 |
| La Spada, AR | 1 |
| Ellerby, LM | 1 |
| Hao, P | 1 |
| Adav, SS | 1 |
| Gallart-Palau, X | 1 |
| Sze, SK | 1 |
| Donadieu, M | 1 |
| Le Fur, Y | 1 |
| Confort-Gouny, S | 1 |
| Le Troter, A | 1 |
| Guye, M | 1 |
| Ranjeva, JP | 1 |
| Corsini, S | 1 |
| Tortora, M | 1 |
| Nistri, A | 1 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 1 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 1 |
| Saudou, F | 1 |
| Humbert, S | 1 |
| Yang, XW | 1 |
| Osmand, A | 1 |
| Steffan, JS | 1 |
| Masliah, E | 1 |
| Finkbeiner, S | 1 |
| Francis, JS | 1 |
| Wojtas, I | 1 |
| Markov, V | 1 |
| Gray, SJ | 1 |
| McCown, TJ | 1 |
| Samulski, RJ | 1 |
| Bilaniuk, LT | 1 |
| Wang, DJ | 1 |
| De Vivo, DC | 1 |
| Janson, CG | 1 |
| Leone, P | 1 |
| Boban, J | 1 |
| Kozic, D | 1 |
| Turkulov, V | 1 |
| Ostojic, J | 1 |
| Semnic, R | 1 |
| Lendak, D | 1 |
| Brkic, S | 1 |
| Wu, YR | 1 |
| Chen, CM | 1 |
| Chao, CY | 1 |
| Lyu, RK | 1 |
| Lee-Chen, GJ | 1 |
| Borisova, T | 1 |
| Krisanova, N | 1 |
| Sivko, R | 1 |
| Borysov, A | 1 |
| Surendran, S | 1 |
| Bhatnagar, M | 1 |
| Totenhagen, JW | 1 |
| Yoshimaru, ES | 1 |
| Erickson, RP | 1 |
| Trouard, TP | 1 |
| Moshkin, MP | 1 |
| Akulov, AE | 1 |
| Petrovskiĭ, DV | 1 |
| Saĭk, OV | 1 |
| Petrovskiĭ, ED | 1 |
| Savelov, AA | 1 |
| Koptug, IV | 1 |
| Gillessen, T | 1 |
| Budd, SL | 1 |
| Lipton, SA | 1 |
| Kantarci, K | 1 |
| Petersen, RC | 1 |
| Boeve, BF | 1 |
| Knopman, DS | 1 |
| Tang-Wai, DF | 1 |
| O'Brien, PC | 1 |
| Weigand, SD | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Jack, CR | 1 |
| Schuff, N | 1 |
| Meyerhoff, DJ | 1 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Weiner, MW | 1 |
| Huisman, TA | 1 |
| Klein, A | 1 |
| Werner, B | 1 |
| Straube, T | 1 |
| Boltshauser, E | 1 |
| Dreha-Kulaczewski, SF | 1 |
| Dechent, P | 1 |
| Finsterbusch, J | 1 |
| Brockmann, K | 1 |
| Gärtner, J | 1 |
| Frahm, J | 1 |
| Hanefeld, FA | 1 |
| Nakase, T | 1 |
| Mizuno, T | 1 |
| Takanashi, Y | 1 |
| Nakajima, K | 1 |
| Imahori, Y | 1 |
| Furuya, S | 1 |
| Naruse, S | 1 |
| Gurwitz, D | 1 |
| Kloog, Y | 1 |
| Terakawa, H | 1 |
| Abe, K | 1 |
| Watanabe, Y | 1 |
| Nakamura, M | 1 |
| Fujita, N | 1 |
| Hirabuki, N | 1 |
| Yanagihara, T | 1 |
| Dautry, C | 1 |
| Vaufrey, F | 1 |
| Brouillet, E | 1 |
| Bizat, N | 1 |
| Henry, PG | 1 |
| Condé, F | 1 |
| Bloch, G | 1 |
| Hantraye, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1/2, Open Label, Sequential Cohort Study of a Single Intracranial Dose of AVASPA Gene Therapy for Treatment of Children With Typical Canavan Disease[NCT04833907] | Phase 1/Phase 2 | 24 participants (Anticipated) | Interventional | 2021-04-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for aspartic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Involvement of protein L-isoaspartyl methyltransferase in the physiopathology of neurodegenerative diseases: Possible substrates associated with synaptic function.
