aspartic acid has been researched along with Idiopathic Parkinson Disease in 84 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (7.14) | 18.7374 |
1990's | 23 (27.38) | 18.2507 |
2000's | 26 (30.95) | 29.6817 |
2010's | 25 (29.76) | 24.3611 |
2020's | 4 (4.76) | 2.80 |
Authors | Studies |
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Alger, JR; Bui, V; Choupan, J; Donahue, EK; Duran, JJ; Foreman, RP; Jakowec, MW; O'Neill, J; Petzinger, GM; Van Horn, JD; Venkadesh, S | 1 |
Annunziato, L; Della Notte, S; Scorziello, A; Secondo, A; Sisalli, MJ; Ventra, C | 1 |
Du, N; Song, Z; Yuan, M | 1 |
Butterfield, DA; Hinchie, A; Powell, DK; Ren, X; Swomley, A | 1 |
Chaudhary, S; Goyal, V; Jagannathan, NR; Kalaivani, M; Kaloiya, GS; Kumaran, SS; Mehta, N; Sagar, R; Srivastava, AK | 1 |
Arabia, G; Barbagallo, G; Caracciolo, M; Cherubini, A; Morelli, M; Nisticò, R; Novellino, F; Quattrone, A; Rocca, F; Sabatini, U; Salsone, M | 1 |
Moriya, M; Nojo, T; Waragai, M | 1 |
Robertson, DS | 1 |
Gröger, A; Klose, U; Kolb, R; Schäfer, R | 1 |
Bergamaschi, MM; Chagas, MH; Crippa, JA; dos Santos, AC; Hallak, JE; Pena-Pereira, MA; Sobreira, ET; Teixeira, AL; Tumas, V; Zuardi, AW | 1 |
Bramanti, P; Ciurleo, R; Di Lorenzo, G; Marino, S | 1 |
Bonanno, L; Bramanti, P; Ciurleo, R; Di Lorenzo, G; Marino, S | 1 |
Öz, G | 1 |
Bao, F; Caon, C; Chorostecki, J; George, E; Gorden, V; Khan, O; Krstevska, S; Santiago, C; Seraji-Bozorgzad, N; Zak, I | 1 |
Almuqbel, M; Anderson, TJ; Dalrymple-Alford, JC; Keenan, RJ; Livingston, L; MacAskill, MR; Melzer, TR; Myall, DJ; Pitcher, TL; Wood, KL | 1 |
Chen, J; Huang, MH; Liu, Y; Shen, YJ; Wu, G; Xing, Z | 1 |
Auburger, G; Azizov, M; Bonin, M; Gasser, T; Gispert, S; Hoepken, HH; Klinkenberg, M; Kögel, D; Kurz, A; Morales-Gordo, B; Ricciardi, F; Riess, O; Steinmetz, H | 1 |
Bardien, S; Carr, J; Keyser, R; Lombard, D; Yako, Y | 1 |
Camicioli, RM; Gee, M; Hanstock, CC; Martin, WR; Wieler, M | 1 |
den Hollander, JA; Griffith, HR; Marson, DC; O'Brien, T; Okonkwo, OC; Watts, RL | 1 |
Fan, Z; Feany, MB; Hyman, BT; McFarland, NR; McLean, PJ; Schwarzschild, MA; Xu, K | 1 |
Rajasankar, S; Surendran, S | 1 |
Barker, GJ; Blain, CR; Guevara, CA; Leigh, PN; Lythgoe, DJ; Stahl, D | 1 |
Austin, PJ; Betts, MJ; Broadstock, M; Duty, S; Mitchell, SN; O'Neill, MJ | 1 |
Berg, D; Chadzynski, G; Godau, J; Gröger, A; Klose, U | 1 |
Cuellar-Baena, S; Dahlberg, C; Denisov, V; Hall, H; In't Zandt, R; Kirik, D | 1 |
Cao, L; Chen, S; Chen, SD; Liu, J; Ma, JF; Rong, TY; Wang, G; Wang, Y; Xiao, Q; Zhang, Y | 1 |
