aspartic acid has been researched along with Leukemia in 22 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aminomalonic acid is a strong in vitro inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR and from mouse pancreas; the agent is formally competitive with L-aspartic acid (Ki = 0." | 3.66 | Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. ( Cooney, DA; Milman, HA; Muth, R, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (54.55) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, H | 1 |
| Motoyoshi, N | 1 |
| Itagaki, T | 1 |
| Suzuki, M | 1 |
| Inokuchi, N | 1 |
| Zhao, M | 1 |
| Duan, XF | 1 |
| Wen, DH | 1 |
| Chen, GQ | 2 |
| CUTTS, JH | 1 |
| Roy, MK | 1 |
| Thalang, VN | 1 |
| Trakoontivakorn, G | 1 |
| Nakahara, K | 1 |
| Weng, C | 1 |
| Li, Y | 1 |
| Xu, D | 1 |
| Shi, Y | 1 |
| Tang, H | 1 |
| Dorak, MT | 1 |
| Viola, A | 1 |
| Pagano, L | 1 |
| Laudati, D | 1 |
| D'Elia, R | 1 |
| D'Amico, MR | 1 |
| Ammirabile, M | 1 |
| Palmieri, S | 1 |
| Prossomariti, L | 1 |
| Ferrara, F | 1 |
| Lu, Y | 1 |
| Peng, ZG | 1 |
| Yuan, TT | 1 |
| Yin, QQ | 1 |
| Xia, L | 1 |
| Prager, MD | 1 |
| Young, JE | 1 |
| Atkins, IC | 1 |
| Leyva, A | 1 |
| Appel, H | 1 |
| Smith, P | 1 |
| Lankelma, J | 1 |
| Pinedo, HM | 1 |
| Noordhuis, P | 1 |
| Kazemier, KM | 1 |
| Kasperrs, GJ | 1 |
| Peters, GJ | 1 |
| Cleaveland, ES | 1 |
| Zaharevitz, DW | 1 |
| Kelley, JA | 1 |
| Paull, K | 1 |
| Cooney, DA | 2 |
| Ford, H | 1 |
| Cizman, BB | 1 |
| Heron, SD | 1 |
| McKeen, ME | 1 |
| Kearns, DJ | 1 |
| Bassinger, S | 1 |
| Griffith, BB | 1 |
| Argyris, EG | 1 |
| Kamoun, M | 1 |
| Zmijewski, CM | 1 |
| Williams, TM | 1 |
| Monos, DS | 1 |
| Milman, HA | 1 |
| Muth, R | 1 |
| Blouquit, Y | 1 |
| Thillet, J | 1 |
| Beuzard, Y | 1 |
| Vernant, JP | 1 |
| Dreyfus, B | 1 |
| Wiseman, C | 1 |
| McGregor, RF | 1 |
| McCredie, KB | 1 |
| O'Dwyer, PJ | 1 |
| King, SA | 1 |
| Hoth, DF | 1 |
| Leyland-Jones, B | 1 |
| Kotlarek-Haus, S | 1 |
| Ohnuma, T | 1 |
| Holland, JF | 1 |
| Freeman, A | 1 |
| Sinks, LF | 1 |
| Haskell, CM | 2 |
| Canellos, GP | 2 |
| Stjernholm, RL | 1 |
| Noble, EP | 1 |
| Dimitrov, NV | 1 |
| Kellermeyer, RW | 1 |
| Falor, WH | 1 |
1 review available for aspartic acid and Leukemia
| Article | Year |
|---|---|
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic A | 1987 |
21 other studies available for aspartic acid and Leukemia
| Article | Year |
|---|---|
Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Asparagine; Aspartic Acid; Basi | 2015 |
PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; Aspartic Acid; Camptothecin; Caspase 3; Caspase Inhibitors; Cell L | 2009 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cor | 1964 |
Mechanism of mahanine-induced apoptosis in human leukemia cells (HL-60).
Topics: Antineoplastic Agents; Apoptosis; Aspartic Acid; Carbazoles; Caspase 3; Caspase Inhibitors; Caspases | 2004 |
Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells.
Topics: Amino Acid Sequence; Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; bcl-X Protein | 2005 |
HFE H63D variant and leukemia susceptibility.
Topics: Aspartic Acid; Genetic Predisposition to Disease; Histidine; Humans; Leukemia; Mutation | 2006 |
HFE gene mutations in patients with acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Female; Genotype; Hemochro | 2006 |
Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity.
Topics: Amino Acid Substitution; Apoptosis; Aspartic Acid; Binding Sites; Caspase 3; Cell Line, Tumor; Core | 2008 |
A study of the possible role of feedback inhibition of aspartate transcarbamylase in regulation of pyrimidine synthesis in human leukocytes.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Humans; Hydrogen-Ion Concentration; Leukemia; Leukocytes; L | 1967 |
Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro.
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Cell Division; Cell L | 1981 |
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cytarabine; C | 1996 |
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, N | 1996 |
Identification of DRB1 allele (DRB1*1316) with aspartate at position 86: evolutionary considerations and functional implications.
Topics: Alleles; Aspartic Acid; Base Sequence; Biological Evolution; DNA; HLA-DR Antigens; HLA-DRB1 Chains; | 1996 |
Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Aspartate-Ammonia Ligase; Aspartic Acid; Cells, | 1979 |
Structural and functional studies of hemoglobin J Cala-bria: beta64 (E8) Gly leads to Asp.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Female; Glycine; Hemoglobin J; Hemoglobins, Abnormal; Heter | 1977 |
Urinary amino acid excretion in acute leukemia.
Topics: Amino Acids; Antineoplastic Agents; Aspartic Acid; Female; Humans; Leukemia; Male; Remission, Sponta | 1976 |
[Behavior of aminopeptidase activity in human leukemic leukocytes].
Topics: Acyltransferases; Adolescent; Adult; Aged; Aminopeptidases; Aspartic Acid; Child; Clinical Enzyme Te | 1971 |
Biochemical and pharmacological studies with asparaginase in man.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Colo | 1970 |
l-asparaginase resistance in human leukemia--asparagine synthetase.
Topics: Acute Disease; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Chronic Dis | 1969 |
Studies of resistance to L-asparaginase in human leukemia.
Topics: Asparaginase; Asparagine; Aspartic Acid; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Drug Resis | 1970 |
Differentiation of normal and leukemic leukocytes into three groups by propionate metabolism.
Topics: Acids; Amino Acids; Anemia, Pernicious; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Citric Acid | 1970 |