aspartic acid has been researched along with Mitochondrial Diseases in 20 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Semiquantitative analysis of NAA relative to creatine-containing compounds (Cr) and choline (Cho) was carried out from proton spectra obtained by means of chemical shift (CS) imaging and single-voxel (SV) methods in 25 patients with severe traumatic brain injuries (TBIs) (Glasgow Coma Scale scores < or = 8) using a 1." | 5.13 | Assessment of mitochondrial impairment in traumatic brain injury using high-resolution proton magnetic resonance spectroscopy. ( Aygok, GA; Bullock, RM; Fatouros, PP; Marmarou, A; Portella, G; Signoretti, S, 2008) |
| "Patients with mitochondrial disorders offer a unique window through which we can begin to understand the association between psychiatric symptoms and mitochondrial dysfunction in vivo." | 1.38 | Psychiatric symptoms correlate with metabolic indices in the hippocampus and cingulate in patients with mitochondrial disorders. ( Anglin, RE; Mazurek, MF; Noseworthy, MD; Rosebush, PI; Tarnopolsky, M, 2012) |
| "Recently, the clinical spectrum of dominant optic atrophy has been extended to frequent syndromic forms, exhibiting various degrees of neurological and muscle impairments frequently found in mitochondrial diseases." | 1.38 | The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse. ( Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuda, M | 1 |
| Nagao, Y | 1 |
| Iannetti, EF | 1 |
| Smeitink, JAM | 1 |
| Willems, PHGM | 1 |
| Beyrath, J | 1 |
| Koopman, WJH | 1 |
| Takanashi, J | 1 |
| Nitta, N | 1 |
| Iwasaki, N | 1 |
| Saito, S | 1 |
| Tanaka, R | 1 |
| Barkovich, AJ | 1 |
| Aoki, I | 1 |
| Profilo, E | 1 |
| Peña-Altamira, LE | 1 |
| Corricelli, M | 1 |
| Castegna, A | 1 |
| Danese, A | 1 |
| Agrimi, G | 1 |
| Petralla, S | 1 |
| Giannuzzi, G | 1 |
| Porcelli, V | 1 |
| Sbano, L | 1 |
| Viscomi, C | 1 |
| Massenzio, F | 1 |
| Palmieri, EM | 1 |
| Giorgi, C | 1 |
| Fiermonte, G | 1 |
| Virgili, M | 1 |
| Palmieri, L | 1 |
| Zeviani, M | 1 |
| Pinton, P | 1 |
| Monti, B | 1 |
| Palmieri, F | 1 |
| Lasorsa, FM | 1 |
| Chandrashekar, KN | 1 |
| Aygok, GA | 3 |
| Marmarou, A | 3 |
| Fatouros, P | 2 |
| Kettenmann, B | 1 |
| Bullock, RM | 2 |
| Haller, RG | 1 |
| Vissing, J | 1 |
| Friedman, SD | 1 |
| Shaw, DW | 1 |
| Ishak, G | 1 |
| Gropman, AL | 1 |
| Saneto, RP | 1 |
| Quintanilla, RA | 1 |
| Dolan, PJ | 1 |
| Jin, YN | 1 |
| Johnson, GV | 1 |
| Anglin, RE | 1 |
| Rosebush, PI | 1 |
| Noseworthy, MD | 1 |
| Tarnopolsky, M | 1 |
| Mazurek, MF | 1 |
| Llorente-Folch, I | 1 |
| Sahún, I | 1 |
| Contreras, L | 1 |
| Casarejos, MJ | 1 |
| Grau, JM | 1 |
| Saheki, T | 1 |
| Mena, MA | 1 |
| Satrústegui, J | 1 |
| Dierssen, M | 1 |
| Pardo, B | 1 |
| Sarzi, E | 1 |
| Angebault, C | 1 |
| Seveno, M | 1 |
| Gueguen, N | 1 |
| Chaix, B | 1 |
| Bielicki, G | 1 |
| Boddaert, N | 1 |
| Mausset-Bonnefont, AL | 1 |
| Cazevieille, C | 1 |
| Rigau, V | 1 |
| Renou, JP | 1 |
| Wang, J | 1 |
| Delettre, C | 1 |
| Brabet, P | 1 |
| Puel, JL | 1 |
| Hamel, CP | 1 |
| Reynier, P | 1 |
| Lenaers, G | 1 |
| Haut, S | 1 |
| de Villemeur, TB | 1 |
| Brivet, M | 1 |
| Guiochon-Mantel, A | 1 |
| Boutron, A | 1 |
| Rustin, P | 1 |
| Legrand, A | 1 |
| Slama, A | 1 |
| Schweinsburg, BC | 1 |
| Taylor, MJ | 1 |
| Alhassoon, OM | 1 |
| Gonzalez, R | 1 |
| Brown, GG | 1 |
| Ellis, RJ | 1 |
| Letendre, S | 1 |
| Videen, JS | 1 |
| McCutchan, JA | 1 |
| Patterson, TL | 1 |
| Grant, I | 1 |
| Dinopoulos, A | 1 |
| Cecil, KM | 1 |
| Schapiro, MB | 1 |
| Papadimitriou, A | 1 |
| Hadjigeorgiou, GM | 1 |
| Wong, B | 1 |
| deGrauw, T | 1 |
| Egelhoff, JC | 1 |
| Signoretti, S | 2 |
| Bullock, R | 1 |
| Correia, C | 1 |
| Coutinho, AM | 1 |
| Diogo, L | 1 |
| Grazina, M | 1 |
| Marques, C | 1 |
| Miguel, T | 1 |
| Ataíde, A | 1 |
| Almeida, J | 1 |
| Borges, L | 1 |
| Oliveira, C | 1 |
| Oliveira, G | 1 |
| Vicente, AM | 1 |
| Vielhaber, S | 1 |
| Niessen, HG | 1 |
| Debska-Vielhaber, G | 1 |
| Kudin, AP | 1 |
| Wellmer, J | 1 |
| Kaufmann, J | 1 |
| Schönfeld, MA | 1 |
| Fendrich, R | 1 |
| Willker, W | 1 |
| Leibfritz, D | 1 |
| Schramm, J | 1 |
| Elger, CE | 1 |
| Heinze, HJ | 1 |
| Kunz, WS | 1 |
| Fatouros, PP | 1 |
