Page last updated: 2024-11-08

aspartic acid and Glioma

aspartic acid has been researched along with Glioma in 151 studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."9.13Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)."7.77Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."7.73Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells."7.67Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987)
" This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells."5.40Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. ( Davies, MT; Driscoll, HE; Jaworski, DM; Lawler, SE; Long, PM; Penar, PL; Pendlebury, WW; Spees, JL; Teasdale, BA; Tsen, AR; Viapiano, MS, 2014)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."5.13Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
" There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids."4.89Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013)
" These methods were evaluated for segmentation of volumetric MRSI studies of gliomas using maps of the choline to N-acetylaspartate ratio, and a qualitative comparison of lesion volumes carried out."3.91Lesion segmentation for MR spectroscopic imaging using the convolution difference method. ( Maudsley, AA, 2019)
"There is significant elevation of the choline (Cho) /creatine (Cr) ratio, Cho peak and depression of the N-acetylaspartate (NAA) peak in gliomas."3.78Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas. ( Shang, HB; Zhang, WF; Zhao, WG, 2012)
"This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)."3.77Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011)
" The aim of this work is to evaluate whether regional cerebral blood volume (rCBV), as well as choline (Cho), N-acetyl-aspartate (NAA) and myo-inositol (mIns) concentrations differ between tumefactive lesions and World Health Organization (WHO) grade II-III gliomas."3.77Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. ( Blasel, S; Hattingen, E; Jansen, V; Mueller, K; Pfeilschifter, W; Zanella, F, 2011)
"Diffusion tensor imaging (DTI) and MR spectroscopy are noninvasive, quantitative tools for the preoperative assessment of gliomas with which the quantitative parameter fractional anisotropy (FA) and the concentration of neurometabolites N-acetylaspartate (NAA), choline (Cho), creatine (Cr) of the brain can be determined."3.73Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. ( Ding, XQ; Fiehler, J; Goebell, E; Hagel, C; Heese, O; Kucinski, T; Nietz, S; Paustenbach, S; Westphal, M; Zeumer, H, 2006)
"In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)."3.73In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."3.73Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"To evaluate an intracranial polymer implant containing bromodeoxyuridine (BrdUrd) and N-(phosphonacetyl)-L-aspartic acid (PALA) in combination with external beam radiotherapy (EBRT) in the treatment of a rat glioma."3.72Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. ( Lehnert, S; Li, Y; Owusu, A, 2004)
" The concentration of taurine (Tau) in medulloblastomas was 29."3.72In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004)
" The concentration of taurine (Tau) in medulloblastomas was 29."3.72In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004)
"Data obtained preoperatively from three-dimensional (3D)/proton magnetic resonance (MR) spectroscopy were compared with the results of histopathological assays of tissue biopsies obtained during surgery to verify the sensitivity and specificity of a choline-containing compound-N-acetylaspartate index (CNI) used to distinguish tumor from nontumorous tissue within T2-hyperintense and contrast-enhancing lesions of patients with untreated gliomas."3.71Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. ( Berger, MS; Dillon, WP; Graves, EE; Lu, Y; McDermott, MW; McKnight, TR; Nelson, SJ; Pirzkall, A; Vigneron, DB; von dem Bussche, MH, 2002)
" MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis."3.71[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002)
" Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA."3.71Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. ( Herminghaus, S; Krings, T; Lanfermann, H; Marquardt, G; Möller-Hartmann, W; Pilatus, U; Zanella, FE, 2002)
"We found in cultured glioma (C6BU-1) cells that excitatory amino acids (EAAs) such as glutamate, N-methyl-D-aspartate (NMDA), aspartate, and metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylate caused an increase in the inositol 1,4,5-trisphosphate formation and the intracellular Ca2+ concentration ([Ca2+]i) in the absence of extracellular Mg2+ and Ca2+."3.69Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction. ( Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S, 1994)
" Spectroscopy is a reliable technique for grading of gliomas when N-acetyl-aspartate/choline and choline/creatine ratios and presence of lipids are used in combination."3.69Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995)
" The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4."3.69Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy. ( Bandou, K; Harada, M; Kannuki, S; Miyoshi, H; Nishitani, H; Tanouchi, M, 1995)
"(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas."3.69Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995)
" We used proton nuclear magnetic resonance spectroscopy to detect the presence of simple metabolites (such as lactic acid, creatine/phosphocreatine, N-acetyl aspartate, and the "choline" pool) in extracts of a human glioma grown subcutaneously in athymic ("nu/nu") mice."3.69Effects of therapy on the 1H NMR spectrum of a human glioma line. ( Cazzaniga, S; Charles, HC; Schold, SC; Sostman, HD, 1994)
" Oligodendrogliomas had higher choline levels than astrocytomas."3.68[1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia]. ( Felber, SR, 1993)
"Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells."3.68Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. ( Chuang, DM; Lee, CY; Lin, WW, 1991)
"Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells."3.67Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987)
"Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood."1.62Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas. ( Abe, M; Hirose, Y; Inamasu, J; Kumon, M; Kuwahara, K; Murayama, K; Nakae, S; Ohba, S; Sasaki, H; Yamada, S, 2021)
"Chordoid gliomas are extremely rare entities, which are generally considered occurring exclusively in the third ventricle."1.56Chordoid glioma: an entity occurring not exclusively in the third ventricle. ( Du, J; Fang, J; Li, G; Wang, S; Xu, Y; Yang, B; Yang, C, 2020)
"Glioma is the most common type of the primary CNS tumor."1.43Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro. ( Cui, Y; Li, FY; Li, HX; Shi, WQ; Wang, JZ; Xu, YJ; Zeng, QS, 2016)
" This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells."1.40Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. ( Davies, MT; Driscoll, HE; Jaworski, DM; Lawler, SE; Long, PM; Penar, PL; Pendlebury, WW; Spees, JL; Teasdale, BA; Tsen, AR; Viapiano, MS, 2014)
"High grade gliomas are known to release excitotoxic concentrations of glutamate, a process thought to contribute to their malignant phenotype through enhanced autocrine stimulation of their proliferation and destruction of the surrounding nervous tissue."1.35Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat. ( Abarca-Quinones, J; Gallez, B; Hermans, E; Jordan, BF; Maloteaux, JM; Vanhoutte, N, 2009)
"Using discriminant analysis, this study found that MR spectroscopy in combination with ADC ratio, rather than ADC value, can improve the ability to differentiate recurrent glioma and radiation injury."1.34Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. ( Feng, DC; Li, CF; Liu, H; Zeng, QS; Zhen, JH, 2007)
"Ten patients with untreated gliomas were examined on a 1."1.32Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas. ( Buslei, R; Fahlbusch, R; Ganslandt, O; Gruber, S; Moser, E; Nimsky, C; Stadlbauer, A, 2004)
"Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells."1.31Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000)
"The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods."1.31Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001)
"High-grade brain tumors are known to have a high rate of glucose (Glc) consumption."1.31High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001)
"First, it allows to distinguish brain tumors from abscesses."1.31[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis]. ( Berry, I; Ibarrola, D; Malet-Martino, M; Sabatier, J, 2001)
"Seventeen brain tumors were measured by 1H-CSI (chemical shift imaging) in a 1."1.30Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method. ( Furuya, S; Ide, M; Kizu, O; Maeda, T; Morishita, H; Naruse, S; Ueda, S, 1997)
"Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas."1.29Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. ( Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL, 1993)
"Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy."1.29Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives. ( Calabrese, G; Falini, A; Lipari, S; Losa, M; Origgi, D; Scotti, G; Triulzi, F, 1996)
"Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values."1.29Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996)

