aspartic acid has been researched along with Migraine Disorders in 21 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Platelet levels of glutamic and aspartic acid and glycine were measured in patients with migraine with aura, migraine without aura, tension headache and cluster headache." | 7.68 | Platelet glycine, glutamate and aspartate in primary headache. ( Cananzi, AR; D'Andrea, G; Ferro Milone, F; Grunfeld, S; Joseph, R; Morra, M; Welch, KM; Zamberlan, F, 1991) |
| "To investigate the metabolite concentration ratios including N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine plus phosphocreatine (Cr) in thalami of patients with migraine without aura, patients with trigeminal neuralgia and healthy comparison subjects using multi-voxel proton magnetic resonance spectroscopy (1H-MRS)." | 3.74 | Metabolite concentration ratios in thalami of patients with migraine and trigeminal neuralgia measured with 1H-MRS. ( Gu, T; Li, CF; Ma, XX; Xiu, JJ; Xu, YH, 2008) |
| "Platelet levels of glutamic and aspartic acid and glycine were measured in patients with migraine with aura, migraine without aura, tension headache and cluster headache." | 3.68 | Platelet glycine, glutamate and aspartate in primary headache. ( Cananzi, AR; D'Andrea, G; Ferro Milone, F; Grunfeld, S; Joseph, R; Morra, M; Welch, KM; Zamberlan, F, 1991) |
| "To investigate the role of glutamic (Glu) and aspartic acid (Asp) in migraine, we measured the plasma amino acids in migraine patients with and without aura, between and during attacks, and compared the profiles with the plasma amino acid profiles of tension headache patients and healthy controls." | 3.68 | Neuroexcitatory plasma amino acids are elevated in migraine. ( Bos, KD; Bruyn, GW; Ferrari, MD; Malessy, MJ; Odink, J, 1990) |
| "Patients with two to six migraine attacks per month without aura, and history of migraine of at least 2 years, were included." | 2.68 | Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study. ( Evers, S; Fischer, M; Göbel, H; Grotemeyer, KH; Isler, HR; Meyer, C; Pfaffenrath, V; Soyka, D; Taneri, Z; Wessely, P, 1996) |
| "Several biochemical aspects of the migraine pathophysiology remain to be elucidated using MRS, such as the migraine attack, correlation to disease severity, and medication efficacy." | 2.55 | Migraine and magnetic resonance spectroscopy: a systematic review. ( Ashina, M; Hougaard, A; Larsson, HBW; Vestergaard, MB; Younis, S, 2017) |
| "The biochemistry of migraine is complex." | 2.38 | Biochemistry of migraine. ( Ferrari, MD, 1992) |
| "Chronic migraine was associated with N-acetyl-aspartate reductions in the bilateral thalami and in the right anterior cingulate." | 1.48 | Neurochemical changes in the medial wall of the brain in chronic migraine. ( Chen, WT; Fuh, JL; Lai, KL; Lin, YR; Niddam, DM; Tsai, SY; Wang, SJ, 2018) |
| "Despite the prevalence of migraine, the pathophysiology of the disease remains unclear." | 1.43 | A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. ( Becerra, L; Borsook, D; Burstein, R; Jensen, JE; Prescot, A; Renshaw, P; Scrivani, S; Spierings, ELH; Veggeberg, R, 2016) |
| "Twenty-seven patients with migraine (8 with aura and 19 without aura) and 19 matched healthy controls were included in the study." | 1.39 | Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state. ( Alvarez-Linera, J; González de la Aleja, J; Hernández-Gallego, J; Hernández-Tamames, JA; Martínez-Salio, A; Mato-Abad, V; Molina, JA; Ramos, A, 2013) |
| "A total of 147 migraine patients (including migraine without aura, with aura and chronic migraine), 65 tension-type headache (including chronic and frequent episodic tension-type headache) and 34 sex- and age-matched controls were selected." | 1.38 | Serum levels of N-acetyl-aspartate in migraine and tension-type headache. ( Ceci, E; de Tommaso, M; Delussi, M; Franco, G; Livrea, P; Pica, C; Ruggieri, M; Trojano, M, 2012) |
