aspartic acid has been researched along with Infarction, Middle Cerebral Artery in 24 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactate/choline ratio measured in the acute infarct core by 1H MRS improves the prediction of stroke outcome and provides prognostic information complementary to DWI." | 5.09 | Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome. ( Barber, PA; Darby, DG; Davis, SM; Desmond, PM; Gerraty, RP; Li, T; Parsons, MW; Tress, BM; Yang, Q, 2000) |
| " Although a number of studies have investigated that ginkgolide B, a purified terpene lactone component extracted from Ginkgo biloba leaves, is available "platelet activating factor (PAF) receptors antagonist", "antioxidant" with a variety of actions, very little has been performed to explore the effect of ginkgolide B on extracellular amino acids in experimental animal of focal cerebral ischemia/reperfusion." | 3.77 | Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats. ( Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ, 2011) |
| " T2 weighted-imaging (T2WI) and 1H-magnetic resonance spectroscopy (1H-MRS) were performed, to study the changes of the imaging and the neuronal metabolites N-acetyl aspartate (NAA), creatine/phosphocreatine (Cr/PCr), choline (Cho) and lactose (Lac) in cerebrum following cerebral ischemia." | 3.72 | [The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats]. ( Fan, M; Li, LY; Liao, WJ; Liu, ML; Yang, WT; Yang, YH, 2003) |
| "NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue." | 2.70 | Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. ( Beley, A; Brunotte, F; Demougeot, C; Giroud, M; Marie, C; Rouaud, O; Walker, P, 2002) |
| "Those that developed cerebral ischemia after MCAO were randomized to receive propylene glycol salt water and ligustrazine respectively." | 1.40 | Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury. ( Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY, 2014) |
| "Regarding MCA infarction, contralateral tissue remote from the lesion behaves abnormally in the presence of hypertension, the NAA ratios in hypertensive patients being significantly lower." | 1.33 | Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors? ( Ben Salem, D; Brunotte, F; Giroud, M; Walker, PM, 2006) |
| "Reversible middle cerebral artery occlusion (rMCAo) was induced in anesthetized rats using the intraluminal suture technique." | 1.32 | Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra. ( Feustel, PJ; Jin, Y; Kimelberg, HK, 2004) |
| "A case of cerebral infarction with transient cerebral arteriopathy in a 12-year-old female is described." | 1.32 | MR imaging and 1H-MR spectroscopy in a case of cerebral infarction with transient cerebral arteriopathy. ( Ariki, M; Hattori, T; Horikoshi, H; Imamura, A; Matsuo, N, 2004) |
| "Using middle cerebral artery occlusion (MCAO) and in vivo microdialysis, we have evaluated the changes in extracellular concentrations of the excitatory amino acids (EAA) glutamate and aspartate during varying periods of MCAO (0, 30, 60 min) in the striatum of spontaneously hypertensive rats (SHR)." | 1.31 | Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats. ( Dawson, LA; Djali, S; Gonzales, C; Vinegra, MA; Zaleska, MM, 2000) |
| "The effects of middle cerebral artery occlusion (MCAO) on neuronal and astrocytic intermediary metabolism were studied in rats 30, 60, 120, and 240 minutes after MCAO using in vivo injection of [1-13C]glucose and [1,2- 13C]acetate combined with ex vivo 13C magnetic resonance spectroscopy and high-performance liquid chromatography analysis of the ischemic core (lateral caudoputamen and lower parietal cortex) and penumbra (upper frontoparietal cortex)." | 1.31 | Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival. ( Håberg, A; Haraldseth, O; Qu, H; Saether, O; Sonnewald, U; Unsgård, G, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (62.50) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jolly, S | 1 |
| Bazargani, N | 1 |
| Quiroga, AC | 1 |
| Pringle, NP | 1 |
| Attwell, D | 1 |
| Richardson, WD | 1 |
| Li, H | 1 |
| Han, J | 1 |
| Wan, HT | 1 |
| Yang, JH | 1 |
| Zhang, YY | 1 |
| Ge, LJ | 1 |
| Bie, XD | 1 |
| Hinzman, JM | 1 |
| DiNapoli, VA | 1 |
| Mahoney, EJ | 1 |
| Gerhardt, GA | 1 |
| Hartings, JA | 1 |
| Lei, H | 3 |
| Berthet, C | 2 |
| Hirt, L | 2 |
| Gruetter, R | 2 |
| Woo, CW | 1 |
| Lee, BS | 1 |
| Kim, ST | 1 |
| Kim, KS | 1 |
| Bar-Shir, A | 1 |
| Shemesh, N | 1 |
| Nossin-Manor, R | 1 |
| Cohen, Y | 1 |
| Yang, ZZ | 1 |
| Li, J | 1 |
| Li, SX | 1 |
| Feng, W | 1 |
| Wang, H | 1 |
| Alf, MF | 1 |
| Mlynarik, V | 1 |
| Ramanathan, M | 1 |
| Babu, CS | 1 |
| Justin, A | 1 |
| Shanthakumari, S | 1 |
| Qian, J | 1 |
| Qian, B | 1 |
| Roitberg, B | 1 |
| Khan, N | 1 |
| Tuccar, E | 1 |
| Kompoliti, K | 1 |
| Chu, Y | 1 |
| Alperin, N | 1 |
| Kordower, JH | 1 |
| Emborg, ME | 1 |
| Wei, J | 1 |
| Cohen, DM | 1 |
| Quast, MJ | 1 |
