aspartic acid has been researched along with Nervous System Diseases in 36 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Possible biochemical events involved in L-2-chloropropionic acid (L-CPA)-induced delayed cerebellar granule cell necrosis following N-methyl-D-aspartate activation were studied in vivo." | 7.69 | Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis. ( Coutts, CT; Foster, J; Gyte, A; Upton, R; Widdowson, PS; Wyatt, I, 1997) |
| "Possible biochemical events involved in L-2-chloropropionic acid (L-CPA)-induced delayed cerebellar granule cell necrosis following N-methyl-D-aspartate activation were studied in vivo." | 3.69 | Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis. ( Coutts, CT; Foster, J; Gyte, A; Upton, R; Widdowson, PS; Wyatt, I, 1997) |
| " 5-Fluorouracil at high dosage may cause cerebellar ataxia, but may also do so at low dosage when combined with thymidine infusions." | 2.37 | Neurological complications of antineoplastic therapy. ( Shapiro, WR; Young, DF, 1984) |
| "The progression of Wilson disease (WD), a disorder of copper metabolism, can be arrested by chelation therapy." | 1.32 | Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease. ( Davie, CA; Lees, AJ; MacManus, D; Miller, DH; Miszkiel, KA; Page, RA; Schapira, AH; Walshe, JM, 2004) |
| "A current hypothesis for migraine suggests that neuroexcitatory amino acids may participate in the triggering of attacks." | 1.29 | Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks. ( Castillo, J; Leira, R; Martínez, F; Noya, M; Rodríguez, JR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (27.78) | 18.7374 |
| 1990's | 7 (19.44) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 5 (13.89) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Kirov, II | 1 |
| Tal, A | 1 |
| Xu, J | 1 |
| Jakher, Y | 1 |
| Ahrens-Nicklas, RC | 1 |
| Baymeeva, NV | 1 |
| Miroshnichenko, II | 1 |
| Choudhary, AK | 1 |
| Lee, YY | 1 |
| Takeda, A | 1 |
| Itoh, H | 1 |
| Tamano, H | 1 |
| Yuzurihara, M | 1 |
| Oku, N | 1 |
| Xu, V | 1 |
| Chan, H | 1 |
| Lin, AP | 1 |
| Sailasuta, N | 1 |
| Valencerina, S | 1 |
| Tran, T | 1 |
| Hovener, J | 1 |
| Ross, BD | 1 |
| Shemesh, N | 1 |
| Sadan, O | 1 |
| Melamed, E | 1 |
| Offen, D | 1 |
| Cohen, Y | 1 |
| Inácio, V | 1 |
| Turkman, AA | 1 |
| Nakas, CT | 1 |
| Alonzo, TA | 1 |
| Spalice, A | 1 |
| Del Balzo, F | 1 |
| Nicita, F | 1 |
| Papetti, L | 1 |
| Ursitti, F | 1 |
| Salvatori, G | 1 |
| Zicari, AM | 1 |
| Properzi, E | 1 |
| Duse, M | 1 |
| Gillessen, T | 1 |
| Budd, SL | 1 |
| Lipton, SA | 1 |
| Rocca, MA | 1 |
| Mezzapesa, DM | 1 |
| Falini, A | 1 |
| Ghezzi, A | 1 |
| Martinelli, V | 2 |
| Scotti, G | 1 |
| Comi, G | 2 |
| Filippi, M | 2 |
| LOGOTHETIS, J | 1 |
| Page, RA | 1 |
| Davie, CA | 1 |
| MacManus, D | 1 |
| Miszkiel, KA | 1 |
| Walshe, JM | 1 |
| Miller, DH | 1 |
| Lees, AJ | 1 |
| Schapira, AH | 1 |
| Madhavarao, CN | 1 |
| Namboodiri, AM | 1 |
| Burlina, AP | 1 |
| Schmitt, B | 1 |
| Engelke, U | 1 |
| Wevers, RA | 1 |
| Burlina, AB | 1 |
| Boltshauser, E | 1 |
| Yücel, M | 1 |
| Harrison, BJ | 1 |
| Wood, SJ | 1 |
| Fornito, A | 1 |
| Clarke, K | 1 |
| Wellard, RM | 1 |
| Cotton, S | 1 |
| Pantelis, C | 1 |
| Pulizzi, A | 1 |
| Rovaris, M | 1 |
| Judica, E | 1 |
| Sormani, MP | 1 |
| Benarroch, EE | 1 |