Research

Studies (151)

TimeframeStudies, this research(%)All Research%
pre-19905 (3.31)18.7374
1990's29 (19.21)18.2507
2000's58 (38.41)29.6817
2010's51 (33.77)24.3611
2020's8 (5.30)2.80

Authors

AuthorsStudies
Rudnay, M1
Waczulikova, I1
Bullova, A1
Rjaskova, G1
Chorvath, M1
Jezberova, M1
Lehotska, V1
Tran, D3
Nguyen, DH3
Nguyen, HK3
Nguyen-Thanh, VA3
Dong-Van, H3
Nguyen, MD3
De Stefano, FA1
Morell, AA1
Smith, G1
Warner, T1
Soldozy, S1
Elarjani, T1
Eichberg, DG1
Luther, E1
Komotar, RJ1
Yang, B1
Yang, C1
Du, J1
Fang, J1
Li, G1
Wang, S1
Xu, Y1
Goryawala, M1
Saraf-Lavi, E1
Nagornaya, N1
Heros, D1
Komotar, R1
Maudsley, AA2
Wang, AP1
Suryavanshi, T1
Marcucci, M1
Fong, C1
Whitton, AC1
Reddy, KKV1
Nakae, S1
Kumon, M1
Murayama, K1
Ohba, S1
Sasaki, H1
Inamasu, J1
Kuwahara, K1
Yamada, S1
Abe, M1
Hirose, Y1
Alirezaei, Z1
Amouheidari, A1
Hassanpour, M1
Davanian, F1
Iraji, S1
Shokrani, P1
Nazem-Zadeh, MR1
Ditter, P1
Hattingen, E3
Liu, Z1
Zhang, J4
Lai, M1
Vassallo, I1
Lanz, B1
Poitry-Yamate, C1
Hamou, MF1
Cudalbu, C1
Gruetter, R1
Hegi, ME1
Gao, W1
Wang, X1
Li, F2
Shi, W1
Li, H1
Zeng, Q2
Pedrosa de Barros, N1
Meier, R1
Pletscher, M1
Stettler, S1
Knecht, U1
Herrmann, E1
Schucht, P1
Reyes, M1
Gralla, J1
Wiest, R1
Slotboom, J1
Corbetta, C1
Di Ianni, N1
Bruzzone, MG2
Patanè, M1
Pollo, B1
Cantini, G1
Cominelli, M1
Zucca, I1
Pisati, F1
Poliani, PL1
Finocchiaro, G2
Pellegatta, S1
Choi, C3
Ganji, S1
Hulsey, K1
Madan, A2
Kovacs, Z2
Dimitrov, I1
Zhang, S1
Pichumani, K1
Mendelsohn, D1
Mickey, B1
Malloy, C1
Bachoo, R1
Deberardinis, R1
Maher, E1
Balos, DR1
Gavrilović, S1
Lavrnić, S1
Vasić, B1
Macvanski, M1
Damjanović, D1
Opinćal, TS1
Tsen, AR1
Long, PM1
Driscoll, HE1
Davies, MT1
Teasdale, BA1
Penar, PL1
Pendlebury, WW1
Spees, JL1
Lawler, SE1
Viapiano, MS1
Jaworski, DM1
Roder, C1
Skardelly, M1
Ramina, KF1
Beschorner, R1
Honneger, J1
Nägele, T1
Tatagiba, MS1
Ernemann, U1
Bisdas, S1
Bertolino, N1
Marchionni, C1
Ghielmetti, F1
Burns, B1
Anghileri, E1
Minati, L1
Pereira, MS1
Zenki, K1
Cavalheiro, MM1
Thomé, CC1
Filippi-Chiela, EC1
Lenz, G1
de Souza, DO1
de Oliveira, DL1
Raschke, F1
Jones, TL1
Barrick, TR1
Howe, FA1
Ganji, SK2
An, Z1
Choe, KS1
Pinho, MC1
Bachoo, RM2
Maher, EM1
Stadler, KL1
Ober, CP1
Feeney, DA1
Jessen, CR1
Yamamoto, T1
Isobe, T1
Akutsu, H1
Masumoto, T1
Ando, H1
Sato, E1
Takada, K1
Anno, I1
Matsumura, A1
Ranjith, G1
Parvathy, R1
Vikas, V1
Chandrasekharan, K1
Nair, S1
Ghasemi, K1
Khanmohammadi, M1
Saligheh Rad, H1
Tong, T1
Yang, Z1
Chen, JW1
Zhu, J1
Yao, Z1
Lotumolo, A2
Caivano, R2
Rabasco, P2
Iannelli, G1
Villonio, A2
D' Antuono, F1
Gioioso, M1
Zandolino, A2
Macarini, L2
Guglielmi, G1
Cammarota, A2
Wang, Q1
Zhang, H1
Wu, C1
Zhu, W1
Chen, X1
Xu, B1
Zhuang, DX1
Yao, CJ1
Lin, CP1
Wang, TL1
Qin, ZY1
Wu, JS1
Jarmusch, AK1
Pirro, V1
Baird, Z1
Hattab, EM1
Cohen-Gadol, AA1
Cooks, RG1
Carrera, I1
Richter, H1
Beckmann, K1
Meier, D1
Dennler, M1
Kircher, PR1
Wang, C1
Chen, H2
Zhang, M1
Wei, X1
Ying, W1
Xu, YJ1
Cui, Y1
Li, HX1
Shi, WQ1
Li, FY1
Wang, JZ1
Zeng, QS3
Roldan-Valadez, E1
Rios, C1
Motola-Kuba, D1
Matus-Santos, J1
Villa, AR1
Moreno-Jimenez, S1
Sankar, T2
Caramanos, Z2
Assina, R1
Villemure, JG1
Leblanc, R1
Langleben, A1
Arnold, DL3
Preul, MC2
Li, Y2
Srinivasan, R1
Ratiney, H1
Lu, Y3
Chang, SM2
Nelson, SJ6
Douis, H1
Jafri, M1
Sherlala, K1
Murphy, A1
Vines, A1
McBean, GJ1
Vanhoutte, N1
Abarca-Quinones, J1
Jordan, BF1
Gallez, B1
Maloteaux, JM1
Hermans, E1
Blamek, S1
Larysz, D1
Ficek, K1
Sokół, M2
Miszczyk, L1
Tarnawski, R1
Matsusue, E1
Fink, JR1
Rockhill, JK1
Ogawa, T1
Maravilla, KR1
Goenka, AH1
Kumar, A1
Sharma, R1
Kuznetsov, YE1
Ryan, RW1
Antel, SB1
Server, A3
Josefsen, R2
Kulle, B2
