aspartic acid has been researched along with Neoplasm Metastasis in 34 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-two patients with advanced malignant melanoma were entered in a pilot study receiving combination chemotherapy with PALA, vindesine, and cisplatin (PVP)." | 7.67 | PALA, vindesine, and cisplatin combination chemotherapy in advanced malignant melanoma. A pilot study. ( Kleeberg, UR; Voigt, H, 1984) |
| "Peritumoral N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, Cho/NAA and rCBV significantly differentiated glioblastomas from intracranial metastases." | 3.78 | Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. ( Fezoulidis, I; Fountas, K; Kapsalaki, E; Kousi, E; Svolos, P; Theodorou, K; Tsougos, I, 2012) |
| " MRS (two patients with medulloblastoma and one with a SPNET), showed elevated choline, decreased N-acetyl aspartate, and a small taurine peak in all three patients." | 3.74 | Paediatric PNET: pre-surgical MRI features. ( Chawla, A; Emmanuel, JV; Lim, CC; Lou, J; Seow, WT; Teo, HE, 2007) |
| "Twenty-two patients with advanced malignant melanoma were entered in a pilot study receiving combination chemotherapy with PALA, vindesine, and cisplatin (PVP)." | 3.67 | PALA, vindesine, and cisplatin combination chemotherapy in advanced malignant melanoma. A pilot study. ( Kleeberg, UR; Voigt, H, 1984) |
| "Sixty-three patients with Stage IV breast carcinoma refractory to standard combination chemotherapy agents such as 5-fluorouracil (5-FU) were entered into a study to determine the efficacy of a multiple dose schedule of N-(phosphonacetyl)-L-aspartic acid (PALA) and whether the addition of PALA improves the therapeutic efficacy of 5-FU." | 2.66 | A comparative study of PALA, PALA plus 5-FU, and 5-FU in advanced breast cancer. ( Buzdar, AU; Hortobagyi, GN; Mann, GB; Valdivieso, M; Yap, HY, 1985) |
| "necrosis in patients with primary brain tumors or brain metastasis." | 2.53 | Differentiating Radiation-Induced Necrosis from Recurrent Brain Tumor Using MR Perfusion and Spectroscopy: A Meta-Analysis. ( Chen, YC; Chuang, MT; Liu, YS; Tsai, YS; Wang, CK, 2016) |
| "The Y1235D mutation identified in metastases was shown to induce constitutive activation and a motile-invasive phenotype on transduced carcinoma cells." | 1.33 | Regulation of the wild-type and Y1235D mutant Met kinase activation. ( Cristiani, C; Isacchi, A; Kalisz, HM; Knapp, S; Perego, R; Rusconi, L; Schiering, N, 2005) |
| "Bone metastasis, clinical T-stage, tumor grade, and serum prostate-specific antigen (PSA) have been shown to have prognostic importance in the outcome of prostate cancer." | 1.31 | Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7. ( Costa, S; Ferreira, P; Lopes, C; Medeiros, RM; Morais, A; Oliveira, J; Pinto, D; Vasconcelos, A, 2002) |
| "Once positive the circulating tumor cells persisted in subsequent multiple blood samples." | 1.31 | K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells. ( Krygier, S; Luchtefeld, MA; Senagore, AJ; Thebo, JS, 2001) |
| "Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy." | 1.29 | Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives. ( Calabrese, G; Falini, A; Lipari, S; Losa, M; Origgi, D; Scotti, G; Triulzi, F, 1996) |
| " Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures." | 1.27 | Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer. ( Camacho, FJ; Engstrom, PF; Green, MD; Greenwald, ES; Kaplan, BH; Muggia, FM; Wernz, JC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 12 (35.29) | 29.6817 |
| 2010's | 6 (17.65) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, JP | 1 |
| Cui, CX | 1 |
| Wang, JC | 1 |
| Su, HW | 1 |
| Duan, CF | 1 |
| Liu, XJ | 1 |
| Bacci, M | 1 |
| Lorito, N | 1 |
| Ippolito, L | 1 |
| Ramazzotti, M | 1 |
| Luti, S | 1 |
| Romagnoli, S | 1 |
| Parri, M | 1 |
| Bianchini, F | 1 |
| Cappellesso, F | 1 |
| Virga, F | 1 |
| Gao, Q | 1 |
| Simões, BM | 1 |
| Marangoni, E | 1 |
| Martin, LA | 1 |
| Comito, G | 1 |
| Ferracin, M | 1 |
| Giannoni, E | 1 |
| Mazzone, M | 1 |
| Chiarugi, P | 1 |
| Morandi, A | 1 |
| Chuang, MT | 1 |
| Liu, YS | 1 |
| Tsai, YS | 1 |
| Chen, YC | 1 |
| Wang, CK | 1 |
| Graboń, W | 1 |
| Otto-Ślusarczyk, D | 1 |
| Chrzanowska, A | 1 |
| Mielczarek-Puta, M | 1 |
| Joniec-Maciejak, I | 1 |
| Słabik, K | 1 |
| Barańczyk-Kuźma, A | 1 |
| Normanno, N | 1 |
| Tejpar, S | 1 |
| Morgillo, F | 1 |
| De Luca, A | 1 |
| Van Cutsem, E | 1 |
| Ciardiello, F | 1 |
| Liu, X | 1 |
| Germin, BI | 1 |
| Zhong, J | 1 |
| Ekholm, S | 1 |
| Rachagani, S | 1 |
| Senapati, S | 1 |
| Chakraborty, S | 1 |
| Ponnusamy, MP | 1 |
| Kumar, S | 1 |
| Smith, LM | 1 |
| Jain, M | 1 |
| Batra, SK | 1 |
| Tsougos, I | 1 |
| Svolos, P | 1 |
| Kousi, E | 1 |
| Fountas, K | 1 |
| Theodorou, K | 1 |
| Fezoulidis, I | 1 |
| Kapsalaki, E | 1 |
| Medeiros, RM | 1 |
| Morais, A | 1 |
| Vasconcelos, A | 1 |
| Costa, S | 1 |
| Pinto, D | 1 |
| Oliveira, J | 1 |
| Ferreira, P | 1 |
| Lopes, C | 1 |
| Li, F | 2 |
| Yu, G | 2 |
| Li, S | 1 |
| Peng, S | 2 |
| Fu, J | 1 |
| Wu, D | 1 |
| Hwang, YH | 1 |
| Suh, CK | 1 |
| Park, SP | 1 |
| Whitehead, RP | 1 |
| Benedetti, JK | 1 |
| Abbruzzese, JL | 1 |
| Ardalan, B | 1 |
| Williamson, S | 1 |
| Gaynor, ER | 1 |
| Balcerzak, SP | 1 |
| Macdonald, JS | 1 |
| Ramponi, G | 1 |
| Cristiani, C | 1 |
| Rusconi, L | 1 |
| Perego, R | 1 |
| Schiering, N | 1 |
| Kalisz, HM | 1 |
| Knapp, S | 1 |
| Isacchi, A | 1 |
| Céspedes, MV | 1 |
| Sancho, FJ | 1 |
| Guerrero, S | 1 |
| Parreño, M | 1 |
| Casanova, I | 1 |
| Pavón, MA | 1 |
| Marcuello, E | 1 |
| Trias, M | 1 |
| Cascante, M | 1 |
| Capellà, G | 1 |
| Mangues, R | 1 |
| Chawla, A | 1 |
| Emmanuel, JV | 1 |
| Seow, WT | 1 |
| Lou, J | 1 |
| Teo, HE | 1 |
| Lim, CC | 1 |
| Xiong, XB | 1 |
| Mahmud, A | 1 |
| Uludağ, H | 1 |
| Lavasanifar, A | 1 |
| Paridaens, R | 1 |
| Mouridsen, HT | 1 |
| Palshof, T | 1 |
| Cocconi, G | 1 |
| Van Oosterom, A | 1 |
| Rotmensz, N | 1 |
| Sylvester, R | 1 |
| Heuson, JC | 1 |
| Rozencweig, M | 1 |
| Voigt, H | 1 |
| Kleeberg, UR | 1 |
| Rubin, J | 1 |
| Schutt, AJ | 1 |
| O'Connell, MJ | 1 |
| Gertz, MA | 1 |
| Moertel, CG | 2 |
| Muss, HB | 1 |
| Slavik, M | 1 |
| Bundy, B | 1 |
| Stehman, FB | 1 |
| Creasman, WT | 1 |
| Natale, RB | 1 |
| Yagoda, A | 1 |
| Kelsen, DP | 1 |
| Gralla, RJ | 1 |
| Watson, RC | 1 |
