aspartic acid has been researched along with Hypoglycemia in 49 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It was noted that hypoglycemic seizures were generated less frequently, and had less impact on synaptic transmission in hippocmpi from PD 22-24 as compared to hippocampi from mice PD 15-19 or PD 8-13." | 5.35 | Factors which abolish hypoglycemic seizures do not increase cerebral glycogen content in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Weisspapir, M, 2008) |
| "Glucagon is a life-saving medication used in the treatment of hypoglycemia." | 3.76 | Optimization of the native glucagon sequence for medicinal purposes. ( Chabenne, JR; DiMarchi, MA; DiMarchi, RD; Gelfanov, VM, 2010) |
| "Postembedding immunocytochemistry was used to localize aspartate, glutamate, gamma-aminobutyric acid (GABA), and glutamine in hippocampus and striatum during normo- and hypoglycemia in rat." | 3.71 | Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study. ( Fonnum, F; Gundersen, V; Ottersen, OP; Storm-Mathisen, J, 2001) |
| "Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM)." | 1.40 | Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. ( Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC, 2014) |
| "It was noted that hypoglycemic seizures were generated less frequently, and had less impact on synaptic transmission in hippocmpi from PD 22-24 as compared to hippocampi from mice PD 15-19 or PD 8-13." | 1.35 | Factors which abolish hypoglycemic seizures do not increase cerebral glycogen content in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Weisspapir, M, 2008) |
| "Hypoglycemic coma increases extracellular excitatory amino acids, which mediate hypoglycemic neuronal degeneration." | 1.31 | MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets. ( Ichord, RN; Johnston, MV; Traystman, RJ, 2001) |
| "Eleven IDDM patients with no history of severe hypoglycemia (group A) were compared with 11 IDDM patients who had a history of five or more episodes of severe hypoglycemia (group B)." | 1.30 | Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of recurrent severe hypoglycemia. ( Best, JJ; Deary, IJ; Frier, BM; Perros, P; Sellar, RJ, 1997) |
| "As the effects of ischemia or anoxia on glutamate and aspartate release from the heart appear to be comparable to those observed in the brain, it is proposed that the heart preparation may be a suitable model in which to study the ischemia-evoked release of these amino acids in the absence of complications arising from their depolarizing and excitotoxic actions on central neurons." | 1.29 | Release of the excitotoxic amino acids, glutamate and aspartate, from the isolated ischemic/anoxic rat heart. ( O'Regan, MH; Phillis, JW; Song, D, 1996) |
| "Chemically induced hypoglycemia and anoxia were evaluated in embryonic day 13 chicken retina to determine if excitotoxicity was a consequence of these conditions and if this was preceded by the net release of glutamate or aspartate." | 1.28 | Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina. ( Nicklas, WJ; Zeevalk, GD, 1990) |
| "Hypoglycemia or anoxia alone affected the release only marginally." | 1.27 | Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. ( Benveniste, H; Diemer, NH; Drejer, J; Schousboe, A, 1985) |
| "Onset of symptoms (severe catalepsy and loss of righting reflex, but before the onset of convulsions) was accompanied by marked decreases of glutamate and glutamine in striatum and hippocampus." | 1.26 | Regional amino acid distribution in relation to function in insulin hypoglycaemia. ( Butterworth, RF; Landreville, F; Merkel, AD, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (48.98) | 18.7374 |
