aspartic acid has been researched along with Hypoxia-Ischemia, Brain in 41 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Excerpt | Relevance | Reference |
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" Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet." | 7.79 | Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013) |
" Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet." | 3.79 | Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013) |
"CSF glycine value was related to erythrocyte count, and CSF taurine value was related to its plasmatic level." | 2.69 | Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy. ( Deulofeu, R; Figueras-Aloy, J; Jiménez, R; Roldán, A, 1999) |
"These four children all had seizure activity and abnormal initial neurological examinations and required admission to the PICU." | 1.33 | Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. ( Ball, WS; Care, M; Cecil, KM; Makoroff, KL, 2005) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (4.88) | 18.2507 |
2000's | 17 (41.46) | 29.6817 |
2010's | 19 (46.34) | 24.3611 |
2020's | 3 (7.32) | 2.80 |
Authors | Studies |
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Barta, H | 2 |
Jermendy, A | 2 |
Kovacs, L | 1 |
Schiever, N | 1 |
Rudas, G | 2 |
Szabo, M | 2 |
Lee, JW | 1 |
Sreepada, LP | 1 |
Bevers, MB | 1 |
Li, K | 1 |
Scirica, BM | 1 |
Santana da Silva, D | 1 |
Henderson, GV | 1 |
Bay, C | 1 |
Lin, AP | 1 |
Kyng, KJ | 1 |
Kerrn-Jespersen, S | 1 |
Bennedsgaard, K | 1 |
Skajaa, T | 1 |
Pedersen, M | 1 |
Holm, IE | 1 |
Henriksen, TB | 1 |
Mitra, S | 2 |
Bale, G | 2 |
Highton, D | 1 |
Gunny, R | 1 |
Uria-Avellanal, C | 2 |
Bainbridge, A | 6 |
Sokolska, M | 1 |
Price, D | 2 |
Huertas-Ceballos, A | 1 |
Kendall, GS | 1 |
Meek, J | 2 |
Tachtsidis, I | 4 |
Robertson, NJ | 8 |
Crespo-Eguilaz, N | 1 |
Dominguez, PD | 1 |
Vaquero, M | 1 |
Narbona, J | 1 |
Shibasaki, J | 1 |
Aida, N | 1 |
Morisaki, N | 1 |
Tomiyasu, M | 1 |
Nishi, Y | 1 |
Toyoshima, K | 1 |
Kolossvary, M | 1 |
Kozak, LR | 1 |
Lakatos, A | 1 |
Meder, U | 1 |
Lally, PJ | 1 |
Montaldo, P | 1 |
Oliveira, V | 1 |
Soe, A | 1 |
Swamy, R | 1 |
Bassett, P | 1 |
Mendoza, J | 1 |
Atreja, G | 1 |
Kariholu, U | 1 |
Pattnayak, S | 1 |
Sashikumar, P | 1 |
Harizaj, H | 1 |
Mitchell, M | 1 |
Ganesh, V | 1 |
Harigopal, S | 1 |
Dixon, J | 1 |
English, P | 1 |
Clarke, P | 1 |
Muthukumar, P | 1 |
Satodia, P | 1 |
Wayte, S | 1 |
Abernethy, LJ | 1 |
Yajamanyam, K | 1 |
Huertas, A | 1 |
Sharp, DJ | 1 |
Kalra, V | 1 |
Chawla, S | 1 |
Shankaran, S | 1 |
Thayyil, S | 3 |
Oliva, I | 1 |
Fernández, M | 1 |
Martín, ED | 1 |
Brandão, LA | 1 |
Caires, C | 1 |
Seo, H | 1 |
Lim, KH | 2 |
Choi, JH | 1 |
Jeong, SM | 1 |
Goergen, SK | 1 |
Ang, H | 1 |
Wong, F | 1 |
Carse, EA | 1 |
Charlton, M | 1 |
Evans, R | 1 |
Whiteley, G | 1 |
Clark, J | 1 |
Shipp, D | 1 |
Jolley, D | 1 |
Paul, E | 1 |
Cheong, JL | 2 |
Cady, EB | 3 |
Raivich, G | 2 |
Ezzati, M | 2 |
Broad, KD | 2 |
Kawano, G | 2 |
Oliver-Taylor, A | 1 |
Rocha-Ferreira, E | 2 |
Alonso-Alconada, D | 2 |
Fierens, I | 2 |
Rostami, J | 1 |
Jane Hassell, K | 1 |
