aspartic acid has been researched along with Myocardial Ischemia in 25 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isoproterenol was injected subcutaneously (30 mg/kg BW, twice, at an interval of 24 hours) on the day 70 of the study, when plasma and erythrocyte Mg level in rats fed a low Mg diet were significantly decreased by 47% and 45% compared to intact animals." | 1.39 | [Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats]. ( Iezhitsa, IN; Kharitonova, MV; Pan'shin, NG; Smirnov, AV; Spasov, AA; Zheltova, AA, 2013) |
| "As the effects of ischemia or anoxia on glutamate and aspartate release from the heart appear to be comparable to those observed in the brain, it is proposed that the heart preparation may be a suitable model in which to study the ischemia-evoked release of these amino acids in the absence of complications arising from their depolarizing and excitotoxic actions on central neurons." | 1.29 | Release of the excitotoxic amino acids, glutamate and aspartate, from the isolated ischemic/anoxic rat heart. ( O'Regan, MH; Phillis, JW; Song, D, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Wang, YT | 1 |
| Miller, JH | 1 |
| Day, MM | 1 |
| Munger, JC | 1 |
| Brookes, PS | 1 |
| Zhao, JV | 1 |
| Kwok, MK | 1 |
| Schooling, CM | 1 |
| Kharitonova, MV | 1 |
| Zheltova, AA | 1 |
| Spasov, AA | 1 |
| Smirnov, AV | 1 |
| Pan'shin, NG | 1 |
| Iezhitsa, IN | 1 |
| Banke, NH | 1 |
| Lewandowski, ED | 2 |
| Jespersen, NR | 1 |
| Yokota, T | 1 |
| Støttrup, NB | 1 |
| Bergdahl, A | 1 |
| Paelestik, KB | 1 |
| Povlsen, JA | 1 |
| Dela, F | 1 |
| Bøtker, HE | 1 |
| Lu, M | 1 |
| Zhou, L | 2 |
| Stanley, WC | 2 |
| Cabrera, ME | 2 |
| Saidel, GM | 2 |
| Yu, X | 2 |
| Farzaneh-Far, R | 1 |
| Desir, GV | 1 |
| Na, B | 1 |
| Schiller, NB | 1 |
| Whooley, MA | 1 |
| Bäckström, T | 1 |
| Goiny, M | 1 |
| Lockowandt, U | 1 |
| Liska, J | 1 |
| Franco-Cereceda, A | 1 |
| Pisarenko, OI | 2 |
| Serebryakova, LI | 1 |
| Studneva, IM | 2 |
| Tskitishvili, OV | 1 |
| Tamemoto, H | 1 |
| Ishikawa, SE | 1 |
| Kawakami, M | 1 |
| Sumegi, B | 1 |
| Butwell, NB | 1 |
| Malloy, CR | 1 |
| Sherry, AD | 1 |
| Shulzhenko, VS | 1 |
| Kapelko, VI | 1 |
| Choong, YS | 1 |
| Gavin, JB | 1 |
| Cottier, DS | 1 |
| Buckberg, GD | 1 |
| Song, D | 1 |
| O'Regan, MH | 1 |
| Phillis, JW | 1 |
| Sett, SS | 1 |
| Tearle, H | 1 |
| LeBlanc, JG | 1 |
| Ghomeshi, HR | 1 |
| Tian, G | 1 |
| Ye, J | 1 |
| Sun, J | 1 |
| Hoffenberg, EF | 1 |
| Salerno, TA | 1 |
| Deslauriers, R | 1 |
| Schulz, R | 1 |
| Kappeler, C | 1 |
| Coenen, H | 1 |
| Bockisch, A | 1 |
| Heusch, G | 1 |
| Arsenian, M | 1 |
| O'Donnell, JM | 1 |
| White, LT | 1 |
| Talmud, PJ | 1 |
| Bujac, SR | 1 |
| Hall, S | 1 |
| Miller, GJ | 1 |
| Humphries, SE | 1 |
| Bar-Or, D | 1 |
| Curtis, G | 1 |
| Rao, N | 1 |
| Bampos, N | 1 |
| Lau, E | 1 |
| Khogali, SE | 1 |
| Pringle, SD | 1 |
| Weryk, BV | 1 |
| Rennie, MJ | 1 |
| Mizoguchi, K | 1 |
| Maeta, H | 1 |
| Yamamoto, A | 1 |
| Oe, M | 1 |
| Kosaka, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cardiac Mitochondrial Function After Heart Transplantation[NCT04105803] | 64 participants (Anticipated) | Observational | 2019-04-25 | Enrolling by invitation | |||
| Cardiac Mitochondrial Function in Explanted Human Hearts[NCT04500938] | 24 participants (Anticipated) | Observational | 2020-08-30 | Not yet recruiting | |||
| Oral Glutamine Reduces Myocardial Damage After Coronary Revascularization Under Cardiopulmonary Bypass[NCT02491931] | 28 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aspartic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Potential cardiovascular applications of glutamate, aspartate, and other amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Cardioplegic Solutions; Clinical Trials as Topic; Glutamic Acid | 1998 |
1 trial available for aspartic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Is glutamine beneficial in ischemic heart disease?
