aspartic acid has been researched along with Nerve Degeneration in 134 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (23.13) | 18.7374 |
| 1990's | 34 (25.37) | 18.2507 |
| 2000's | 53 (39.55) | 29.6817 |
| 2010's | 16 (11.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cortese, ICM; Ercan, E; Reich, DS; Ronen, I; Sati, P; Wood, ET | 1 |
| Arahuetes, RM; de Munck, E; Gil, C; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Ojeda, I; Solas, MT | 1 |
| Brandt, AU; Doss, S; Endres, M; Oberwahrenbrock, T; Paul, F; Rinnenthal, JL | 1 |
| Abdel-Aziz, K; Altmann, DR; Ciccarelli, O; Day, BL; Peters, AL; Schneider, T; Solanky, BS; Thompson, AJ; Wheeler-Kingshott, CA; Yiannakas, MC | 1 |
| Eckhardt, M; Gieselmann, V; Hartmann, D; Maier, H; Wang-Eckhardt, L | 1 |
| Bulik, M; Burkon, P; Dobiaskova, M; Hynkova, L; Jancalek, R; Kazda, T; Laack, NN; Pospisil, P; Slampa, P | 1 |
| Armitage, PA; Bastin, ME; Chappell, FM; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM | 1 |
| Erichsen, AK; Landrø, NI; Sandvik, L; Server, A; Tallaksen, CM | 1 |
| Guo, Y; Li, B; Li, C; Sun, M; Yu, J; Zhang, Y | 1 |
| Aresi, A; Bizzi, A; Giovagnoli, AR; Gobbo, C; Reati, F; Riva, A | 1 |
| Blom, HJ; Bouwman, F; Brundin, L; Dijkstra, CD; Iacobaeus, E; Jakobs, C; Khademi, M; Koel-Simmelink, MJ; Norgren, N; Schepens, M; Teunissen, CE; Twaalfhoven, HA | 1 |
| Atmaca, M; Koc, M; Ozdemir, H; Ozler, S; Tezcan, E; Yildirim, H | 1 |
| Herrera, JJ; Narayana, PA; Qian, J | 1 |
| Finkbeiner, S; Greiner, ER; Gu, X; Kodali, R; Mishra, R; Osmand, A; Steffan, JS; Thompson, LM; Wetzel, R; Yang, XW | 1 |
| Altmann, DR; Ciccarelli, O; McLean, MA; Miller, DH; Thompson, AJ; Wheeler-Kingshott, CA; Wimpey, K | 1 |
| Geurts, JJ; van Horssen, J | 1 |
| Grieb, P; Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A | 1 |
| Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S | 1 |
| Hanstock, C; Hui, B; Johnston, W; Kalra, S; Pyra, T; Sudharshan, N | 1 |
| Concha, MI; Lerchundi, R; Neira, R; Otth, C; Valdivia, S; Vio, K; Zambrano, A | 1 |
| Camicioli, R; Choi, C; Johnston, W; Kalra, S; Lynch, M; Sekhon, R; Seres, P; Usman, U | 1 |
| Baudrexel, S; Berg, D; Brockmann, K; Csoti, I; Gasser, T; Hattingen, E; Hauser, AK; Hilker, R; Magerkurth, J; Merten, CD; Pilatus, U; Schulte, C; Srulijes, K | 1 |
| Boĭko, AN; Davydovskaia, MV; Gusev, EI; Kornienko, VN; Podoprigora, AE; Pronin, IN | 1 |
| Benz, AM; Hammerman, SB; Izumi, Y; Olney, JW; Shimamoto, K; Zorumski, CF | 1 |
| Loopuijt, LD | 1 |
| Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U | 1 |
| Zheng, S; Zuo, Z | 1 |
| Alecci, M; Cifelli, A; Jezzard, P; Matthews, PM; Palace, J; Wylezinska, M | 1 |
| Ahmed, Z; Baker, D; Croxford, JL; Cuzner, ML; Giovannoni, G; Hankey, DJ; Jackson, SJ; Ledent, C; Petzold, A; Pocock, JM; Pryce, G; Thompson, AJ | 1 |
| Barr, J; Bell, JD; Bhakoo, K; Chung, YL; Fraser, JR; Williams, SC | 1 |
| Balcar, VJ; Bubeníková, V; Fitzgibbon, T; Pliss, L; Pokorný, J; St'astný, F | 1 |
| Al-Semaan, Y; Densmore, M; Drost, DJ; Menon, RS; Neufeld, RW; Rajakumar, N; Schaefer, B; Théberge, J; Williamson, PC | 1 |
| Heresco-Levy, U | 1 |
| Zaffaroni, M | 1 |
| Bartolozzi, ML; De Stefano, N; Federico, A; Guidi, L; Stromillo, ML | 1 |
| Barbiroli, B; Iotti, S; Lodi, R; Montagna, P; Plazzi, G; Tonon, C; Vignatelli, L | 1 |
| Dijkstra, C; Polman, C; Teunissen, CE | 1 |
| Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K | 1 |
| Benner, EJ; Boska, MD; Destache, CJ; Gendelman, HE; Lewis, TB; Mosley, RL; Nelson, JA; Uberti, M | 1 |
| Chen, L; Feany, MB | 1 |
| Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X | 1 |
| Axelson, D; Birmaher, B; Brambilla, P; Keshavan, MS; Nicoletti, MA; Ramos, RT; Ryan, N; Sassi, RB; Soares, JC; Stanley, JA | 1 |
