aspartic acid has been researched along with Memory Disorders in 28 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 14 (50.00) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Gao, H | 1 |
| Zhang, X | 1 |
| Qian, S | 1 |
| Wang, C | 1 |
| Deng, L | 1 |
| Zhong, M | 1 |
| Qing, G | 1 |
| Lombardo, B | 1 |
| Pagani, M | 1 |
| De Rosa, A | 1 |
| Nunziato, M | 1 |
| Migliarini, S | 1 |
| Garofalo, M | 1 |
| Terrile, M | 1 |
| D'Argenio, V | 1 |
| Galbusera, A | 1 |
| Nuzzo, T | 1 |
| Ranieri, A | 1 |
| Vitale, A | 1 |
| Leggiero, E | 1 |
| Di Maio, A | 1 |
| Barsotti, N | 1 |
| Borello, U | 1 |
| Napolitano, F | 1 |
| Mandarino, A | 1 |
| Carotenuto, M | 1 |
| Heresco-Levy, U | 1 |
| Pasqualetti, M | 1 |
| Malatesta, P | 1 |
| Gozzi, A | 1 |
| Errico, F | 2 |
| Salvatore, F | 1 |
| Pastore, L | 1 |
| Usiello, A | 2 |
| Biundo, F | 1 |
| d'Abramo, C | 1 |
| Tambini, MD | 1 |
| Zhang, H | 1 |
| Del Prete, D | 1 |
| Vitale, F | 1 |
| Giliberto, L | 1 |
| Arancio, O | 1 |
| D'Adamio, L | 1 |
| Shan, Y | 1 |
| Jia, Y | 1 |
| Zhong, S | 1 |
| Li, X | 1 |
| Zhao, H | 1 |
| Chen, J | 1 |
| Lu, Q | 1 |
| Zhang, L | 2 |
| Li, Z | 1 |
| Lai, S | 1 |
| Wang, Y | 1 |
| Calderón-Garcidueñas, L | 1 |
| Mora-Tiscareño, A | 1 |
| Franco-Lira, M | 1 |
| Zhu, H | 1 |
| Lu, Z | 1 |
| Solorio, E | 1 |
| Torres-Jardón, R | 1 |
| D'Angiulli, A | 1 |
| Mazgaj, R | 1 |
| Tal, A | 1 |
| Goetz, R | 1 |
| Lazar, M | 1 |
| Rothman, K | 1 |
| Messinger, JW | 1 |
| Malaspina, D | 1 |
| Gonen, O | 1 |
| Jayaweera, HK | 1 |
| Lagopoulos, J | 1 |
| Duffy, SL | 1 |
| Lewis, SJ | 1 |
| Hermens, DF | 1 |
| Norrie, L | 1 |
| Hickie, IB | 1 |
| Naismith, SL | 1 |
| Yoon, KJ | 1 |
| Lee, YT | 1 |
| Chae, SW | 1 |
| Park, CR | 1 |
| Kim, DY | 1 |
| Moon, CM | 1 |
| Sundaram, T | 1 |
| Choi, NG | 1 |
| Jeong, GW | 1 |
| Henry, LC | 1 |
| Tremblay, S | 1 |
| Boulanger, Y | 1 |
| Ellemberg, D | 1 |
| Lassonde, M | 1 |
| Mantoan, MA | 1 |
| Caboclo, LO | 1 |
| de Figueiredo Ferreira Guilhoto, LM | 1 |
| Lin, K | 1 |
| da Silva Noffs, MH | 1 |
| de Souza Silva Tudesco, I | 1 |
| Belzunces, E | 1 |
| Carrete, H | 1 |
| Bussoletti, RT | 1 |
| Centeno, RS | 1 |
| Sakamoto, AC | 1 |
| Yacubian, EM | 1 |
| Kozora, E | 1 |
| Brown, MS | 1 |
| Filley, CM | 1 |
| Miller, DE | 1 |
| West, SG | 1 |
| Pelzman, J | 1 |
| Arciniegas, DB | 1 |
| Bertolino, A | 1 |
| Sciota, D | 1 |
| Brudaglio, F | 1 |
| Altamura, M | 1 |
| Blasi, G | 1 |
| Bellomo, A | 1 |
| Antonucci, N | 1 |
| Callicott, JH | 1 |
| Goldberg, TE | 1 |
| Scarabino, T | 1 |
| Weinberger, DR | 1 |
| Nardini, M | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Neylan, TC | 1 |
| Lenoci, M | 1 |
| Rothlind, J | 1 |
| Metzler, TJ | 1 |
| Schuff, N | 1 |
| Du, AT | 1 |
| Franklin, KW | 1 |
| Weiss, DS | 1 |
| Weiner, MW | 1 |
| Marmar, CR | 1 |
| Hanoğlu, L | 1 |
| Ozkara, C | 1 |
| Keskinkiliç, C | 1 |
| Altin, U | 1 |
| Uzan, M | 1 |
| Tuzgen, S | 1 |
| Dinçer, A | 1 |
| Ozyurt, E | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 1 |
| Renshaw, PF | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 2 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Pelliccioli, GP | 2 |
| Gobbi, G | 2 |
| Senin, U | 2 |
| Mecocci, P | 1 |
| Hermann, D | 1 |
| Sartorius, A | 1 |
| Welzel, H | 1 |
| Walter, S | 2 |
| Skopp, G | 1 |
| Ende, G | 2 |
| Mann, K | 1 |
| Charlton, RA | 1 |
| McIntyre, DJ | 1 |
| Howe, FA | 1 |
| Morris, RG | 1 |
| Markus, HS | 1 |
| Nisticò, R | 1 |
| Palma, G | 1 |
| Federici, M | 1 |
| Affuso, A | 1 |
| Brilli, E | 1 |
| Topo, E | 1 |
| Centonze, D | 1 |
| Bernardi, G | 1 |
| Bozzi, Y | 1 |
| D'Aniello, A | 1 |
| Di Lauro, R | 1 |
| Mercuri, NB | 1 |
| Zimmerman, ME | 1 |
| Pan, JW | 1 |
| Hetherington, HP | 1 |
| Katz, MJ | 1 |
| Verghese, J | 1 |
| Buschke, H | 1 |
| Derby, CA | 1 |
| Lipton, RB | 1 |
| Parnetti, L | 1 |
| Lowenthal, DT | 1 |
| Presciutti, O | 1 |
| Palumbo, R | 1 |
| Chiarini, P | 1 |
| Palumbo, B | 1 |
| Raber, J | 1 |
| Heim, C | 1 |
| Zhang, J | 1 |
| Lan, J | 1 |
| Sieklucka, M | 1 |
| Kurz, T | 1 |
| Riederer, P | 1 |
| Gerlach, M | 1 |
| Sontag, KH | 1 |
| Braus, DF | 1 |
| Weber-Fahr, W | 1 |
| Henn, FA | 1 |
| Lin, A | 1 |
| Nguy, CH | 1 |
| Shic, F | 1 |
| Ross, BD | 1 |
| Abe, E | 1 |
| Murai, S | 1 |
| Masuda, Y | 1 |
| Saito, H | 1 |
| Itoh, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Functional Near Infrared Spectroscopy as a Biomarker of Response in Patients With Post-concussion Syndrome Treated With Transcranial Magnetic Stimulation[NCT04568369] | 91 participants (Actual) | Interventional | 2020-05-02 | Active, not recruiting | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Effects of Cannabidiol (CBD) on the Brain[NCT04831294] | 15 participants (Actual) | Interventional | 2021-07-15 | Active, not recruiting | |||
