aspartic acid and Glioma studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

Excerpt	Relevance	Reference
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."	9.13	Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)."	7.77	Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."	7.73	Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells."	7.67	Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987)
" This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells."	5.40	Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. ( Davies, MT; Driscoll, HE; Jaworski, DM; Lawler, SE; Long, PM; Penar, PL; Pendlebury, WW; Spees, JL; Teasdale, BA; Tsen, AR; Viapiano, MS, 2014)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."	5.13	Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
" There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids."	4.89	Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013)
" These methods were evaluated for segmentation of volumetric MRSI studies of gliomas using maps of the choline to N-acetylaspartate ratio, and a qualitative comparison of lesion volumes carried out."	3.91	Lesion segmentation for MR spectroscopic imaging using the convolution difference method. ( Maudsley, AA, 2019)
"There is significant elevation of the choline (Cho) /creatine (Cr) ratio, Cho peak and depression of the N-acetylaspartate (NAA) peak in gliomas."	3.78	Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas. ( Shang, HB; Zhang, WF; Zhao, WG, 2012)
"This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)."	3.77	Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011)
" The aim of this work is to evaluate whether regional cerebral blood volume (rCBV), as well as choline (Cho), N-acetyl-aspartate (NAA) and myo-inositol (mIns) concentrations differ between tumefactive lesions and World Health Organization (WHO) grade II-III gliomas."	3.77	Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. ( Blasel, S; Hattingen, E; Jansen, V; Mueller, K; Pfeilschifter, W; Zanella, F, 2011)
"Diffusion tensor imaging (DTI) and MR spectroscopy are noninvasive, quantitative tools for the preoperative assessment of gliomas with which the quantitative parameter fractional anisotropy (FA) and the concentration of neurometabolites N-acetylaspartate (NAA), choline (Cho), creatine (Cr) of the brain can be determined."	3.73	Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. ( Ding, XQ; Fiehler, J; Goebell, E; Hagel, C; Heese, O; Kucinski, T; Nietz, S; Paustenbach, S; Westphal, M; Zeumer, H, 2006)
"In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)."	3.73	In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005)
"The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas."	3.73	Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. ( Coenen, H; Floeth, FW; Hamacher, K; Langen, KJ; Messing-Jünger, M; Müller, HW; Pauleit, D; Reifenberger, G; Sabel, M; Steiger, HJ; Stummer, W; Weber, F; Wittsack, HJ; Woebker, G; Zilles, K, 2005)
"To evaluate an intracranial polymer implant containing bromodeoxyuridine (BrdUrd) and N-(phosphonacetyl)-L-aspartic acid (PALA) in combination with external beam radiotherapy (EBRT) in the treatment of a rat glioma."	3.72	Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. ( Lehnert, S; Li, Y; Owusu, A, 2004)
" The concentration of taurine (Tau) in medulloblastomas was 29."	3.72	In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004)
" The concentration of taurine (Tau) in medulloblastomas was 29."	3.72	In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004)
"Data obtained preoperatively from three-dimensional (3D)/proton magnetic resonance (MR) spectroscopy were compared with the results of histopathological assays of tissue biopsies obtained during surgery to verify the sensitivity and specificity of a choline-containing compound-N-acetylaspartate index (CNI) used to distinguish tumor from nontumorous tissue within T2-hyperintense and contrast-enhancing lesions of patients with untreated gliomas."	3.71	Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. ( Berger, MS; Dillon, WP; Graves, EE; Lu, Y; McDermott, MW; McKnight, TR; Nelson, SJ; Pirzkall, A; Vigneron, DB; von dem Bussche, MH, 2002)
" MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis."	3.71	[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002)
" Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA."	3.71	Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. ( Herminghaus, S; Krings, T; Lanfermann, H; Marquardt, G; Möller-Hartmann, W; Pilatus, U; Zanella, FE, 2002)
"We found in cultured glioma (C6BU-1) cells that excitatory amino acids (EAAs) such as glutamate, N-methyl-D-aspartate (NMDA), aspartate, and metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylate caused an increase in the inositol 1,4,5-trisphosphate formation and the intracellular Ca2+ concentration ([Ca2+]i) in the absence of extracellular Mg2+ and Ca2+."	3.69	Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction. ( Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S, 1994)
" Spectroscopy is a reliable technique for grading of gliomas when N-acetyl-aspartate/choline and choline/creatine ratios and presence of lipids are used in combination."	3.69	Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995)
" The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4."	3.69	Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy. ( Bandou, K; Harada, M; Kannuki, S; Miyoshi, H; Nishitani, H; Tanouchi, M, 1995)
"(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas."	3.69	Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995)
" We used proton nuclear magnetic resonance spectroscopy to detect the presence of simple metabolites (such as lactic acid, creatine/phosphocreatine, N-acetyl aspartate, and the "choline" pool) in extracts of a human glioma grown subcutaneously in athymic ("nu/nu") mice."	3.69	Effects of therapy on the 1H NMR spectrum of a human glioma line. ( Cazzaniga, S; Charles, HC; Schold, SC; Sostman, HD, 1994)