| Chakrabarti, L; La Spada, AR; Martinez, RA; Miles, M; Neal, JT; Smith, AC; Sopher, BL | 1 |
| Berman, RF; Bzdega, T; Jiang, J; Kozikowski, AP; Lyeth, BG; Neale, JH; O'Connor, WT; Smyth, A; Van, KC; Zhao, X; Zhong, C; Zhou, J | 1 |
| Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR | 1 |
| Camacho, A; Massieu, L; Montiel, T | 1 |
| Boucard, CC; Cornelissen, FW; Hoogduin, JM; van der Grond, J | 1 |
| Angenstein, F; Debska-Vielhaber, G; Heinze, HJ; Hilfert, L; Kunz, WS; Leibfritz, D; Ludolph, AC; Niessen, HG; Sander, K; Vielhaber, S; Willker, W | 1 |
| Blezer, EL; Jongsma, MJ; Olivier, B; Philippens, IH; van Vliet, SA; van Vlieta, SA; Vanwersch, RA | 1 |
| Bhattacharjee, MB; Brunetti-Pierri, N; Hunter, J; Potocki, L; Scaglia, F; Wang, ZJ; Wenger, DA | 1 |
| Bliss, RM; Coles, J; Finckbone, V; Henne, WM; Hoffman, TC; Oomman, SK; Strahlendorf, H; Strahlendorf, J | 1 |
| Casey, PA; Fiskum, G; McKenna, MC; Robertson, CL; Saraswati, M | 1 |
| Donaldson, PL; Duce, IR; Usherwood, PN | 1 |
| Berl, S; Plaitakis, A | 1 |
| Coull, BM; Woodward, WR | 1 |
| Collins, GG; Probett, GA | 1 |
| Kaul, R; Matalon, R; Michals, K | 1 |
| Bamonti, F; Rango, M; Scarlato, G; Spagnoli, D; Tomei, G; Zetta, L | 1 |
| Feliciano, M; Potashner, SJ | 1 |
| Asano, S; Endo, N; Furiya, Y; Ishii, K; Mori, H; Sahara, N; Shirasawa, T; Takio, K; Tomiyama, T | 1 |
| de Koster, A; Heerschap, A; Horstink, MW; Thijssen, HO; van 't Hof, MA; Zijlmans, JC | 1 |
| Bruhn, H; Frahm, J; Hanefeld, F; Kruse, B | 1 |
| Fedele, E; Foster, AC | 1 |
| Choe, BY; Choi, KH; Kang, JK; Park, CK; Shinn, KS; Suh, TS | 1 |
| Alger, JR; Barnett, AS; Bertolino, A; Bonavita, S; Campbell, G; Hallett, M; Massaquoi, SG; Patronas, NJ; Tedeschi, G | 1 |
| Beal, MF; Brouillet, E; Chen, YC; Jenkins, BG; Kirschner, P; Rosen, BR; Schulz, JB; Storey, E | 1 |
| Godfrey, DA; Godfrey, TG; Li, H; Rubin, AM | 1 |
| Brooks, DJ; Bryant, DJ; Harding, AE; Marcus, CD; Sargentoni, J; Taylor-Robinson, SD; Weeks, RA | 1 |
| Massieu, L; Tapia, R; Velasco, I | 1 |
| Maier, M; Ron, MA | 1 |
| Fletcher, EL; Kalloniatis, M | 1 |
| Alford, M; DeTeresa, R; Hansen, L; Mallory, M; Masliah, E | 1 |
| Chang, L; Ernst, T; Mehringer, CM; Melchor, R | 1 |
| Massieu, L; Tapia, R | 1 |
| Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G | 1 |
| Deicken, RF; Schuff, N; Weiner, MW; Zhou, L | 1 |
| Abbamondi, AL; Bugiani, O; Giaccone, G; Macchi, G; Mancia, D; Rossi, G; Tagliavini, F | 1 |
| Schwartz, M; Yoles, E | 1 |
| Massieu, L; Sánchez-Carbente, MR | 1 |
| Bar-Peled, O; Knudson, M; Korsmeyer, SJ; Rothstein, JD | 1 |
| Majors, AW; Mitsumoto, H; Nelson, DR; Ng, TC; Pioro, EP | 1 |
| Liu, D; McAdoo, DJ; Pan, E; Xu, GY | 1 |
| Akimitsu, T; Kitada, K; Kondo, A; Kuramoto, T; Maihara, T; Sasa, M; Serikawa, T; Shigematsu, Y; Yokoi, N | 1 |
| Chang, C; Lee, CS; Lee, WT; Pan, YL | 1 |
| Abrahám, I; Harkany, T; Kónya, C; Korf, J; Laskay, G; Luiten, PG; Nyakas, C; Penke, B; Sasvári, M; Sebens, JB; Soós, K; Timmerman, W; Tóth, B; Zarándi, M | 1 |
| Favalli, L; Govoni, S; Lanza, E; Masoero, E; Montalbetti, L; Rizzo, V; Rozza, A | 1 |
| Mori, H; Ogawara, M; Shimizu, T; Shirasawa, T; Watanabe, A | 1 |
| Antel, J; Arnold, DL; Arnoutelis, R; Jenkinson, M; Matthews, PM; Narayanan, S; Reddy, H | 1 |
| Fujishima, M; Ibayashi, S; Kondo, A; Ooboshi, H; Sadoshima, S; Takano, K; Uchimura, H | 1 |
| Bellacosa, A; Carrara, D; Federico, F; Giannini, P; Liguori, M; Livrea, P; Lucivero, V; Simone, IL; Tortorella, C | 1 |
| Barker, GJ; Chard, D; Griffin, CM; Kapeller, P; McLean, MA; Miller, DH; Parker, GJ; Thompson, AJ | 1 |
| Bjartmar, C; Trapp, BD | 1 |
| Krasnewich, D; Pearl, PL | 1 |