| "Among migraine patients, NAA/Cr ratios at dorsal pons were inversely correlated with headache frequency (right, r = -0." | 1.38 | Brainstem 1H-MR spectroscopy in episodic and chronic migraine. ( Fuh, JL; Lai, TH; Lin, CP; Lirng, JF; Wang, SJ, 2012) |
| "After nitroglycerin administration, the migraine rat model was established according to ethology evaluation." | 1.35 | Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo. ( Gu, T; Li, CF; Ma, XX; Ma, Z; Wang, SJ, 2008) |
| "47 patients were recruited with episodic cluster headache (35 in cluster period and 12 in remission), 21 normal controls, and 16 patients with chronic migraine." | 1.33 | Reduction in hypothalamic 1H-MRS metabolite ratios in patients with cluster headache. ( Chen, JJ; Fuh, JL; Lirng, JF; Wang, SJ, 2006) |
| "Fifteen children with migraine with aura (mean age +/- SD = 10." | 1.30 | Erythrocyte and plasma levels of glutamate and aspartate in children affected by migraine. ( Celli, M; D'Eufemia, P; Finocchiaro, R; Giardini, O; Lendvai, D; Troiani, P; Turri, E; Viozzi, L, 1997) |
| "To determine whether migraine in systemic lupus erythematosus (SLE) is associated with accentuated brain injury and disease activity." | 1.30 | Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus. ( Brooks, WM; Rozell, CL; Sibbitt, WL, 1998) |
| "A current hypothesis for migraine suggests that neuroexcitatory amino acids may participate in the triggering of attacks." | 1.29 | Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks. ( Castillo, J; Leira, R; Martínez, F; Noya, M; Rodríguez, JR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero-Toro, C | 1 |
| Koroleva, K | 1 |
| Ermakova, E | 1 |
| Gafurov, O | 1 |
| Abushik, P | 1 |
| Tavi, P | 1 |
| Sitdikova, G | 1 |
| Giniatullin, R | 1 |
| Niddam, DM | 1 |
| Lai, KL | 1 |
| Tsai, SY | 1 |
| Lin, YR | 1 |
| Chen, WT | 1 |
| Fuh, JL | 3 |
| Wang, SJ | 4 |
| Erdélyi-Bótor, S | 1 |
| Aradi, M | 1 |
| Kamson, DO | 1 |
| Kovács, N | 1 |
| Perlaki, G | 1 |
| Orsi, G | 1 |
| Nagy, SA | 1 |
| Schwarcz, A | 1 |
| Dóczi, T | 1 |
| Komoly, S | 1 |
| Deli, G | 1 |
| Trauninger, A | 1 |
| Pfund, Z | 1 |
| Becerra, L | 1 |
| Veggeberg, R | 1 |
| Prescot, A | 1 |
| Jensen, JE | 1 |
| Renshaw, P | 1 |
| Scrivani, S | 1 |
| Spierings, ELH | 1 |
| Burstein, R | 1 |
| Borsook, D | 1 |
| Choudhary, AK | 1 |
| Lee, YY | 1 |
| Younis, S | 1 |
| Hougaard, A | 1 |
| Vestergaard, MB | 1 |
| Larsson, HBW | 1 |
| Ashina, M | 1 |
| Ma, Z | 1 |
| Li, CF | 2 |
| Ma, XX | 2 |
| Gu, T | 2 |
| de Tommaso, M | 1 |
| Ceci, E | 1 |
| Pica, C | 1 |
| Trojano, M | 1 |
| Delussi, M | 1 |
| Franco, G | 1 |
| Livrea, P | 1 |
| Ruggieri, M | 1 |
| Lai, TH | 1 |
| Lirng, JF | 2 |
| Lin, CP | 1 |
| González de la Aleja, J | 1 |
| Ramos, A | 1 |
| Mato-Abad, V | 1 |
| Martínez-Salio, A | 1 |
| Hernández-Tamames, JA | 1 |
| Molina, JA | 1 |
| Hernández-Gallego, J | 1 |
| Alvarez-Linera, J | 1 |
| Chen, JJ | 1 |
| Xu, YH | 1 |
| Xiu, JJ | 1 |
| Martínez, F | 2 |
| Castillo, J | 2 |
| Rodríguez, JR | 1 |
| Leira, R | 2 |
| Noya, M | 2 |
| Prieto, JM | 1 |
| Lema, M | 1 |
| Pfaffenrath, V | 1 |
| Wessely, P | 1 |
| Meyer, C | 1 |
| Isler, HR | 1 |
| Evers, S | 1 |
| Grotemeyer, KH | 1 |
| Taneri, Z | 1 |
| Soyka, D | 1 |
| Göbel, H | 1 |
| Fischer, M | 1 |
| D'Eufemia, P | 1 |
| Finocchiaro, R | 1 |
| Lendvai, D | 1 |
| Celli, M | 1 |
| Viozzi, L | 1 |
| Troiani, P | 1 |
| Turri, E | 1 |
| Giardini, O | 1 |
| Rozell, CL | 1 |
| Sibbitt, WL | 1 |
| Brooks, WM | 1 |
| Saurugg, D | 1 |
| Hodkewitsch, E | 1 |
| Ferrari, MD | 2 |
| D'Andrea, G | 1 |
| Cananzi, AR | 1 |
| Joseph, R | 1 |
| Morra, M | 1 |
| Zamberlan, F | 1 |
| Ferro Milone, F | 1 |
| Grunfeld, S | 1 |
| Welch, KM | 1 |
| Odink, J | 1 |
| Bos, KD | 1 |
| Malessy, MJ | 1 |
| Bruyn, GW | 1 |
3 reviews available for aspartic acid and Migraine Disorders
| Article | Year |
|---|---|
Neurophysiological symptoms and aspartame: What is the connection?
