aspartic acid has been researched along with Motor Neuron Disease in 12 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In these patients spasticity began in the legs and progressed slowly and steadily." | 1.32 | Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes? ( Butman, JA; Floeter, MK; Pagan, F; Statland, J; Zhai, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nelles, M | 1 |
| Block, W | 2 |
| Träber, F | 2 |
| Wüllner, U | 1 |
| Schild, HH | 1 |
| Urbach, H | 1 |
| Bonanno, G | 1 |
| Fumagalli, E | 1 |
| Milanese, M | 1 |
| Zappettini, S | 1 |
| Mennini, T | 1 |
| Flacke, S | 1 |
| Jessen, F | 1 |
| Pohl, C | 1 |
| Schild, H | 1 |
| Zhai, P | 1 |
| Pagan, F | 1 |
| Statland, J | 1 |
| Butman, JA | 1 |
| Floeter, MK | 1 |
| Martyshkin, DV | 1 |
| Mirov, SB | 1 |
| Zhuang, YX | 1 |
| Crow, JP | 1 |
| Ermilov, V | 1 |
| Beckman, JS | 1 |
| Wang, S | 1 |
| Poptani, H | 1 |
| Woo, JH | 1 |
| Desiderio, LM | 1 |
| Elman, LB | 1 |
| McCluskey, LF | 1 |
| Krejza, J | 1 |
| Melhem, ER | 1 |
| Mitsumoto, H | 2 |
| Ulug, AM | 1 |
| Pullman, SL | 1 |
| Gooch, CL | 1 |
| Chan, S | 2 |
| Tang, MX | 1 |
| Mao, X | 1 |
| Hays, AP | 1 |
| Floyd, AG | 1 |
| Battista, V | 1 |
| Montes, J | 1 |
| Hayes, S | 1 |
| Dashnaw, S | 1 |
| Kaufmann, P | 1 |
| Gordon, PH | 1 |
| Hirsch, J | 1 |
| Levin, B | 1 |
| Rowland, LP | 2 |
| Shungu, DC | 2 |
| Khan, JK | 1 |
| Kuo, YH | 1 |
| Haque, A | 1 |
| Lambein, F | 1 |
| Shaw, PJ | 1 |
| Chinnery, RM | 1 |
| Ince, PG | 1 |
| Pioro, EP | 1 |
| Wang, Y | 1 |
| Moore, JK | 1 |
| Ng, TC | 1 |
| Trapp, BD | 1 |
| Klinkosz, B | 1 |
| Douglas-Akinwande, A | 1 |
| Lange, DJ | 1 |
| Schuff, N | 1 |
| Rooney, WD | 1 |
| Miller, R | 1 |
| Gelinas, DF | 1 |
| Amend, DL | 1 |
| Maudsley, AA | 1 |
| Weiner, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis[NCT00023075] | 55 participants | Observational | 2001-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for aspartic acid and Motor Neuron Disease
| Article | Year |
|---|---|
Combined 3T diffusion tensor tractography and 1H-MR spectroscopy in motor neuron disease.
Topics: Adult; Aged; Anisotropy; Aspartic Acid; Brain; Bulbo-Spinal Atrophy, X-Linked; Choline; Diagnosis, D | 2008 |
Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease.
Topics: Animals; Aspartic Acid; Cervical Vertebrae; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; M | 2009 |
In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Spectr | 2002 |
Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes?
Topics: Adult; Aspartic Acid; Atrophy; Brain Stem; Choline; Creatinine; Disease Progression; Evoked Potentia | 2003 |
Fluorescence assay for monitoring Zn-deficient superoxide dismutase in vitro.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Copper; Humans; Kinetics; Motor Neuron Disease; | 2003 |
Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T.
Topics: Adult; Age Factors; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion | 2006 |
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; | 2007 |
Inhibitory and excitatory amino acids in cerebrospinal fluid of neurolathyrism patients, a highly prevalent motorneurone disease.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Eating; Excitatory Amino Acids; Fabaceae; Glutamic | 1995 |
[3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Autoradiography; Femal | 1994 |
Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Axons; Caudate Nucleus; Creatine; Disease Mod | 1998 |
Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resona | 1999 |
Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Proce | 2001 |