| Belmadani, A; Collins, MA; Neafsey, EJ; Schipma, MJ; Zou, JY | 1 |
| Kaneko, I; Kubo, T; Morimoto, K | 1 |
| Bard, C; Boulanger, Y; Khiat, A; Lacroix, A; Yared, Z | 1 |
| Bruhn, T; Christensen, T; Diemer, NH | 1 |
| Iidaka, T; Itoh, H; Kado, H; Kimura, H; Kosaka, H; Murata, T; Omori, M; Wada, Y | 1 |
| Battistuta, J; Bjartmar, C; Dupree, E; Terada, N; Trapp, BD | 1 |
| Collins, GG | 1 |
| Gulley, RL; Wenthold, RJ | 1 |
| Wenthold, RJ | 1 |
| den Hollander, JA; Luyten, PR; Nauta, JJ; Valk, J; van der Grond, J; van der Knaap, MS | 1 |
| Kelley, RI; Stamas, JN | 1 |
| Du, F; Schwarcz, R | 1 |
| Barash, V; Boneh, A; Elpeleg, ON; Flhor, D; Gilon, C; Morag, B | 1 |
| Baimbridge, KG; Choi, DW; Koh, J; Weiss, JH | 1 |
| Miyamoto, T; Okada, Y; Sakurai, T | 1 |
| Choi, DW; Hartley, DM; Monyer, H | 1 |
| Gürçay, O; Onol, B; Ozcan, OE; Renda, Y; Topaloğlu, H; Topçu, M; Yalaz, K | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Amir, N; Barash, V; Elpeleg, ON; Glick, B; Gross-Tsur, V; Shachar, E; Shapira, Y; Tzelnik, N | 1 |
| Ikonomidou, C; Labruyere, J; Mosinger, JL; Olney, JW; Salles, KS | 1 |
| Finger, S; Olney, JW; Stewart, GR; Wozniak, DF | 1 |
| Divry, P; Mathieu, M | 1 |
| Meldrum, B | 2 |
| Meldrum, B; Schwarcz, R | 1 |
| Dempster, DW; Sloviter, RS | 1 |
| Dymczyk, L; Potashner, SJ | 1 |
| Bowen, DM; Murphy, E; Neary, D; Palmer, AM; Procter, AW | 1 |
| Morgan, IG | 1 |
| Benavides, J; Carter, C; Fage, D; Scatton, B | 1 |
| Hugon, J; Leboutet, MJ; Vallat, JM | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Garthwaite, G; Garthwaite, J | 2 |
| Foster, AC; Gill, R; Kemp, JA; Woodruff, GN | 1 |
| Bissoli, R; Chiodini, O; Contestabile, A; Munarini, A; Villani, L | 1 |
| Potashner, SJ; Tran, PL | 1 |
| Ho, OL; Olney, JW; Rhee, V | 1 |
| Keen, P; Roberts, PJ | 1 |
| Nagata, Y; Tsukada, Y | 1 |
| Heller, A; Margolis, RK; Moore, RY | 1 |
9 review(s) available for aspartic acid and Nerve Degeneration
| Article | Year |
|---|---|
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality.
Topics: Animals; Antipsychotic Agents; Aspartic Acid; Glutamic Acid; Glycine; Humans; Nerve Degeneration; Neurotoxins; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2003 |
Biological indicators of the neurodegenerative phase of multiple sclerosis.
Topics: Aspartic Acid; Axons; Biomarkers; Cytoskeletal Proteins; Humans; Multiple Sclerosis; Nerve Degeneration | 2003 |
Imaging neuronal and axonal degeneration in multiple sclerosis.
Topics: Aspartic Acid; Atrophy; Axons; Brain; Humans; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Degeneration; Radiography | 2003 |
Biological markers in CSF and blood for axonal degeneration in multiple sclerosis.
Topics: 14-3-3 Proteins; Actins; Amyloid beta-Protein Precursor; Apolipoproteins E; Aspartic Acid; Axons; Biomarkers; Humans; Hydroxycholesterols; Multiple Sclerosis; Nerve Degeneration; Phosphopyruvate Hydratase; Predictive Value of Tests; tau Proteins; Tubulin | 2005 |
Canavan disease: from spongy degeneration to molecular analysis.
Topics: Age of Onset; Aspartic Acid; Brain; Canavan Disease; Child; Diagnosis, Differential; Humans; Jews; Magnetic Resonance Imaging; Male; Muscle Hypotonia; Nerve Degeneration; Prenatal Diagnosis; Survival Rate | 1995 |
Isoaspartate formation and neurodegeneration in Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Aspartic Acid; Blood Vessels; Brain; Cerebrovascular Circulation; Humans; In Vitro Techniques; Isomerism; Mice; Mice, Knockout; Molecular Sequence Data; Nerve Degeneration; Plaque, Amyloid; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; tau Proteins | 2000 |
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences.
