aspartic acid has been researched along with Neuroblastoma in 31 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of muscarinic cholinergic receptors (mAChRs) to regulate the volume-sensitive efflux of two organic osmolytes, namely, taurine and d-aspartate, from human SH-SY5Y neuroblastoma cells has been examined." | 7.72 | Potentiation of the osmosensitive release of taurine and D-aspartate from SH-SY5Y neuroblastoma cells after activation of M3 muscarinic cholinergic receptors. ( Fisher, SK; Gurda, GT; Heacock, AM; Kerley, D; VanTroostenberghe, AT, 2004) |
| "We have previously demonstrated cleavage of alpha-spectrin by caspase-3 and calpain during apoptosis in SH-SY5Y neuroblastoma cells (Nath, R." | 7.70 | Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis. ( Gnegy, ME; McGinnis, KM; Wang, KK; Whitton, MM, 1998) |
| "Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells." | 7.67 | Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987) |
| "Riluzole is a glutamatergic modulating agent used to treat ALS, but there are conflicting results in the literature concerning the recovery of NAA after riluzole treatment." | 5.36 | Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells. ( Arun, P; Moffett, JR; Namboodiri, AM, 2010) |
| " In the present study we have used high performance liquid chromatography to determine the effects of the antipsychotic drugs haloperidol and clozapine on NAA and NAAG levels in SH-SY5Y human neuroblastoma cells, a model system used to test the responses of dopaminergic neurons in vitro." | 3.74 | Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells. ( Arun, P; Madhavarao, CN; Moffett, JR; Namboodiri, AM, 2008) |
| "Persistent infection of mouse neuroblastoma NB41A3 cells with yellow fever 17D virus generates viral variants which exhibit defective cell penetration, poor cell-to-cell spread, small plaque size and reduced growth efficiency, caused by substitution of glycine for aspartic acid or glutamic acid at positions 360 and 362 in the envelope protein." | 3.73 | Neuroblastoma cell-adapted yellow fever virus: mutagenesis of the E protein locus involved in persistent infection and its effects on virus penetration and spread. ( Chambers, TJ; Droll, DA; Nickells, M; Vlaycheva, L, 2005) |
| "The ability of muscarinic cholinergic receptors (mAChRs) to regulate the volume-sensitive efflux of two organic osmolytes, namely, taurine and d-aspartate, from human SH-SY5Y neuroblastoma cells has been examined." | 3.72 | Potentiation of the osmosensitive release of taurine and D-aspartate from SH-SY5Y neuroblastoma cells after activation of M3 muscarinic cholinergic receptors. ( Fisher, SK; Gurda, GT; Heacock, AM; Kerley, D; VanTroostenberghe, AT, 2004) |
| " While examining the caspase-dependence of staurosporine (STS)-induced neuroblastoma cell death, we found that zVAD-fmk but not zAsp-CH2-DCB inhibits apoptosis." | 3.71 | A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH(2)-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays. ( Kayama, T; Kitanaka, C; Kokubu, A; Kuchino, Y; Sakurada, K; Sunayama, J; Tomiyama, A, 2002) |