| Mantle, PG | 1 |
| Hammond, EJ | 1 |
| Wilder, BJ | 1 |
| Bruni, J | 1 |
| Shapiro, WR | 1 |
| Young, DF | 1 |
| Dave, V | 1 |
| Mullaney, KJ | 1 |
| Goderie, S | 1 |
| Kimelberg, HK | 1 |
| Aschner, M | 1 |
| Martínez, F | 1 |
| Castillo, J | 1 |
| Rodríguez, JR | 1 |
| Leira, R | 1 |
| Noya, M | 1 |
| Widdowson, PS | 1 |
| Gyte, A | 1 |
| Upton, R | 1 |
| Foster, J | 1 |
| Coutts, CT | 1 |
| Wyatt, I | 1 |
| Bernasconi, A | 1 |
| Cendes, F | 1 |
| Shoubridge, EA | 1 |
| Andermann, E | 1 |
| Li, LM | 1 |
| Arnold, DL | 1 |
| Andermann, F | 1 |
| Thompson, RB | 1 |
| Allen, PS | 1 |
| Barker, PB | 1 |
| Martin, E | 1 |
| Capone, A | 1 |
| Schneider, J | 1 |
| Hennig, J | 1 |
| Thiel, T | 1 |
| Saurugg, D | 1 |
| Hodkewitsch, E | 1 |
| Kawai, M | 1 |
| Horikawa, Y | 1 |
| Ishihara, T | 1 |
| Shimamoto, K | 1 |
| Ohfune, Y | 1 |
| Ozand, PT | 1 |
| Feryal, RR | 1 |
| Gascon, GG | 1 |
| Gleispach, H | 1 |
| al Aqeel, A | 1 |
| Cook, JD | 1 |
| Nester, MJ | 1 |
| al Odaib, A | 1 |
| Leis, HJ | 1 |
| Millan, MH | 1 |
| Wardley-Smith, B | 1 |
| Halsey, MJ | 1 |
| Meldrum, BS | 1 |
| Elpeleg, ON | 1 |
| Amir, N | 1 |
| Barash, V | 1 |
| Glick, B | 1 |
| Gross-Tsur, V | 1 |
| Shachar, E | 1 |
| Shapira, Y | 1 |
| Tzelnik, N | 1 |
| Meldrum, B | 1 |
| Kim, JP | 1 |
| Goldberg, MP | 1 |
| Choi, DW | 1 |
| Stegink, LD | 1 |
| Shepherd, JA | 1 |
| Brummel, MC | 1 |
| Murray, LM | 1 |
10 reviews available for aspartic acid and Nervous System Diseases
| Article | Year |
|---|---|
Potential clinical impact of multiparametric quantitative MR spectroscopy in neurological disorders: A review and analysis.
Topics: Algorithms; Area Under Curve; Aspartic Acid; Biomarkers; Computer Simulation; Diagnosis, Computer-As | 2020 |
Brain Branched-Chain Amino Acids in Maple Syrup Urine Disease: Implications for Neurological Disorders.
Topics: Amino Acids, Branched-Chain; Aspartic Acid; Brain; Central Nervous System; Disease Susceptibility; G | 2020 |
[N-acetylaspartate is a biomarker of psychiatric and neurological disorders].
Topics: Aspartic Acid; Biomarkers; Brain Chemistry; Humans; Magnetic Resonance Spectroscopy; Mental Disorder | 2015 |
Neurophysiological symptoms and aspartame: What is the connection?
Topics: Affect; Animals; Aspartame; Aspartic Acid; Brain; Cognitive Dysfunction; Disease Models, Animal; Dop | 2018 |
MR spectroscopy in diagnosis and neurological decision-making.
Topics: Aspartic Acid; Choline; Creatine; Decision Making; Humans; Magnetic Resonance Spectroscopy; Nervous | 2008 |
Excitatory amino acid neurotoxicity.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Calcium; Epilepsy; Glutamic Acid; Hum | 2002 |
NAA synthesis and functional roles.
Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Enzyme Stability; Humans; Mitochondria; | 2006 |
N-acetylaspartate and N-acetylaspartylglutamate: neurobiology and clinical significance.
Topics: Animals; Aspartic Acid; Biomarkers; Dipeptides; Humans; Nervous System Diseases; Neurobiology; Neuro | 2008 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
Neurological complications of antineoplastic therapy.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemother | 1984 |
2 trials available for aspartic acid and Nervous System Diseases
| Article | Year |
|---|---|
Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis.