Topics: Aspartic Acid; Atrophy; Axons; Brain; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Nerve Degeneration; Neurons | 2001 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases | 1991 |
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats | 1985 |
1 trial(s) available for aspartic acid and Nerve Degeneration
| Article | Year |
|---|---|
Mesial prefrontal cortex degeneration in amyotrophic lateral sclerosis: a high-field proton MR spectroscopy study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Female; Frontotemporal Lobar Degeneration; Gliosis; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Prefrontal Cortex; Protons | 2011 |
124 other study(ies) available for aspartic acid and Nerve Degeneration
| Article | Year |
|---|---|
Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent
Topics: Adult; Aged; Aspartic Acid; Axons; Brain; Female; Humans; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Young Adult | 2017 |
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Creatinine; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Magnetic Resonance Spectroscopy; Male; Mitochondria; Motor Activity; Motor Cortex; Nerve Degeneration; Neurologic Examination; Phenotype; Rats; Rats, Wistar; Spinal Cord; Time Factors | 2013 |
Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Nerve Fibers, Myelinated; Spinocerebellar Ataxias | 2014 |
Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Brain; Case-Control Studies; Cervical Cord; Disability Evaluation; Early Diagnosis; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Degeneration; Proton Magnetic Resonance Spectroscopy; Spinal Cord; White Matter; Young Adult | 2015 |
N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.
Topics: Acetyltransferases; Amidohydrolases; Animals; Aspartic Acid; Axons; Behavior, Animal; Canavan Disease; Enzyme Inhibitors; Female; Genotype; Gliosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Nerve Degeneration; Sphingolipids; Survival Analysis | 2015 |
Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study.
Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Cognitive Dysfunction; Cranial Irradiation; Female; Follow-Up Studies; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Prospective Studies; Quality of Life; Surveys and Questionnaires | 2017 |
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cell Death; Diffusion Magnetic Resonance Imaging; Disease Progression; Down-Regulation; Energy Metabolism; Female; Humans; Lactic Acid; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Stroke; Time Factors | 2008 |
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations.
Topics: Adenosine Triphosphatases; Adult; Aspartic Acid; Biomarkers; Choline; Cognition Disorders; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Nerve Degeneration; Protons; Spastic Paraplegia, Hereditary; Spastin | 2009 |
Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cation Transport Proteins; Deferoxamine; Ferritins; Glutamic Acid; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Iron; Iron Chelating Agents; L-Lactate Dehydrogenase; Lipid Peroxidation; Motor Neurons; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Spinal Cord | 2009 |
The neuropsychological and neuroradiological correlates of slowly progressive visual agnosia.
Topics: Agnosia; Aspartic Acid; Atrophy; Brain; Brain Mapping; Disease Progression; Energy Metabolism; Female; Fluorodeoxyglucose F18; Functional Laterality; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Occipital Lobe; Parietal Lobe; Positron-Emission Tomography; Temporal Lobe | 2009 |
Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis.
Topics: Amino Acids; Aspartic Acid; Axons; Biomarkers; Cohort Studies; Disease Progression; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Neurofilament Proteins; tau Proteins | 2009 |
Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales | 2009 |
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Immunohistochemistry; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Wallerian Degeneration | 2010 |
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Molecular Weight; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Nuclear Proteins; Phenotype; Protein Structure, Tertiary; Serine; Trinucleotide Repeat Expansion | 2009 |
Spinal cord repair in MS: does mitochondrial metabolism play a role?
Topics: Adult; Aspartic Acid; Axons; Cervical Vertebrae; Disease Progression; Female; Follow-Up Studies; Humans; Linear Models; Logistic Models; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors | 2010 |
The brake on neurodegeneration: Increased mitochondrial metabolism in the injured MS spinal cord.
Topics: Aspartic Acid; Cervical Vertebrae; Disease Progression; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mitochondria; Multiple Sclerosis; Nerve Degeneration; Organ Size; Reactive Oxygen Species; Spinal Cord; Time Factors | 2010 |
Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Membrane; Cytoplasm; Endoplasmic Reticulum; Erythropoietin; Nerve Degeneration; Neurons; Neuropil; Neuroprotective Agents; Organ Culture Techniques; Rats; Spinal Cord; Vacuoles | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Female; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Nerve Degeneration; Neural Pathways; Thalamus | 2011 |
Tau cleavage at D421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Caspase 3; Cells, Cultured; Chlorocebus aethiops; Enzyme Induction; Herpes Simplex; Herpesvirus 1, Human; Mice; Nerve Degeneration; Neurons; tau Proteins; Vero Cells | 2011 |
GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure.
Topics: Adenosine Diphosphate; Adult; Age of Onset; Aged; Algorithms; Aspartic Acid; Brain Chemistry; Choline; Creatine; DNA; Energy Metabolism; Female; Glucosylceramidase; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Membranes; Middle Aged; Mitochondria; Nerve Degeneration; Neurons; Parkinson Disease; Phospholipids; Software | 2012 |
[The neurodegenerative process in multiple sclerosis and the possible neuroprotective effect of treatment with Β-interferon 1a (avonex)].