" Oligodendrogliomas had higher choline levels than astrocytomas."	3.68	[1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia]. ( Felber, SR, 1993)
"Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells."	3.68	Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. ( Chuang, DM; Lee, CY; Lin, WW, 1991)
"Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells."	3.67	Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987)
"Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood."	1.62	Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas. ( Abe, M; Hirose, Y; Inamasu, J; Kumon, M; Kuwahara, K; Murayama, K; Nakae, S; Ohba, S; Sasaki, H; Yamada, S, 2021)
"Chordoid gliomas are extremely rare entities, which are generally considered occurring exclusively in the third ventricle."	1.56	Chordoid glioma: an entity occurring not exclusively in the third ventricle. ( Du, J; Fang, J; Li, G; Wang, S; Xu, Y; Yang, B; Yang, C, 2020)
"Glioma is the most common type of the primary CNS tumor."	1.43	Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro. ( Cui, Y; Li, FY; Li, HX; Shi, WQ; Wang, JZ; Xu, YJ; Zeng, QS, 2016)
" This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells."	1.40	Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. ( Davies, MT; Driscoll, HE; Jaworski, DM; Lawler, SE; Long, PM; Penar, PL; Pendlebury, WW; Spees, JL; Teasdale, BA; Tsen, AR; Viapiano, MS, 2014)
"High grade gliomas are known to release excitotoxic concentrations of glutamate, a process thought to contribute to their malignant phenotype through enhanced autocrine stimulation of their proliferation and destruction of the surrounding nervous tissue."	1.35	Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat. ( Abarca-Quinones, J; Gallez, B; Hermans, E; Jordan, BF; Maloteaux, JM; Vanhoutte, N, 2009)
"Using discriminant analysis, this study found that MR spectroscopy in combination with ADC ratio, rather than ADC value, can improve the ability to differentiate recurrent glioma and radiation injury."	1.34	Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. ( Feng, DC; Li, CF; Liu, H; Zeng, QS; Zhen, JH, 2007)
"Ten patients with untreated gliomas were examined on a 1."	1.32	Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas. ( Buslei, R; Fahlbusch, R; Ganslandt, O; Gruber, S; Moser, E; Nimsky, C; Stadlbauer, A, 2004)
"Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells."	1.31	Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000)
"The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods."	1.31	Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001)
"High-grade brain tumors are known to have a high rate of glucose (Glc) consumption."	1.31	High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001)
"First, it allows to distinguish brain tumors from abscesses."	1.31	[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis]. ( Berry, I; Ibarrola, D; Malet-Martino, M; Sabatier, J, 2001)
"Seventeen brain tumors were measured by 1H-CSI (chemical shift imaging) in a 1."	1.30	Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method. ( Furuya, S; Ide, M; Kizu, O; Maeda, T; Morishita, H; Naruse, S; Ueda, S, 1997)
"Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas."	1.29	Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. ( Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL, 1993)
"Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy."	1.29	Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives. ( Calabrese, G; Falini, A; Lipari, S; Losa, M; Origgi, D; Scotti, G; Triulzi, F, 1996)
"Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values."	1.29	Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (3.31)	18.7374
1990's	29 (19.21)	18.2507
2000's	58 (38.41)	29.6817
2010's	51 (33.77)	24.3611
2020's	8 (5.30)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Prospective Study About the Validity of MRS-guided Resection on Prognosis High-grade Gliomas[NCT02795364]		50 participants (Anticipated)	Interventional	2016-06-30	Not yet recruiting
Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206]		12 participants (Anticipated)	Observational	2020-12-31	Not yet recruiting
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2015-12-31	Withdrawn (stopped due to NIH funding resulted in new clinical trial)
Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla[NCT04233788]		55 participants (Anticipated)	Observational	2021-09-01	Recruiting
Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318]		100 participants (Actual)	Interventional	2012-01-31	Completed
Study of Clinical Biomarkers in Human Health and Disease (Healthiomics)[NCT05106725]		3,500 participants (Anticipated)	Observational	2021-10-11	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Unique magnetic resonance spectroscopy profile of intracranial meningiomas compared to gliomas: a systematic review. Acta neurologica Belgica, 2023, Volume: 123, Issue:6 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Spectr	2023
The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade gliomas: A systematic review and meta-analysis. European radiology, 2016, Volume: 26, Issue:8 Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Databases, Factual; Glioma; Hum	2016
Potential of MR spectroscopy for assessment of glioma grading. Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:2 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol	2013
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature. The International journal of neuroscience, 2013, Volume: 123, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ	2013
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism. Seminars in oncology, 2004, Volume: 31, Issue:5 Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans	2004
Brain stem involvement in children with neurofibromatosis type 1: role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma. Neurosurgery, 1997, Volume: 40, Issue:2 Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Choline; Creatine;	1997

Article	Year