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aged; Angina Pectoris; Animals; | 2002 |
23 other studies available for aspartic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.
Topics: Animals; Aspartic Acid; Autophagy; Citric Acid Cycle; Electron Transport Complex II; Energy Metaboli | 2018 |
Effect of glutamate and aspartate on ischemic heart disease, blood pressure, and diabetes: a Mendelian randomization study.
Topics: Aspartic Acid; Blood Pressure; Diabetes Mellitus; Dietary Supplements; Female; Genome-Wide Associati | 2019 |
[Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats].
Topics: Animals; Aspartic Acid; Diet; Disease Models, Animal; Isoproterenol; Magnesium; Magnesium Chloride; | 2013 |
Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts.
Topics: Animals; Aspartic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Carrier Proteins; Citric Acid Cyc | 2015 |
Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Cell Respiration; Citric Acid Cycle | 2017 |
Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Cell Respiration; Citric Acid Cycle | 2017 |
Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Cell Respiration; Citric Acid Cycle | 2017 |
Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Cell Respiration; Citric Acid Cycle | 2017 |
Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.
Topics: Animals; Aspartic Acid; Computer Simulation; Coronary Circulation; Cytosol; Energy Metabolism; Glyco | 2008 |
A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study.
Topics: Aged; Aspartic Acid; Cardiomegaly; Female; Glutamic Acid; Humans; Male; Middle Aged; Monoamine Oxida | 2010 |
Cardiac outflow of amino acids and purines during myocardial ischemia and reperfusion.
Topics: Amino Acids; Animals; Aspartic Acid; Female; Guanosine; Hemodynamics; Hypoxanthine; Inosine; Male; M | 2003 |
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.
Topics: Animals; Aspartic Acid; Computer Simulation; Cytosol; Energy Metabolism; Glycolysis; Humans; Ischemi | 2005 |
Metabolic correction reduces the area of acute ischemic myocardial infarction in rats.
Topics: Animals; Aspartic Acid; Glucose; Male; Mannitol; Myocardial Infarction; Myocardial Ischemia; Myocard | 2006 |
Association of the Glu298Asp polymorphism of the eNOS Gene with ischemic heart disease in Japanese diabetic subjects.
Topics: Amino Acid Substitution; Aspartic Acid; Diabetic Angiopathies; DNA; Glutamic Acid; Glycated Hemoglob | 2008 |
Lipoamide influences substrate selection in post-ischaemic perfused rat hearts.
Topics: Acetates; Acetylation; Animals; Aspartic Acid; Binding, Competitive; Carbon Isotopes; Glutamates; Gl | 1994 |
Effects of gradual reperfusion on postischemic metabolism and functional recovery of isolated guinea pig heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Cardiac Output; En | 1993 |
Cardioplegic protection of hearts with pre-arrest ischaemic injury: effect of glucose, aspartate, and lactobionate.
Topics: Animals; Aspartic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Chlorides; Disacchar | 1995 |
Invited editorial on "effects of glutamate and aspartate on myocardial substrate oxidation during potassium arrest".
Topics: Animals; Aspartic Acid; Citric Acid Cycle; Confounding Factors, Epidemiologic; Glutamic Acid; Heart; | 1996 |
Release of the excitotoxic amino acids, glutamate and aspartate, from the isolated ischemic/anoxic rat heart.
Topics: Animals; Aspartic Acid; Brain; Excitatory Amino Acids; Glutamic Acid; Hypoglycemia; Hypoxia; Male; M | 1996 |
Effect of glutamate-aspartate reperfusion on postischemic neonatal myocardium.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cardioplegic Solutions; Disease Models, Animal; Glucose; G | 1997 |
Aspartate/glutamate-enriched blood does not improve myocardial energy metabolism during ischemia-reperfusion: a 31P magnetic resonance spectroscopic study in isolated pig hearts.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Cardioplegic Solutions; Chromatography, High Pressur | 1997 |
Positron emission tomography analysis of [1-(11)C] acetate kinetics in short-term hibernating myocardium.
Topics: Acetates; Animals; Aspartic Acid; Carbon Radioisotopes; Glutamic Acid; Myocardial Ischemia; Myocardi | 1998 |
Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischemic hearts.
Topics: Animals; Aspartic Acid; Biological Transport; Malates; Mitochondria, Heart; Myocardial Contraction; | 1999 |
Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers.
Topics: Asparagine; Aspartic Acid; Confidence Intervals; Genotype; Heterozygote; Humans; Lipoprotein Lipase; | 2000 |
Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia.
Topics: Alanine; Albumins; Aspartic Acid; Chromatography, Liquid; Cobalt; Histidine; Humans; Hydrogen-Ion Co | 2001 |
Amelioration of myocardial global ischemia/reperfusion injury with volume-regulatory chloride channel inhibitors in vivo.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Apoptosis; Aspartic Acid; Caspase 3; Casp | 2002 |