Topics: Aspartic Acid; Humans; Isoaspartic Acid; Neurodegenerative Diseases; Protein D-Aspartate-L-Isoaspart | 2023 |
PIMT-Mediated Protein Repair: Mechanism and Implications.
Topics: Animals; Aspartic Acid; Bacteria; Bacterial Proteins; Humans; Isoaspartic Acid; Neurodegenerative Di | 2019 |
Recent advances in mass spectrometric analysis of protein deamidation.
Topics: Aging; Aspartic Acid; Databases, Protein; Humans; Mass Spectrometry; Neurodegenerative Diseases; Pep | 2017 |
Upregulation of N-acetylaspartic acid induces oxidative stress to contribute in disease pathophysiology.
Topics: Animals; Antioxidants; Aspartic Acid; Brain Diseases, Metabolic; Humans; Neurodegenerative Diseases; | 2011 |
Excitatory amino acid neurotoxicity.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Calcium; Epilepsy; Glutamic Acid; Hum | 2002 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
21 other studies available for aspartic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer's Disease.
Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; D-Aspartic Acid; Humans; Neurodegenerativ | 2023 |
Pathological Bergmann glia alterations and disrupted calcium dynamics in ataxic Canavan disease mice.
Topics: Animals; Aspartic Acid; Ataxia; Atrophy; Calcium; Canavan Disease; Child; Humans; Infant; Mice; Neur | 2023 |
Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Corpus Striatum; Disease Models, Animal; Female; Gene Kno | 2019 |
Novel Homozygous Mutation of the AIMP1 Gene: A Milder Neuroimaging Phenotype With Preservation of the Deep White Matter.
Topics: Adolescent; Adult; Aspartic Acid; Child; Consanguinity; Cytokines; Developmental Disabilities; Epile | 2019 |
Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction.
Topics: Animals; Aspartic Acid; Ataxin-7; Caspase 7; Disease Models, Animal; Genetic Therapy; Humans; Mice; | 2015 |
Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Healthy Volunteers; Hu | 2016 |
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Brain Stem; Endoplasmic Re | 2016 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
Topics: Amidohydrolases; Animals; Aspartic Acid; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcri | 2016 |
HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Choline; Creat | 2017 |
Pantothenate kinase-associated neurodegeneration in two Taiwanese siblings: identification of a novel PANK2 gene mutation.
Topics: Aspartic Acid; DNA Mutational Analysis; Glycine; Humans; Magnetic Resonance Imaging; Male; Middle Ag | 2009 |
Cholesterol depletion attenuates tonic release but increases the ambient level of glutamate in rat brain synaptosomes.
Topics: Animals; Aspartic Acid; beta-Cyclodextrins; Brain; Brain Chemistry; Brain Diseases, Metabolic; Carbo | 2010 |
(1) H magnetic resonance spectroscopy of neurodegeneration in a mouse model of niemann-pick type C1 disease.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Choline; Magnetic Resonance Spectroscopy; Mice; Mice, Inb | 2013 |
[Magnetic resonance spectroscopy of metabolic changes in mice brain after 2-deoxy-D-glucose injection].
Topics: Animals; Aspartic Acid; Brain; Choline; Deoxyglucose; gamma-Aminobutyric Acid; Glutamic Acid; Glutam | 2012 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
Early reduction of total N-acetyl-aspartate-compounds in patients with classical vanishing white matter disease. A long-term follow-up MRS study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain Diseases; Cerebrum; Child; Child, Preschool; Creatine | 2008 |
[A lateralized reduction of NAA in a case of corticobasal degeneration (CBD): application of proton magnetic resonance spectroscopy (1H-MRS)].
Topics: Aged; Aspartic Acid; Basal Ganglia Diseases; Brain; Cerebral Cortex; Cerebrovascular Circulation; Fe | 1998 |
Peroxynitrite generation might explain elevated glutamate and aspartate levels in multiple sclerosis cerebrospinal fluid.
Topics: Animals; Aspartic Acid; Glutamic Acid; Humans; Models, Biological; Multiple Sclerosis; Neurodegenera | 1998 |
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Pro | 1999 |
Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid.
Topics: Animals; Aspartic Acid; Biomarkers; Cerebral Cortex; Corpus Striatum; Dyskinesia, Drug-Induced; In S | 2000 |