Gressens, P | 2 |
Hristova, M | 2 |
Bennett, K | 1 |
Lebon, S | 1 |
Fleiss, B | 2 |
Yellon, D | 1 |
Hausenloy, DJ | 1 |
Golay, X | 2 |
Hassell, J | 1 |
Ma, D | 1 |
Sanders, RD | 1 |
Baron, JC | 1 |
Munkeby, BH | 1 |
De Lange, C | 1 |
Emblem, KE | 1 |
Bjørnerud, A | 1 |
Kro, GA | 1 |
Andresen, J | 1 |
Winther-Larssen, EH | 1 |
Løberg, EM | 1 |
Hald, JK | 1 |
Chandrasekaran, M | 2 |
Taylor, A | 1 |
Chong, WK | 1 |
Murad, S | 1 |
Omar, RZ | 1 |
Azzopardi, D | 1 |
Edwards, AD | 1 |
Park, HK | 1 |
Seol, IJ | 1 |
Kim, KS | 2 |
Bonifacio, SL | 1 |
Saporta, A | 1 |
Glass, HC | 1 |
Lee, P | 1 |
Glidden, DV | 1 |
Ferriero, DM | 1 |
Barkovich, AJ | 1 |
Xu, D | 1 |
Jian, H | 1 |
Yi-Fang, W | 1 |
Qi, L | 1 |
Xiao-Song, H | 1 |
Gui-Yun, Z | 1 |
Kato, T | 1 |
Iwata, O | 1 |
Kapetanakis, A | 1 |
Faulkner, S | 1 |
Cheong, J | 1 |
Iwata, S | 1 |
Cady, E | 2 |
Brooks, KJ | 1 |
Hargreaves, I | 1 |
Bhakoo, K | 1 |
Sellwood, M | 1 |
O'Brien, F | 1 |
Noone, M | 1 |
Sakata, Y | 1 |
Wylezinska, M | 1 |
Thornton, J | 1 |
Ordidge, R | 1 |
Nguyen, Q | 1 |
Clemence, M | 1 |
Wyatt, J | 1 |
Bates, TE | 1 |
Fan, G | 1 |
Wu, Z | 1 |
Chen, L | 1 |
Guo, Q | 1 |
Ye, B | 1 |
Mao, J | 1 |
Wartenberg, KE | 1 |
Patsalides, A | 1 |
Yepes, MS | 1 |
Vial, F | 1 |
Serriere, S | 1 |
Barantin, L | 1 |
Montharu, J | 1 |
Nadal-Desbarats, L | 1 |
Pourcelot, L | 1 |
Seguin, F | 1 |
Vidwans, AS | 1 |
Hewett, SJ | 1 |
Makoroff, KL | 1 |
Cecil, KM | 1 |
Care, M | 1 |
Ball, WS | 1 |
Boichot, C | 1 |
Walker, PM | 1 |
Durand, C | 1 |
Grimaldi, M | 1 |
Chapuis, S | 1 |
Gouyon, JB | 1 |
Brunotte, F | 1 |
da Silva, LF | 1 |
Höefel Filho, JR | 1 |
Anés, M | 1 |
Nunes, ML | 1 |
Williams, JA | 1 |
Barreiro, CJ | 1 |
Nwakanma, LU | 1 |
Lange, MS | 1 |
Kratz, LE | 1 |
Blue, ME | 1 |
Berrong, J | 1 |
Patel, ND | 1 |
Gott, VL | 1 |
Troncoso, JC | 1 |
Johnston, MV | 1 |
Baumgartner, WA | 1 |
Penrice, J | 1 |
Wyatt, JS | 1 |
Cox, IJ | 1 |
Han, TR | 1 |
Chun, MH | 1 |
Jang, DH | 1 |
Cho, HJ | 1 |
Gwak, M | 1 |
Park, P | 1 |
Kim, K | 1 |
Lim, K | 1 |
Jeong, S | 1 |
Baek, C | 1 |
Lee, J | 1 |
Papazisis, G | 1 |
Pourzitaki, C | 1 |
Sardeli, C | 1 |
Lallas, A | 1 |
Amaniti, E | 1 |
Kouvelas, D | 1 |
Gücüyener, K | 1 |
Atalay, Y | 1 |
Aral, YZ | 1 |
Hasanoğlu, A | 1 |
Türkyilmaz, C | 1 |
Biberoglu, G | 1 |
Roldán, A | 1 |
Figueras-Aloy, J | 1 |
Deulofeu, R | 1 |
Jiménez, R | 1 |
Dawson, DA | 1 |
Wadsworth, G | 1 |
Palmer, AM | 1 |
Engidawork, E | 1 |
Loidl, F | 1 |
Chen, Y | 1 |
Kohlhauser, C | 1 |
Stoeckler, S | 1 |
Dell'Anna, E | 1 |
Lubec, B | 1 |
Lubec, G | 1 |
Goiny, M | 1 |
Gross, J | 1 |
Andersson, K | 1 |
Herrera-Marschitz, M | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Darbepoetin in Neonatal Encephalopathy (EDEN) Trial[NCT04432662] | Phase 2 | 150 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | ||
A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy[NCT01309711] | 180 participants (Anticipated) | Observational | 2011-03-30 | Completed | |||
Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770] | 140 participants (Anticipated) | Interventional | 2019-10-10 | Active, not recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for aspartic acid and Hypoxia-Ischemia, Brain