| "We have previously demonstrated cleavage of alpha-spectrin by caspase-3 and calpain during apoptosis in SH-SY5Y neuroblastoma cells (Nath, R." | 3.70 | Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis. ( Gnegy, ME; McGinnis, KM; Wang, KK; Whitton, MM, 1998) |
| "We characterized the activation of interleukin-1beta-converting enzyme (ICE)-like proteases (caspases) in human neuroblastoma cells (SH-SY5Y) following challenge with staurosporine, an established agent known to induce apoptosis." | 3.69 | Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells. ( Gilbertsen, RB; McGinnis, K; Nadimpalli, R; Posmantur, R; Wang, KK, 1997) |
| "The mouse neuroblastoma--Chinese hamster brain hybrid cell line NCB-20 is the only clonal cell line in which binding studies indicate the presence of phencyclidine (PCP) receptors." | 3.67 | mRNA from NCB-20 cells encodes the N-methyl-D-aspartate/phencyclidine receptor: a Xenopus oocyte expression study. ( Bennett, MV; Kushner, L; Lerma, J; Spray, DC; Zukin, RS, 1989) |
| "Four different amino acids (kainate, N-methyl-D-aspartate, L-cysteine sulfinate and D,L-2-amino-5-phosphonovalerate) have been observed to stimulate uptake of 45Ca2+ into human neuroblastoma cells." | 3.67 | Amino acids modulate calcium permeability of the plasma membrane of human neuroblastoma cells. ( Pastuszko, A; Wilson, DF, 1988) |
| "Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells." | 3.67 | Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987) |
| "Neuroblastoma is the most commonly extra-cranial solid tumor of childhood frequently diagnosed." | 1.43 | N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents. ( Agriesti, F; Capitanio, N; Fratello, A; Laurenzana, I; Mazzoccoli, C; Piccoli, C; Ruggieri, V; Tataranni, T, 2016) |
| "Riluzole is a glutamatergic modulating agent used to treat ALS, but there are conflicting results in the literature concerning the recovery of NAA after riluzole treatment." | 1.36 | Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells. ( Arun, P; Moffett, JR; Namboodiri, AM, 2010) |
| "Calycanthine was also found to directly inhibit GABA-mediated currents (K(B) approximately 135 microM) from human alpha(1)beta(2)gamma(2L) GABA(A) receptors expressed in Xenopus laevis oocytes but had no effect at 100 microM on human rho(1) GABA(c) receptors." | 1.32 | Convulsant actions of calycanthine. ( Chebib, M; Connor, M; Duke, CC; Duke, RK; Johnston, GA; Mewett, KN, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (29.03) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 8 (25.81) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Sisalli, MJ | 1 |
| Della Notte, S | 1 |
| Secondo, A | 1 |
| Ventra, C | 1 |
| Annunziato, L | 1 |
| Scorziello, A | 1 |
| Song, L | 1 |
| Oseid, DE | 1 |
| Wells, EA | 1 |
| Robinson, AS | 1 |
| Zhao, M | 1 |
| Zhang, B | 1 |
| Deng, L | 1 |
| Zhao, L | 1 |
| Wang, X | 1 |
| Guo, Y | 1 |
| Chen, G | 1 |
| Fang, E | 1 |
| Wang, J | 1 |
| Li, Q | 1 |
| Li, D | 1 |
| Hu, A | 1 |
| Bao, B | 1 |
| Zhou, Y | 1 |
| Gao, H | 1 |
| Song, J | 1 |
| Du, X | 1 |
| Zheng, L | 1 |
| Tong, Q | 1 |
| Lesage, S | 1 |
| Anheim, M | 1 |
| Letournel, F | 1 |
| Bousset, L | 1 |
| Honoré, A | 1 |
| Rozas, N | 1 |
| Pieri, L | 1 |
| Madiona, K | 1 |
| Dürr, A | 1 |