Baudrexel, S; Berg, D; Brockmann, K; Csoti, I; Gasser, T; Hattingen, E; Hauser, AK; Hilker, R; Magerkurth, J; Merten, CD; Pilatus, U; Schulte, C; Srulijes, K | 1 |
Duffy, S; Halliday, G; Lewis, SJ; Naismith, SL; Shine, JM | 1 |
Fukazawa, Y; Mito, Y; Tajima, Y; Yanai, M | 1 |
Ando, M; Funayama, M; Hashimoto, T; Hatano, T; Hattori, N; Ishizu, N; Kashihara, K; Kokubo, Y; Kuzuhara, S; Li, Y; Murakami, Y; Nakano, N; Noguchi, K; Ogaki, K; Sasaki, R; Tomiyama, H; Toyoda, C; Yamashita, C; Yoshino, H | 1 |
Delfino, M; García-Sánchez, C; Gironell, A; Gómez-Ansón, B; Kulisevsky, J; Llebaria, G; Pagonabarraga, J; Pascual-Sedano, B; Rotger, R; Ruscalleda, J | 1 |
Gan, R; Huang, B; Huang, Z; Nie, K; Wang, L; Zhang, Y; Zhao, J | 1 |
Burgunder, J; Cao, B; Chen, K; Chen, X; Chen, Y; Guo, X; Huang, R; Li, J; Shang, HF; Song, W; Zhao, B | 1 |
Aasly, J; Axelson, D; Bakken, IJ; Ehrnholm, B; Nilsen, G; Susann Gribbestad, I | 1 |
Firbank, MJ; Harrison, RM; O'Brien, JT | 1 |
Rottenberg, DA | 1 |
Bianchi, L; Bolam, JP; Della Corte, L; Galeffi, F | 1 |
Baik, HM; Choe, BY; Jeun, SS; Kim, BS; Kim, MC; Lee, HK; Lee, JM; Lee, KS; Son, BC; Suh, TS | 1 |
Liu, Y; Ruan, LX; Shang, DS; Yuan, M; Zhang, LJ; Zheng, XN; Zhu, XC | 1 |
Bastos, AC; Camicioli, RM; Emery, DJ; Fisher, NJ; Foster, SL; Hanstock, CC; Korzan, JR | 1 |
Fukatsu, H; Hamada, K; Hirayama, M; Ishigaki, T; Katsuno, M; Okada, Y; Sobue, G; Sugiura, M; Watanabe, H | 1 |
Afridi, S; Andrews, H; Clark, LN; Cote, LJ; Fahn, S; Ford, B; Frucht, S; Harris, J; Louis, ED; Marder, K; Mayeux, R; Mejia-Santana, H; Nicolai, A; Ottman, R; Strug, L; Waters, C | 1 |
Chen, L; Feany, MB | 1 |
Mignon, LJ; Wolf, WA | 1 |
Dincer, A; Hanoglu, L; Meral, H; Ozer, F | 1 |
Aia, P; Gruetter, R; Lowary, J; Oz, G; Terpstra, M; Tkác, I; Tuite, PJ | 1 |
Akbas, N; Bauer, P; Behnke, S; Berg, D; Deplazes, J; Hochstrasser, H; Riess, O; Tomiuk, J; Walter, U | 1 |
Durif, F; Fraix, V; Kickler, N; Krack, P; Krainik, A; Lamalle, L; Lebas, JF; Pollak, P; Rémy, C; Segebarth, C | 1 |
Berti, C; Bianchi, MC; Bonuccelli, U; Ceravolo, R; Del Dotto, P; Gambaccini, G; Logi, C; Lucetti, C; Murri, L; Rossi, G; Tosetti, M | 1 |
Balas, I; Dóczi, TP; Kovacs, N; Llumiguano, C; Schwarcz, A; Usprung, Z | 1 |
Arosio, P; Biasiotto, G; Finazzi, D; Goldwurm, S; Pezzoli, G; Sironi, F; Tunesi, S; Zecchinelli, A | 1 |
McLennan, H | 1 |
Berl, S; Plaitakis, A | 1 |
Mizuno, Y; Tanaka, Y | 1 |
Heerschap, A; Hinshaw, DB; Holshouser, BA; Kolem, H; Komu, M; Masur, H; Möller, HE; Sonninen, P; Vermathen, P; Zijlmans, J | 1 |