| 1990's | 13 (26.53) | 18.2507 |
| 2000's | 9 (18.37) | 29.6817 |
| 2010's | 3 (6.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, X | 1 |
| Hamner, MA | 1 |
| Brown, AM | 1 |
| Evans, RD | 1 |
| Ye, ZC | 1 |
| Chen, S | 1 |
| Ransom, BR | 1 |
| Lin, YJ | 1 |
| Ho, CS | 1 |
| Chiu, NC | 1 |
| Tseng, HS | 1 |
| Hsu, CH | 1 |
| Huang, JK | 1 |
| Chabenne, JR | 1 |
| DiMarchi, MA | 1 |
| Gelfanov, VM | 1 |
| DiMarchi, RD | 1 |
| Gorell, JM | 1 |
| Dolkart, PH | 1 |
| Ferrendelli, JA | 1 |
| FREINKEL, N | 1 |
| COHEN, AK | 1 |
| ARKY, RA | 1 |
| FOSTER, AE | 1 |
| Parrot, S | 1 |
| Cottet-Emard, JM | 1 |
| Sauvinet, V | 1 |
| Pequignot, JM | 1 |
| Denoroy, L | 1 |
| Rankins, D | 1 |
| Wellard, RM | 1 |
| Cameron, F | 1 |
| McDonnell, C | 1 |
| Northam, E | 1 |
| Abdelmalik, PA | 1 |
| Liang, P | 1 |
| Weisspapir, M | 1 |
| Samoilova, M | 1 |
| Burnham, WM | 1 |
| Carlen, PL | 1 |
| Fortney, SR | 1 |
| Clark, DA | 1 |
| Stein, E | 1 |
| Butterworth, RF | 1 |
| Merkel, AD | 1 |
| Landreville, F | 1 |
| O'Neill, CM | 1 |
| Ball, SG | 1 |
| Vaughan, PF | 1 |
| Koretz, B | 1 |
| von B Ahern, K | 1 |
| Wang, N | 1 |
| Lustig, HS | 1 |
| Greenberg, DA | 1 |
| Sappey-Marinier, D | 1 |
| Chileuitt, L | 1 |
| Weiner, MW | 1 |
| Faden, AI | 1 |
| Weinstein, PR | 1 |
| Song, D | 1 |
| O'Regan, MH | 2 |
| Phillis, JW | 2 |
| Perros, P | 1 |
| Deary, IJ | 1 |
| Sellar, RJ | 1 |
| Best, JJ | 1 |
| Frier, BM | 1 |
| Bakken, IJ | 1 |
| White, LR | 1 |
| Unsgård, G | 1 |
| Aasly, J | 1 |
| Sonnewald, U | 2 |
| Gundersen, V | 2 |
| Chaudhry, FA | 1 |
| Bjaalie, JG | 1 |
| Fonnum, F | 4 |
| Ottersen, OP | 2 |
| Storm-Mathisen, J | 2 |
| Aral, YZ | 1 |
| Gücüyener, K | 1 |
| Atalay, Y | 1 |
| Hasanoğlu, A | 1 |
| Türkyilmaz, C | 1 |
| Sayal, A | 1 |
| Biberoğlu, G | 1 |
| Boris-Möller, F | 1 |
| Wieloch, T | 5 |
| Guyot, LL | 1 |
| Diaz, FG | 1 |
| Ren, J | 1 |
| Ichord, RN | 1 |
| Johnston, MV | 1 |
| Traystman, RJ | 1 |
| Darling, BK | 1 |
| Abdel-Rahim, M | 1 |
| Moores, RR | 1 |
| Chang, AS | 1 |
| Howard, RS | 1 |
| O'Neill, JT | 1 |
| Oja, SS | 1 |
| Saransaari, P | 1 |
| McKenna, M | 1 |
| Mestyán, J | 1 |
| Schultz, K | 1 |
| Soltész, G | 1 |
| Horváth, M | 1 |
| Tasker, RC | 1 |
| Coyle, JT | 1 |
| Vornov, JJ | 1 |
| Rosenberg, GA | 1 |
| White, J | 1 |
| Gasparovic, C | 1 |
| Crisostomo, EA | 1 |
| Griffey, RH | 1 |
| Zeevalk, GD | 1 |
| Nicklas, WJ | 1 |
| Zhang, ET | 1 |
| Hansen, AJ | 1 |
| Lauritzen, M | 1 |
| Siesjö, BK | 1 |
| Bengtsson, F | 1 |
| Westerberg, E | 1 |
| Wieloch, TW | 1 |
| Behar, KL | 1 |
| den Hollander, JA | 1 |
| Petroff, OA | 1 |
| Hetherington, HP | 1 |
| Prichard, JW | 1 |
| Shulman, RG | 1 |
| Drejer, J | 1 |
| Benveniste, H | 1 |
| Diemer, NH | 1 |
| Schousboe, A | 1 |
| Butcher, SP | 1 |
| Sandberg, M | 2 |
| Hagberg, H | 1 |
| Hamberger, A | 2 |
| Paulsen, RE | 1 |
| Paulsen, RH | 1 |
| Fosse, VM | 1 |
| Engelsen, B | 1 |
| Nyström, B | 1 |
| Watanabe, S | 1 |
| Otsuki, S | 1 |
| Nakashima, Y | 1 |
| Edamatsu, K | 1 |
| Mitsunobu, K | 1 |
| Bergman, EN | 1 |
| Kaufman, CF | 1 |
| Wolff, JE | 1 |
| Williams, HH | 1 |
| Stone, WE | 2 |
| Tews, JK | 2 |
| Whisler, KE | 1 |
| Brown, DJ | 1 |
| Tarkowski, S | 1 |
| Cremer, JE | 1 |
| Flock, EV | 1 |
| Tyce, G | 1 |
| Owen, CA | 1 |
| Carter, SH | 1 |
| Curatolo, A | 1 |
| D'Arcangelo, P | 1 |
| O'Neal, RM | 1 |
| Koeppe, RE | 1 |
2 reviews available for aspartic acid and Hypoglycemia
| Article | Year |
|---|---|
Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.