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Creatine; Female; Humans; Interferon beta-1a; Interferon-beta; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Neuroprotective Agents; Neuropsychological Tests; Retrospective Studies; Young Adult | 2012 |
Glutamate transporters and retinal excitotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Glutamic Acid; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; Retina | 2002 |
Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Mapping; Catalepsy; Cell Count; Coloring Agents; Locomotion; Male; Malonates; Muscle Rigidity; Nerve Degeneration; Neurons; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2002 |
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Progression; Female; Gliosis; Humans; Infant; Inositol; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Radiography | 2003 |
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.
Topics: Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Cell Death; Cell Survival; Cerebellar Diseases; Disease Models, Animal; Glyburide; Ischemic Preconditioning; Isoflurane; Male; Nerve Degeneration; Organ Culture Techniques; Organophosphonates; Potassium Channel Blockers; Purkinje Cells; Rats; Rats, Sprague-Dawley | 2003 |
Thalamic neurodegeneration in relapsing-remitting multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Body Water; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Nuclear Magnetic Resonance, Biomolecular; Thalamus | 2003 |
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis | 2003 |
N-acetyl aspartate estimation: a potential method for determining neuronal loss in the transmissible spongiform encephalopathies.
Topics: Animals; Aspartic Acid; Cell Count; Chromatography, High Pressure Liquid; Hippocampus; Magnetic Resonance Spectroscopy; Mice; Models, Animal; Nerve Degeneration; Neurons; Scrapie | 2003 |
Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate.
Topics: Animals; Aspartic Acid; Cell Count; Cell Death; Dipeptides; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neuropeptides; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Chronic Disease; Dominance, Cerebral; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Psychiatric Status Rating Scales; Reference Values; Schizophrenia; Thalamus | 2003 |
In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Cataplexy; Creatine; Female; Humans; Hypothalamus; Intracellular Signaling Peptides and Proteins; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Narcolepsy; Nerve Degeneration; Neurons; Neuropeptides; Orexins; Polysomnography | 2004 |
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Coma; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Occipital Lobe; Parietal Lobe; Predictive Value of Tests; Recovery of Function; Up-Regulation | 2004 |
Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease.
Topics: Adoptive Transfer; Animals; Aspartic Acid; Cell Count; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Glatiramer Acetate; Immunization; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Microglia; MPTP Poisoning; Myelin Basic Protein; Nerve Degeneration; Nerve Tissue Proteins; Ovalbumin; Parkinsonian Disorders; Peptides; Substantia Nigra; T-Lymphocyte Subsets; Tyrosine 3-Monooxygenase | 2005 |
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; beta-Adrenergic Receptor Kinases; Brain; Central Nervous System; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dopamine; Drosophila; Drosophila Proteins; G-Protein-Coupled Receptor Kinase 2; Inclusion Bodies; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Point Mutation; Retina; Serine; Synucleins | 2005 |
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; Brain Ischemia; Cell Death; Cell Survival; Chromatography, High Pressure Liquid; Clonidine; Glutamic Acid; Heart Rate; Hyperglycemia; Lactic Acid; Male; Nerve Degeneration; Prosencephalon; Rats; Rats, Sprague-Dawley; Visual Fields | 2005 |
Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients.
Topics: Adolescent; Adult; Age Factors; Aspartic Acid; Bipolar Disorder; Child; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Phosphocreatine; Prefrontal Cortex; Recurrence | 2005 |
The Purkinje cell degeneration 5J mutation is a single amino acid insertion that destabilizes Nna1 protein.
Topics: Alleles; Amino Acid Sequence; Animals; Aspartic Acid; Cell Line; Cerebellum; GTP-Binding Proteins; Humans; Male; Mice; Molecular Sequence Data; Mutation; Nerve Degeneration; Purkinje Cells; Retina; RNA, Messenger; Serine-Type D-Ala-D-Ala Carboxypeptidase | 2006 |
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.
Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Up-Regulation | 2006 |
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspartic Acid; Binding Sites; Caspase 3; Caspases; Cerebral Cortex; Epitopes; Female; Humans; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Peptide Hydrolases; Phosphorylation; Serine; tau Proteins | 2006 |
The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cell Death; Energy Metabolism; Excitatory Amino Acids; Exocytosis; Extracellular Fluid; Glycolysis; Hippocampus; Male; Microdialysis; Nerve Degeneration; Nitrobenzoates; Phloretin; Rats; Rats, Wistar; Riluzole; Stilbenes; Tamoxifen; Vesicular Glutamate Transport Proteins; Voltage-Dependent Anion Channels | 2006 |
Occipital proton magnetic resonance spectroscopy (1H-MRS) reveals normal metabolite concentrations in retinal visual field defects.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glaucoma; Humans; Macular Degeneration; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Occipital Lobe; Protons; Scotoma; Visual Fields | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Superoxide Dismutase; Time Factors | 2007 |
Exploring the neuroprotective effects of modafinil in a marmoset Parkinson model with immunohistochemistry, magnetic resonance imaging and spectroscopy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Benzhydryl Compounds; Biomarkers; Brain; Callithrix; Disease Models, Animal; Dopamine; Drug Administration Schedule; Immunohistochemistry; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Modafinil; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Phosphocreatine; Predictive Value of Tests; Reproducibility of Results; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase | 2008 |
Brain proton magnetic resonance spectroscopy and neuromuscular pathology in a patient with GM1 gangliosidosis.