Barker, GJ; Davie, CA; Kingsley, DP; Lees, AJ; Miller, PH; Pirtosek, Z | 1 |
Barker, GJ; Davie, CA; Kendall, BE; Marsden, CD; McDonald, WI; Miller, DH; Quinn, N; Tofts, PS; Wenning, GK | 1 |
de Koster, A; Heerschap, A; Horstink, MW; Thijssen, HO; van 't Hof, MA; Zijlmans, JC | 1 |
Block, RE; Bowen, BC; Lampman, DA; Murdoch, JB; Pattany, PM; Quencer, RM; Sanchez-Ramos, J | 1 |
Barker, GJ; Brennan, A; Davie, CA; Miller, DH; Quinn, N; Wenning, GK | 1 |
Akiguchi, I; Handa, J; Inubushi, T; Matsuda, M; Morikawa, S; Shiino, A | 1 |
Chaudhuri, KR; Leigh, PN; Lemmens, G; Williams, SC | 1 |
Arenas, J; Benito-León, J; Cisneros, E; Gasalla, T; Gómez, P; Jiménez-Jiménez, FJ; Molina, JA; Navarro, JA; Ortí-Pareja, M; Vargas, C | 1 |
Aotsuka, A; Hattori, T; Shinotoh, H | 1 |
De Mari, M; Federico, F; Giannini, P; Iliceto, G; Lamberti, P; Lucivero, V; Mezzapesa, DM; Simone, IL | 1 |
Clarke, CE; Horsman, A; Lowry, M | 1 |
Chaudhuri, KR; Dawson, J; Ellis, CM; Leigh, PN; Lemmens, G; Simmons, A; Williams, SC | 1 |
Aminoff, MJ; Cruz, CJ; Graham, SH; Meyerhoff, DJ; Weiner, MW | 1 |
Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G | 1 |
De Mari, M; Federico, F; Giannini, P; Iliceto, G; Lamberti, P; Lucivero, V; Mezzapesa, DM; Simone, IL; Tarantino, A | 1 |
Choe, BY; Kim, BS; Kim, MC; Lee, HK; Lee, KS; Park, JW; Shinn, KS; Son, BC; Suh, TS | 1 |
Akiyama, H; Arai, T; Ikeda, K; Kondo, H; Mori, H | 1 |
Bhattacharya, S; Brooks, DJ; Bryant, DJ; Cox, IJ; Sargentoni, J; Seery, JP; Taylor-Robinson, SD; Turjanski, N | 1 |
Blüml, S; Dubowitz, D; Hoang, TQ; Jacques, DB; Kopyov, OV; Lin, A; Ross, BD; Seymour, K; Tan, J | 1 |
Im, JH; Jeong, Y; Kim, HS; Kim, JS; Sohn, YH | 1 |
Clarke, CE; Lowry, M | 1 |
Bernardini, S; Bianchi, MC; Bonuccelli, U; Del Dotto, P; Gambaccini, G; Lucetti, C; Tosetti, M | 1 |
Ikeda, K; Iwasaki, Y; Kinoshita, M; Shiojima, T | 1 |
Carlsson, A; Carlsson, M | 1 |
Bonham, JR; Candy, JM; Marshall, E; Perry, EK; Perry, RH; Xuereb, JH | 1 |
Cross, AJ; Deakin, JF; Perry, EK; Perry, RH; Royston, C; Simpson, M; Slater, P | 1 |
Meldrum, B | 1 |
Amsler, U; Cuénod, M; Perschak, H; Siegfried, J; Vischer, A | 1 |
6 review(s) available for aspartic acid and Idiopathic Parkinson Disease
Article | Year |
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Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Molecular Imaging; Parkinson Disease; Reproducibility of Results; Sensitivity and Specificity | 2014 |
Parkinson's disease: oxidative stress and therapeutic approaches.