Topics: Aspartic Acid; Biological Transport, Active; Brain; Brain Ischemia; Calcium; Calcium Channels; Cell | 1989 |
Neurochemical correlates to selective neuronal vulnerability.
Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlor | 1985 |
47 other studies available for aspartic acid and Hypoglycemia
| Article | Year |
|---|---|
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Di | 2014 |
The Reversible Corpus Callosum Splenium Lesion in A Neonate with Hypoglycemia and Seizure.
Topics: Aspartic Acid; Corpus Callosum; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Ma | 2015 |
Optimization of the native glucagon sequence for medicinal purposes.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Cell Line; Chemistry, Pharmaceutical; Chromatography | 2010 |
Regional levels of glucose, amino acids, high energy phosphates, and cyclic nucleotides in the central nervous system during hypoglycemic stupor and behavioral recovery.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Behavior, Anim | 1976 |
ALCOHOL HYPOGLYCEMIA. II. A POSTULATED MECHANISM OF ACTION BASED ON EXPERIMENTS WITH RAT LIVER SLICES.
Topics: Alanine; Amino Acids; Aspartic Acid; Autoradiography; Carbohydrate Metabolism; Carbon Dioxide; Carbo | 1965 |
Effects of acute hypoxic conditions on extracellular excitatory amino acids and dopamine in the striatum of freely-moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Ex | 2003 |
The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes.
Topics: Acute Disease; Aspartic Acid; Attention; Blood Glucose; Child; Diabetes Mellitus, Type 1; Female; Fo | 2005 |
Factors which abolish hypoglycemic seizures do not increase cerebral glycogen content in vitro.
Topics: Age Factors; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Aspartic Acid; Cer | 2008 |
Inhibition of gluconeogenesis by hydrazine administration in rats.
Topics: Alanine; Animals; Aspartic Acid; Blood Glucose; Carbon Isotopes; Gluconeogenesis; Hydrazines; Hypogl | 1967 |
Regional amino acid distribution in relation to function in insulin hypoglycaemia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Catalepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1982 |
Effects of ischaemic conditions on uptake of glutamate, aspartate, and noradrenaline by cell lines derived from the human nervous system.
Topics: Aspartic Acid; Astrocytoma; Biological Transport; Cell Hypoxia; Cell Line; Glutamates; Glutamic Acid | 1994 |
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebr | 1994 |
Hypoglycemia prevents increase in lactic acidosis during reperfusion after temporary cerebral ischemia in rats.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Energy Metabolism; Hydrogen | 1995 |
Release of the excitotoxic amino acids, glutamate and aspartate, from the isolated ischemic/anoxic rat heart.
Topics: Animals; Aspartic Acid; Brain; Excitatory Amino Acids; Glutamic Acid; Hypoglycemia; Hypoxia; Male; M | 1996 |
Brain abnormalities demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of recurrent severe hypoglycemia.
Topics: Adult; Aspartic Acid; Atrophy; Blood Glucose; Brain; Cerebral Cortex; Choline; Cognition; Cohort Stu | 1997 |
[U-13C]glutamate metabolism in astrocytes during hypoglycemia and hypoxia.
Topics: Animals; Aspartic Acid; Astrocytes; Carbon Isotopes; Cell Hypoxia; Cells, Cultured; Glucose; Glutami | 1998 |
Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Calcium; Electrophysiology; Exocytosis; Glutamic Acid; | 1998 |
Role of excitatory aminoacids in neonatal hypoglycemia.
Topics: Aspartic Acid; Copper; Excitatory Amino Acids; Glutamic Acid; Humans; Hypoglycemia; Infant, Newborn; | 1998 |
Changes in the extracellular levels of glutamate and aspartate during ischemia and hypoglycemia. Effects of hypothermia.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Extracellular Space; Glutamic Acid; Hypogl | 1998 |
The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Energy Metabolism; gamma-Aminobutyric Acid | 2000 |
Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Glutam | 2001 |
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebrovascular Circulation; Coma; Dizocilpine Maleate; Dos | 2001 |
Brain excitatory amino acid concentrations are lower in the neonatal pig: a buffer against excitotoxicity?
Topics: Animals; Animals, Newborn; Aspartic Acid; Blood Pressure; Brain; Brain Chemistry; Electroencephalogr | 2001 |
Transport of D-aspartate in cerebellar granule cells under cell-damaging conditions.