Topics: Affect; Animals; Aspartame; Aspartic Acid; Brain; Cognitive Dysfunction; Disease Models, Animal; Dop | 2018 |
Migraine and magnetic resonance spectroscopy: a systematic review.
Topics: Aspartic Acid; Biomarkers; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Migrain | 2017 |
Biochemistry of migraine.
Topics: Aspartic Acid; beta-Endorphin; Catecholamines; Enkephalin, Methionine; Estrogens; Female; Glutamates | 1992 |
2 trials available for aspartic acid and Migraine Disorders
| Article | Year |
|---|---|
Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study.
Topics: Adolescent; Adult; Aspartic Acid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admini | 1996 |
[Clinical experiences with an analgesic-acting infusion solution in neurological painful conditions].
Topics: Arthritis, Rheumatoid; Aspartic Acid; Dipyrone; Facial Neuralgia; Humans; Injections, Intravenous; M | 1977 |
16 other studies available for aspartic acid and Migraine Disorders
| Article | Year |
|---|---|
Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamic Acid; Male; Migraine Disorders; N-Methyla | 2022 |
Neurochemical changes in the medial wall of the brain in chronic migraine.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Chronic Disease; Correlation of Data; C | 2018 |
Changes of migraine-related white matter hyperintensities after 3 years: a longitudinal MRI study.
Topics: Adult; Aged; Aspartic Acid; Creatine; Diffusion Magnetic Resonance Imaging; Female; Frontal Lobe; Fu | 2015 |
A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Cohort Studies; Female; Glutamic Acid; Gluta | 2016 |
Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo.
Topics: Animals; Aspartic Acid; Cerebellum; Choline; Creatine; Disease Models, Animal; Magnetic Resonance Im | 2008 |
Serum levels of N-acetyl-aspartate in migraine and tension-type headache.
Topics: Adult; Analysis of Variance; Aspartic Acid; Chromatography, Liquid; Female; Humans; Linear Models; M | 2012 |
Brainstem 1H-MR spectroscopy in episodic and chronic migraine.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain Mapping; Brain Stem; Creatine; Cumulative Trauma D | 2012 |
Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state.
Topics: Adult; Analysis of Variance; Aspartic Acid; Case-Control Studies; Epilepsy; Female; Glutamic Acid; G | 2013 |
Reduction in hypothalamic 1H-MRS metabolite ratios in patients with cluster headache.
Topics: Adult; Aspartic Acid; Choline; Chronic Disease; Cluster Headache; Creatinine; Diagnosis, Differentia | 2006 |
Metabolite concentration ratios in thalami of patients with migraine and trigeminal neuralgia measured with 1H-MRS.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Functional Laterality; Humans; Image Processing, Co | 2008 |
Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks.
Topics: Adult; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Migraine Disorders; Nervous S | 1993 |
[Changes in neuroexcitatory amino acids during and between migraine attacks].
Topics: Adult; Amino Acids; Aspartic Acid; Brain; Glutamates; Humans; Hypoxia; Middle Aged; Migraine Disorde | 1994 |
Erythrocyte and plasma levels of glutamate and aspartate in children affected by migraine.
Topics: Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Erythrocytes; Female; Glutamic Aci | 1997 |
Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Cohort Studies; Di | 1998 |
Platelet glycine, glutamate and aspartate in primary headache.
Topics: Aspartic Acid; Blood Platelets; Cluster Headache; Glutamates; Glutamic Acid; Glycine; Headache; Huma | 1991 |
Neuroexcitatory plasma amino acids are elevated in migraine.
Topics: Adult; Aging; Aspartic Acid; Female; Glutamates; Glutamic Acid; Headache; Humans; Male; Middle Aged; | 1990 |