Maehlen, J1
Schellhorn, T1
Gadmar, Ø1
Kumar, T2
Haakonsen, M1
Langberg, CW1
Nakstad, PH2
Sijens, PE1
Stadlbauer, A5
Buchfelder, M2
Doelken, MT1
Hammen, T3
Ganslandt, O5
Gadmar, ØB1
Liu, X1
Germin, BI1
Zhong, J1
Ekholm, S1
Blasel, S1
Pfeilschifter, W1
Jansen, V1
Mueller, K1
Zanella, F1
Weber, MA1
Henze, M1
Tüttenberg, J1
Stieltjes, B1
Meissner, M1
Zimmer, F1
Burkholder, I1
Kroll, A1
Combs, SE1
Vogt-Schaden, M1
Giesel, FL1
Zoubaa, S1
Haberkorn, U1
Kauczor, HU1
Essig, M1
Liu, H3
Zhang, K2
Li, C1
Zhou, G1
Widhalm, G1
Krssak, M1
Minchev, G1
Wöhrer, A1
Traub-Weidinger, T1
Czech, T1
Asenbaum, S1
Marosi, C1
Knosp, E1
Hainfellner, JA1
Prayer, D1
Wolfsberger, S1
Guillevin, R1
Menuel, C1
Taillibert, S1
Capelle, L1
Costalat, R1
Abud, L1
Habas, C1
De Marco, G1
Hoang-Xuan, K1
Chiras, J1
Vallée, JN1
Amin, A1
Moustafa, H1
Ahmed, E1
El-Toukhy, M1
DeBerardinis, RJ1
Hatanpaa, KJ1
Rakheja, D1
Yang, XL1
Mashimo, T1
Raisanen, JM1
Marin-Valencia, I1
Pascual, JM1
Madden, CJ1
Mickey, BE1
Malloy, CR1
Maher, EA1
Nicolasjilwan, M1
Lopes, MB1
Larner, J1
Wintermark, M1
Schiff, D1
Steffen-Smith, EA1
Venzon, DJ1
Bent, RS1
Hipp, SJ1
Warren, KE1
Mertens, K1
Acou, M1
Van den Broecke, C1
Nuyts, R1
Van Roost, D1
Achten, E1
Goethals, I1
Guo, J1
Yao, C1
Zhuang, D1
Tang, W1
Ren, G1
Wang, Y1
Wu, J1
Huang, F1
Zhou, L1
Shang, HB1
Zhao, WG1
Zhang, WF1
Bulik, M1
Jancalek, R1
Vanicek, J1
Skoch, A1
Mechl, M1
Ali, ZS1
Lang, SS1
Sutton, LN1
D'Antuono, F1
Lancellotti, MI1
Saindane, AM1
Cha, S3
Law, M2
Xue, X1
Knopp, EA3
Zagzag, D2
McKnight, TR6
von dem Bussche, MH1
Vigneron, DB4
Berger, MS2
McDermott, MW1
Dillon, WP4
Graves, EE2
Pirzkall, A3
Bulakbasi, N1
Kocaoglu, M1
Ors, F1
Tayfun, C1
Uçöz, T1
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Viout, P1
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Simonetti, AW1
Melssen, WJ1
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Houkin, K2
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Lu, CY1
Yeung, KW1
Lin, WC1
Sheu, FO1
Liu, GC1
Moser, E3
Gruber, S3
Buslei, R4
Nimsky, C4
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Magalhaes, A1
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Zilles, K1
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Stummer, W1
Steiger, HJ1
Woebker, G1
Müller, HW1
Coenen, H1
Sabel, M1
Chernov, MF1
Muragaki, Y1
Ochiai, T1
Maruyama, T1
Izawa, M1
Hayashi, M1
Ono, Y2
Kubo, O1
Hori, T1
Kamada, K1
Blumcke, I1
Laprie, A1
Haas-Kogan, DA1
Banerjee, A1
Le, TP1
Nelson, S1
Tong, ZY1
Toshiaki, Y1
Wang, YJ1
Balmaceda, C1
Critchell, D1
Mao, X1
Cheung, K1
Pannullo, S1
DeLaPaz, RL1
Shungu, DC1
Cohen, BA1
Rusinek, H1
Babb, JS1
Gonen, O1
Pulkkinen, J1
Häkkinen, AM1
Lundbom, N2
Paetau, A1
Kauppinen, RA1
Hiltunen, Y1
Likavcanová, K1
Dobrota, D1
Liptaj, T1
Prónayová, N1
Mlynárik, V1
Belan, V1
Galanda, M1
Béres, A1
De Riggo, J1
Tomandl, B1
Di Costanzo, A1
Scarabino, T1
Trojsi, F1
Giannatempo, GM1
Popolizio, T1
Catapano, D1
Bonavita, S2
Maggialetti, N1
Tosetti, M1
Salvolini, U1
d'Angelo, VA1
Tedeschi, G2
Kim, JH1
Chang, KH1
Na, DG1
Song, IC1
Kwon, BJ1
Han, MH1
Kim, K1
Goebell, E1
Fiehler, J1
Ding, XQ1
Paustenbach, S1
Nietz, S1
Heese, O1
Kucinski, T1
Hagel, C1
Westphal, M1
Zeumer, H1
Matulewicz, Ł1
Michnik, A1
Wydmański, J1
Fan, G1
Porto, L1
Pilatus, U2
Kieslich, M1
Yan, B1
Schwabe, D1
Zanella, FE2
Lanfermann, H2
Li, CF2
Zhen, JH2
Feng, DC1
Pinker, K1
Lamborn, KR1
Love, TD1
Chang, S2
Bollen, A1
Kang, XS1
Zonari, P1
Baraldi, P1
Crisi, G1
Alimenti, A1
Delavelle, J1
Lazeyras, F1
Yilmaz, H1
Dietrich, PY1
de Tribolet, N1
Lövblad, KO1
Bianchi, MG1
Gazzola, GC1
Tognazzi, L1
Bussolati, O1
Bartha, R1
Megyesi, JF1
Watling, CJ1
Hagberg, G1
