aspartic acid has been researched along with Movement Disorders in 19 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Canavan disease is a major point of focus for efforts to define NAA function, with available evidence suggesting NAA serves as an acetyl donor for fatty acid synthesis during myelination." | 1.43 | N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase. ( Bilaniuk, LT; De Vivo, DC; Francis, JS; Gray, SJ; Janson, CG; Leone, P; Markov, V; McCown, TJ; Samulski, RJ; Wang, DJ; Wojtas, I, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Scheidegger, MD | 1 |
| Gerber, V | 1 |
| Dolf, G | 1 |
| Burger, D | 1 |
| Flammer, SA | 1 |
| Ramseyer, A | 1 |
| Cirstea, CM | 2 |
| Lee, P | 2 |
| Craciunas, SC | 2 |
| Choi, IY | 2 |
| Burris, JE | 1 |
| Nudo, RJ | 2 |
| Francis, JS | 1 |
| Wojtas, I | 1 |
| Markov, V | 1 |
| Gray, SJ | 1 |
| McCown, TJ | 1 |
| Samulski, RJ | 1 |
| Bilaniuk, LT | 1 |
| Wang, DJ | 1 |
| De Vivo, DC | 1 |
| Janson, CG | 1 |
| Leone, P | 1 |
| Kim, DH | 1 |
| Gu, M | 1 |
| Cunningham, C | 1 |
| Chen, A | 1 |
| Baumer, F | 1 |
| Glenn, OA | 1 |
| Vigneron, DB | 1 |
| Spielman, DM | 1 |
| Barkovich, AJ | 1 |
| Brooks, WM | 1 |
| Popescu, EA | 1 |
| Yeh, HW | 1 |
| Savage, CR | 1 |
| Williams, JA | 1 |
| Barreiro, CJ | 1 |
| Nwakanma, LU | 1 |
| Lange, MS | 1 |
| Kratz, LE | 1 |
| Blue, ME | 1 |
| Berrong, J | 1 |
| Patel, ND | 1 |
| Gott, VL | 1 |
| Troncoso, JC | 1 |
| Johnston, MV | 1 |
| Baumgartner, WA | 1 |
| Aoyama, K | 1 |
| Matsumura, N | 1 |
| Watabe, M | 1 |
| Nakaki, T | 1 |
| Barkhatova, VP | 1 |
| Panteleeva, EA | 1 |
| Alferova, VP | 1 |
| Rebrova, OIu | 1 |
| Niiazbekova, AS | 1 |
| Zavalishin, IA | 1 |
| Chapman, A | 1 |
| Keane, PE | 1 |
| Meldrum, BS | 1 |
| Simiand, J | 1 |
| Vernieres, JC | 1 |
| Zelnik, N | 1 |
| Luder, AS | 1 |
| Elpeleg, ON | 1 |
| Gross-Tsur, V | 1 |
| Amir, N | 1 |
| Hemli, JA | 1 |
| Fattal, A | 1 |
| Harel, S | 1 |
| Taylor-Robinson, SD | 1 |
| Turjanski, N | 1 |
| Bhattacharya, S | 1 |
| Seery, JP | 1 |
| Sargentoni, J | 1 |
| Brooks, DJ | 1 |
| Bryant, DJ | 1 |
| Cox, IJ | 1 |
| Pouwels, PJ | 1 |
| Brockmann, K | 1 |
| Kruse, B | 1 |
| Wilken, B | 1 |
| Wick, M | 1 |
| Hanefeld, F | 1 |
| Frahm, J | 1 |
| Lee, MA | 2 |
| Blamire, AM | 3 |
| Pendlebury, S | 1 |
| Ho, KH | 1 |
| Mills, KR | 1 |
| Styles, P | 3 |
| Palace, J | 1 |
| Matthews, PM | 3 |
| Pineiro, R | 1 |
| Pendlebury, ST | 2 |
| Smith, S | 1 |
| Flitney, D | 1 |
| Meldrum, B | 1 |
| Turova, NF | 1 |
| Ermolina, LA | 1 |
| Baryshnikov, VA | 1 |
| Davidoff, RA | 1 |
| Graham, LT | 1 |
| Shank, RP | 1 |
| Werman, R | 1 |
| Aprison, MH | 1 |
| Schor, NA | 1 |
| Archer, K | 1 |
| Hartmann, HA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1/2, Open Label, Sequential Cohort Study of a Single Intracranial Dose of AVASPA Gene Therapy for Treatment of Children With Typical Canavan Disease[NCT04833907] | Phase 1/Phase 2 | 24 participants (Anticipated) | Interventional | 2021-04-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aspartic acid and Movement Disorders
| Article | Year |
|---|---|
Mechanism of anticonvulsant action of valproate.
