aspartic acid has been researched along with Lupus Erythematosus, Systemic in 22 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The N-acetylaspartate-to-creatine/phosphocreatine ratio was smaller in those patients with significant cerebral atrophy (1." | 3.69 | Analysis of cerebral structural changes in systemic lupus erythematosus by proton MR spectroscopy. ( Griffey, RH; Hart, BL; Haseler, LJ; Matwiyoff, NA; Sibbitt, RR; Sibbitt, WL, 1994) |
| " mI/Cr ratio correlated with cumulative glucocorticoids dosage (r = 0." | 1.72 | Axonal dysfunction is associated with interferon-γ levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study. ( Appenzeller, S; Castellano, G; Cendes, F; Fernandes, PT; Frittoli, RB; Lapa, AT; Marini, R; Niewold, TB; Pereira, DR; Postal, M; Rittner, L; Sinicato, NA, 2022) |
| " Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex hormones to target tissues." | 1.36 | Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence. ( Cieślak, D; Gasik, R; Hrycaj, P; Jagodziński, PP; Lianeri, M; Piotrowski, P; Wudarski, M; Łacki, JK, 2010) |
| "Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin." | 1.35 | Depression is an early disease manifestation in lupus-prone MRL/lpr mice. ( Campbell, SR; Cui, MH; Gao, HX; Gulinello, M; Hee-Hwang, J; Putterman, C; Zong, P, 2009) |
| "To determine whether migraine in systemic lupus erythematosus (SLE) is associated with accentuated brain injury and disease activity." | 1.30 | Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus. ( Brooks, WM; Rozell, CL; Sibbitt, WL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Hooftman, A | 1 |
| Peace, CG | 1 |
| Ryan, DG | 1 |
| Day, EA | 1 |
| Yang, M | 1 |
| McGettrick, AF | 1 |
| Yin, M | 1 |
| Montano, EN | 1 |
| Huo, L | 1 |
| Toller-Kawahisa, JE | 1 |
| Zecchini, V | 1 |
| Ryan, TAJ | 1 |
| Bolado-Carrancio, A | 1 |
| Casey, AM | 1 |
| Prag, HA | 1 |
| Costa, ASH | 1 |
| De Los Santos, G | 1 |
| Ishimori, M | 1 |
| Wallace, DJ | 1 |
| Venuturupalli, S | 1 |
| Nikitopoulou, E | 1 |
| Frizzell, N | 1 |
| Johansson, C | 1 |
| Von Kriegsheim, A | 1 |
| Murphy, MP | 1 |
| Jefferies, C | 1 |
| Frezza, C | 1 |
| O'Neill, LAJ | 1 |
| Frittoli, RB | 1 |
| Pereira, DR | 1 |
| Lapa, AT | 1 |
| Postal, M | 1 |
| Sinicato, NA | 1 |
| Fernandes, PT | 1 |
| Cendes, F | 2 |
| Castellano, G | 1 |
| Rittner, L | 1 |
| Marini, R | 1 |
| Niewold, TB | 1 |
| Appenzeller, S | 2 |
| Cagnoli, P | 1 |
| Harris, RE | 1 |
| Frechtling, D | 1 |
| Berkis, G | 1 |
| Gracley, RH | 1 |
| Graft, CC | 1 |
| Lowe, SE | 1 |
| Chenevert, TL | 1 |
| McCune, WJ | 1 |
| Gebarski, S | 1 |
| Sundgren, PC | 1 |
| Gao, HX | 1 |
| Campbell, SR | 1 |
| Cui, MH | 1 |
| Zong, P | 1 |
| Hee-Hwang, J | 1 |
| Gulinello, M | 1 |
| Putterman, C | 1 |
| Filley, CM | 3 |
| Kozora, E | 3 |
| Brown, MS | 3 |
| Miller, DE | 2 |
| West, SG | 3 |
| Arciniegas, DB | 3 |
| Grimm, A | 1 |
| Zhang, L | 2 |
| Piotrowski, P | 1 |
| Gasik, R | 1 |
| Lianeri, M | 1 |
| Cieślak, D | 1 |
| Wudarski, M | 1 |
| Hrycaj, P | 1 |
| Łacki, JK | 1 |
| Jagodziński, PP | 1 |
| Pelzman, J | 1 |
| VOLKOV, VP | 1 |
| Handa, R | 1 |
| Sahota, P | 1 |
| Kumar, M | 1 |
| Jagannathan, NR | 1 |
| Bal, CS | 1 |
| Gulati, M | 1 |
| Tripathi, BM | 1 |
| Wali, JP | 1 |
| Ellison, MC | 1 |
| Simon, JH | 1 |
| Li, LM | 1 |
| Costallat, LT | 1 |
| Yang, ML | 1 |
| Doyle, HA | 2 |
| Gee, RJ | 1 |
| Lowenson, JD | 1 |
| Clarke, S | 1 |
| Lawson, BR | 1 |
| Aswad, DW | 1 |
| Mamula, MJ | 2 |
| Sibbitt, WL | 7 |
| Haseler, LJ | 2 |
| Griffey, RH | 1 |
| Hart, BL | 2 |
| Sibbitt, RR | 1 |
| Matwiyoff, NA | 1 |
| Griffey, RR | 1 |
| Friedman, SD | 1 |
| Brooks, WM | 6 |
| Sabet, A | 2 |
| Barker, PB | 1 |
| van Zijl, PC | 1 |
| Duyn, JH | 1 |
| Moonen, CT | 1 |
| Rozell, CL | 1 |
| Stidley, CA | 1 |
| Danska, J | 1 |
| Jung, RE | 2 |
| Ford, CC | 2 |
| Greinel, EJ | 1 |
| McNearney, T | 1 |
| Speegle, D | 1 |
| Lawand, N | 1 |
| Lisse, J | 1 |
| Westlund, KN | 1 |
| Axford, JS | 1 |
| Howe, FA | 1 |
| Heron, C | 1 |
| Griffiths, JR | 1 |
| Yan, J | 1 |
| Liang, B | 1 |
| Yeo, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus[NCT00858884] | 68 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aspartic acid and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Lupus autoantigens: their origins, forms, and presentation.