Burlina, AP1
Mader, I1
Roser, W1
Radue, EW1
Seelig, J1
Poptani, H1
Gupta, RK1
Roy, R1
Pandey, R1
Jain, VK1
Chhabra, DK1
Shinno, H1
Mikuni, M1
Saitoh, K1
Tomita, U1
Yamawaki, S1
Takahashi, K1
de Graaf, RA1
Luo, Y1
Terpstra, M1
Garwood, M2
Go, KG2
Kamman, RL2
Mooyaart, EL2
Heesters, MA2
Pruim, J1
Vaalburg, W1
Paans, AM1
Harada, M1
Tanouchi, M1
Nishitani, H1
Miyoshi, H1
Bandou, K1
Kannuki, S1
Castillo, M1
Green, C1
Kwock, L1
Smith, K1
Wilson, D1
Schiro, S1
Greenwood, R1
Portais, JC1
Schuster, R1
Merle, M2
Canioni, P2
Green, AR1
Cross, AJ1
Cazzaniga, S1
Schold, SC1
Sostman, HD1
Charles, HC1
Gyngell, ML2
Els, T1
Hoehn-Berlage, M1
Hossmann, KA1
Barker, PB1
Blackband, SJ1
Chatham, JC1
Soher, BJ1
Samphilipo, MA1
Magee, CA1
Hilton, JD1
Strandberg, JD1
Anderson, JH1
Felber, SR1
Shimizu, H1
Kumabe, T1
Tominaga, T1
Kayama, T1
Hara, K1
Sato, K1
Arai, N1
Fujiwara, S1
Yoshimoto, T1
Dowd, LA1
Robinson, MB1
Falini, A1
Calabrese, G1
Origgi, D1
Lipari, S1
Triulzi, F1
Losa, M1
Scotti, G1
Broniscer, A1
Gajjar, A1
Bhargava, R1
Langston, JW1
Heideman, R1
Jones, D1
Kun, LE1
Taylor, J1
Furuya, S1
Naruse, S2
Ide, M1
Morishita, H1
Kizu, O1
Ueda, S1
Maeda, T1
Raman, R1
Duyn, JH1
Alger, JR1
Di Chiro, G1
Burtscher, IM1
Ståhlberg, F1
Holtås, S1
Kort, JJ1
Bouzier, AK1
Quesson, B1
Valeins, H1
Henry, RG1
Fischbein, NJ1
Grant, PE1
Day, MR1
Noworolski, SM2
Star-Lack, JM1
Wald, LL1
Shinohara, H1
Yagita, H1
Ikawa, Y1
Oyaizu, N1
Wilken, B1
Dechent, P1
Herms, J1
Maxton, C1
Markakis, E1
Hanefeld, F1
Frahm, J2
Nelson , SJ1
Hsu, L1
Rockenstein, E1
Mallory, M1
Hashimoto, M1
Masliah, E1
Verhey, L1
McDermott, M1
Larson, D1
Prados, MD1
Son, BC1
Kim, MC1
Choi, BG1
Kim, EN1
Baik, HM1
Choe, BY1
Kang, JK1
Ziegler, A2
von Kienlin , M1
Décorps, M1
Rémy, C2
García-Martín, ML1
Hérigault, G1
Farion, R1
Ballesteros, P1
Coles, JA1
Cerdán, S1
Croteau, D1
Scarpace, L1
Hearshen, D1
Gutierrez, J1
Fisher, JL1
Rock, JP1
Mikkelsen, T1
Sabatier, J1
Ibarrola, D1
Malet-Martino, M1
Berry, I1
Johnson, G1
Arnett, J1
Litt, AW1
Möller-Hartmann, W1
Herminghaus, S1
Krings, T1
Marquardt, G1
Johnson, RK1
Swyryd, EA1
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Matthews, PM1
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O'Connor, J1
Antel, JP1
Chuang, DM1
Lin, WW1
Lee, CY1
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Staewen, RS1
Segebarth, CM1
Balériaux, DF1
Luyten, PR1
den Hollander, JA1
Bruhn, H1
Merboldt, KD1
Hänicke, W1
Sauter, R1
Hamburger, C1
Lacoste, L1
Hertz, L1
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Hannuniemi, R1
Pajari-Backas, M1
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Nadler, JV1
Cooper, JR1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Study About the Validity of MRS-guided Resection on Prognosis High-grade Gliomas[NCT02795364]50 participants (Anticipated)Interventional2016-06-30Not yet recruiting
Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206]12 participants (Anticipated)Observational2020-12-31Not yet recruiting
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526]Phase 1/Phase 20 participants (Actual)Interventional2015-12-31Withdrawn (stopped due to NIH funding resulted in new clinical trial)
Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla[NCT04233788]55 participants (Anticipated)Observational2021-09-01Recruiting
Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318]100 participants (Actual)Interventional2012-01-31Completed
Study of Clinical Biomarkers in Human Health and Disease (Healthiomics)[NCT05106725]3,500 participants (Anticipated)Observational2021-10-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for aspartic acid and Glioma