Topics: Animals; Antimetabolites; Aspartic Acid; Cell Hypoxia; Cells, Cultured; Cerebellum; Cerebrovascular | 2001 |
Metabolic compartmentation in cortical synaptosomes: influence of glucose and preferential incorporation of endogenous glutamate into GABA.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Citric Acid Cycle; Drug Synergism; gamma-Aminobutyric Acid; | 2002 |
The metabolic effects of glucagon infusion in normoglycaemic and hypoglycaemic small-for-gestational-age infants. II. Changes in plasma amino acids.
Topics: Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Citrulline; Glucagon; Gluconeogenesis; Glycine; | 1976 |
The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.
Topics: Animals; Aspartic Acid; Culture Techniques; Deoxyglucose; Dizocilpine Maleate; Glucose; Glutamates; | 1992 |
Effect of hypoxia on cerebral metabolites measured by proton nuclear magnetic resonance spectroscopy in rats.
Topics: Animals; Aspartic Acid; Brain; Hyperglycemia; Hypoglycemia; Hypoxia; Lactates; Lactic Acid; Magnetic | 1991 |
Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Chick Embryo; Electron Transport; Glyco | 1990 |
Influence of MK-801 on brain extracellular calcium and potassium activities in severe hypoglycemia.
Topics: Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain; Calcium; Cerebral Cortex; Dibenzocyclo | 1990 |
Changes in excitatory amino acid receptor binding in the intact and decorticated rat neostriatum following insulin-induced hypoglycemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Caudate Nuc | 1989 |
Effect of hypoglycemic encephalopathy upon amino acids, high-energy phosphates, and pHi in the rat brain in vivo: detection by sequential 1H and 31P NMR spectroscopy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; Glutamates; Glutamic Acid; Gluta | 1985 |
Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro.
Topics: Animals; Aspartic Acid; Astrocytes; Brain; Calcium; Cells, Cultured; Cerebellum; Dialysis; Glutamate | 1985 |
Endogenous excitotoxins as possible mediators of ischemic and hypoglycemic brain damage.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Corpus Striatum; Gluta | 1986 |
Cellular origins of endogenous amino acids released into the extracellular fluid of the rat striatum during severe insulin-induced hypoglycemia.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Denervation; Ethanolamines; E | 1987 |
Regulation of transmitter gamma-aminobutyric acid (GABA) synthesis and metabolism illustrated by the effect of gamma-vinyl GABA and hypoglycemia.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobu | 1988 |
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Electroencephalog | 1985 |
Synthesis and release of amino acid transmitters.
Topics: Animals; Aspartic Acid; Brain; Citrates; Corpus Striatum; gamma-Aminobutyric Acid; Glutamates; Hypog | 1986 |
Metabolically derived aspartate--elevated extracellular levels in vivo in lodoacetate poisoning.
Topics: Amino Acids; Animals; Aspartic Acid; Ethanolamine; Ethanolamines; Extracellular Space; Hippocampus; | 1985 |
Glutamic acid metabolism in perfused cat brain studied with 14C-labelled glutamic acid.
Topics: Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain; Carbon Dioxide; Carbon Isotopes; Cats; Ce | 1970 |
Renal metabolism of amino acids and ammonia in fed and fasted pregnant sheep.
Topics: Acidosis; Alanine; Amino Acids; Ammonia; Animals; Arginine; Aspartic Acid; Catheterization; Citrulli | 1974 |
Incorporation of carbon from glucose into cerebral amino acids, proteins and lipids, and alterations during recovery from hypoglycaemia.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Blood Glucose; Carbon Isotopes; Cerebr | 1972 |
Metabolism of glucose and free amino acids in brain, studies with 14C-labelled glucose and butyrate in rats intoxicated with carbon disulphide.
Topics: Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Blood Glucose; Brain; Brain Chemistry; | 1972 |
Regulatory effects of insulin and liver on brain glucose metabolism.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Blood Glucose; Brain; Carbon Isotopes | 1969 |
Chemical changes in the brain during insulin hypoglycaemia and recovery.
Topics: Acetylcholine; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain; Brain C | 1965 |
[Concentration of N-acetylaspartic acid at various levels of the rabbit brain in hypoglycemic coma induced with insulin].
Topics: Animals; Aspartic Acid; Brain; Hypoglycemia; Insulin Coma; Rabbits | 1964 |
Precursors in vivo of glutamate, aspartate and their derivatives of rat brain.
Topics: Acyltransferases; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamates; Glutamine; Glutathione | 1966 |