aspartic acid has been researched along with Intellectual Disability in 40 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3." | 7.74 | Neuroimaging findings in hyperargininemia. ( Akinci, A; Alkan, A; Firat, AK; Güngör, S; Tabel, Y, 2008) |
| " We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3." | 3.74 | Neuroimaging findings in hyperargininemia. ( Akinci, A; Alkan, A; Firat, AK; Güngör, S; Tabel, Y, 2008) |
| "Autism is a neuro-developmental syndrome that affects 0." | 1.32 | Disorder-associated mutations lead to functional inactivation of neuroligins. ( Afridi, SK; Chih, B; Clark, L; Scheiffele, P, 2004) |
| "The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) gene leading to the absence of the encoded fragile X mental retardation protein 1 (FMRP)." | 1.31 | Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. ( Braun, K; Gruss, M, 2001) |
| "At age 3(1/2) years she has profound mental retardation, spasticity, and grand mal and myoclonic seizures only partially controlled by anticonvulsants." | 1.30 | Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. ( Ahmad, A; Artigas-Lopez, M; Kahler, SG; Kishnani, PS; Millington, DS; Pappu, AS; Steiner, R; Van Hove, JL, 1999) |
| "This report examines the safety issues related to the nutritive sweetener aspartame, including possible toxic effects of aspartame's component amino acids, aspartic acid and phenylalanine, and its major decomposition products, methanol and diketopiperazine, and the potential synergistic effect of aspartame and dietary carbohydrate on brain neurochemicals." | 1.27 | Aspartame. Review of safety issues. Council on Scientific Affairs. ( , 1985) |
| "Angiokeratoma corporis diffusum was observed in one patient." | 1.26 | Clinical and biochemical delineation of aspartyl-glycosaminuria as observed in two members of an Italian family. ( Becker, C; Gehler, J; Hartmann, J; Sewell, AC; Spranger, J, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (62.50) | 18.7374 |
| 1990's | 5 (12.50) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, B | 1 |
| Pagani, M | 1 |
| De Rosa, A | 1 |
| Nunziato, M | 1 |
| Migliarini, S | 1 |
| Garofalo, M | 1 |
| Terrile, M | 1 |
| D'Argenio, V | 1 |
| Galbusera, A | 1 |
| Nuzzo, T | 1 |
| Ranieri, A | 1 |
| Vitale, A | 1 |
| Leggiero, E | 1 |
| Di Maio, A | 1 |
| Barsotti, N | 1 |
| Borello, U | 1 |
| Napolitano, F | 1 |
| Mandarino, A | 1 |
| Carotenuto, M | 1 |
| Heresco-Levy, U | 1 |
| Pasqualetti, M | 1 |
| Malatesta, P | 1 |
| Gozzi, A | 1 |
| Errico, F | 1 |
| Salvatore, F | 1 |
| Pastore, L | 1 |
| Usiello, A | 1 |
| Chang, MC | 1 |
| Staklinski, SJ | 1 |
| Malut, VR | 1 |
| Pierre, GL | 1 |
| Kilberg, MS | 1 |
| Merritt, ME | 1 |
| Striano, P | 1 |
| Morana, G | 1 |
| Pezzella, M | 1 |
| Bellini, T | 1 |
| Rossi, A | 1 |
| Alkan, A | 2 |
| Kutlu, R | 1 |