Topics: Animals; Antigen Presentation; Antigens, CD; Aspartic Acid; Autoantigens; B-Lymphocytes; B7-1 Antige | 2001 |
21 other studies available for aspartic acid and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Topics: Argininosuccinate Synthase; Argininosuccinic Acid; Aspartic Acid; Cell Respiration; Cytosol; Fumarat | 2023 |
Axonal dysfunction is associated with interferon-γ levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Humans; Interferon-gamma; | 2022 |
Reduced Insular Glutamine and N-acetylaspartate in systemic lupus erythematosus: a single-voxel (1)H-MR spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Cerebral Cortex; Female; Glutamine; Humans; Lupus Erythemato | 2013 |
Depression is an early disease manifestation in lupus-prone MRL/lpr mice.
Topics: Animals; Aspartic Acid; Autoantibodies; Brain; Cardiolipins; Choline; Chromatin; Creatine; Depressio | 2009 |
White matter microstructure and cognition in non-neuropsychiatric systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Cognition; Cognition Disorders; Creati | 2009 |
Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Case-Control Studies; Estradiol; Female; Gene Fr | 2010 |
Memory impairment associated with neurometabolic abnormalities of the hippocampus in patients with non-neuropsychiatric systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Lu | 2011 |
[FREE AMINO ACIDS IN THE BLOOD AND URINE OF PATIENTS WITH SOME FORMS OF DERMATOSIS].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Blood; Cystine; Dermatitis; Eczema; Erythema Multifor | 1964 |
In vivo proton magnetic resonance spectroscopy (MRS) and single photon emission computerized tomography (SPECT) in systemic lupus erythematosus (SLE).
Topics: Adult; Aspartic Acid; Brain; Cerebrovascular Circulation; Creatine; Female; Humans; Lupus Erythemato | 2003 |
Cognition, MRS neurometabolites, and MRI volumetrics in non-neuropsychiatric systemic lupus erythematosus: preliminary data.
Topics: Adult; Aspartic Acid; Attention; Brain; Brain Chemistry; Choline; Cognition Disorders; Female; Front | 2005 |
Evidence of reversible axonal dysfunction in systemic lupus erythematosus: a proton MRS study.
Topics: Adult; Analysis of Variance; Antibodies, Antiphospholipid; Aspartic Acid; Axons; Biomarkers; Brain; | 2005 |
Intracellular protein modification associated with altered T cell functions in autoimmunity.
Topics: Age Factors; Animals; Aspartic Acid; Autoimmunity; B-Lymphocytes; Brain; Cell Proliferation; Erythro | 2006 |
Analysis of cerebral structural changes in systemic lupus erythematosus by proton MR spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Atrophy; Brain; Choline; Creatine; Energy Metabolism; Female; Huma | 1994 |
Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Damage, Chronic; Brain Ischemia; Brain Mapping; Choline; Creatine | 1997 |
Neurochemistry of brain lesions determined by spectroscopic imaging in systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Biomarkers; Cerebral Ventricles; Choline; Creatine; Female; Humans; Lactic Aci | 1997 |
Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Cohort Studies; Di | 1998 |
Neurometabolite markers of cerebral injury in the antiphospholipid antibody syndrome of systemic lupus erythematosus.
Topics: Adult; Antiphospholipid Syndrome; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Diseases; Cerebr | 1998 |
Relationship between neurometabolite derangement and neurocognitive dysfunction in systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Female; Humans; Lupus Erythemat | 1999 |
Excitatory amino acid profiles of synovial fluid from patients with arthritis.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Reactive; Aspartic Acid; Child; Child, Preschool; Chr | 2000 |
Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Fem | 2001 |
Gerstmann syndrome in systemic lupus erythematosus: neuropsychological, neuroimaging and spectroscopic findings.
Topics: Adult; Agraphia; Apraxias; Aspartic Acid; Atrophy; Cerebral Infarction; Choline; Dominance, Cerebral | 2001 |