Topics: Aspartic Acid; Axons; Biomarkers; Brain; Female; Gangliosidosis, GM1; Gliosis; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Microcirculation; Muscle, Smooth, Vascular; Nerve Degeneration; Nerve Fibers, Myelinated; Neuroglia; Oligosaccharides; Predictive Value of Tests; Schwann Cells; Sensitivity and Specificity | 2008 |
AMPA-induced dark cell degeneration is associated with activation of caspases in pyramidal neurons of the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Caspases; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Nerve Degeneration; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2008 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; Choline; Creatine; Disease Progression; Energy Metabolism; Glycolysis; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Nerve Degeneration; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Investigations into the mechanism of excitant amino acid cytotoxicity using a well-characterized glutamatergic system.
Topics: Animals; Aspartic Acid; Concanavalin A; Cysteine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Grasshoppers; Kainic Acid; Nerve Degeneration; Neuromuscular Junction; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Cell Surface; Receptors, Glutamate; Synaptic Transmission | 1983 |
Oral glutamate loading in disorders with spinocerebellar and extrapyramidal involvement: effect on plasma glutamate, aspartate and taurine.
Topics: Aspartic Acid; Atrophy; Basal Ganglia Diseases; Cerebellar Diseases; Cerebellum; Friedreich Ataxia; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Nerve Degeneration; Olivary Nucleus; Parkinson Disease; Pons; Shy-Drager Syndrome; Sodium Glutamate; Spinal Cord Diseases; Taurine | 1983 |
Studies of effects of kainic acid lesions in the dorsal lateral geniculate nucleus of rat.
Topics: Animals; Aspartic Acid; Autoradiography; Axonal Transport; Evoked Potentials, Visual; Female; Geniculate Bodies; Kainic Acid; Microscopy, Fluorescence; Nerve Degeneration; Nerve Fibers; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Superior Colliculi; Synaptic Transmission; Visual Cortex; Visual Pathways | 1982 |
Aspartate and not glutamate is the likely transmitter of the rat lateral olfactory tract fibres.
Topics: Animals; Aspartic Acid; Central Nervous System; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Nerve Degeneration; Nerve Fibers; Olfactory Bulb; Olfactory Pathways; Rats; Synapses; Synaptic Transmission; Taurine | 1981 |
Central nervous system trans-synaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Axons; Creatine; Female; Geniculate Bodies; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron; Nerve Degeneration; Optic Nerve; Optic Nerve Injuries; Protons; Superior Colliculi; Synapses | 1995 |
Evidence for a glutamatergic pathway from the guinea pig auditory cortex to the inferior colliculus.
Topics: Aspartic Acid; Auditory Cortex; Calcium; Carbon Radioisotopes; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inferior Colliculi; Male; Nerve Degeneration; Nerve Fibers; Neural Pathways; Tritium | 1995 |
Racemization: its biological significance on neuropathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Biopolymers; Brain; Humans; Isomerism; Microscopy, Electron; Molecular Sequence Data; Nerve Degeneration; Nerve Tissue Proteins; Peptide Fragments; Protein Binding; Solubility; Spectrometry, Fluorescence; Stereoisomerism | 1994 |
Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism.
Topics: Aged; Aspartic Acid; Brain; Brain Ischemia; Brain Mapping; Energy Metabolism; Female; Humans; Intracranial Arteriosclerosis; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Parkinson Disease; Regional Blood Flow | 1994 |
In vivo proton magnetic resonance spectroscopy of the brain in a patient with L-2-hydroxyglutaric acidemia.
Topics: Adolescent; Aspartic Acid; Biomarkers; Brain; Female; Glutarates; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolism, Inborn Errors; Nerve Degeneration | 1994 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1993 |
Neuronal dysfunction in patients with closed head injury evaluated by in vivo 1H magnetic resonance spectroscopy.
Topics: Algorithms; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Energy Metabolism; Glasgow Coma Scale; Head Injuries, Closed; Humans; Magnetic Resonance Spectroscopy; Nerve Degeneration; Prognosis; Reference Values | 1995 |
Proton magnetic resonance spectroscopic imaging in patients with cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Humans; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Nerve Degeneration; Protons; Severity of Illness Index | 1996 |
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Multienzyme Complexes; Nerve Degeneration; Neurochemistry; Neurotoxins; Oxidoreductases; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase | 1996 |
Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; gamma-Aminobutyric Acid; Ganglionectomy; Glutamic Acid; Glutamine; Glycine; Male; Nerve Degeneration; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Taurine; Vestibular Nuclei | 1996 |
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory.
Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission | 1996 |
Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Degeneration; Schizophrenia | 1996 |
Neurochemical architecture of the normal and degenerating rat retina.
Topics: Amino Acids; Animals; Antibody Specificity; Arginine; Aspartic Acid; Autoradiography; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; Nerve Degeneration; Neurotransmitter Agents; Photoreceptor Cells; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Taurine; Tritium | 1996 |
Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease.
Topics: Aged; Amino Acid Transport System X-AG; Aspartic Acid; ATP-Binding Cassette Transporters; Autopsy; Biological Transport; Biomarkers; Brain; Frontal Lobe; Humans; Nerve Degeneration; Neurofibrillary Tangles; Organ Specificity; Reference Values; Regression Analysis; Spectrin; Synaptophysin | 1996 |
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe | 1997 |
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar | 1997 |
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Parkinson Disease; Phosphocreatine; Protons; Supranuclear Palsy, Progressive; Tissue Distribution | 1997 |
Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1997 |
Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study.