ArticleYear
Unique magnetic resonance spectroscopy profile of intracranial meningiomas compared to gliomas: a systematic review.
    Acta neurologica Belgica, 2023, Volume: 123, Issue:6

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Spectr

2023
The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade gliomas: A systematic review and meta-analysis.
    European radiology, 2016, Volume: 26, Issue:8

    Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Databases, Factual; Glioma; Hum

2016
Potential of MR spectroscopy for assessment of glioma grading.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:2

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol

2013
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
    The International journal of neuroscience, 2013, Volume: 123, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ

2013
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
    Seminars in oncology, 2004, Volume: 31, Issue:5

    Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans

2004
Brain stem involvement in children with neurofibromatosis type 1: role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma.
    Neurosurgery, 1997, Volume: 40, Issue:2

    Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Choline; Creatine;

1997

Trials

4 trials available for aspartic acid and Glioma

ArticleYear
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
    Journal of neuro-oncology, 2008, Volume: 90, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis

2008
Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings.
    Neuroradiology, 2004, Volume: 46, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choli

2004
Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas.
    Journal of neurosurgery, 2007, Volume: 106, Issue:4

    Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Pro

2007
Multivoxel 3D proton MR spectroscopy in the distinction of recurrent glioma from radiation injury.
    Journal of neuro-oncology, 2007, Volume: 84, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fema

2007

Other Studies

141 other studies available for aspartic acid and Glioma

ArticleYear
Magnetic resonance spectroscopy - its added value in brain glioma multiparametric assessment.
    Bratislavske lekarske listy, 2021, Volume: 122, Issue:10

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectro

2021
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21

    Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson

2022
Chordoid glioma: an entity occurring not exclusively in the third ventricle.
    Neurosurgical review, 2020, Volume: 43, Issue:5

    Topics: Adult; Aged; Aspartic Acid; Cerebellum; Cerebral Ventricle Neoplasms; Choline; Diffusion Magnetic Re

2020
The Association between Whole-Brain MR Spectroscopy and IDH Mutation Status in Gliomas.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020, Volume: 30, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Isocitrate

2020
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020, Volume: 47, Issue:3

    Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err

2020
Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas.
    Scientific reports, 2021, 04-12, Volume: 11, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytes; Brain Neoplasms; Female; Glioma; Glutamic

2021
Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma.
    BioMed research international, 2021, Volume: 2021

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Cognitive Dysfunction; Creatine; Early Diagnosis;

2021
[Magnetic resonance spectroscopy of brain tumors].
    Der Radiologe, 2017, Volume: 57, Issue:6

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging

2017
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas.
    The British journal of radiology, 2017, Volume: 90, Issue:1075

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res

2017
In vivo characterization of brain metabolism by
    International journal of cancer, 2018, 07-01, Volume: 143, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Brain; Brain Neoplasms; Cell Line, Tum

2018
Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2.
    Acta radiologica (Stockholm, Sweden : 1987), 2019, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Proliferation; Chil

2019
On the relation between MR spectroscopy features and the distance to MRI-visible solid tumor in GBM patients.
    Magnetic resonance in medicine, 2018, Volume: 80, Issue:6

    Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Healthy Volunteers; Hu

2018
Lesion segmentation for MR spectroscopic imaging using the convolution difference method.
    Magnetic resonance in medicine, 2019, Volume: 81, Issue:3

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Computer Simulation; Glio

2019
Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma.
    International journal of cancer, 2019, 05-15, Volume: 144, Issue:10

    Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Aspartic Acid; Astrocytes; Benzopyrans; Cell L

2019
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
    NMR in biomedicine, 2013, Volume: 26, Issue:10

    Topics: Adult; Aspartic Acid; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Glutamine; Gl

2013
Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions.
    Vojnosanitetski pregled, 2013, Volume: 70, Issue:7

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diffusion

2013
Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.
    International journal of cancer, 2014, Mar-15, Volume: 134, Issue:6

    Topics: Amidohydrolases; Animals; Antifungal Agents; Aspartic Acid; Astrocytes; Brain; Brain Neoplasms; Cell

2014
Spectroscopy imaging in intraoperative MR suite: tissue characterization and optimization of tumor resection.
    International journal of computer assisted radiology and surgery, 2014, Volume: 9, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Image

2014
Accuracy of 2-hydroxyglutarate quantification by short-echo proton-MRS at 3 T: a phantom study.
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2014, Volume: 30, Issue:6