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. Journal of neuro-oncology, 2008, Volume: 90, Issue:1 Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis	2008
Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings. Neuroradiology, 2004, Volume: 46, Issue:8 Topics: Adult; Aged; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choli	2004
Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas. Journal of neurosurgery, 2007, Volume: 106, Issue:4 Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Pro	2007
Multivoxel 3D proton MR spectroscopy in the distinction of recurrent glioma from radiation injury. Journal of neuro-oncology, 2007, Volume: 84, Issue:1 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fema	2007

Article	Year
Magnetic resonance spectroscopy - its added value in brain glioma multiparametric assessment. Bratislavske lekarske listy, 2021, Volume: 122, Issue:10 Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectro	2021
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:21 Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson	2022
Chordoid glioma: an entity occurring not exclusively in the third ventricle. Neurosurgical review, 2020, Volume: 43, Issue:5 Topics: Adult; Aged; Aspartic Acid; Cerebellum; Cerebral Ventricle Neoplasms; Choline; Diffusion Magnetic Re	2020
The Association between Whole-Brain MR Spectroscopy and IDH Mutation Status in Gliomas. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020, Volume: 30, Issue:1 Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Isocitrate	2020
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020, Volume: 47, Issue:3 Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err	2020
Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas. Scientific reports, 2021, 04-12, Volume: 11, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytes; Brain Neoplasms; Female; Glioma; Glutamic	2021
Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma. BioMed research international, 2021, Volume: 2021 Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Cognitive Dysfunction; Creatine; Early Diagnosis;	2021
[Magnetic resonance spectroscopy of brain tumors]. Der Radiologe, 2017, Volume: 57, Issue:6 Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging	2017
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas. The British journal of radiology, 2017, Volume: 90, Issue:1075 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res	2017
In vivo characterization of brain metabolism by International journal of cancer, 2018, 07-01, Volume: 143, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Brain; Brain Neoplasms; Cell Line, Tum	2018
Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2. Acta radiologica (Stockholm, Sweden : 1987), 2019, Volume: 60, Issue:1 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Proliferation; Chil	2019
On the relation between MR spectroscopy features and the distance to MRI-visible solid tumor in GBM patients. Magnetic resonance in medicine, 2018, Volume: 80, Issue:6 Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Healthy Volunteers; Hu	2018
Lesion segmentation for MR spectroscopic imaging using the convolution difference method. Magnetic resonance in medicine, 2019, Volume: 81, Issue:3 Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Computer Simulation; Glio	2019
Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma. International journal of cancer, 2019, 05-15, Volume: 144, Issue:10 Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Aspartic Acid; Astrocytes; Benzopyrans; Cell L	2019
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors. NMR in biomedicine, 2013, Volume: 26, Issue:10 Topics: Adult; Aspartic Acid; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Glutamine; Gl	2013
Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions. Vojnosanitetski pregled, 2013, Volume: 70, Issue:7 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diffusion	2013
Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. International journal of cancer, 2014, Mar-15, Volume: 134, Issue:6 Topics: Amidohydrolases; Animals; Antifungal Agents; Aspartic Acid; Astrocytes; Brain; Brain Neoplasms; Cell	2014
Spectroscopy imaging in intraoperative MR suite: tissue characterization and optimization of tumor resection. International journal of computer assisted radiology and surgery, 2014, Volume: 9, Issue:4 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Image	2014
Accuracy of 2-hydroxyglutarate quantification by short-echo proton-MRS at 3 T: a phantom study. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2014, Volume: 30, Issue:6 Topics: Aspartic Acid; Brain; Glioma; Glutamic Acid; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation;	2014
Cellular senescence induced by prolonged subculture adversely affects glutamate uptake in C6 lineage. Neurochemical research, 2014, Volume: 39, Issue:5 Topics: Animals; Aspartic Acid; Cellular Senescence; Glioma; Glutamic Acid; Rats, Wistar; Tritium; Tumor Cel	2014
Delineation of gliomas using radial metabolite indexing. NMR in biomedicine, 2014, Volume: 27, Issue:9 Topics: Algorithms; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Diagnosis, Computer-Assisted	2014
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo. Magnetic resonance in medicine, 2015, Volume: 73, Issue:6 Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female;	2015
Multivoxel proton magnetic resonance spectroscopy of inflammatory and neoplastic lesions of the canine brain at 3.0 T. American journal of veterinary research, 2014, Volume: 75, Issue:11 Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis,	2014
Influence of echo time in quantitative proton MR spectroscopy using LCModel. Magnetic resonance imaging, 2015, Volume: 33, Issue:5 Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer	2015
Machine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy. The neuroradiology journal, 2015, Volume: 28, Issue:2 Topics: Algorithms; Artificial Intelligence; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Cre	2015
