aspartic acid has been researched along with Hyperglycemia in 17 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques." | 7.73 | The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005) |
| "The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques." | 3.73 | The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005) |
| " Within 5-15 min after the onset of reperfusion, the Lac/NAA peak ratio increased further in all rats; however, only in extremely hyperglycemic rats (serum glucose greater than 960 mg/dl) did the lactic acidosis progress rather than recover later during reperfusion." | 3.68 | Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. ( Abiko, H; Faden, AI; James, TL; Weinstein, PR; Widmer, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Auer, MK | 1 |
| Sack, M | 1 |
| Lenz, JN | 1 |
| Jakovcevski, M | 1 |
| Biedermann, SV | 1 |
| Falfán-Melgoza, C | 1 |
| Deussing, J | 1 |
| Steinle, J | 1 |
| Bielohuby, M | 1 |
| Bidlingmaier, M | 1 |
| Pfister, F | 1 |
| Stalla, GK | 1 |
| Ende, G | 1 |
| Weber-Fahr, W | 1 |
| Fuss, J | 1 |
| Gass, P | 1 |
| Wang, WT | 1 |
| Lee, P | 1 |
| Yeh, HW | 1 |
| Smirnova, IV | 1 |
| Choi, IY | 1 |
| Glaser, N | 1 |
| Ngo, C | 1 |
| Anderson, S | 1 |
| Yuen, N | 1 |
| Trifu, A | 1 |
| O'Donnell, M | 1 |
| Wei, J | 1 |
| Cohen, DM | 1 |
| Quast, MJ | 1 |
| Jellish, WS | 1 |
| Murdoch, J | 1 |
| Kindel, G | 1 |
| Zhang, X | 1 |
| White, FA | 1 |
| Maddock, RJ | 1 |
| Buonocore, MH | 1 |
| Lavoie, SP | 1 |
| Copeland, LE | 1 |
| Kile, SJ | 1 |
| Richards, AL | 1 |
| Ryan, JM | 1 |
| Guyot, LL | 2 |
| Diaz, FG | 2 |
| O'Regan, MH | 2 |
| Song, D | 2 |
| Phillis, JW | 2 |
| Nishikawa, T | 1 |
| Edelstein, D | 1 |
| Du, XL | 1 |
| Yamagishi, S | 1 |
| Matsumura, T | 1 |
| Kaneda, Y | 1 |
| Yorek, MA | 1 |
| Beebe, D | 1 |
| Oates, PJ | 1 |
| Hammes, HP | 1 |
| Giardino, I | 1 |
| Brownlee, M | 1 |
| Andreassen, OA | 1 |
| Dedeoglu, A | 1 |
| Ferrante, RJ | 1 |
| Jenkins, BG | 1 |
| Ferrante, KL | 1 |
| Thomas, M | 1 |
| Friedlich, A | 1 |
| Browne, SE | 1 |
| Schilling, G | 1 |
| Borchelt, DR | 1 |
| Hersch, SM | 1 |
| Ross, CA | 1 |
| Beal, MF | 1 |
| Lai, PH | 1 |
| Chen, PC | 1 |
| Chang, MH | 1 |
| Pan, HB | 1 |
| Yang, CF | 1 |
| Wu, MT | 1 |
| Li, JY | 1 |
| Chen, C | 1 |
| Liang, HL | 1 |
| Chen, WL | 1 |
| Gylfe, E | 1 |
| Sehlin, J | 1 |
| Widmer, H | 1 |
| Abiko, H | 1 |
| Faden, AI | 1 |
| James, TL | 1 |
| Weinstein, PR | 1 |
| Rosenberg, GA | 1 |
| White, J | 1 |
| Gasparovic, C | 1 |
| Crisostomo, EA | 1 |
| Griffey, RH | 1 |
| Boehm, BO | 1 |
| Manfras, B | 1 |
| Rosak, C | 1 |
| Schöffling, K | 1 |
| Trucco, M | 1 |
| Flock, EV | 2 |
| Tyce, G | 1 |
| Owen, CA | 2 |
| Tyce, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569] | Early Phase 1 | 15 participants (Actual) | Interventional | 2019-02-04 | Completed | ||
| Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)[NCT00712426] | Phase 3 | 553 participants (Actual) | Interventional | 2009-09-30 | Terminated (stopped due to Results of an interim analysis showed that it was unlikely that creatine was effective in slowing loss of function in early symptomatic Huntington's Disease.) | ||
| Creatine Safety and Tolerability in Premanifest HD: PRECREST[NCT00592995] | Phase 2 | 64 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | percentage (Mean) |
|---|---|
| Octreotide- Euglycemia | -4.15 |
| Octreotide - Euglycemia- Insulin Clamp | -2.23 |
| Octreotide- Hyperglycemia | -4.80 |
