aspartic acid has been researched along with Narcolepsy in 7 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " As neuronal loss and gliosis have been described in narcolepsy, metabolites of primary interest are N-acetylaspartate (NAA), a marker of neuronal integrity and myo-Inositol (ml), a glial marker and second messenger involved in the regulation of intracellular calcium." | 3.75 | Evidence for metabolic hypothalamo-amygdala dysfunction in narcolepsy. ( Bassetti, CL; Boesiger, P; Dydak, U; Khatami, R; Meier, D; Poryazova, R; Schnepf, B; Werth, E, 2009) |
| "Most cases of the narcoleptic syndrome are considered to be idiopathic because no structural lesion is detectable, although some cases of secondary narcolepsy are known to be associated with no structural brainstem lesions." | 2.69 | Proton spectroscopy in the narcoleptic syndrome. Is there evidence of a brainstem lesion? ( Ellis, CM; Lemmens, G; Parkes, JD; Simmons, A; Williams, SC, 1998) |
| "Narcolepsy has been linked to a loss of hypothalamic neurons producing hypocretins, neuropeptides implicated in the regulation of the arousal system." | 1.35 | Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy: An in vivo brain proton MR spectroscopy study. ( Barbiroli, B; Franceschini, C; Lodi, R; Manners, DN; Mignot, E; Montagna, P; Mostacci, B; Plazzi, G; Poli, F; Testa, C; Tonon, C, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tonon, C | 3 |
| Franceschini, C | 1 |
| Testa, C | 1 |
| Manners, DN | 1 |
| Poli, F | 1 |
| Mostacci, B | 1 |
| Mignot, E | 2 |
| Montagna, P | 3 |
| Barbiroli, B | 3 |
| Lodi, R | 3 |
| Plazzi, G | 3 |
| Picchioni, D | 1 |
| Poryazova, R | 1 |
| Schnepf, B | 1 |
| Werth, E | 1 |
| Khatami, R | 1 |
| Dydak, U | 1 |
| Meier, D | 1 |
| Boesiger, P | 1 |
| Bassetti, CL | 1 |
| Vignatelli, L | 1 |
| Iotti, S | 1 |
| Parmeggiani, A | 1 |
| Lin, L | 1 |
| Scano, MC | 1 |
| Posar, A | 1 |
| Bernardi, F | 1 |
| Cicognani, A | 1 |
| Ellis, CM | 1 |
| Simmons, A | 1 |
| Lemmens, G | 1 |
| Williams, SC | 1 |
| Parkes, JD | 2 |
| Fenton, G | 1 |
| Struthers, G | 1 |
| Curzon, G | 1 |
| Kantamaneni, BD | 1 |
| Buxton, BH | 1 |
| Record, C | 1 |
1 trial available for aspartic acid and Narcolepsy
| Article | Year |
|---|---|
Proton spectroscopy in the narcoleptic syndrome. Is there evidence of a brainstem lesion?
Topics: Adolescent; Adult; Aspartic Acid; Brain Diseases; Creatine; Female; Humans; Magnetic Resonance Spect | 1998 |
6 other studies available for aspartic acid and Narcolepsy
| Article | Year |
|---|---|
Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy: An in vivo brain proton MR spectroscopy study.
Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Cell Death; Female; Humans; Hypothalamus; Image Processi | 2009 |
Using magnetic resonance spectroscopy in narcolepsy to study the limbic mechanisms of cataplexy.
Topics: Amygdala; Aspartic Acid; Cataplexy; Energy Metabolism; Humans; Hypothalamus; Inositol; Magnetic Reso | 2009 |
Evidence for metabolic hypothalamo-amygdala dysfunction in narcolepsy.
Topics: Adult; Amygdala; Aspartic Acid; Cataplexy; Creatine; Dominance, Cerebral; Energy Metabolism; Female; | 2009 |
In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Cataplexy; Creatine; Female; Humans; Hypothalamus; | 2004 |
Narcolepsy-cataplexy associated with precocious puberty.
Topics: Aspartic Acid; Benzhydryl Compounds; Cataplexy; Child; Creatine; Cyclohexanols; Disorders of Excessi | 2006 |
Narcolepsy and cataplexy. Clinical features, treatment and cerebrospinal fluid findings.
Topics: Adult; Amphetamine; Aspartic Acid; Body Weight; Cataplexy; Cerebrospinal Fluid Proteins; Dextroamphe | 1974 |