aspartic acid has been researched along with Hypophosphatasia in 3 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One point mutation which converts glycine-317 to aspartate of tissue-nonspecific alkaline phosphatase (TNSALP) was reported to be associated with lethal hypophosphatasia (Greenberg, C." | 3.70 | Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a Gly317-->Asp substitution associated with lethal hypophosphatasia. ( Amizuka, N; Fukushi, M; Hoshi, K; Ikehara, Y; Kumagai, H; Misumi, Y; Oda, K; Omura, S; Ozawa, H, 1998) |
| "Upon treatment with brefeldin A, TNSALP (N153D) was still co-localized with GM-130, further supporting the finding that this mutant is localized in the cis-Golgi." | 1.31 | Retention at the cis-Golgi and delayed degradation of tissue-non-specific alkaline phosphatase with an Asn153-->Asp substitution, a cause of perinatal hypophosphatasia. ( Amizuka, N; Ito, M; Oda, K; Ozawa, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukushi, M | 1 |
| Amizuka, N | 3 |
| Hoshi, K | 1 |
| Ozawa, H | 3 |
| Kumagai, H | 1 |
| Omura, S | 2 |
| Misumi, Y | 1 |
| Ikehara, Y | 2 |
| Oda, K | 3 |
| Fukushi-Irié, M | 1 |
| Ito, M | 2 |
| Amaya, Y | 1 |
3 other studies available for aspartic acid and Hypophosphatasia
| Article | Year |
|---|---|
Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a Gly317-->Asp substitution associated with lethal hypophosphatasia.
Topics: Alkaline Phosphatase; Aspartic Acid; Biological Transport; Cell Compartmentation; Glycine; Humans; H | 1998 |
Possible interference between tissue-non-specific alkaline phosphatase with an Arg54-->Cys substitution and acounterpart with an Asp277-->Ala substitution found in a compound heterozygote associated with severe hypophosphatasia.
Topics: Alanine; Alkaline Phosphatase; Amino Acid Substitution; Animals; Arginine; Aspartic Acid; COS Cells; | 2000 |
Retention at the cis-Golgi and delayed degradation of tissue-non-specific alkaline phosphatase with an Asn153-->Asp substitution, a cause of perinatal hypophosphatasia.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Asparagine; Aspartic Acid; Biological Transport; Biotiny | 2002 |