Topics: Animals; Aspartic Acid; Cats; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Half-Life; | 1982 |
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; | 1985 |
17 other studies available for aspartic acid and Movement Disorders
| Article | Year |
|---|---|
Quantitative Gait Analysis Before and After a Cross-country Test in a Population of Elite Eventing Horses.
Topics: Animals; Aspartic Acid; Biomechanical Phenomena; Creatine Kinase; Forelimb; Gait Analysis; Head; Hor | 2022 |
Pre-therapy Neural State of Bilateral Motor and Premotor Cortices Predicts Therapy Gain After Subcortical Stroke: A Pilot Study.
Topics: Aspartic Acid; Biomarkers; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Mag | 2018 |
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
Topics: Amidohydrolases; Animals; Aspartic Acid; Autophagy-Related Proteins; Basic Helix-Loop-Helix Transcri | 2016 |
Fast 3D (1)H MRSI of the corticospinal tract in pediatric brain.
Topics: Aspartic Acid; Cerebral Cortex; Child, Preschool; Diffusion Magnetic Resonance Imaging; Feasibility | 2009 |
Motor and premotor cortices in subcortical stroke: proton magnetic resonance spectroscopy measures and arm motor impairment.
Topics: Adult; Aged; Aspartic Acid; Female; Functional Laterality; Humans; Imaging, Three-Dimensional; Magne | 2013 |
Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery.
Topics: Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Biomarkers; Brain; Brain Chemistry; Brain Damag | 2006 |
Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Aspartic Acid; Behavior, Animal; Cysteine; Dis | 2008 |
[Neurotransmission mechanism of movement disorders in multiple sclerosis].
Topics: Adolescent; Adult; Aspartic Acid; Disease Progression; Female; Glutamic Acid; Humans; Male; Middle A | 2007 |
Protracted clinical course for patients with Canavan disease.
Topics: Adolescent; Amidohydrolases; Aspartic Acid; Brain Diseases; Child; Child, Preschool; Female; Fibrobl | 1993 |
A proton magnetic resonance spectroscopy study of the striatum and cerebral cortex in Parkinson's disease.
Topics: Aged; Aspartic Acid; Cerebral Cortex; Choline; Corpus Striatum; Creatine; Female; Glutamic Acid; Glu | 1999 |
Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS.
Topics: Adolescent; Age Factors; Aspartic Acid; Basal Ganglia; Brain; Brain Neoplasms; Cerebellum; Child; Ch | 1999 |
Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Axons; Electric Stimulation; Female; Humans; Internal Capsule; Magnetic | 2000 |
Relating MRI changes to motor deficit after ischemic stroke by segmentation of functional motor pathways.
Topics: Adult; Aged; Aspartic Acid; Brain Ischemia; Disability Evaluation; Female; Humans; Internal Capsule; | 2000 |
Correlating magnetic resonance imaging markers of axonal injury and demyelination in motor impairment secondary to stroke and multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Axons; Female; Functional Laterality; Humans; Internal Capsule; Magnetic | 2000 |
[Characteristics of the amino acid spectrum of the blood of children with intellectual deficiency].
Topics: Amino Acids; Ammonia; Arginine; Aspartic Acid; Child; Female; Glutamates; Glutamic Acid; Humans; Int | 1986 |
Changes in amino acid concentrations associated with loss of spinal interneurons.
Topics: Aminobutyrates; Animals; Aorta, Thoracic; Aortic Valve Stenosis; Aspartic Acid; Cats; Freezing; Glut | 1967 |
Enzyme activities in the anterior horn of spinal cord after , -iminodipropionitrile.
Topics: Age Factors; Animals; Aspartate Aminotransferases; Aspartic Acid; Axons; Gluconates; Glucosephosphat | 1971 |