| Aslan, M | 1 |
| Sigirci, A | 1 |
| Orkan, I | 1 |
| Yakinci, C | 1 |
| Chih, B | 1 |
| Afridi, SK | 1 |
| Clark, L | 1 |
| Scheiffele, P | 1 |
| Bodensteiner, JB | 1 |
| Kerrigan, JF | 1 |
| Johnsen, SD | 1 |
| Güngör, S | 1 |
| Akinci, A | 1 |
| Firat, AK | 1 |
| Tabel, Y | 1 |
| Gehler, J | 1 |
| Sewell, AC | 1 |
| Becker, C | 1 |
| Hartmann, J | 1 |
| Spranger, J | 1 |
| Hashimoto, T | 2 |
| Tayama, M | 2 |
| Miyazaki, M | 2 |
| Yoneda, Y | 2 |
| Yoshimoto, T | 2 |
| Harada, M | 2 |
| Miyoshi, H | 2 |
| Tanouchi, M | 2 |
| Kuroda, Y | 2 |
| Pouwels, PJ | 2 |
| Brockmann, K | 1 |
| Kruse, B | 1 |
| Wilken, B | 1 |
| Wick, M | 1 |
| Hanefeld, F | 1 |
| Frahm, J | 1 |
| Ahmad, A | 1 |
| Kahler, SG | 1 |
| Kishnani, PS | 1 |
| Artigas-Lopez, M | 1 |
| Pappu, AS | 1 |
| Steiner, R | 1 |
| Millington, DS | 1 |
| Van Hove, JL | 1 |
| van der Knaap, MS | 1 |
| Verhoeven, NM | 1 |
| Maaswinkel-Mooij, P | 1 |
| Onkenhout, W | 1 |
| Peeters, EA | 1 |
| Stöckler-Ipsiroglu, S | 1 |
| Jakobs, C | 1 |
| Critchley, HD | 1 |
| Simmons, A | 1 |
| Daly, EM | 1 |
| Russell, A | 1 |
| van Amelsvoort, T | 1 |
| Robertson, DM | 1 |
| Glover, A | 1 |
| Murphy, DG | 1 |
| Gruss, M | 1 |
| Braun, K | 1 |
| Borud, O | 2 |
| Strömme, JH | 1 |
| Lie, SO | 1 |
| Torp, KH | 2 |
| Dahl, T | 1 |
| Somer, H | 1 |
| Palo, J | 4 |
| Savolainen, H | 1 |
| Konttinen, A | 1 |
| Lejeune, J | 1 |
| Rethoré, MO | 1 |
| Peeters, M | 1 |
| de Blois, MC | 1 |
| Rabier, D | 1 |
| Parvy, P | 1 |
| Bardet, J | 1 |
| Kamoun, P | 1 |
| Swarna, M | 1 |
| Rao, DN | 1 |
| Reddy, PP | 1 |
| Turova, NF | 1 |
| Ermolina, LA | 1 |
| Baryshnikov, VA | 1 |
| Hagenfeldt, L | 1 |
| Bollgren, I | 1 |
| Venizelos, N | 1 |
| Pollitt, RJ | 3 |
| Jenner, FA | 3 |
| Merskey, H | 1 |
| Autio, S | 4 |
| Visakorpi, JK | 1 |
| Järvinen, H | 1 |
| Gaffuri, G | 1 |
| Galewicz, A | 1 |
| Gorska, D | 1 |
| Rodo, M | 1 |
| Zaremba, J | 1 |
| Pretty, KM | 1 |
| de Groot, CJ | 1 |
| Hommes, FA | 1 |
| Sabater, J | 1 |
| Ferre, C | 1 |
| Antich, J | 1 |
| Schweikhardt, F | 1 |
| Hessing, J | 1 |
| Mattsson, K | 1 |
| Sprinkle, T | 1 |
| Greer, M | 1 |
| Williams, CM | 1 |
| Hirsch, W | 1 |
| Mex, A | 1 |
| Vogel, F | 1 |
| Solitare, GB | 1 |
| Shih, VE | 1 |
| Nelligan, DJ | 1 |
| Dolan, TF | 1 |
1 review available for aspartic acid and Intellectual Disability
| Article | Year |
|---|---|
Aspartylglycosaminuria. Analysis of thirty-four patients.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Birth Order; Birth Weight; C | 1972 |
39 other studies available for aspartic acid and Intellectual Disability
| Article | Year |
|---|---|
D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.
Topics: Adult; Animals; Aspartic Acid; Autism Spectrum Disorder; D-Aspartate Oxidase; D-Aspartic Acid; Gene | 2022 |
Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells.