Topics: Adult; Asparagine; Aspartic Acid; Codon; Creutzfeldt-Jakob Syndrome; Fatal Outcome; Female; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Point Mutation; Prions; Reference Values; Sleep Initiation and Maintenance Disorders; Thalamic Nuclei | 1997 |
Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve.
Topics: Animals; Aqueous Humor; Aspartic Acid; Cell Death; Chromatography, High Pressure Liquid; Glutamic Acid; Male; Nerve Crush; Nerve Degeneration; Nerve Fibers; Optic Nerve Diseases; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1998 |
Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired.
Topics: Animals; Antihypertensive Agents; Aspartic Acid; Biological Transport; Brain Chemistry; Corpus Striatum; Dicarboxylic Acids; Energy Metabolism; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neurotoxins; Neurotransmitter Uptake Inhibitors; Nitro Compounds; Propionates; Pyrrolidines; Rats; Rats, Wistar | 1999 |
Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.
Topics: Animals; Aspartic Acid; Astrocytes; bcl-2-Associated X Protein; Cell Death; Cell Division; Cell Nucleus; Cell Size; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Female; Genotype; Kainic Acid; Male; Mice; Motor Neurons; Nerve Degeneration; Paraquat; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Spinal Cord; Superoxides | 1999 |
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values | 1999 |
Neurotoxicity of glutamate at the concentration released upon spinal cord injury.
Topics: Animals; Aspartic Acid; Contusions; Glutamic Acid; Male; Microdialysis; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 1999 |
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
Topics: Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Blotting, Southern; Central Nervous System; Chromosome Mapping; Cloning, Molecular; Electroencephalography; Epilepsy, Absence; Gene Deletion; Genome; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Nerve Degeneration; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Tremor | 2000 |
Temporal changes of cerebral metabolites and striatal lesions in acute 3-nitropropionic acid intoxication in the rat.
Topics: Acetates; Animals; Aspartic Acid; Cerebrovascular Circulation; Corpus Striatum; Image Processing, Computer-Assisted; Male; Nerve Degeneration; Neurotoxins; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Basal Nucleus of Meynert; Calcium; Calcium Radioisotopes; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 2000 |
Influence of different anaesthetics on extracellular aminoacids in rat brain.
Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Wistar | 2000 |
Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis.
Topics: Aspartic Acid; Axons; Fingers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Motor Cortex; Movement; Multiple Sclerosis; Nerve Degeneration; Nerve Fibers, Myelinated; Neuronal Plasticity; Recovery of Function | 2000 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Hypothermia, Induced; Nerve Degeneration; Neural Inhibition; Neurons; Rats; Rats, Inbred SHR; Taurine | 2000 |
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Tritium | 2001 |
Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study.
Topics: Adult; Aspartic Acid; Brain; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nerve Degeneration; Time Factors | 2001 |
Neurologic course of congenital disorders of glycosylation.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Congenital Disorders of Glycosylation; Developmental Disabilities; Epilepsy; Female; Humans; Infant; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Neurologic Examination; Stroke | 2001 |
Ethanol pre-exposure suppresses HIV-1 glycoprotein 120-induced neuronal degeneration by abrogating endogenous glutamate/Ca2+-mediated neurotoxicity.
Topics: AIDS Dementia Complex; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Calcium; Drug Interactions; Ethanol; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; Immunohistochemistry; Interleukin-6; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 2001 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptides; Animals; Aspartic Acid; Chymotrypsin; Coloring Agents; Endopeptidases; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Acid; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; PC12 Cells; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Serine | 2001 |
Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Brain Injuries; Cell Membrane; Choline; Creatine; Cushing Syndrome; Drug Administration Schedule; Energy Metabolism; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neurons; Prednisone | 2001 |
In vivo cellular uptake of glutamate is impaired in the rat hippocampus during and after transient cerebral ischemia: a microdialysis extraction study.
Topics: Animals; Aspartic Acid; Brain Ischemia; Carrier Proteins; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission; Tritium | 2001 |
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Reference Values | 2001 |
N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve.
Topics: Age Factors; Animals; Aspartic Acid; Axons; Biomarkers; Cell Division; Dipeptides; Immunohistochemistry; Male; Myelin Proteins; Nerve Degeneration; Oligodendroglia; Optic Nerve; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Stem Cells | 2002 |
Effect of chronic bulbectomy on the depth distribution of amino acid transmitter candidates in rat olfactory cortex.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Denervation; gamma-Aminobutyric Acid; Glutamates; Glutamine; Glycine; Interneurons; Nerve Degeneration; Neurotransmitter Agents; Olfactory Bulb; Olfactory Pathways; Rats; Taurine | 1979 |
Glutamic acid and aspartic acid in the cochlear nucleus of the waltzing guinea pig.
Topics: Age Factors; Animals; Aspartic Acid; Choline O-Acetyltransferase; Cochlear Nerve; Glutamate Decarboxylase; Glutamates; Guinea Pigs; Hair Cells, Auditory; Mechanoreceptors; Nerve Degeneration | 1978 |
Release of endogenous glutamic acid, aspartic acid and GABA from cochlear nucleus slices.
Topics: Animals; Aspartic Acid; Calcium; Cochlear Nerve; Female; gamma-Aminobutyric Acid; Glutamates; Guinea Pigs; Nerve Degeneration; Potassium | 1979 |
1H and 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Child; Creatine; Demyelinating Diseases; Humans; Hydrogen; Magnetic Resonance Imaging; Nerve Degeneration; Neurons; Phosphorus Isotopes | 1992 |
Quantification of N-acetyl-L-aspartic acid in urine by isotope dilution gas chromatography-mass spectrometry.