| Promotion of Synaptic Plasticity With D-Aspartate to Favour Recovery Form Cerebral Damage[NCT03228524] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2017-11-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
1 review available for aspartic acid and Memory Disorders
| Article | Year |
|---|---|
Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits.
Topics: Acquired Immunodeficiency Syndrome; Adrenocorticotropic Hormone; Amygdala; Animals; Arginine Vasopre | 1998 |
1 trial available for aspartic acid and Memory Disorders
| Article | Year |
|---|---|
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
Topics: Administration, Oral; Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dimethy | 2001 |
26 other studies available for aspartic acid and Memory Disorders
| Article | Year |
|---|---|
Aspartic Acid-Modified Phospholipids Regulate Cell Response and Rescue Memory Deficits in APP/PS1 Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br | 2022 |
D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.
Topics: Adult; Animals; Aspartic Acid; Autism Spectrum Disorder; D-Aspartate Oxidase; D-Aspartic Acid; Gene | 2022 |
Abolishing Tau cleavage by caspases at Aspartate
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Caspases; Memory; Memory Disorders; Mice; Mice, Tra | 2017 |
Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Depressive Disorder, | 2018 |
Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution.
Topics: Adolescent; Age Factors; Air Pollution; Analysis of Variance; Apolipoprotein E4; Aspartic Acid; Brai | 2015 |
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc | 2016 |
Spectroscopic markers of memory impairment, symptom severity and age of onset in older people with lifetime depression: Discrete roles of N-acetyl aspartate and glutamate.
Topics: Aged; Aspartic Acid; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Glutamic Aci | 2015 |
Effects of anodal transcranial direct current stimulation (tDCS) on behavioral and spatial memory during the early stage of traumatic brain injury in the rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain Edema; Brain Injuries, Traumatic; Brain-Derived | 2016 |
Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creati | 2016 |
Neurometabolic changes in the acute phase after sports concussions correlate with symptom severity.
Topics: Acute Disease; Adult; Aspartic Acid; Athletic Injuries; Brain; Brain Concussion; Cognition Disorders | 2010 |
Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis.
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Functional Laterality; Hum | 2009 |
Memory impairment associated with neurometabolic abnormalities of the hippocampus in patients with non-neuropsychiatric systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Lu | 2011 |
Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder.
Topics: Adult; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; | 2003 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Attention, learning, and memory in posttraumatic stress disorder.
Topics: Alcoholism; Anthropometry; Aspartic Acid; Attention; Hippocampus; Humans; Learning; Male; Memory Dis | 2004 |
Correlation between 1H MRS and memory before and after surgery in mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatinine; Electroencephalography; Epilep | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users.
Topics: Adult; Alcohol Drinking; Aspartic Acid; Attention; Creatine; Globus Pallidus; Gyrus Cinguli; Hair; H | 2007 |
The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Cognition; Cognition Disorders; Cross-Sectiona | 2007 |
Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility.
Topics: Animals; Aspartic Acid; Cognition; D-Aspartate Oxidase; Hippocampus; Long-Term Potentiation; Male; M | 2008 |
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Reson | 2008 |
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Stud | 1996 |
Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carotid Stenosis; Cognition Disorders; Corpu | 2000 |
The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study.
Topics: Adult; Aspartic Acid; Cell Death; Choline; Creatine; Electroconvulsive Therapy; Female; Hippocampus; | 2000 |
Reversal by 3,3',5-triido-L-thyronine of the working memory deficit, and the decrease in acetylcholine, glutamate and gamma-aminobutyric acid induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Animals; Aspartic Acid; Aziridines; Behavior, Animal; Brain; Choline; gamma-Aminobuty | 1992 |