| Liu, YJ | 1 |
| Chen, CY | 1 |
| Chung, HW | 1 |
| Huang, IJ | 1 |
| Lee, CS | 1 |
| Chin, SC | 1 |
| Liou, M | 1 |
| Liao, WJ | 1 |
| Yang, YH | 1 |
| Fan, M | 1 |
| Yang, WT | 1 |
| Li, LY | 1 |
| Liu, ML | 1 |
| Feustel, PJ | 2 |
| Jin, Y | 1 |
| Kimelberg, HK | 2 |
| Imamura, A | 1 |
| Matsuo, N | 1 |
| Ariki, M | 1 |
| Horikoshi, H | 1 |
| Hattori, T | 1 |
| Xu, L | 1 |
| Dayal, M | 1 |
| Ouyang, YB | 1 |
| Sun, Y | 1 |
| Yang, CF | 1 |
| Frydman, J | 1 |
| Giffard, RG | 1 |
| Walker, PM | 1 |
| Ben Salem, D | 1 |
| Giroud, M | 2 |
| Brunotte, F | 2 |
| Zhang, Y | 1 |
| Zhang, H | 1 |
| Parsons, MW | 1 |
| Li, T | 1 |
| Barber, PA | 1 |
| Yang, Q | 1 |
| Darby, DG | 1 |
| Desmond, PM | 1 |
| Gerraty, RP | 1 |
| Tress, BM | 1 |
| Davis, SM | 1 |
| Mauler, F | 1 |
| Fahrig, T | 1 |
| Horváth, E | 1 |
| Jork, R | 1 |
| Dawson, LA | 1 |
| Djali, S | 1 |
| Gonzales, C | 1 |
| Vinegra, MA | 1 |
| Zaleska, MM | 1 |
| Håberg, A | 1 |
| Qu, H | 1 |
| Saether, O | 1 |
| Unsgård, G | 1 |
| Haraldseth, O | 1 |
| Sonnewald, U | 1 |
| Demougeot, C | 1 |
| Walker, P | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Rouaud, O | 1 |
2 trials available for aspartic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Diffusion; Female; Humans; Infarction, Middl | 2000 |
Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity.
Topics: Aspartic Acid; Choline; Creatine; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; M | 2002 |
22 other studies available for aspartic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astro | 2018 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid | 2014 |
Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.
Topics: Analysis of Variance; Animals; Aspartic Acid; Blood Gas Analysis; Blood Pressure; Brain Injuries; Ce | 2015 |
Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain.
Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Corpus Striatum; Glucose; Glutamic Acid; Glutam | 2009 |
Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: An in vivo 1H magnetic resonance spectroscopic (1H-MRS) study.
Topics: Analysis of Variance; Animals; Apoptosis; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Creatini | 2010 |
Late stimulation of the sphenopalatine-ganglion in ischemic rats: improvement in N-acetyl-aspartate levels and diffusion weighted imaging characteristics as seen by MR.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Diffusion Magnetic Resonance Imaging; Electric Stimul | 2010 |
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkg | 2011 |
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarct | 2012 |
Elucidation of neuroprotective role of endogenous GABA and energy metabolites middle cerebral artery occluded model in rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Disease Models, Animal; Excitatory Amino Acid | 2012 |
Reversible loss of N-acetylaspartate after 15-min transient middle cerebral artery occlusion in rat: a longitudinal study with in vivo proton magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Creatine; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Lo | 2013 |
Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Chronic Disease; Follow-Up Studies; Immunohistochemis | 2003 |
Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats.
Topics: Animals; Antimetabolites; Aspartic Acid; Deoxyglucose; Hyperglycemia; Infarction, Middle Cerebral Ar | 2003 |
Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging.
Topics: Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Co | 2003 |
[The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats].
Topics: Animals; Aspartic Acid; Asteraceae; Brain; Brain Ischemia; Choline; Creatine; Drugs, Chinese Herbal; | 2003 |
Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra.
Topics: Amino Acid Transport System X-AG; Animals; Anion Transport Proteins; Aspartic Acid; Astrocytes; Brai | 2004 |
MR imaging and 1H-MR spectroscopy in a case of cerebral infarction with transient cerebral arteriopathy.
Topics: Aspartic Acid; Brain; Carotid Artery, Internal, Dissection; Cerebral Infarction; Child; Choline; Cre | 2004 |
Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Blotting, Western; Brain | 2006 |
Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors?
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dominance, Cerebral; Female | 2006 |
DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra.
Topics: Animals; Aspartic Acid; Brain Infarction; Chromatography, High Pressure Liquid; Cyclopentanes; Dialy | 2008 |
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.
Topics: Animals; Aspartic Acid; Benzopyrans; Brain Ischemia; Disease Models, Animal; Dose-Response Relations | 2001 |
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; | 2000 |
Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival.
Topics: Acetate-CoA Ligase; Alanine; Anesthetics, Inhalation; Animals; Aspartic Acid; Astrocytes; Blood Gluc | 2001 |