    Topics: Aspartic Acid; Brain; Glioma; Glutamic Acid; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation;

2014
Cellular senescence induced by prolonged subculture adversely affects glutamate uptake in C6 lineage.
    Neurochemical research, 2014, Volume: 39, Issue:5

    Topics: Animals; Aspartic Acid; Cellular Senescence; Glioma; Glutamic Acid; Rats, Wistar; Tritium; Tumor Cel

2014
Delineation of gliomas using radial metabolite indexing.
    NMR in biomedicine, 2014, Volume: 27, Issue:9

    Topics: Algorithms; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Diagnosis, Computer-Assisted

2014
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
    Magnetic resonance in medicine, 2015, Volume: 73, Issue:6

    Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female;

2015
Multivoxel proton magnetic resonance spectroscopy of inflammatory and neoplastic lesions of the canine brain at 3.0 T.
    American journal of veterinary research, 2014, Volume: 75, Issue:11

    Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis,

2014
Influence of echo time in quantitative proton MR spectroscopy using LCModel.
    Magnetic resonance imaging, 2015, Volume: 33, Issue:5

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer

2015
Machine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy.
    The neuroradiology journal, 2015, Volume: 28, Issue:2

    Topics: Algorithms; Artificial Intelligence; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Cre

2015
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
    Magnetic resonance in chemistry : MRC, 2016, Volume: 54, Issue:2

    Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra

2016
Dynamic 1H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma.
    Oncotarget, 2015, Oct-13, Volume: 6, Issue:31

    Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Choline; Diagnosis, Differe

2015
Comparison between magnetic resonance spectroscopy and diffusion weighted imaging in the evaluation of gliomas response after treatment.
    European journal of radiology, 2015, Volume: 84, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Diffusion Magnetic Resonanc

2015
Metabolic approach for tumor delineation in glioma surgery: 3D MR spectroscopy image-guided resection.
    Journal of neurosurgery, 2016, Volume: 124, Issue:6

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diffusion Tensor Imaging; Feasibility S

2016
Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Feb-09, Volume: 113, Issue:6

    Topics: Aspartic Acid; Brain; Brain Neoplasms; Cell Differentiation; Glioma; Gray Matter; Humans; Lipid Meta

2016
Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla.
    American journal of veterinary research, 2016, Volume: 77, Issue:5

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Creatine; Dog Diseases; Dogs; Female;

2016
Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis.
    Cancer letters, 2016, 08-01, Volume: 378, Issue:1

    Topics: Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Antineoplastic Agents; Apoptosis; Aspartic Aci

2016
Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro.
    Magnetic resonance imaging, 2016, Volume: 34, Issue:8

    Topics: Aspartic Acid; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Choline; C

2016
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas.
    The British journal of radiology, 2016, Volume: 89, Issue:1067

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre

2016
Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T.
    Journal of magnetic resonance imaging : JMRI, 2008, Volume: 28, Issue:2

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Gliom

2008
Bilateral thalamic glioma.
    Archives of neurology, 2008, Volume: 65, Issue:12

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imagin

2008
Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx.
    Biochimica et biophysica acta, 2009, Volume: 1788, Issue:2

    Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Cell Line, Tumor; Excitatory Amino Acid Trans

2009
Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat.
    Experimental neurology, 2009, Volume: 218, Issue:1

    Topics: Animals; Aspartic Acid; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Disease Progressi

2009
MR spectroscopic evaluation of brain tissue damage after treatment for pediatric brain tumors.
    Acta neurochirurgica. Supplement, 2010, Volume: 106

    Topics: Adolescent; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Ependymoma; Female; Gli

2010
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging.
    Neuroradiology, 2010, Volume: 52, Issue:4

    Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr

2010
MR spectroscopy for differentiation of recurrent glioma from radiation-induced changes.
    AJR. American journal of roentgenology, 2009, Volume: 193, Issue:6

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast

2009
The metabolic epicenter of supratentorial gliomas: a 1H-MRSI study.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2009, Volume: 36, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Chi-Square Distribution; Cholin

2009
Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media;

2010
Response to article "Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors".
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc

2010
Response to a letter by Paul E. Sijens.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc

2010
Magnetic resonance spectroscopic imaging for visualization of the infiltration zone of glioma.
    Central European neurosurgery, 2011, Volume: 72, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Choline; Data Interpretation, Statistica

2011
Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas.
    European journal of radiology, 2011, Volume: 80, Issue:2

    Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Im

2011
N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas.
    Magnetic resonance imaging, 2010, Volume: 28, Issue:9

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Diagn

2010
Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas.
    Journal of neurology, 2011, Volume: 258, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain Neoplasms; Cerebrovas

2011
Biopsy targeting gliomas: do functional imaging techniques identify similar target areas?
    Investigative radiology, 2010, Volume: 45, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Contras

2010
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy.
    Magnetic resonance imaging, 2011, Volume: 29, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Creatine; Female; Glioma; H

2011
Value of 1H-magnetic resonance spectroscopy chemical shift imaging for detection of anaplastic foci in diffusely infiltrating gliomas with non-significant contrast-enhancement.
    Journal of neurology, neurosurgery, and psychiatry, 2011, Volume: 82, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; H

2011
Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.
    British journal of cancer, 2011, Jun-07, Volume: 104, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Brain Neoplasms; Choline; Creatine; D

2011
Glioma residual or recurrence versus radiation necrosis: accuracy of pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT compared to proton magnetic resonance spectroscopy (1H-MRS): initial results.
    Journal of neuro-oncology, 2012, Volume: 106, Issue:3

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Follow-Up Studie

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
    Nature medicine, 2012, Jan-26, Volume: 18, Issue:4

    Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;

2012
Subependymal seeding of low-grade oligodendroglial neoplasms: a case series.
    Journal of neuro-oncology, 2012, Volume: 108, Issue:1