| Portella, G | 1 |
| Bizzi, A | 1 |
| Castelli, G | 1 |
| Bugiani, M | 1 |
| Barker, PB | 1 |
| Herskovits, EH | 1 |
| Danesi, U | 1 |
| Erbetta, A | 1 |
| Moroni, I | 1 |
| Farina, L | 1 |
| Uziel, G | 1 |
1 review available for aspartic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
The use of neuroimaging in the diagnosis of mitochondrial disease.
Topics: Adenosine Triphosphate; Aspartic Acid; Brain; Child; Developmental Disabilities; Diagnosis, Differen | 2010 |
3 trials available for aspartic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Brain mitochondrial injury in human immunodeficiency virus-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitors.
Topics: Adult; Aspartic Acid; Brain; Cell Respiration; Didanosine; Female; HIV Infections; Humans; Lamivudin | 2005 |
Mitochondrial injury measured by proton magnetic resonance spectroscopy in severe head trauma patients.
Topics: Adult; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Choline; Craniocerebral Trauma; Creatine; F | 2005 |
Assessment of mitochondrial impairment in traumatic brain injury using high-resolution proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Brain Injuries; Choline; Creatine; Female; Follow-Up Studies; Huma | 2008 |
16 other studies available for aspartic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Dynamic derangement in amino acid profile during and after a stroke-like episode in adult-onset mitochondrial disease: a case report.
Topics: Arginine; Aspartic Acid; Biomarkers; Deafness; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Growth | 2019 |
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibr | 2018 |
Neurochemistry in shiverer mouse depicted on MR spectroscopy.
Topics: Amino Acid Transport Systems, Acidic; Analysis of Variance; Animals; Antiporters; Aspartic Acid; Bra | 2014 |
Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells.
Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Acidic; Antiporters; Aspartic Acid; Cell | 2017 |
D-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats.
Topics: Animals; Aspartic Acid; Biomarkers; Calcium Signaling; Dose-Response Relationship, Drug; Lipid Perox | 2010 |
Assessment of mitochondrial impairment and cerebral blood flow in severe brain injured patients.
Topics: Aspartic Acid; Blood Flow Velocity; Brain Injuries; Cerebrovascular Circulation; Diffusion Magnetic | 2008 |
Drilling for energy in mitochondrial disease.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Aspartic Acid; Cell Survival; Cells, Cultured; DNA Mutat | 2009 |
Truncated tau and Aβ cooperatively impair mitochondria in primary neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Cell Line, Transformed; Down-Regul | 2012 |
Psychiatric symptoms correlate with metabolic indices in the hippocampus and cingulate in patients with mitochondrial disorders.
Topics: Adult; Aged; Anxiety; Aspartic Acid; Case-Control Studies; Caudate Nucleus; Creatine; Female; Glutam | 2012 |
AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Corpus Striatum; Dopamine | 2013 |
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Topics: Acoustic Stimulation; Age Factors; Aging, Premature; Animals; Aspartic Acid; Chi-Square Distribution | 2012 |
The deleterious G15498A mutation in mitochondrial DNA-encoded cytochrome b may remain clinically silent in homoplasmic carriers.
Topics: Amino Acid Sequence; Aspartic Acid; Child, Preschool; Cytochromes b; DNA, Mitochondrial; Electron Tr | 2004 |
Brain MRI and proton MRS findings in infants and children with respiratory chain defects.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Child; Child, Preschool; Female; Humans; Infan | 2005 |
Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene.
Topics: Aspartic Acid; Autistic Disorder; Chromosome Mapping; DNA Mutational Analysis; DNA Primers; DNA, Mit | 2006 |
Subfield-specific loss of hippocampal N-acetyl aspartate in temporal lobe epilepsy.
Topics: Aconitate Hydratase; Adult; Aged; Aspartic Acid; Cell Count; Electroencephalography; Epilepsy, Tempo | 2008 |
Classification of childhood white matter disorders using proton MR spectroscopic imaging.
Topics: Adrenoleukodystrophy; Adult; Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choli | 2008 |