Topics: Animals; Antioxidants; Aspartic Acid; Brain; Catecholamines; Humans; Lipid Peroxidation; Nitric Oxide; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Ubiquitins | 2010 |
A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; Parkinson Disease; Reference Values; Temporal Lobe | 2002 |
[Magnetic resonance spectroscopy in Parkinson's disease and multiple system atrophy].
Topics: Aspartic Acid; Autonomic Nervous System Diseases; Basal Ganglia Diseases; Brain; Choline; Creatine; Diagnosis, Differential; Humans; Magnetic Resonance Spectroscopy; Parkinson Disease; Protons | 1997 |
Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
Topics: Animals; Anticonvulsants; Aspartic Acid; Basal Ganglia; Biogenic Amines; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Parkinson Disease; Schizophrenia | 1990 |
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats | 1985 |
7 trial(s) available for aspartic acid and Idiopathic Parkinson Disease
Article | Year |
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Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain-Derived Neurotrophic Factor; Cannabidiol; Creatine; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Parkinson Disease; Proton Magnetic Resonance Spectroscopy; Putamen; Quality of Life; Severity of Illness Index; Treatment Outcome | 2014 |
MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms.
Topics: Aged; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Multiple regional 1H-MR spectroscopy in multiple system atrophy: NAA/Cr reduction in pontine base as a valuable diagnostic marker.
Topics: Aspartic Acid; Brain Stem; Case-Control Studies; Cerebral Cortex; Creatine; Diagnosis, Differential; Female; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple System Atrophy; Parkinson Disease; Putamen; Reference Values | 2004 |
Influences of dopaminergic treatment on motor cortex in Parkinson disease: a MRI/MRS study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatinine; Dopamine Agonists; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Parkinson Disease; Pergolide; Protons; Treatment Outcome | 2007 |
1H-MRS experiences after bilateral DBS of the STN in Parkinson's disease.
Topics: Aged; Aspartic Acid; Choline; Creatine; Deep Brain Stimulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Protons; Subthalamic Nucleus | 2008 |
Localized proton NMR spectroscopy in the striatum of patients with idiopathic Parkinson's disease: a multicenter pilot study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antiparkinson Agents; Aspartic Acid; Carbidopa; Choline; Corpus Striatum; Dopamine Agonists; Drug Combinations; Female; Humans; Levodopa; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Pilot Projects; Protons | 1995 |
Proton magnetic resonance spectroscopy in Parkinson's disease and progressive supranuclear palsy.
Topics: Aged; Aspartic Acid; Corpus Striatum; Creatine; Globus Pallidus; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Parkinson Disease; Phosphocreatine; Putamen; Statistics, Nonparametric; Supranuclear Palsy, Progressive | 1997 |
71 other study(ies) available for aspartic acid and Idiopathic Parkinson Disease
Article | Year |
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Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson's disease: a pilot and feasibility study.
Topics: Aspartic Acid; Brain; Creatine; Feasibility Studies; Humans; Inflammation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Parkinson Disease; Pilot Projects | 2022 |
L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson's Disease Models.
Topics: Aspartic Acid; Calcium; Dipeptides; Dopaminergic Neurons; Fluorescent Dyes; Homeostasis; Humans; Mitochondria; Neuroblastoma; Ornithine; Oxidopamine; Parkinson Disease; Reactive Oxygen Species; Rotenone | 2022 |
Primary motor area-related injury of anterior central gyrus in Parkinson's disease with dyskinesia: A study based on MRS and Q-space.
Topics: Aspartic Acid; Brain; Choline; Creatine; Dyskinesias; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Motor Cortex; Parkinson Disease | 2023 |
Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Corpus Striatum; Disease Models, Animal; Female; Gene Knockout Techniques; Glutamine; Glutathione; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Protein Kinases; Rats; Taurine | 2019 |
Frontal lobe metabolic alterations characterizing Parkinson's disease cognitive impairment.