Topics: Amino Acid Metabolism, Inborn Errors; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Atrophy; | 2023 |
Rhombencephalosynapsis in a patient with mental retardation, epilepsy, and dysmorphisms.
Topics: Adolescent; Aspartic Acid; Body Dysmorphic Disorders; Creatine; Epilepsy; Humans; Intellectual Disab | 2011 |
Pyridoxine-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Aspartic Acid; Brain Damage, Chronic; Child; Choline; Consanguinity; Creatine; Diagnosis, Differenti | 2004 |
Disorder-associated mutations lead to functional inactivation of neuroligins.
Topics: Animals; Arginine; Aspartic Acid; Autistic Disorder; Carrier Proteins; Cell Adhesion Molecules, Neur | 2004 |
Leukoencephalopathy with bilateral anterior temporal lobe cysts.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Central Nervous System Cysts; Child; Child, Preschool; F | 2006 |
Neuroimaging findings in hyperargininemia.
Topics: Arginine; Aspartic Acid; Atrophy; Basal Ganglia Cerebrovascular Disease; Brain Diseases; Cerebellum; | 2008 |
Clinical and biochemical delineation of aspartyl-glycosaminuria as observed in two members of an Italian family.
Topics: Abnormalities, Multiple; Acetylglucosamine; Adult; Amidohydrolases; Aspartic Acid; Aspartylglucosami | 1981 |
Reduced N-acetylaspartate in the brain observed on in vivo proton magnetic resonance spectroscopy in patients with mental retardation.
Topics: Adolescent; Aspartic Acid; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Femal | 1995 |
Differences in brain metabolites between patients with autism and mental retardation as detected by in vivo localized proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Autistic Disorder; Brain; Child; Child, Preschool; Choline; Creatine; Female; Humans; | 1997 |
Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS.
Topics: Adolescent; Age Factors; Aspartic Acid; Basal Ganglia; Brain; Brain Neoplasms; Cerebellum; Child; Ch | 1999 |
Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.
Topics: Amino Acids; Aspartic Acid; Child, Preschool; Citric Acid; Dose-Response Relationship, Drug; Female; | 1999 |
Mental retardation and behavioral problems as presenting signs of a creatine synthesis defect.
Topics: Aspartic Acid; Body Fluids; Brain Diseases, Metabolic; Child, Preschool; Creatine; Diagnosis, Differ | 2000 |
Prefrontal and medial temporal correlates of repetitive violence to self and others.
Topics: Adult; Amygdala; Aspartic Acid; Choline; Female; Hippocampus; Humans; Intellectual Disability; Inter | 2000 |
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain St | 2001 |
Aspartylglycosaminuria in Northern Norway in eight patients: clinical heterogeneity and variations with the diet.
Topics: Acetylglucosamine; Adolescent; Adult; Amidohydrolases; Aspartic Acid; Aspartylglucosaminuria; Child; | 1978 |
Aspartylglycosaminuria, urinary excretion of aspartylglycosamines related to mental retardation.
Topics: Adolescent; Adult; Amidohydrolases; Aspartic Acid; Aspartylglucosaminuria; Child; Child, Preschool; | 1978 |
Studies on N-aspartyl-beta-glucosaminidase in aspartylglycosaminuria.
Topics: Animals; Aspartic Acid; Carbohydrate Metabolism, Inborn Errors; Cell Nucleus; Chromatography, Agaros | 1975 |
[Cri-du-chat disease: plasma and urinary amino acids].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Asparagine; Aspartic Acid; Chi | 1990 |
Dicarboxylic aminoaciduria associated with mental retardation.
Topics: Amino Acids, Dicarboxylic; Aspartic Acid; Child; Female; Glutamates; Glutamic Acid; Humans; Intellec | 1989 |
Aspartame. Review of safety issues. Council on Scientific Affairs.
Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplas | 1985 |
[Characteristics of the amino acid spectrum of the blood of children with intellectual deficiency].