| Octreotide- Hyperglycemia - Insulin Clamp | -8.45 |
Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | % change (Mean) |
|---|---|
| Octreotide- Euglycemia | 11.8 |
| Octreotide - Euglycemia- Insulin Clamp | 11.8 |
| Octreotide- Hyperglycemia | 8.9 |
| Octreotide- Hyperglycemia - Insulin Clamp | 8.95 |
The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | m/sec (Mean) |
|---|---|
| Octreotide- Euglycemia | 5.21 |
| Octreotide - Euglycemia- Insulin Clamp | 5.06 |
| Octreotide- Hyperglycemia | 4.79 |
| Octreotide- Hyperglycemia - Insulin Clamp | 5.07 |
17 other studies available for aspartic acid and Hyperglycemia
| Article | Year |
|---|---|
Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study.
Topics: Animals; Aspartic Acid; Brain; Carbohydrate Metabolism; Diet; Dipeptides; Energy Intake; Fatty Acids | 2015 |
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T.
Topics: Acute Disease; Algorithms; Animals; Aspartic Acid; Biological Transport, Active; Blood Glucose; Bloo | 2012 |
Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Edema; Cerebrum; Diabetes Mellitus, Experiment | 2012 |
Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats.
Topics: Animals; Antimetabolites; Aspartic Acid; Deoxyglucose; Hyperglycemia; Infarction, Middle Cerebral Ar | 2003 |
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; B | 2005 |
Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance spectroscopy study at 1.5 Tesla.
Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metabolism; Fasting; Female; H | 2006 |
Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Cortex; Ethanolamin | 2000 |
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Topics: Animals; Aspartic Acid; Blood Glucose; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; | 2000 |
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.
Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Dia | 2000 |
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, A | 2001 |
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, A | 2001 |
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, A | 2001 |
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cell Survival; Creatinine; Disease Models, A | 2001 |
In vivo proton MR spectroscopy of chorea-ballismus in diabetes mellitus.
Topics: Aged; Aspartic Acid; Choline; Chorea; Creatine; Diabetes Complications; Female; Humans; Hyperglycemi | 2001 |
Interactions between the metabolism of L-leucine and D-glucose in the pancreatic beta-cells.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glucose; Glutamates; Glycolysis; Hyperglycemia; Isl | 1976 |
Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Energy Metabolism; Fatty | 1992 |
Effect of hypoxia on cerebral metabolites measured by proton nuclear magnetic resonance spectroscopy in rats.
Topics: Animals; Aspartic Acid; Brain; Hyperglycemia; Hypoglycemia; Hypoxia; Lactates; Lactic Acid; Magnetic | 1991 |
Aspartic acid at position 57 of the HLA-DQ beta chain is protective against future development of insulin-dependent (type 1) diabetes mellitus.
Topics: Adult; Amino Acid Sequence; Aspartic Acid; Autoantibodies; Diabetes Mellitus, Type 1; Female; Geneti | 1991 |
Regulatory effects of insulin and liver on brain glucose metabolism.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Blood Glucose; Brain; Carbon Isotopes | 1969 |
Glucose metabolism in brains of diabetic rats.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Diabetes Mellitus; Diabetes | 1969 |