Topics: Aspartic Acid; Brain; Cognitive Dysfunction; Creatine; Frontal Lobe; Gray Matter; Humans; Magnetic Resonance Imaging; Parkinson Disease | 2021 |
Thalamic neurometabolic alterations in tremulous Parkinson's disease: A preliminary proton MR spectroscopy study.
Topics: Aged; Aspartic Acid; Choline; Creatine; Discriminant Analysis; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Logistic Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; ROC Curve; Thalamus; Tomography, Emission-Computed, Single-Photon; Tremor | 2017 |
Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Gyrus Cinguli; Humans; Inositol; Lewy Body Disease; Male; Mental Status and Dementia Tests; Parkinson Disease; Prodromal Symptoms; Proton Magnetic Resonance Spectroscopy; Retrospective Studies; Risk Factors | 2017 |
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine; Lewy Bodies; Models, Biological; Parkinson Disease; Plaque, Amyloid; Pyruvaldehyde; Quinolinic Acid; Treatment Outcome | 2017 |
Dopamine reduction in the substantia nigra of Parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dopamine; Humans; Magnetic Resonance Imaging; Middle Aged; Parkinson Disease; Substantia Nigra | 2014 |
Metabolic changes in de novo Parkinson's disease after dopaminergic therapy: A proton magnetic resonance spectroscopy study.
Topics: Antiparkinson Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dopamine Agonists; Female; Humans; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Parkinson Disease; Proton Magnetic Resonance Spectroscopy | 2015 |
MR Spectroscopy: A Longitudinal Biomarker for Substantia Nigra Pathology in Parkinson's Disease?
Topics: Aspartic Acid; Creatine; Female; Humans; Male; Parkinson Disease; Proton Magnetic Resonance Spectroscopy; Substantia Nigra | 2015 |
Longitudinal study of the substantia nigra in Parkinson disease: A high-field (1) H-MR spectroscopy imaging study.
Topics: Aged; Aspartic Acid; Biomarkers; Creatine; Female; Humans; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Proton Magnetic Resonance Spectroscopy; Substantia Nigra | 2015 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysfunction; Creatine; Dementia; Disease Progression; Female; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Superior Sagittal Sinus | 2016 |
Proton MR Spectroscopy for Monitoring Pathologic Changes in the Substantia Nigra and Globus Pallidus in Parkinson Disease.
Topics: Aged; Aspartic Acid; Creatine; Female; Globus Pallidus; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Protons; Retrospective Studies; Severity of Illness Index; Substantia Nigra | 2016 |
Parkinson patient fibroblasts show increased alpha-synuclein expression.
Topics: Aged; alpha-Synuclein; Aspartic Acid; Cells, Cultured; Family Health; Female; Fibroblasts; Gene Expression Regulation; Glycine; Humans; Male; Middle Aged; Mitochondria; Mutation; Parkinson Disease; Protein Kinases; Time Factors | 2008 |
Molecular analysis of the parkin gene in South African patients diagnosed with Parkinson's disease.
Topics: Adolescent; Adult; Aged; Arginine; Asparagine; Aspartic Acid; Cysteine; DNA Mutational Analysis; Exons; Female; Gene Frequency; Heterozygote; Humans; Male; Middle Aged; Parkinson Disease; Point Mutation; Sequence Deletion; South Africa; Ubiquitin-Protein Ligases; Young Adult | 2009 |
Intact presupplementary motor area function in early, untreated Parkinson's disease.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Parkinson Disease | 2008 |
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studies; Choline; Creatine; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Parkinson Disease | 2008 |
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Topics: Alanine; alpha-Synuclein; Animals; Aspartic Acid; Basal Ganglia; Cell Count; Dependovirus; Disease Models, Animal; Dopamine; Green Fluorescent Proteins; Humans; Mutation; Nerve Tissue Proteins; Parkinson Disease; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Quantitative magnetic resonance spectroscopic imaging in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.