Topics: Adaptation, Physiological; Adult; Aspartic Acid; Axons; Brain; Brain Mapping; Cerebral Cortex; Femal | 2003 |
[Clinical experiences with an analgesic-acting infusion solution in neurological painful conditions].
Topics: Arthritis, Rheumatoid; Aspartic Acid; Dipyrone; Facial Neuralgia; Humans; Injections, Intravenous; M | 1977 |
24 other studies available for aspartic acid and Nervous System Diseases
| Article | Year |
|---|---|
Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats.
Topics: Animals; Aspartic Acid; Drugs, Chinese Herbal; Extracellular Fluid; Glutamic Acid; Glycine; Hippocam | 2008 |
Longitudinal MRI and MRSI characterization of the quinolinic acid rat model for excitotoxicity: peculiar apparent diffusion coefficients and recovery of N-acetyl aspartate levels.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Diffusion Magnetic Resonance Imaging; Disease Model | 2010 |
Nonparametric Bayesian estimation of the three-way receiver operating characteristic surface.
Topics: Aspartic Acid; Bayes Theorem; Biometry; Creatinine; HIV Infections; Humans; Nervous System Diseases; | 2011 |
Teaching NeuroImages: Acute necrotizing encephalopathy during novel influenza A (H1N1) virus infection.
Topics: Aspartic Acid; Brain; Choline; Humans; Infant; Influenza A Virus, H1N1 Subtype; Influenza, Human; Ma | 2011 |
Cerebrospinal fluid free amino acids in neurologic diseases; observations in aspartic acid concentrations.
Topics: Amino Acids; Aspartic Acid; Ataxia; Nervous System Diseases | 1958 |
Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Chelation Therapy; Copper; Dipeptides; | 2004 |
Hypoacetylaspartia: clinical and biochemical follow-up of a patient.
Topics: Aspartic Acid; Child, Preschool; Dipeptides; Follow-Up Studies; Humans; Magnetic Resonance Spectrosc | 2006 |
State, trait and biochemical influences on human anterior cingulate function.
Topics: Adult; Aspartic Acid; Brain Mapping; Conflict, Psychological; Female; Functional Laterality; Gyrus C | 2007 |
Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study.
Topics: Adult; Aged; Anisotropy; Aspartic Acid; Brain; Cohort Studies; Cross-Sectional Studies; Diffusion Ma | 2007 |
Amino acid neurotransmitter release from cerebrocortical synaptosomes of sheep with severe ryegrass staggers in New Zealand.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Indole Alkaloids; Mycotoxins; Ne | 1983 |
Astrocytes as mediators of methylmercury neurotoxicity: effects on D-aspartate and serotonin uptake.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Autoradiography; Cells, Cultured; Fluoxetine; | 1994 |
Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks.
Topics: Adult; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Migraine Disorders; Nervous S | 1993 |
Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Aspartic Acid; Blotting, Western; Calpai | 1997 |
Spectroscopic imaging of frontal neuronal dysfunction in hyperekplexia.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Frontal Lobe; Humans; Magnetic R | 1998 |
The role of the N-acetylaspartate multiplet in the quantification of brain metabolites.
Topics: Aspartic Acid; Biomarkers; Brain Chemistry; Humans; Magnetic Resonance Spectroscopy; Mathematics; Mo | 1998 |
N-acetyl aspartate--a neuronal marker?
Topics: Aspartic Acid; Biomarkers; Brain; Child, Preschool; Humans; Magnetic Resonance Spectroscopy; Nervous | 2001 |
Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy?
Topics: Aspartic Acid; Brain; Child, Preschool; Dipeptides; Humans; Magnetic Resonance Spectroscopy; Male; N | 2001 |
2-(Carboxycyclopropyl)glycines: binding, neurotoxicity and induction of intracellular free Ca2+ increase.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Calcium; C | 1992 |
Prenatal detection of Canavan disease.
Topics: Amniotic Fluid; Aspartic Acid; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Methods; Nervo | 1991 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; G | 1989 |
Canavan disease and N-acetylaspartic aciduria.
Topics: Aspartic Acid; Humans; Nerve Degeneration; Nervous System Diseases | 1989 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Aci | 1986 |
High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Female; L-Lactate Dehydrogenase; Mice; N-M | 1987 |
Toxicity of protein hydrolysate solutions: correlation of glutamate dose and neuronal necrosis to plasma amino acid levels in young mice.
Topics: Age Factors; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Caseins; Dose-Response Relations | 1974 |