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra. Magnetic resonance in chemistry : MRC, 2016, Volume: 54, Issue:2 Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra	2016
Dynamic 1H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma. Oncotarget, 2015, Oct-13, Volume: 6, Issue:31 Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Choline; Diagnosis, Differe	2015
Comparison between magnetic resonance spectroscopy and diffusion weighted imaging in the evaluation of gliomas response after treatment. European journal of radiology, 2015, Volume: 84, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Diffusion Magnetic Resonanc	2015
Metabolic approach for tumor delineation in glioma surgery: 3D MR spectroscopy image-guided resection. Journal of neurosurgery, 2016, Volume: 124, Issue:6 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diffusion Tensor Imaging; Feasibility S	2016
Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS. Proceedings of the National Academy of Sciences of the United States of America, 2016, Feb-09, Volume: 113, Issue:6 Topics: Aspartic Acid; Brain; Brain Neoplasms; Cell Differentiation; Glioma; Gray Matter; Humans; Lipid Meta	2016
Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla. American journal of veterinary research, 2016, Volume: 77, Issue:5 Topics: Animals; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Creatine; Dog Diseases; Dogs; Female;	2016
Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer letters, 2016, 08-01, Volume: 378, Issue:1 Topics: Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Antineoplastic Agents; Apoptosis; Aspartic Aci	2016
Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro. Magnetic resonance imaging, 2016, Volume: 34, Issue:8 Topics: Aspartic Acid; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Choline; C	2016
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas. The British journal of radiology, 2016, Volume: 89, Issue:1067 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre	2016
Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T. Journal of magnetic resonance imaging : JMRI, 2008, Volume: 28, Issue:2 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Gliom	2008
Bilateral thalamic glioma. Archives of neurology, 2008, Volume: 65, Issue:12 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imagin	2008
Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx. Biochimica et biophysica acta, 2009, Volume: 1788, Issue:2 Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Cell Line, Tumor; Excitatory Amino Acid Trans	2009
Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat. Experimental neurology, 2009, Volume: 218, Issue:1 Topics: Animals; Aspartic Acid; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Disease Progressi	2009
MR spectroscopic evaluation of brain tissue damage after treatment for pediatric brain tumors. Acta neurochirurgica. Supplement, 2010, Volume: 106 Topics: Adolescent; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Ependymoma; Female; Gli	2010
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging. Neuroradiology, 2010, Volume: 52, Issue:4 Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr	2010
MR spectroscopy for differentiation of recurrent glioma from radiation-induced changes. AJR. American journal of roentgenology, 2009, Volume: 193, Issue:6 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast	2009
The metabolic epicenter of supratentorial gliomas: a 1H-MRSI study. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2009, Volume: 36, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Chi-Square Distribution; Cholin	2009
Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors. Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media;	2010
Response to article "Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors". Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3 Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc	2010
Response to a letter by Paul E. Sijens. Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3 Topics: Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Creatinine; Edema; Glioma; Humans; Image Enhanc	2010
Magnetic resonance spectroscopic imaging for visualization of the infiltration zone of glioma. Central European neurosurgery, 2011, Volume: 72, Issue:2 Topics: Adult; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Choline; Data Interpretation, Statistica	2011
Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas. European journal of radiology, 2011, Volume: 80, Issue:2 Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Im	2011
N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas. Magnetic resonance imaging, 2010, Volume: 28, Issue:9 Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Diagn	2010
Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. Journal of neurology, 2011, Volume: 258, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain Neoplasms; Cerebrovas	2011
Biopsy targeting gliomas: do functional imaging techniques identify similar target areas? Investigative radiology, 2010, Volume: 45, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Contras	2010
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy. Magnetic resonance imaging, 2011, Volume: 29, Issue:1 Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Creatine; Female; Glioma; H	2011
Value of 1H-magnetic resonance spectroscopy chemical shift imaging for detection of anaplastic foci in diffusely infiltrating gliomas with non-significant contrast-enhancement. Journal of neurology, neurosurgery, and psychiatry, 2011, Volume: 82, Issue:5 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; H	2011
Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. British journal of cancer, 2011, Jun-07, Volume: 104, Issue:12 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Brain Neoplasms; Choline; Creatine; D	2011