Topics: Aged; Aspartic Acid; Basal Ganglia Diseases; Biomarkers; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple System Atrophy; Neurons; Parkinson Disease; Predictive Value of Tests; Supranuclear Palsy, Progressive | 2010 |
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease.
Topics: Aminobutyrates; Animals; Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Parkinson Disease; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra | 2010 |
Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's disease.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Substantia Nigra | 2011 |
Magnetic resonance spectroscopic methods for the assessment of metabolic functions in the diseased brain.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Humans; Isotopes; Magnetic Resonance Spectroscopy; Parkinson Disease; Protons | 2012 |
Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Asparagine; Aspartic Acid; China; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Vesicular Transport Proteins | 2012 |
GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure.
Topics: Adenosine Diphosphate; Adult; Age of Onset; Aged; Algorithms; Aspartic Acid; Brain Chemistry; Choline; Creatine; DNA; Energy Metabolism; Female; Glucosylceramidase; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Membranes; Middle Aged; Mitochondria; Nerve Degeneration; Neurons; Parkinson Disease; Phospholipids; Software | 2012 |
Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease.
Topics: Aged; Aspartic Acid; Case-Control Studies; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Humans; Linear Models; Magnetic Resonance Spectroscopy; Male; Mental Disorders; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Parkinson Disease | 2012 |
Unusual basal ganglia lesions in a diabetic uraemic patient proven to be demyelination: first pathological observation.
Topics: Aspartic Acid; Basal Ganglia; Basal Ganglia Diseases; Demyelinating Diseases; Diabetic Nephropathies; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Follow-Up Studies; Humans; Japan; Macrophages; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myelinolysis, Central Pontine; Neurologic Examination; Parkinson Disease; Putamen; Shock, Septic; Uremia | 2012 |
VPS35 mutation in Japanese patients with typical Parkinson's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Asparagine; Aspartic Acid; Child; Disability Evaluation; Family Health; Female; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Vesicular Transport Proteins; Young Adult | 2012 |
Spectroscopic changes associated with mild cognitive impairment and dementia in Parkinson's disease.
Topics: Aged, 80 and over; Aspartic Acid; Brain Chemistry; Cognition; Cognitive Dysfunction; Data Interpretation, Statistical; Dementia; Disease Progression; Executive Function; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Prefrontal Cortex; Psychiatric Status Rating Scales; Psychomotor Performance; Temporal Lobe; Tomography, X-Ray Computed | 2012 |
Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment.
Topics: Aged; Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Choline; Cognitive Dysfunction; Early Diagnosis; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease | 2013 |
VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China.
Topics: Adult; Aged; Arginine; Asparagine; Aspartic Acid; Case-Control Studies; China; Eukaryotic Initiation Factor-4G; Female; Histidine; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Vesicular Transport Proteins; Young Adult | 2013 |
Applications of neural network analyses to in vivo 1H magnetic resonance spectroscopy of Parkinson disease patients.
Topics: Aged; Aspartic Acid; Basal Ganglia; Case-Control Studies; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neural Networks, Computer; Parkinson Disease | 2002 |
Why Rome trembles: "E avanti a lui tremava tutta Roma!" (Tosca, Act II).
Topics: Aspartic Acid; Cerebellum; Choline; Creatine; Essential Tremor; Humans; Magnetic Resonance Spectroscopy; Parkinson Disease; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Tomography, Emission-Computed | 2003 |
The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Basal Ganglia; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Microdialysis; Models, Animal; Oxidopamine; Parkinson Disease; Potassium; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2003 |
Proton MR spectroscopic changes in Parkinson's diseases after thalamotomy.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Postoperative Period; Protons; Stereotaxic Techniques; Thalamus; Treatment Outcome; Tremor | 2003 |
Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia.
Topics: Aged; Aspartic Acid; Case-Control Studies; Choline; Cognition; Creatine; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Parkinson Disease | 2004 |
Pilot association study of the beta-glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity.