Topics: Amino Acids; Ammonia; Arginine; Aspartic Acid; Child; Female; Glutamates; Glutamic Acid; Humans; Int | 1986 |
N-acetylaspartic aciduria due to aspartoacylase deficiency--a new aetiology of childhood leukodystrophy.
Topics: Amidohydrolases; Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Brain; Diffuse Cerebral Sclero | 1987 |
Aspartylglycosaminuria. An inborn error of metabolism associated with mental defect.
Topics: Adult; Asparagine; Aspartic Acid; Female; Glucosamine; Glucosidases; Glycoproteins; Humans; Intellec | 1968 |
Aspartylglycosaminuria (AGU). Further aspects on its clinical picture, mode of inheritance and epidemiology based on a series of 57 patients.
Topics: Adolescent; Adult; Amidohydrolases; Aspartic Acid; Bone Marrow; Child; Child, Preschool; Consanguini | 1973 |
[Use of a preparation with a base of L-citrulline and L-acetylaspartic acid in minors with "mental fatigue" and slight "mental retardation"].
Topics: Adolescent; Aspartic Acid; Child; Citrulline; Female; Humans; Intellectual Disability; Male; Mental | 1966 |
A search for aspartylglycosaminuria in Poland.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Child, Institutionalized; Chromatography, Paper | 1974 |
Glycoasparagines in the urine of patients with aspartylglycosaminuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Asparagine; Aspartic Acid; Chromatography; Chroma | 1972 |
Further speculation on the pathogenesis of Leigh's encephalomyelopathy.
Topics: Aspartic Acid; Brain Stem; Citric Acid Cycle; Encephalomalacia; Humans; Intellectual Disability; Lig | 1973 |
Medical research council unit for metabolic studies in psychiatry, Sheffield.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Bipolar Disorder; Catatonia; Circadian Rhythm; | 1973 |
Picture of the Month. Aspartylglucosaminuria.
Topics: Adolescent; Aspartic Acid; Body Height; Child; Child, Preschool; Chromatography, Thin Layer; Chromos | 1974 |
Abnormal levels of aspartic acid, serine and cystine in the plasma in three cases of Rubinstein Taybi's syndrome.
Topics: Abnormalities, Multiple; Aspartic Acid; Chromatography, Ion Exchange; Cystine; Female; Humans; Intel | 1972 |
[Aspartylglucosaminuria].
Topics: Adolescent; Adult; Amidohydrolases; Aspartic Acid; Child; Child, Preschool; Female; Glucosamine; Hum | 1972 |
[Amino acid excretion in urine and enzyme activities in blood of persons from 3 families with mental deficiency].
Topics: Acid Phosphatase; Adolescent; Adult; Alanine; Alkaline Phosphatase; Amino Acids; Aspartate Aminotran | 1969 |
Eleven new cases of aspartylglucosaminuria.
Topics: Abnormalities, Multiple; Acetamides; Adolescent; Adult; Aspartic Acid; Chromatography; Electroenceph | 1970 |
Detection of argininosuccinic aciduria by gas chromatography.
Topics: Arginine; Aspartic Acid; Ataxia; Chemical Precipitation; Chromatography, Gas; Epilepsy; Esters; Huma | 1969 |
Metabolic traits in mentally retarded children as compared with normal populations: monoaminodicarboxylic acids and their half amides and total amino acids.
Topics: Adolescent; Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Child; Child, Preschool; Chro | 1969 |
Enzymatic cleavage of 2-acetamido-1-(beta'-L-aspartamido)-1,2-dideoxy-beta-D-glucose by human plasma and seminal fluid. Failure to detect the heterozygous state for aspartylglycosaminuria.
Topics: Amides; Aspartic Acid; Carbohydrates; Chromatography, Gel; Chromatography, Ion Exchange; Dextrans; E | 1969 |
Argininosuccinic aciduria: clinical, biochemical, anatomical and neuropathological observations.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Arginine; Aspartic Acid; Brain; Cerebell | 1969 |