Article | Year |
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Hypoxic-ischemic injuries: the role of magnetic resonance spectroscopy.
Topics: Americas; Aspartic Acid; Biomarkers; Brain; Humans; Hypoxia-Ischemia, Brain; Lactic Acid; Magnetic R | 2013 |
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas | 2014 |
Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis.
Topics: Aspartic Acid; Basal Ganglia; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactates; Magnetic R | 2010 |
3 trials available for aspartic acid and Hypoxia-Ischemia, Brain
Article | Year |
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Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei.
Topics: Aspartic Acid; Biomarkers; Brain Diseases, Metabolic, Inborn; Choline; Diffusion Magnetic Resonance | 2012 |
Prognostic value of 1H-MRS in neonatal encephalopathy.
Topics: Apgar Score; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Choline; Creatine; Creatinine; Femal | 2006 |
Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy.
Topics: Analysis of Variance; Aspartic Acid; Asphyxia Neonatorum; Chi-Square Distribution; Chromatography, H | 1999 |
35 other studies available for aspartic acid and Hypoxia-Ischemia, Brain
Article | Year |
---|---|
Predictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy.
Topics: Aspartic Acid; Choline; Creatine; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Inositol; Proton | 2022 |
Magnetic Resonance Spectroscopy of Hypoxic-Ischemic Encephalopathy After Cardiac Arrest.
Topics: Aspartic Acid; Brain; Choline; Creatine; Heart Arrest; Humans; Hypoxia-Ischemia, Brain; Magnetic Res | 2022 |
Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain; Diffusion Magnetic Resonance Imaging; D | 2021 |
Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury.
Topics: Adenosine Triphosphate; Aspartic Acid; Blood Pressure; Brain; Cerebrovascular Circulation; Developme | 2019 |
[Developmental amnesia and early brain damage: neuropsychology and neuroimaging].
Topics: Adolescent; Amnesia; Aspartic Acid; Atrophy; Cerebral Palsy; Child; Choline; Creatine; Female; Fetal | 2018 |
Changes in Brain Metabolite Concentrations after Neonatal Hypoxic-ischemic Encephalopathy.
Topics: Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Hypoxia-Ischemia, Br | 2018 |
Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.
Topics: Aspartic Acid; Brain; Creatine; Epilepsy; Female; Hearing Loss; Hospital Mortality; Humans; Hypother | 2018 |
Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.
Topics: Aspartic Acid; Brain; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, | 2019 |
Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.
Topics: Aspartic Acid; Brain; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, | 2019 |
Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.
Topics: Aspartic Acid; Brain; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, | 2019 |
Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.