Topics: Aged; Alleles; Aspartic Acid; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Glucosylceramidase; Humans; Jews; Linkage Disequilibrium; Male; Middle Aged; Parkinson Disease; Pilot Projects; Point Mutation; Serine | 2005 |
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; beta-Adrenergic Receptor Kinases; Brain; Central Nervous System; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dopamine; Drosophila; Drosophila Proteins; G-Protein-Coupled Receptor Kinase 2; Inclusion Bodies; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Point Mutation; Retina; Serine; Synucleins | 2005 |
8-hydroxy-2-(di-n-propylamino)tetralin reduces striatal glutamate in an animal model of Parkinson's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Aspartic Acid; Corpus Striatum; Denervation; Disease Models, Animal; Glutamic Acid; Injections, Subcutaneous; Male; Microdialysis; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Sympatholytics | 2005 |
Brainstem 1H-MR spectroscopy in patients with Parkinson's disease with REM sleep behavior disorder and IPD patients without dream enactment behavior.
Topics: Aged; Aspartic Acid; Brain Stem; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Prospective Studies; REM Sleep Behavior Disorder | 2006 |
Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla: detection of high GABA concentrations.
Topics: Aspartic Acid; Feasibility Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Parkinson Disease; Protons; Substantia Nigra | 2006 |
Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra.
Topics: Aged; Aspartic Acid; Chromatography, High Pressure Liquid; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Testing; Hemochromatosis Protein; Histocompatibility Antigens Class I; Humans; Isoleucine; Male; Membrane Proteins; Middle Aged; Mucoproteins; Mutation; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Threonine | 2006 |
Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.
Topics: Antiparkinson Agents; Aspartic Acid; Corpus Striatum; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Levodopa; Magnetic Resonance Spectroscopy; Parkinson Disease; Reference Values | 2007 |
HFE gene mutations in a population of Italian Parkinson's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Hemochromatosis Protein; Histidine; Histocompatibility Antigens Class I; Humans; Italy; Male; Membrane Proteins; Middle Aged; Mutation; Parkinson Disease; Serine | 2008 |
Excitatory amino acid receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Brain; Glutamates; Glutamic Acid; Humans; Kainic Acid; Kinetics; Neurons; Parkinson Disease; Protein Conformation; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord | 1981 |
Oral glutamate loading in disorders with spinocerebellar and extrapyramidal involvement: effect on plasma glutamate, aspartate and taurine.
Topics: Aspartic Acid; Atrophy; Basal Ganglia Diseases; Cerebellar Diseases; Cerebellum; Friedreich Ataxia; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Nerve Degeneration; Olivary Nucleus; Parkinson Disease; Pons; Shy-Drager Syndrome; Sodium Glutamate; Spinal Cord Diseases; Taurine | 1983 |
[GABA, glutamate, aspartate, glycine, and taurine contents in spinocerebellar degeneration and parkinsonism].
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Brain Chemistry; Cerebellar Ataxia; Chromatography, High Pressure Liquid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease; Taurine | 1984 |
Magnetic resonance spectroscopic study of parkinsonism related to boxing.
Topics: Aged; Aspartic Acid; Boxing; Corpus Striatum; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease | 1995 |
Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Basal Ganglia; Brain Diseases; Choline; Creatine; Diagnosis, Differential; Globus Pallidus; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Parkinson Disease; Protons; Putamen | 1995 |
Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism.
Topics: Aged; Aspartic Acid; Brain; Brain Ischemia; Brain Mapping; Energy Metabolism; Female; Humans; Intracranial Arteriosclerosis; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Parkinson Disease; Regional Blood Flow | 1994 |
Proton MR spectroscopy of the brain in 14 patients with Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dementia; Energy Metabolism; Female; Humans; Lactates; Levodopa; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Oxidation-Reduction; Parkinson Disease; Phosphocreatine; Protons | 1995 |
MRS to differentiate multiple system atrophy from idiopathic Parkinson's disease.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Central Nervous System Diseases; Creatine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease | 1993 |
Proton magnetic resonance spectroscopy with dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatine; Dementia; Female; Humans; Hydrocephalus, Normal Pressure; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Protons; Reference Values | 1993 |
Magnetic resonance spectroscopic study of parkinsonism related to boxing.