    Topics: Adult; Aspartic Acid; Creatine; Disease Progression; Ependyma; Fourth Ventricle; Glioma; Humans; Iso

2012
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.
    International journal of radiation oncology, biology, physics, 2012, Nov-01, Volume: 84, Issue:3

    Topics: Adolescent; Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Feasibi

2012
Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:8

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Fluorodeoxy

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas.
    Acta neurochirurgica, 2012, Volume: 154, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu

2012
Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas.
    Turkish neurosurgery, 2012, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Anisotropy; Aspartic Acid; Brain Neoplasms; Cerebral Cortex; Child; Choline

2012
Conservative management of presumed low-grade gliomas in the asymptomatic pediatric population.
    World neurosurgery, 2014, Volume: 81, Issue:2

    Topics: Adolescent; Aspartic Acid; Astrocytoma; Asymptomatic Diseases; Brain Neoplasms; Child; Child, Presch

2014
Proton MR spectroscopy of tumefactive demyelinating lesions.
    AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:8

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Demyelinating Diseases; Diagnosis, Different

2002
Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence.
    Journal of neurosurgery, 2002, Volume: 97, Issue:4

    Topics: Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Spectroscopy; Pr

2002
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat

2003
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
    Annales de medecine interne, 2002, Volume: 153, Issue:8

    Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia

2002
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
    Analytical chemistry, 2003, Oct-15, Volume: 75, Issue:20

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc

2003
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy.
    International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyu

2004
1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification.
    Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:4

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Dose-Response Relationshi

2004
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; C

2004
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:7

    Topics: Adult; Aged; Aspartic Acid; Body Water; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr

2004
Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas.
    NeuroImage, 2004, Volume: 23, Issue:2

    Topics: Adult; Algorithms; Aspartic Acid; Astrocytoma; Automation; Biopsy; Brain Chemistry; Brain Mapping; B

2004
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
    Academic radiology, 2005, Volume: 12, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin

2005
Clinicopathological examination of glioma by proton magnetic resonance spectroscopy background.
    Brain tumor pathology, 2004, Volume: 21, Issue:1

    Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioma; Humans; Lactic Acid; Magnetic Resona

2004
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy.
    Journal of neurosurgery, 2005, Volume: 102, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Child, Preschool; Cho

2005
Spectroscopy and navigation.
    Journal of neurosurgery, 2005, Volume: 102, Issue:2

    Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Glioma; Humans; Image Processing, Comput

2005
Proton magnetic resonance spectroscopic imaging integrated into image-guided surgery: correlation to standard magnetic resonance imaging and tumor cell density.
    Neurosurgery, 2005, Volume: 56, Issue:2 Suppl

    Topics: Algorithms; Aspartic Acid; Biopsy; Brain Neoplasms; Cell Count; Choline; Feasibility Studies; Glioma

2005
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
    International journal of radiation oncology, biology, physics, 2005, May-01, Volume: 62, Issue:1

    Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression

2005
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
    Chinese medical journal, 2005, Aug-05, Volume: 118, Issue:15

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic

2005
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy.
    Journal of neuro-oncology, 2006, Volume: 76, Issue:2

    Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv

2006
Assessing global invasion of newly diagnosed glial tumors with whole-brain proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:9

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Female; Glioma; Humans; Magnetic Resonance Spect

2005
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
    European journal of radiology, 2005, Volume: 56, Issue:2

    Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio

2005
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
    General physiology and biophysics, 2005, Volume: 24, Issue:3

    Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla

2005
Preoperative grading of gliomas by using metabolite quantification with high-spatial-resolution proton MR spectroscopic imaging.
    Radiology, 2006, Volume: 238, Issue:3

    Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Female;

2006
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy.
    Neuroradiology, 2006, Volume: 48, Issue:9

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio

2006
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma;

2006
Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Adult; Aged; Anisotropy; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Size; Choline; Cre

2006
Long-term normal-appearing brain tissue monitoring after irradiation using proton magnetic resonance spectroscopy in vivo: statistical analysis of a large group of patients.
    International journal of radiation oncology, biology, physics, 2006, Nov-01, Volume: 66, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Blood-Brain Barrier; Brain; Brain Neoplasms; Choline; Creatine; Female;

2006
Comments and controversies: magnetic resonance spectroscopy and gliomas.
    Cancer imaging : the official publication of the International Cancer Imaging Society, 2006, Sep-07, Volume: 6

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy;

2006
Proton magnetic resonance spectroscopy in childhood brainstem lesions.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007, Volume: 23, Issue:3

    Topics: Adolescent; Amino Acids; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neop

2007
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging.
    International journal of radiation oncology, biology, physics, 2007, May-01, Volume: 68, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Diffusion Magn

2007
Proton magnetic resonance spectroscopic imaging in the border zone of gliomas: correlation of metabolic and histological changes at low tumor infiltration--initial results.
    Investigative radiology, 2007, Volume: 42, Issue:4

    Topics: Aspartic Acid; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; Neoplasm Invasive

2007
Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging.
    Neuroradiology, 2007, Volume: 49, Issue:10

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Blood Flow Velocity; Brain; Brain Neoplasms; Choline

2007
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
    European neurology, 2007, Volume: 58, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma;

2007
C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1).
    Neuroscience, 2008, Feb-19, Volume: 151, Issue:4

    Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Differentiation; Cell Line, Tumor; Dose-Response

2008
Low-grade glioma: correlation of short echo time 1H-MR spectroscopy with 23Na MR imaging.
    AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Magnetic Resonance Imaging; Ma

2008
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
    Magnetic resonance in medicine, 1995, Volume: 34, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan

1995
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea

1995
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
    Journal of neurochemistry, 1994, Volume: 63, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine M

1994
Spectral editing with adiabatic pulses.
    Journal of magnetic resonance. Series B, 1995, Volume: 109, Issue:2

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Choline; Creatine; Feasibility Studies; Gl

1995
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
    Neuroradiology, 1995, Volume: 37, Issue:3