| Melki, R | 1 |
| Verny, C | 1 |
| Brice, A | 1 |
| Cheng, FB | 1 |
| Feng, JC | 1 |
| Ma, LY | 1 |
| Miao, J | 1 |
| Ott, T | 1 |
| Wan, XH | 1 |
| Grundmann, K | 1 |
| Mazzoccoli, C | 1 |
| Ruggieri, V | 1 |
| Tataranni, T | 1 |
| Agriesti, F | 1 |
| Laurenzana, I | 1 |
| Fratello, A | 1 |
| Capitanio, N | 1 |
| Piccoli, C | 1 |
| Arun, P | 3 |
| Madhavarao, CN | 2 |
| Moffett, JR | 3 |
| Namboodiri, AM | 2 |
| Wei, Z | 1 |
| Satram-Maharaj, T | 1 |
| Chaharyn, B | 1 |
| Kuski, K | 1 |
| Pennington, PR | 1 |
| Cao, X | 1 |
| Chlan, J | 1 |
| Mousseau, DD | 1 |
| Chebib, M | 1 |
| Duke, RK | 1 |
| Duke, CC | 1 |
| Connor, M | 1 |
| Mewett, KN | 1 |
| Johnston, GA | 1 |
| Heacock, AM | 1 |
| Kerley, D | 1 |
| Gurda, GT | 1 |
| VanTroostenberghe, AT | 1 |
| Fisher, SK | 1 |
| Vlaycheva, L | 1 |
| Nickells, M | 1 |
| Droll, DA | 1 |
| Chambers, TJ | 1 |
| Namboodiri, MA | 1 |
| Kuzuya, A | 1 |
| Uemura, K | 1 |
| Kitagawa, N | 1 |
| Aoyagi, N | 1 |
| Kihara, T | 1 |
| Ninomiya, H | 1 |
| Ishiura, S | 1 |
| Takahashi, R | 1 |
| Shimohama, S | 1 |
| O'Neill, CM | 1 |
| Ball, SG | 1 |
| Vaughan, PF | 1 |
| Gyngell, ML | 1 |
| Els, T | 1 |
| Hoehn-Berlage, M | 1 |
| Hossmann, KA | 1 |
| Gallyas, F | 1 |
| Satoh, J | 1 |
| Takeuchi, AM | 1 |
| Konishi, Y | 1 |
| Kunishita, T | 1 |
| Tabira, T | 1 |
| Posmantur, R | 1 |
| McGinnis, K | 1 |
| Nadimpalli, R | 1 |
| Gilbertsen, RB | 1 |
| Wang, KK | 3 |
| McGinnis, KM | 2 |
| Whitton, MM | 1 |
| Gnegy, ME | 2 |
| Sakurada, K | 1 |
| Kitanaka, C | 1 |
| Kokubu, A | 1 |
| Tomiyama, A | 1 |
| Sunayama, J | 1 |
| Kayama, T | 1 |
| Kuchino, Y | 1 |
| Haber, B | 1 |
| Hutchison, HT | 1 |
| Balcar, VJ | 1 |
| Borg, J | 2 |
| Mandel, P | 2 |
| Mark, J | 1 |
| Biedler, JL | 1 |
| Spengler, BA | 1 |
| Lerma, J | 1 |
| Kushner, L | 1 |
| Spray, DC | 1 |
| Bennett, MV | 1 |
| Zukin, RS | 1 |
| Lacoste, L | 1 |
| Hertz, L | 1 |
| Lapointe, J | 1 |
| Pastuszko, A | 1 |
| Wilson, DF | 1 |
| Hannuniemi, R | 1 |
| Pajari-Backas, M | 1 |
| Oja, OS | 1 |
| Oja, SS | 1 |
| Ohnuma, T | 1 |
| Holland, JF | 1 |
| Freeman, A | 1 |
| Sinks, LF | 1 |
31 other studies available for aspartic acid and Neuroblastoma
| Article | Year |
|---|---|
L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson's Disease Models.
Topics: Aspartic Acid; Calcium; Dipeptides; Dopaminergic Neurons; Fluorescent Dyes; Homeostasis; Humans; Mit | 2022 |
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology.
Topics: Amyloid beta-Peptides; Aspartic Acid; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Phosph | 2022 |
Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis.
Topics: Acrylamides; Animals; Aspartic Acid; Caspase 1; Gasdermins; Humans; Inflammasomes; Interleukin-18; I | 2023 |
Therapeutic targeting of FUBP3 phase separation by GATA2-AS1 inhibits malate-aspartate shuttle and neuroblastoma progression via modulating SUZ12 activity.
Topics: Aspartic Acid; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; GATA2 Transcription Facto | 2023 |
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Amyloid; Aspartic Acid; Blepharospasm; Caspase 3; D | 2013 |
Combined occurrence of a novel TOR1A and a THAP1 mutation in primary dystonia.