| Piedbois, P | 1 |
| Lévy, E | 1 |
| Le Bourgeois, JP | 1 |
| Buyse, M | 1 |
| Grem, JL | 1 |
| McAtee, N | 1 |
| Steinberg, SM | 1 |
| Hamilton, JM | 1 |
| Murphy, RF | 1 |
| Drake, J | 1 |
| Chisena, T | 1 |
| Balis, F | 1 |
| Cysyk, R | 1 |
| Arbuck, SG | 1 |
| Falini, A | 1 |
| Calabrese, G | 1 |
| Origgi, D | 1 |
| Lipari, S | 1 |
| Triulzi, F | 1 |
| Losa, M | 1 |
| Scotti, G | 1 |
| Thebo, JS | 1 |
| Senagore, AJ | 1 |
| Krygier, S | 1 |
| Luchtefeld, MA | 1 |
| Isoai, A | 1 |
| Ueno, Y | 1 |
| Giga-Hama, Y | 1 |
| Goto, H | 1 |
| Kumagai, H | 1 |
| Cillo, C | 2 |
| Ling, V | 2 |
| Hill, RP | 2 |
| Buroker, TR | 1 |
| Fleming, TR | 1 |
| Everson, LK | 1 |
| Cullinan, SA | 1 |
| Krook, JE | 1 |
| Mailliard, JA | 1 |
| Marschke, RF | 1 |
| Klaassen, DJ | 1 |
| Laurie, JA | 1 |
| Dick, JE | 1 |
| Muggia, FM | 1 |
| Camacho, FJ | 1 |
| Kaplan, BH | 1 |
| Green, MD | 1 |
| Greenwald, ES | 1 |
| Wernz, JC | 1 |
| Engstrom, PF | 1 |
| Mann, GB | 1 |
| Hortobagyi, GN | 1 |
| Buzdar, AU | 1 |
| Yap, HY | 1 |
| Valdivieso, M | 1 |
| Nieper, A | 1 |
3 reviews available for aspartic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Differentiating Radiation-Induced Necrosis from Recurrent Brain Tumor Using MR Perfusion and Spectroscopy: A Meta-Analysis.
Topics: Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Hum | 2016 |
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani | 2009 |
[Chemotherapy of metastasizing cancers of the colon and rectum].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neopla | 1993 |
4 trials available for aspartic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
A phase II pilot study of high-dose 24-hour continuous infusion of 5-FU and leucovorin and low-dose PALA for patients with colorectal cancer: a Southwest Oncology Group study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Do | 2004 |
A phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N-(phosphonacetyl)-L-aspartate in metastatic gastrointestinal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1993 |
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluat | 1985 |
A comparative study of PALA, PALA plus 5-FU, and 5-FU in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Breast Neoplasms; Female | 1985 |
27 other studies available for aspartic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Multimodal MR Features of 8 Cases of Epithelioid Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Diffusi | 2020 |
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.
Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Aspartic Acid; Breast | 2019 |
Lactate Formation in Primary and Metastatic Colon Cancer Cells at Hypoxia and Normoxia.
Topics: Aspartate Aminotransferases; Aspartic Acid; Cell Count; Cell Hypoxia; Cell Line, Tumor; Colonic Neop | 2016 |
N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Diagn | 2010 |
Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.
Topics: Adenocarcinoma; Amino Acid Substitution; Animals; Aspartic Acid; Cadherins; Down-Regulation; Gene Ex | 2011 |
Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, D | 2012 |
Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7.