Glioma residual or recurrence versus radiation necrosis: accuracy of pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT compared to proton magnetic resonance spectroscopy (1H-MRS): initial results. Journal of neuro-oncology, 2012, Volume: 106, Issue:3 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Follow-Up Studie	2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nature medicine, 2012, Jan-26, Volume: 18, Issue:4 Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;	2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nature medicine, 2012, Jan-26, Volume: 18, Issue:4 Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;	2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nature medicine, 2012, Jan-26, Volume: 18, Issue:4 Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;	2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nature medicine, 2012, Jan-26, Volume: 18, Issue:4 Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma;	2012
Subependymal seeding of low-grade oligodendroglial neoplasms: a case series. Journal of neuro-oncology, 2012, Volume: 108, Issue:1 Topics: Adult; Aspartic Acid; Creatine; Disease Progression; Ependyma; Fourth Ventricle; Glioma; Humans; Iso	2012
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma. International journal of radiation oncology, biology, physics, 2012, Nov-01, Volume: 84, Issue:3 Topics: Adolescent; Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Feasibi	2012
Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:8 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Fluorodeoxy	2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas. Acta neurochirurgica, 2012, Volume: 154, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu	2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas. Acta neurochirurgica, 2012, Volume: 154, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu	2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas. Acta neurochirurgica, 2012, Volume: 154, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu	2012
The relationship between Cho/NAA and glioma metabolism: implementation for margin delineation of cerebral gliomas. Acta neurochirurgica, 2012, Volume: 154, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Choline; Female; Glioma; Hu	2012
Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas. Turkish neurosurgery, 2012, Volume: 22, Issue:5 Topics: Adolescent; Adult; Aged; Anisotropy; Aspartic Acid; Brain Neoplasms; Cerebral Cortex; Child; Choline	2012
Conservative management of presumed low-grade gliomas in the asymptomatic pediatric population. World neurosurgery, 2014, Volume: 81, Issue:2 Topics: Adolescent; Aspartic Acid; Astrocytoma; Asymptomatic Diseases; Brain Neoplasms; Child; Child, Presch	2014
Proton MR spectroscopy of tumefactive demyelinating lesions. AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:8 Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Demyelinating Diseases; Diagnosis, Different	2002
Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. Journal of neurosurgery, 2002, Volume: 97, Issue:4 Topics: Aspartic Acid; Biopsy; Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Spectroscopy; Pr	2002
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2 Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat	2003
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. Annales de medecine interne, 2002, Volume: 153, Issue:8 Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia	2002
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy. Analytical chemistry, 2003, Oct-15, Volume: 75, Issue:20 Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc	2003
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyu	2004
1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification. Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:4 Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Dose-Response Relationshi	2004
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. Magnetic resonance imaging, 2004, Volume: 22, Issue:5 Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; C	2004
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. Magnetic resonance imaging, 2004, Volume: 22, Issue:7 Topics: Adult; Aged; Aspartic Acid; Body Water; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr	2004
Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas. NeuroImage, 2004, Volume: 23, Issue:2 Topics: Adult; Algorithms; Aspartic Acid; Astrocytoma; Automation; Biopsy; Brain Chemistry; Brain Mapping; B	2004
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology. Academic radiology, 2005, Volume: 12, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin	2005
Clinicopathological examination of glioma by proton magnetic resonance spectroscopy background. Brain tumor pathology, 2004, Volume: 21, Issue:1 Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioma; Humans; Lactic Acid; Magnetic Resona	2004
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. Journal of neurosurgery, 2005, Volume: 102, Issue:2 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Child; Child, Preschool; Cho	2005
Spectroscopy and navigation. Journal of neurosurgery, 2005, Volume: 102, Issue:2 Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Glioma; Humans; Image Processing, Comput	2005
Proton magnetic resonance spectroscopic imaging integrated into image-guided surgery: correlation to standard magnetic resonance imaging and tumor cell density. Neurosurgery, 2005, Volume: 56, Issue:2 Suppl Topics: Algorithms; Aspartic Acid; Biopsy; Brain Neoplasms; Cell Count; Choline; Feasibility Studies; Glioma	2005
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. International journal of radiation oncology, biology, physics, 2005, May-01, Volume: 62, Issue:1 Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression	2005
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study. Chinese medical journal, 2005, Aug-05, Volume: 118, Issue:15 Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic	2005
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy. Journal of neuro-oncology, 2006, Volume: 76, Issue:2 Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv	2006