Topics: Aspartic Acid; Brain; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, | 2019 |
Dopamine release regulation by astrocytes during cerebral ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Astrocytes; Calcium; Corpus Striatum; | 2013 |
Similar neuroprotective effects of ischemic and hypoxic preconditioning on hypoxia-ischemia in the neonatal rat: a proton MRS study.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Brain; Creatine; Hypoxia-Ischemia, B | 2013 |
Early MRI in term infants with perinatal hypoxic-ischaemic brain injury: interobserver agreement and MRI predictors of outcome at 2 years.
Topics: Aspartic Acid; Diffusion Magnetic Resonance Imaging; Female; Humans; Hypoxia-Ischemia, Brain; Infant | 2014 |
Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain Mapping; Disease | 2016 |
Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia.
Topics: Animals; Animals, Newborn; Argon; Aspartic Acid; Asphyxia Neonatorum; Blood Chemical Analysis; Blood | 2016 |
Relationship Between Cerebral Oxygenation and Metabolism During Rewarming in Newborn Infants After Therapeutic Hypothermia Following Hypoxic-Ischemic Brain Injury.
Topics: Aspartic Acid; Biomarkers; Body Temperature Regulation; Cerebrovascular Circulation; Electron Transp | 2016 |
Metabolism of DWI lesions: implications for rescue therapy.
Topics: Acute Disease; Animals; Aspartic Acid; Cell Hypoxia; Cerebrovascular Circulation; Diffusion Magnetic | 2007 |
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatine; | 2008 |
Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy.
Topics: Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Brain; Humans; Hypoxia-Ischemia, Brain; Image Proces | 2010 |
Protective effect of hypoxic preconditioning on hypoxic-ischemic injured newborn rats.
Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Arteries; Creatine; Hypoxia-Isch | 2011 |
Cerebral blood flow and metabolic changes in hippocampal regions of a modified rat model with chronic cerebral hypoperfusion.
Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Creatine; Disease Models, Animal; Hippocampus; | 2013 |
Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model.
Topics: Amiloride; Animals; Aspartic Acid; Asphyxia; Brain; Cell Death; Disease Models, Animal; Hypoxia-Isch | 2013 |
Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Citrate (si)-Synthase; Glutathione; Hypot | 2002 |
Hypoxia-ischemic encephalopathy in full-term neonate: correlation proton MR spectroscopy with MR imaging.
Topics: Apgar Score; Aspartic Acid; Basal Ganglia; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; | 2003 |
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy?
Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance | 2004 |
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulatio | 2004 |
Enhanced release of synaptic glutamate underlies the potentiation of oxygen-glucose deprivation-induced neuronal injury after induction of NOS-2.
Topics: Animals; Aspartic Acid; Cell Death; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; | 2004 |
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Topics: Aspartic Acid; Brain Chemistry; Brain Injuries; Critical Care; Female; Fractures, Bone; Frontal Lobe | 2005 |
Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients.
Topics: Age Factors; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Brain Edema; Cause of Death; Cerebra | 2006 |
Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery.
Topics: Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Biomarkers; Brain; Brain Chemistry; Brain Damag | 2006 |
Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations.
Topics: Aspartic Acid; Birth Injuries; Body Water; Brain; Brain Chemistry; Child Development; Choline; Creat | 2006 |
Neuroprotective effects of growth hormone against hypoxic-ischemic brain injury in neonatal rats: 1H magnetic resonance spectroscopic study.
Topics: Animals; Animals, Newborn; Aspartic Acid; Creatinine; Growth Hormone; Hypoxia-Ischemia, Brain; Lipid | 2007 |
The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Artery, Common; Creatine; Dantro | 2008 |
Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Deferoxamine; Excitatory Amino Acids; Female; Glutamic Aci | 2008 |
Excitatory amino acids and taurine levels in cerebrospinal fluid of hypoxic ischemic encephalopathy in newborn.
Topics: Aspartic Acid; Asphyxia Neonatorum; Case-Control Studies; Excitatory Amino Acids; Female; Follow-Up | 1999 |
A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke.
Topics: Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Hypoxia-Ischemia, Brain; Male; Mice; Mic | 2001 |
Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Behavior, Ani | 2001 |