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl

1995
Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:3

    Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Ependymoma; Glioma; Humans; Magnetic

1995
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
    AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di

1995
Metabolic flux determination in C6 glioma cells using carbon-13 distribution upon [1-13C]glucose incubation.
    European journal of biochemistry, 1993, Oct-01, Volume: 217, Issue:1

    Topics: Alanine; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glioma; Gluconeogenesis; Glucose; Glutam

1993
Attenuation by chlormethiazole of oedema following focal ischaemia in the cerebral cortex of the rat.
    Neuroscience letters, 1994, May-23, Volume: 173, Issue:1-2

    Topics: Animals; Aspartic Acid; Body Water; Brain Edema; Cerebral Cortex; Cerebral Infarction; Cerebrovascul

1994
Effects of therapy on the 1H NMR spectrum of a human glioma line.
    Magnetic resonance imaging, 1994, Volume: 12, Issue:6

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Lactates; Magnetic Resonance Spe

1994
Proton MR spectroscopy of experimental brain tumors in vivo.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho

1994
Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy.
    Journal of neuro-oncology, 1993, Volume: 17, Issue:1

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance I

1993
Quantitative proton spectroscopy and histology of a canine brain tumor model.
    Magnetic resonance in medicine, 1993, Volume: 30, Issue:4

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag

1993
[1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia].
    Der Radiologe, 1993, Volume: 33, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Child; Child, Preschool;

1993
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 1996, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal

1996
Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester.
    Journal of neurochemistry, 1996, Volume: 67, Issue:2

    Topics: Adenylyl Cyclases; Amiloride; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding

1996
Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives.
    Journal of neurology, 1996, Volume: 243, Issue:10

    Topics: Adenoma; Aspartic Acid; Brain Neoplasms; Choline; Craniopharyngioma; Creatinine; Glioma; Humans; Lym

1996
Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method.
    NMR in biomedicine, 1997, Volume: 10, Issue:1

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Evaluation Studies as Topic; Glioma; Humans; Imag

1997
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
    Journal of neurosurgery, 1997, Volume: 87, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas

1997
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
    Acta radiologica (Stockholm, Sweden : 1987), 1997, Volume: 38, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo

1997
Impairment of excitatory amino acid transport in astroglial cells infected with the human immunodeficiency virus type 1.
    AIDS research and human retroviruses, 1998, Oct-10, Volume: 14, Issue:15

    Topics: Aspartic Acid; Astrocytes; Biological Transport; Gene Products, nef; Glioma; Glutamic Acid; HIV Enve

1998
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat.
    Journal of neurochemistry, 1999, Volume: 72, Issue:6

    Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla

1999
Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2

    Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Fema

2000
Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation.
    Cancer research, 2000, Mar-15, Volume: 60, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Caspase Inhibitors; Caspases; Cell Cycle;

2000
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
    Pediatric neurology, 2000, Volume: 23, Issue:1

    Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms;

2000
An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma.
    Journal of magnetic resonance imaging : JMRI, 2001, Volume: 13, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Female; Glioma; Humans; Imaging, Three-Dimens

2001
Altered expression of glutamate transporters under hypoxic conditions in vitro.
    Journal of neuroscience research, 2001, Apr-15, Volume: 64, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Cell Death; Cell Hypoxia

2001
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:4

    Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies;

2001
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
    Acta neurochirurgica, 2001, Volume: 143, Issue:1

    Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene

2001
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
    Cancer research, 2001, Jul-15, Volume: 61, Issue:14

    Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma;

2001
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites.
    Cancer research, 2001, Sep-01, Volume: 61, Issue:17

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S

2001
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
    Neurosurgery, 2001, Volume: 49, Issue:4

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr

2001
[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis].
    Revue neurologique, 2001, Volume: 157, Issue:8-9 Pt 1

    Topics: Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Energy Metabolism;

2001
High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging.
    Radiology, 2002, Volume: 222, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Bra

2002
Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions.
    Neuroradiology, 2002, Volume: 44, Issue:5

    Topics: Aspartic Acid; Brain Abscess; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Diagnosis, Di

2002
Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.
    Cancer research, 1978, Volume: 38, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Cells, Cult

1978
Effect of inhibitors of N-linked oligosaccharide processing on the high-affinity transport of D-aspartate by C6 glioma cells.
    Brain research, 1992, Mar-20, Volume: 575, Issue:2

    Topics: 1-Deoxynojirimycin; Aspartic Acid; Biological Transport; Glioma; Glucosamine; Glucosidases; Glycosyl

1992
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
    Annals of neurology, 1992, Volume: 31, Issue:3

    Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De

1992
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types.
    Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 7

    Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Endothelins; Glioma; Inositol; Neurons

1991
Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma.
    Magnetic resonance in medicine, 1992, Volume: 23, Issue:1

    Topics: Animals; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Female; Glioma; Hydrogen; Lactates; Lactic

1992
Inhibition by trypsin of the high-affinity acidic amino acid transport system in C6 glioma cells.
    Brain research, 1990, Jun-25, Volume: 521, Issue:1-2

    Topics: Animals; Aspartic Acid; Energy Metabolism; Glioma; Rats; Trypsin; Tumor Cells, Cultured

1990
Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1H NMR spectroscopic imaging.
    Magnetic resonance in medicine, 1990, Volume: 13, Issue:1

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Creatine; Glioma; Humans; Magnetic Resona

1990
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
    Radiology, 1989, Volume: 172, Issue:2

    Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts;

1989
Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.
    Brain research, 1986, Volume: 387, Issue:1

    Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Aspartic Acid; Brain; Catalysis; Cell Line; Glioma;

1986
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells.
    Acta physiologica Scandinavica, 1987, Volume: 131, Issue:4

    Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblast

1987
N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues.
    Journal of neurochemistry, 1972, Volume: 19, Issue:2

    Topics: Animals; Aspartic Acid; Brain Neoplasms; Cattle; Cerebral Cortex; Craniopharyngioma; Glioblastoma; G

1972