Assessing global invasion of newly diagnosed glial tumors with whole-brain proton MR spectroscopy. AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:9 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Female; Glioma; Humans; Magnetic Resonance Spect	2005
Independent component analysis to proton spectroscopic imaging data of human brain tumours. European journal of radiology, 2005, Volume: 56, Issue:2 Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio	2005
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. General physiology and biophysics, 2005, Volume: 24, Issue:3 Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla	2005
Preoperative grading of gliomas by using metabolite quantification with high-spatial-resolution proton MR spectroscopic imaging. Radiology, 2006, Volume: 238, Issue:3 Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Female;	2006
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy. Neuroradiology, 2006, Volume: 48, Issue:9 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio	2006
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences. AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7 Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma;	2006
Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7 Topics: Adult; Aged; Anisotropy; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Size; Choline; Cre	2006
Long-term normal-appearing brain tissue monitoring after irradiation using proton magnetic resonance spectroscopy in vivo: statistical analysis of a large group of patients. International journal of radiation oncology, biology, physics, 2006, Nov-01, Volume: 66, Issue:3 Topics: Adult; Aged; Aspartic Acid; Blood-Brain Barrier; Brain; Brain Neoplasms; Choline; Creatine; Female;	2006
Comments and controversies: magnetic resonance spectroscopy and gliomas. Cancer imaging : the official publication of the International Cancer Imaging Society, 2006, Sep-07, Volume: 6 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy;	2006
Proton magnetic resonance spectroscopy in childhood brainstem lesions. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007, Volume: 23, Issue:3 Topics: Adolescent; Amino Acids; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neop	2007
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. International journal of radiation oncology, biology, physics, 2007, May-01, Volume: 68, Issue:1 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Diffusion Magn	2007
Proton magnetic resonance spectroscopic imaging in the border zone of gliomas: correlation of metabolic and histological changes at low tumor infiltration--initial results. Investigative radiology, 2007, Volume: 42, Issue:4 Topics: Aspartic Acid; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; Neoplasm Invasive	2007
Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging. Neuroradiology, 2007, Volume: 49, Issue:10 Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Blood Flow Velocity; Brain; Brain Neoplasms; Choline	2007
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas. European neurology, 2007, Volume: 58, Issue:4 Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma;	2007
C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1). Neuroscience, 2008, Feb-19, Volume: 151, Issue:4 Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Differentiation; Cell Line, Tumor; Dose-Response	2008
Low-grade glioma: correlation of short echo time 1H-MR spectroscopy with 23Na MR imaging. AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:3 Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Magnetic Resonance Imaging; Ma	2008
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification. Magnetic resonance in medicine, 1995, Volume: 34, Issue:2 Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan	1995
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:8 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea	1995
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction. Journal of neurochemistry, 1994, Volume: 63, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine M	1994
Spectral editing with adiabatic pulses. Journal of magnetic resonance. Series B, 1995, Volume: 109, Issue:2 Topics: Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Choline; Creatine; Feasibility Studies; Gl	1995
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography. Neuroradiology, 1995, Volume: 37, Issue:3 Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl	1995
Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy. Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:3 Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Ependymoma; Glioma; Humans; Magnetic	1995
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:1 Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di	1995
Metabolic flux determination in C6 glioma cells using carbon-13 distribution upon [1-13C]glucose incubation. European journal of biochemistry, 1993, Oct-01, Volume: 217, Issue:1 Topics: Alanine; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glioma; Gluconeogenesis; Glucose; Glutam	1993
Attenuation by chlormethiazole of oedema following focal ischaemia in the cerebral cortex of the rat. Neuroscience letters, 1994, May-23, Volume: 173, Issue:1-2 Topics: Animals; Aspartic Acid; Body Water; Brain Edema; Cerebral Cortex; Cerebral Infarction; Cerebrovascul	1994
Effects of therapy on the 1H NMR spectrum of a human glioma line. Magnetic resonance imaging, 1994, Volume: 12, Issue:6 Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Lactates; Magnetic Resonance Spe	1994
Proton MR spectroscopy of experimental brain tumors in vivo. Acta neurochirurgica. Supplementum, 1994, Volume: 60 Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho	1994
Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. Journal of neuro-oncology, 1993, Volume: 17, Issue:1 Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance I	1993
