aspartic acid has been researched along with Heart Arrest in 13 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A cardiac arrest was induced with intravenous KCl, and the times until electroencephalograph isoelectricity and terminal depolarization were recorded." | 1.29 | Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. ( Nakashima, K; Todd, MM, 1996) |
| "Fifteen minutes after cardiac arrest, the levels of GABA were 617 and 774% of the resting release in the striatum and hippocampus, respectively." | 1.27 | Increases in striatal and hippocampal impedance and extracellular levels of amino acids by cardiac arrest in freely moving rats. ( Klein, HC; Korf, J; Postema, F; Venema, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JW | 1 |
| Sreepada, LP | 1 |
| Bevers, MB | 1 |
| Li, K | 1 |
| Scirica, BM | 1 |
| Santana da Silva, D | 1 |
| Henderson, GV | 1 |
| Bay, C | 1 |
| Lin, AP | 1 |
| Wartenberg, KE | 1 |
| Patsalides, A | 1 |
| Yepes, MS | 1 |
| Peuhkurinen, KJ | 1 |
| Nuutinen, EM | 1 |
| Pietiläinen, EP | 1 |
| Hiltunen, JK | 1 |
| Hassinen, IE | 1 |
| Anyanwu, E | 1 |
| Krefting, ER | 1 |
| Dittrich, H | 1 |
| Berek, K | 1 |
| Lechleitner, P | 1 |
| Luef, G | 1 |
| Felber, S | 1 |
| Saltuari, L | 1 |
| Schinnerl, A | 1 |
| Traweger, C | 1 |
| Dienstl, F | 1 |
| Aichner, F | 1 |
| Suleiman, MS | 1 |
| Chapman, RA | 1 |
| Nakashima, K | 1 |
| Todd, MM | 1 |
| Ashwal, S | 1 |
| Holshouser, BA | 1 |
| Hinshaw, DB | 1 |
| Schell, RM | 1 |
| Bailey, L | 1 |
| Ebel, H | 1 |
| Classen, HG | 1 |
| Marquardt, P | 1 |
| Späth, M | 1 |
| Döring, V | 1 |
| Bleese, N | 1 |
| Gercken, G | 1 |
| Kalmár, P | 1 |
| Lierse, W | 1 |
| Pokar, H | 1 |
| Rodewald, G | 1 |
| Beyersdorf, F | 1 |
| Kirsh, M | 1 |
| Buckberg, GD | 1 |
| Allen, BS | 1 |
| Korf, J | 1 |
| Klein, HC | 1 |
| Venema, K | 1 |
| Postema, F | 1 |
| Mendler, N | 1 |
| Hagl, S | 1 |
| Sebening, F | 1 |
| Theobald, KP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827] | Phase 3 | 865 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 147 |
| Saline Infusion | 152 |
ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay
| Intervention | hours (Median) |
|---|---|
| Intravenous Glutamate | 21 |
| Saline Infusion | 21 |
(NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 31 |
| Saline Infusion | 25 |
Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 4 |
| Saline Infusion | 6 |
Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 1 |
| Saline Infusion | 5 |
maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days
| Intervention | µmol/L (Mean) |
|---|---|
| Intravenous Glutamate | 106 |
| Saline Infusion | 106 |
Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 3 |
| Saline Infusion | 16 |
p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative
| Intervention | µg/L (Median) | |
|---|---|---|
| CK-MB day 1 | Troponin-T day 3 | |
| Intravenous Glutamate | 14 | 0.27 |
| Saline Infusion | 14 | 0.24 |
Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU
| Intervention | percentage of saturated hemoglobin (Mean) | |
|---|---|---|
| SvO2 at weaning from CPB | SvO2 on arrival to ICU | |
| Intravenous Glutamate | 72.0 | 65.0 |
| Saline Infusion | 72.2 | 64.9 |
13 other studies available for aspartic acid and Heart Arrest
| Article | Year |
|---|---|
Magnetic Resonance Spectroscopy of Hypoxic-Ischemic Encephalopathy After Cardiac Arrest.
Topics: Aspartic Acid; Brain; Choline; Creatine; Heart Arrest; Humans; Hypoxia-Ischemia, Brain; Magnetic Res | 2022 |
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy?
Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance | 2004 |
Role of pyruvate carboxylation in the energy-linked regulation of pool sizes of tricarboxylic acid-cycle intermediates in the myocardium.
Topics: Alanine; Animals; Aspartic Acid; Bicarbonates; Citrates; Citric Acid; Citric Acid Cycle; Female; Glu | 1982 |
Myocardial intra- and extracellular calcium changes following cardioplegic cardiac arrest.
Topics: Adult; Aspartic Acid; Biopsy; Body Fluids; Calcium; Cardiac Surgical Procedures; Drug Combinations; | 1983 |
Early determination of neurological outcome after prehospital cardiopulmonary resuscitation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Cardiopulmonary Resuscitation; Ele | 1995 |
Changes in the principal free intracellular amino acids in the Langendorff perfused guinea pig heart during arrest with calcium-free or high potassium media.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Calcium; Chromatography, High Pressure Liquid; Culture | 1993 |
Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.
Topics: Analysis of Variance; Animals; Aspartic Acid; Body Temperature; Brain Ischemia; Cerebral Cortex; Ele | 1996 |
Proton magnetic resonance spectroscopy in the evaluation of children with congenital heart disease and acute central nervous system injury.
Topics: Aspartic Acid; Brain; Brain Injuries; Cardiopulmonary Bypass; Case-Control Studies; Child, Preschool | 1996 |
[Pharmacology and pharmacokinetics of magnesium (author's transl)].
Topics: Adult; Animals; Aspartic Acid; Blood Pressure; Cats; Chlorides; Circadian Rhythm; Dose-Response Rela | 1975 |
[Metabolism and ultrastructure of magnesium aspartate-procaine arrested hearts of rabbit and man (author's transl)].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartic Acid; Coronary Disease; Glycogen; Hea | 1975 |
Warm glutamate/aspartate-enriched blood cardioplegic solution for perioperative sudden death.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Cardioplegic Solutions; Cardiopulmonary Resuscitation; Coron | 1992 |
Increases in striatal and hippocampal impedance and extracellular levels of amino acids by cardiac arrest in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Electrop | 1988 |
[Substrates of energy metabolism in parabiotically perfused rat hearts during and after cardioplegy by ischemia, potassium chloride and potassium-magnesium-aspartate].
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Heart Arrest; Ischemia; Lactates; Magnesium; Male; Myoc | 1972 |