Topics: Aged; Aspartic Acid; Bone Neoplasms; Disease Progression; Exons; Genotype; Glutamic Acid; Humans; Lo | 2002 |
[An antimetastatic study of Arg-Asp (RD) on salivary adenoid cystic carcinoma in vivo].
Topics: Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Carcinoma, Adenoid Cystic; Dose-Response Re | 2002 |
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain | 2003 |
Low molecular weight protein tyrosine phosphatase: catalytic mechanism and physiologic function.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Cysteine; Mice; Molecular Weight; Mutagenesis | 2004 |
Regulation of the wild-type and Y1235D mutant Met kinase activation.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Carbazoles; Enzyme Inhibitors; Gene Silencing; | 2005 |
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
Topics: Animals; Apoptosis; Aspartic Acid; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Nud | 2006 |
Paediatric PNET: pre-surgical MRI features.
Topics: Aspartic Acid; Cerebrospinal Fluid; Child; Child, Preschool; Choline; Creatine; Databases, Factual; | 2007 |
Conjugation of arginine-glycine-aspartic acid peptides to poly(ethylene oxide)-b-poly(epsilon-caprolactone) micelles for enhanced intracellular drug delivery to metastatic tumor cells.
Topics: Aldehydes; Arginine; Aspartic Acid; Cell Line, Tumor; Drug Delivery Systems; Glycine; Humans; Lacton | 2007 |
N-(phosphonacetyl)-L-aspartate (PALA) in advanced breast cancer: a phase II trial of the EORTC breast cancer cooperative group.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Breast Neoplasms; Digestive System; Dru | 1982 |
PALA, vindesine, and cisplatin combination chemotherapy in advanced malignant melanoma. A pilot study.
Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bone Marrow; C | 1984 |
A phase II study of the combination, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and N-(phosphonacetyl)-L-aspartate (PALA), in patients with advanced large bowel cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carmusti | 1984 |
A phase II study of PALA (NSC 224131) in patients with advanced ovarian carcinoma. A Gynecologic Oncology Group study.
Topics: Adult; Aged; Aspartic Acid; Blood Cell Count; Drug Evaluation; Female; Humans; Middle Aged; Neoplasm | 1984 |
Phase II trial of PALA in hypernephroma and urinary bladder cancer.
Topics: Adenocarcinoma; Aspartic Acid; Drug Evaluation; Humans; Kidney Neoplasms; Neoplasm Metastasis; Organ | 1982 |
Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives.
Topics: Adenoma; Aspartic Acid; Brain Neoplasms; Choline; Craniopharyngioma; Creatinine; Glioma; Humans; Lym | 1996 |
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
Topics: Aspartic Acid; Colorectal Neoplasms; Disease Progression; DNA Mutational Analysis; Genes, ras; Glyci | 2001 |
[Antimetastatic effects of arginine-aspartate on salivary adenoid cystic carcinoma in vitro].
Topics: Antineoplastic Agents; Arginine; Aspartic Acid; Carcinoma, Adenoid Cystic; Cell Adhesion; Extracellu | 2001 |
A novel Arg-Gly-Asp containing peptide specific for platelet aggregation and its effect on tumor metastasis: a possible mechanism of RGD peptide-mediated inhibition of tumor metastasis.
Topics: Animals; Anticarcinogenic Agents; Arginine; Aspartic Acid; Carcinoma, Squamous Cell; Cell Adhesion; | 1992 |
Drug resistance in KHT fibrosarcoma cell lines with different metastatic ability.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line; Drug Resistance; Fibrosarcoma; Gene Amplif | 1989 |
Generation of drug-resistant variants in metastatic B16 mouse melanoma cell lines.
Topics: Animals; Aspartic Acid; Cell Line; Drug Resistance; Gene Amplification; Mathematics; Melanoma; Metho | 1987 |
Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Central Nervous System D | 1987 |
Recalcification of bone metastases by calcium diorotate.
Topics: Adult; Aspartic Acid; Biological Transport, Active; Bone and Bones; Bone Neoplasms; Breast Neoplasms | 1970 |