Topics: Aspartic Acid; Boxing; Humans; Magnetic Resonance Spectroscopy; Parkinson Disease; Pilot Projects | 1995 |
Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease.
Topics: Aged; Amino Acids; Asparagine; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease | 1996 |
Unchanged basal ganglia N-acetylaspartate and glutamate in idiopathic Parkinson's disease measured by proton magnetic resonance spectroscopy.
Topics: Aged; Apomorphine; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Parkinson Disease | 1997 |
Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Antiparkinson Agents; Aspartic Acid; Choline; Creatine; Dopamine Agents; Humans; Levodopa; Magnetic Resonance Spectroscopy; Middle Aged; Parkinson Disease; Phosphocreatine; Protons; Putamen; Reference Values | 1997 |
Proton MR spectroscopic imaging of the striatum in Parkinson's disease.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Creatine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Thalamus | 1997 |
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Parkinson Disease; Phosphocreatine; Protons; Supranuclear Palsy, Progressive; Tissue Distribution | 1997 |
Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.
Topics: Aged; Antiparkinson Agents; Aspartic Acid; Atrophy; Cerebral Cortex; Choline; Corpus Striatum; Creatinine; Female; Globus Pallidus; Humans; Levodopa; Magnetic Resonance Spectroscopy; Middle Aged; Parkinson Disease; Parkinson Disease, Secondary; Phosphocreatine; Protons; Putamen; Supranuclear Palsy, Progressive | 1997 |
Neuronal laterality in Parkinson's disease with unilateral symptom by in vivo 1H magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Globus Pallidus; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease; Putamen; Substantia Nigra | 1998 |
Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Cerebral Cortex; Down Syndrome; Humans; Immunohistochemistry; Parkinson Disease; Tissue Distribution | 1999 |
A proton magnetic resonance spectroscopy study of the striatum and cerebral cortex in Parkinson's disease.
Topics: Aged; Aspartic Acid; Cerebral Cortex; Choline; Corpus Striatum; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Movement Disorders; Parietal Lobe; Parkinson Disease; Reference Values; Temporal Lobe | 1999 |
In vivo magnetic resonance spectroscopy of human fetal neural transplants.
Topics: Adult; Aspartic Acid; Brain; Fetal Tissue Transplantation; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Parkinson Disease | 1999 |
The brain lesion responsible for parkinsonism after carbon monoxide poisoning.
Topics: Aspartic Acid; Brain Chemistry; Carbon Monoxide Poisoning; Carrier Proteins; Choline; Cognition Disorders; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Phosphocreatine; Tomography, Emission-Computed, Single-Photon | 2000 |
Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple System Atrophy; Parkinson Disease; Pilot Projects; Reference Values | 2000 |
Proton magnetic resonance spectroscopy (1H-MRS) of motor cortex and basal ganglia in de novo Parkinson's disease patients.
Topics: Aged; Aspartic Acid; Basal Ganglia; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Parkinson Disease | 2001 |
Increased plasma concentrations of aspartate, glutamate and glycine in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Parkinson Disease | 1992 |
Distribution of neurofibrillary tangle formation and [3H]-D-aspartate receptor binding in the thalamus in the normal elderly brain, in Alzheimer's disease and in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Humans; Male; Neurons; Parkinson Disease; Receptors, Amino Acid; Receptors, Cell Surface; Reference Values; Thalamus; Tritium | 1990 |
Sodium dependent D-[3H]aspartate binding in cerebral cortex in patients with Alzheimer's and Parkinson's diseases.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Choline O-Acetyltransferase; Humans; In Vitro Techniques; Kinetics; Parkinson Disease; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium | 1987 |
Ventricular cerebrospinal fluid concentrations of putative amino acid transmitters in Parkinson's disease and other disorders.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Ethanolamine; Ethanolamines; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease; Proline; Tremor | 1987 |