Topics: Aspartic Acid; Central Nervous System Diseases; Child; Child, Preschool; Gas Chromatography-Mass Spectrometry; Humans; Infant; Nerve Degeneration; Syndrome | 1992 |
A radiometric assay for aspartoacylase activity in human fibroblasts: application for the diagnosis of Canavan's disease.
Topics: Acetates; Amidohydrolases; Aspartic Acid; Cells, Cultured; Clinical Enzyme Tests; Diffuse Cerebral Sclerosis of Schilder; Fibroblasts; Heterozygote; Humans; Kinetics; Nerve Degeneration; Radiometry; Spectrophotometry; Tritium | 1991 |
Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; Muscle Proteins; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Oxazoles; Parvalbumins; Somatostatin | 1990 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex | 1990 |
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glucose; Lipid Peroxidation; Lipid Peroxides; Membrane Potentials; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Pregnatrienes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
N-acetylaspartic aciduria in Canavan disease: another proof in two infants.
Topics: Amidohydrolases; Aspartic Acid; Biopsy; Brain Diseases, Metabolic; Diffuse Cerebral Sclerosis of Schilder; Frontal Lobe; Humans; Infant; Male; Muscle Hypotonia; Nerve Degeneration | 1990 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Canavan disease and N-acetylaspartic aciduria.
Topics: Aspartic Acid; Humans; Nerve Degeneration; Nervous System Diseases | 1989 |
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity.
Topics: Air Pressure; Animals; Animals, Newborn; Aspartic Acid; Atmospheric Pressure; Brain; Brain Ischemia; Disease Susceptibility; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains | 1989 |
Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat.
Topics: Animals; Aspartic Acid; Basal Ganglia; Behavior, Animal; Cholinergic Fibers; Discrimination Learning; Emotions; Male; Memory; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains; Somatosensory Cortex | 1989 |
Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease.
Topics: Amidohydrolases; Aspartic Acid; Central Nervous System Diseases; Genes, Recessive; Humans; Metabolism, Inborn Errors; Nerve Degeneration | 1989 |
Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Glutamates; Humans; Hypoxia, Brain; Infant; N-Methylaspartate; Nerve Degeneration; Neurotransmitter Agents; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1985 |
"Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Hippocampus; Immunoenzyme Techniques; Injections, Intraventricular; Male; Motor Activity; Nerve Degeneration; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Nerve Degeneration; Neural Pathways; Neurons, Afferent; Spinal Cord; Spinal Nerve Roots | 1986 |
Glutamatergic denervation in Alzheimer's disease--a cautionary note.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Nerve Degeneration | 1987 |
AMPA is a powerful neurotoxin in the chicken retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Ibotenic Acid; Injections; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Oxadiazoles; Oxazoles; Quisqualic Acid; Retina; Retinal Ganglion Cells; Vitreous Body | 1987 |
Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Cytotoxic properties of glutamate and aspartate in rat peripheral nerves: histological findings.
Topics: Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Sciatic Nerve | 1987 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellum; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats | 1987 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship | 1986 |
Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains | 1987 |
Amino acid neurotoxicity: intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cell Nucleus; Cerebellum; Golgi Apparatus; In Vitro Techniques; Microscopy, Electron; N-Methylaspartate; Nerve Degeneration; Organoids; Rats | 1986 |
Modification of ultrastructural and neurochemical parameters in synaptosomes of the retino-deprived goldfish optic tectum.
Topics: Acetylcholine; Animals; Aspartic Acid; Choline; Functional Laterality; Goldfish; Microscopy, Electron; Nerve Degeneration; Nerve Endings; Retina; Sensory Deprivation; Superior Colliculi; Synaptosomes | 1986 |
Decreased uptake and release of D-aspartate in the guinea pig spinal cord after partial cordotomy.
Topics: Animals; Aspartic Acid; Biological Transport; gamma-Aminobutyric Acid; Guinea Pigs; Nerve Degeneration; Spinal Cord; Spinal Cord Injuries | 1985 |
Brain-damaging potential of protein hydrolysates.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Damage, Chronic; Caseins; Fibrin; Glutamates; Humans; Hypothalamus; Injections, Subcutaneous; Mice; Nerve Degeneration; Parenteral Nutrition; Protein Hydrolysates; Sulfonic Acids | 1973 |
Effect of dorsal root section on amino acids of rat spinal cord.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Centrifugation, Density Gradient; Glutamates; Glutamine; Glycine; Lumbosacral Region; Lysine; Male; Mitochondria; Myelin Sheath; Nerve Degeneration; Nerve Endings; Nerve Tissue Proteins; Rats; Serine; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission; Tritium | 1974 |
Effect of degeneration of sympathetic ganglion cells on amino acid metabolism in cervical ganglion from the rat.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Paper; DNA; Ganglia, Autonomic; Ganglia, Spinal; Glucose; Glutamates; Nerve Degeneration; Rats; RNA; Schwann Cells; Sympathectomy | 1968 |
Effects of changes in cellular composition following neuronal degeneration on amino acids in brain.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Carbon Isotopes; Denervation; Geniculate Bodies; Glutamates; Glutamine; Male; Nerve Degeneration; Ophthalmologic Surgical Procedures; Rabbits; Visual Cortex | 1968 |