Topics: Adult; Apoptosis Regulatory Proteins; Asian People; Aspartic Acid; Cell Line, Tumor; Cohort Studies; | 2014 |
N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.
Topics: Antipsychotic Agents; Aspartic Acid; Cell Line, Tumor; Clozapine; Dipeptides; Dose-Response Relation | 2008 |
Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.
Topics: Aspartic Acid; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Rel | 2010 |
Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation.
Topics: Analysis of Variance; Animals; Aspartic Acid; bcl-X Protein; Bromodeoxyuridine; Calcium; Catalysis; | 2012 |
Convulsant actions of calycanthine.
Topics: Acetylcholine; Algorithms; Animals; Aspartic Acid; Calcium Channels; Cerebellum; Cerebral Cortex; Ch | 2003 |
Potentiation of the osmosensitive release of taurine and D-aspartate from SH-SY5Y neuroblastoma cells after activation of M3 muscarinic cholinergic receptors.
Topics: Aspartic Acid; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Ion Ch | 2004 |
Neuroblastoma cell-adapted yellow fever virus: mutagenesis of the E protein locus involved in persistent infection and its effects on virus penetration and spread.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Cell Line, Tumor; Chlorocebus aethiops; Glycine; Mi | 2005 |
Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.
Topics: Aspartic Acid; Bucladesine; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Dipeptides; Dose | 2006 |
Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Aspartic Acid; Aspartic Acid En | 2007 |
Effects of ischaemic conditions on uptake of glutamate, aspartate, and noradrenaline by cell lines derived from the human nervous system.
Topics: Aspartic Acid; Astrocytoma; Biological Transport; Cell Hypoxia; Cell Line; Glutamates; Glutamic Acid | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
Identifying monoaminergic, GABAergic, and cholinergic characteristics in immortalized neuronal cell lines.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Cell Line, Transformed; Cell | 1997 |
Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells.
Topics: Antibody Specificity; Apoptosis; Aspartic Acid; Caspase 1; Caspase 3; Caspases; Coumarins; Cysteine | 1997 |
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aspartic Acid; Calcium-Calmodulin-Dependent Pro | 1998 |
Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Topics: Apoptosis; Aspartic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Ca | 2001 |
A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH(2)-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aspartic Acid; Caspase Inhibitors; Caspases; Cytoplasm; | 2002 |
Uptake of neurotransmitters and precursors by clonal cell lines of neural origin.
Topics: Amino Acids; Aminooxyacetic Acid; Aspartic Acid; Astrocytoma; Biogenic Amines; Cell Line; Cell Membr | 1976 |
High affinity uptake of L-glutamate and L-aspartate by glial cells.
Topics: 4-Chloromercuribenzenesulfonate; Amino Acids; Aminooxyacetic Acid; Aspartic Acid; Atropine; Biologic | 1977 |
Effects of amino acids on calcium uptake by glial and neuroblastoma cells.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Neoplasms; Calcimycin; Calcium; Clone Cells; Cricetinae; | 1979 |
Metaphase chromosome anomaly: association with drug resistance and cell-specific products.
Topics: Aspartic Acid; Cell Line; Chromosome Aberrations; Chromosomes; DNA Replication; Drug Resistance; Met | 1976 |
mRNA from NCB-20 cells encodes the N-methyl-D-aspartate/phencyclidine receptor: a Xenopus oocyte expression study.
Topics: Animals; Aspartic Acid; Brain; Cell Line; Evoked Potentials; Female; Hybrid Cells; In Vitro Techniqu | 1989 |
Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.
Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Aspartic Acid; Brain; Catalysis; Cell Line; Glioma; | 1986 |
Amino acids modulate calcium permeability of the plasma membrane of human neuroblastoma cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Calcium; Cell Membrane Permeability; Cystei | 1988 |
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells.
Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblast | 1987 |
Biochemical and pharmacological studies with asparaginase in man.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Colo | 1970 |