Quantitative proton spectroscopy and histology of a canine brain tumor model. Magnetic resonance in medicine, 1993, Volume: 30, Issue:4 Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag	1993
[1H magnetic resonance spectroscopy in intracranial tumors and cerebral ischemia]. Der Radiologe, 1993, Volume: 33, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Child; Child, Preschool;	1993
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. AJNR. American journal of neuroradiology, 1996, Volume: 17, Issue:4 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal	1996
Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester. Journal of neurochemistry, 1996, Volume: 67, Issue:2 Topics: Adenylyl Cyclases; Amiloride; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding	1996
Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives. Journal of neurology, 1996, Volume: 243, Issue:10 Topics: Adenoma; Aspartic Acid; Brain Neoplasms; Choline; Craniopharyngioma; Creatinine; Glioma; Humans; Lym	1996
Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method. NMR in biomedicine, 1997, Volume: 10, Issue:1 Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Evaluation Studies as Topic; Glioma; Humans; Imag	1997
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. Journal of neurosurgery, 1997, Volume: 87, Issue:4 Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas	1997
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions. Acta radiologica (Stockholm, Sweden : 1987), 1997, Volume: 38, Issue:6 Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo	1997
Impairment of excitatory amino acid transport in astroglial cells infected with the human immunodeficiency virus type 1. AIDS research and human retroviruses, 1998, Oct-10, Volume: 14, Issue:15 Topics: Aspartic Acid; Astrocytes; Biological Transport; Gene Products, nef; Glioma; Glutamic Acid; HIV Enve	1998
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat. Journal of neurochemistry, 1999, Volume: 72, Issue:6 Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla	1999
Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas. AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2 Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Fema	2000
Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation. Cancer research, 2000, Mar-15, Volume: 60, Issue:6 Topics: Animals; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Caspase Inhibitors; Caspases; Cell Cycle;	2000
Quantitative proton magnetic resonance spectroscopy of focal brain lesions. Pediatric neurology, 2000, Volume: 23, Issue:1 Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms;	2000
An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. Journal of magnetic resonance imaging : JMRI, 2001, Volume: 13, Issue:2 Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Female; Glioma; Humans; Imaging, Three-Dimens	2001
Altered expression of glutamate transporters under hypoxic conditions in vitro. Journal of neuroscience research, 2001, Apr-15, Volume: 64, Issue:2 Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Cell Death; Cell Hypoxia	2001
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:4 Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies;	2001
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy. Acta neurochirurgica, 2001, Volume: 143, Issue:1 Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene	2001
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. Cancer research, 2001, Jul-15, Volume: 61, Issue:14 Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma;	2001
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites. Cancer research, 2001, Sep-01, Volume: 61, Issue:17 Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S	2001
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma. Neurosurgery, 2001, Volume: 49, Issue:4 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr	2001
[Brain tumors: interest of magnetic resonance spectroscopy for the diagnosis and the prognosis]. Revue neurologique, 2001, Volume: 157, Issue:8-9 Pt 1 Topics: Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Energy Metabolism;	2001
High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology, 2002, Volume: 222, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Bra	2002
Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology, 2002, Volume: 44, Issue:5 Topics: Aspartic Acid; Brain Abscess; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Diagnosis, Di	2002
Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase. Cancer research, 1978, Volume: 38, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Cells, Cult	1978
Effect of inhibitors of N-linked oligosaccharide processing on the high-affinity transport of D-aspartate by C6 glioma cells. Brain research, 1992, Mar-20, Volume: 575, Issue:2 Topics: 1-Deoxynojirimycin; Aspartic Acid; Biological Transport; Glioma; Glucosamine; Glucosidases; Glycosyl	1992
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Annals of neurology, 1992, Volume: 31, Issue:3 Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De	1992
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 7 Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Endothelins; Glioma; Inositol; Neurons	1991
Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma. Magnetic resonance in medicine, 1992, Volume: 23, Issue:1 Topics: Animals; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Female; Glioma; Hydrogen; Lactates; Lactic	1992
Inhibition by trypsin of the high-affinity acidic amino acid transport system in C6 glioma cells. Brain research, 1990, Jun-25, Volume: 521, Issue:1-2 Topics: Animals; Aspartic Acid; Energy Metabolism; Glioma; Rats; Trypsin; Tumor Cells, Cultured	1990
Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1H NMR spectroscopic imaging. Magnetic resonance in medicine, 1990, Volume: 13, Issue:1 Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Creatine; Glioma; Humans; Magnetic Resona	1990
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors. Radiology, 1989, Volume: 172, Issue:2 Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts;	1989
Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells. Brain research, 1986, Volume: 387, Issue:1 Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Aspartic Acid; Brain; Catalysis; Cell Line; Glioma;	1986
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. Acta physiologica Scandinavica, 1987, Volume: 131, Issue:4 Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblast	1987
N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues. Journal of neurochemistry, 1972, Volume: 19, Issue:2 Topics: Animals; Aspartic Acid; Brain Neoplasms; Cattle; Cerebral Cortex; Craniopharyngioma; Glioblastoma; G	1972

aspartic acid and Glioma

Research Excerpts

Research

Studies (151)

Authors

Clinical Trials (6)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Rudnay, M	1
Waczulikova, I	1
Bullova, A	1
Rjaskova, G	1
Chorvath, M	1
Jezberova, M	1
Lehotska, V	1
Tran, D	3
Nguyen, DH	3
Nguyen, HK	3
Nguyen-Thanh, VA	3
Dong-Van, H	3
Nguyen, MD	3
De Stefano, FA	1
Morell, AA	1
Smith, G	1
Warner, T	1
Soldozy, S	1
Elarjani, T	1
Eichberg, DG	1
Luther, E	1
Komotar, RJ	1
Yang, B	1
Yang, C	1
Du, J	1
Fang, J	1
Li, G	1
Wang, S	1
Xu, Y	1
Goryawala, M	1
Saraf-Lavi, E	1
Nagornaya, N	1
Heros, D	1
Komotar, R	1
Maudsley, AA	2
Wang, AP	1
Suryavanshi, T	1
Marcucci, M	1
Fong, C	1
Whitton, AC	1
Reddy, KKV	1
Nakae, S	1
Kumon, M	1
Murayama, K	1
Ohba, S	1
Sasaki, H	1
Inamasu, J	1
Kuwahara, K	1
Yamada, S	1
Abe, M	1
Hirose, Y	1
Alirezaei, Z	1
Amouheidari, A	1
Hassanpour, M	1
Davanian, F	1
Iraji, S	1
Shokrani, P	1
Nazem-Zadeh, MR	1
Ditter, P	1
Hattingen, E	3
Liu, Z	1
Zhang, J	4
Lai, M	1
Vassallo, I	1
Lanz, B	1
Poitry-Yamate, C	1
Hamou, MF	1
Cudalbu, C	1
Gruetter, R	1
Hegi, ME	1
Gao, W	1
Wang, X	1
Li, F	2
Shi, W	1
Li, H	1
Zeng, Q	2
Pedrosa de Barros, N	1
Meier, R	1
Pletscher, M	1
Stettler, S	1
Knecht, U	1
Herrmann, E	1
Schucht, P	1
Reyes, M	1
Gralla, J	1
Wiest, R	1
Slotboom, J	1
Corbetta, C	1
Di Ianni, N	1
Bruzzone, MG	2
Patanè, M	1
Pollo, B	1
Cantini, G	1
Cominelli, M	1
Zucca, I	1
Pisati, F	1
Poliani, PL	1
Finocchiaro, G	2
Pellegatta, S	1
Choi, C	3
Ganji, S	1
Hulsey, K	1
Madan, A	2
Kovacs, Z	2
Dimitrov, I	1
Zhang, S	1
Pichumani, K	1
Mendelsohn, D	1
Mickey, B	1
Malloy, C	1
Bachoo, R	1
Deberardinis, R	1
Maher, E	1
Balos, DR	1
Gavrilović, S	1
Lavrnić, S	1
Vasić, B	1
Macvanski, M	1
Damjanović, D	1
Opinćal, TS	1
Tsen, AR	1
Long, PM	1
Driscoll, HE	1
Davies, MT	1
Teasdale, BA	1
Penar, PL	1
Pendlebury, WW	1
Spees, JL	1
Lawler, SE	1
Viapiano, MS	1
Jaworski, DM	1
Roder, C	1
Skardelly, M	1
Ramina, KF	1
Beschorner, R	1
Honneger, J	1
Nägele, T	1
Tatagiba, MS	1
Ernemann, U	1
Bisdas, S	1
Bertolino, N	1
Marchionni, C	1
Ghielmetti, F	1
Burns, B	1
Anghileri, E	1
Minati, L	1
Pereira, MS	1
Zenki, K	1
Cavalheiro, MM	1
Thomé, CC	1
Filippi-Chiela, EC	1
Lenz, G	1
de Souza, DO	1
de Oliveira, DL	1
Raschke, F	1
Jones, TL	1
Barrick, TR	1
Howe, FA	1
Ganji, SK	2
An, Z	1
Choe, KS	1
Pinho, MC	1
Bachoo, RM	2
Maher, EM	1
Stadler, KL	1
Ober, CP	1
Feeney, DA	1
Jessen, CR	1
Yamamoto, T	1
Isobe, T	1
Akutsu, H	1
Masumoto, T	1
Ando, H	1
Sato, E	1
Takada, K	1
Anno, I	1
Matsumura, A	1
Ranjith, G	1
Parvathy, R	1
Vikas, V	1
Chandrasekharan, K	1
Nair, S	1
Ghasemi, K	1
Khanmohammadi, M	1
Saligheh Rad, H	1
Tong, T	1
Yang, Z	1
Chen, JW	1
Zhu, J	1
Yao, Z	1
Lotumolo, A	2
Caivano, R	2
Rabasco, P	2
Iannelli, G	1
Villonio, A	2
D' Antuono, F	1
Gioioso, M	1
Zandolino, A	2
Macarini, L	2
Guglielmi, G	1
Cammarota, A	2
Wang, Q	1
Zhang, H	1
Wu, C	1
Zhu, W	1
Chen, X	1
Xu, B	1
Zhuang, DX	1
Yao, CJ	1
Lin, CP	1
Wang, TL	1
Qin, ZY	1
Wu, JS	1
Jarmusch, AK	1
Pirro, V	1
Baird, Z	1
Hattab, EM	1
Cohen-Gadol, AA	1
Cooks, RG	1
Carrera, I	1
Richter, H	1
Beckmann, K	1
Meier, D	1
Dennler, M	1
Kircher, PR	1
Wang, C	1
Chen, H	2
Zhang, M	1
Wei, X	1
Ying, W	1
Xu, YJ	1
Cui, Y	1
Li, HX	1
Shi, WQ	1
Li, FY	1
Wang, JZ	1
Zeng, QS	3
Roldan-Valadez, E	1
Rios, C	1
Motola-Kuba, D	1
Matus-Santos, J	1
Villa, AR	1
Moreno-Jimenez, S	1
Sankar, T	2
Caramanos, Z	2
Assina, R	1
Villemure, JG	1
Leblanc, R	1
Langleben, A	1
Arnold, DL	3
Preul, MC	2
Li, Y	2
Srinivasan, R	1
Ratiney, H	1
Lu, Y	3
Chang, SM	2
Nelson, SJ	6
Douis, H	1
Jafri, M	1
Sherlala, K	1
Murphy, A	1
Vines, A	1
McBean, GJ	1
Vanhoutte, N	1
Abarca-Quinones, J	1
Jordan, BF	1
Gallez, B	1
Maloteaux, JM	1
Hermans, E	1
Blamek, S	1
Larysz, D	1
Ficek, K	1
Sokół, M	2
Miszczyk, L	1
Tarnawski, R	1
Matsusue, E	1
Fink, JR	1
Rockhill, JK	1
Ogawa, T	1
Maravilla, KR	1
Goenka, AH	1
Kumar, A	1
Sharma, R	1
Kuznetsov, YE	1
Ryan, RW	1
Antel, SB	1
Server, A	3
Josefsen, R	2
Kulle, B	2
Maehlen, J	1
Schellhorn, T	1
Gadmar, Ø	1
Kumar, T	2
Haakonsen, M	1
Langberg, CW	1
Nakstad, PH	2
Sijens, PE	1
Stadlbauer, A	5
Buchfelder, M	2
Doelken, MT	1
Hammen, T	3
Ganslandt, O	5
Gadmar, ØB	1
Liu, X	1
Germin, BI	1
Zhong, J	1
Ekholm, S	1
Blasel, S	1
Pfeilschifter, W	1
Jansen, V	1
Mueller, K	1
Zanella, F	1
Weber, MA	1
Henze, M	1
Tüttenberg, J	1
Stieltjes, B	1
Meissner, M	1
Zimmer, F	1
Burkholder, I	1
Kroll, A	1
Combs, SE	1
Vogt-Schaden, M	1
Giesel, FL	1
Zoubaa, S	1
Haberkorn, U	1
Kauczor, HU	1
Essig, M	1
Liu, H	3
Zhang, K	2
Li, C	1
Zhou, G	1
Widhalm, G	1
Krssak, M	1
Minchev, G	1
Wöhrer, A	1
Traub-Weidinger, T	1
Czech, T	1
Asenbaum, S	1
Marosi, C	1
Knosp, E	1
Hainfellner, JA	1
Prayer, D	1
Wolfsberger, S	1
Guillevin, R	1
Menuel, C	1
Taillibert, S	1
Capelle, L	1
Costalat, R	1
Abud, L	1
Habas, C	1
De Marco, G	1
Hoang-Xuan, K	1
Chiras, J	1
Vallée, JN	1
Amin, A	1
Moustafa, H	1
Ahmed, E	1
El-Toukhy, M	1
DeBerardinis, RJ	1
Hatanpaa, KJ	1
Rakheja, D	1
Yang, XL	1
Mashimo, T	1
Raisanen, JM	1
Marin-Valencia, I	1
Pascual, JM	1
Madden, CJ	1
Mickey, BE	1
Malloy, CR	1
Maher, EA	1
Nicolasjilwan, M	1
Lopes, MB	1
Larner, J	1
Wintermark, M	1
Schiff, D	1
Steffen-Smith, EA	1
Venzon, DJ	1
Bent, RS	1
Hipp, SJ	1
Warren, KE	1
Mertens, K	1
Acou, M	1
Van den Broecke, C	1
Nuyts, R	1
Van Roost, D	1
Achten, E	1
Goethals, I	1
Guo, J	1
Yao, C	1
Zhuang, D	1
Tang, W	1
Ren, G	1
Wang, Y	1
Wu, J	1
Huang, F	1
Zhou, L	1
Shang, HB	1
Zhao, WG	1
Zhang, WF	1
Bulik, M	1
Jancalek, R	1
Vanicek, J	1
Skoch, A	1
Mechl, M	1
Ali, ZS	1
Lang, SS	1
Sutton, LN	1
D'Antuono, F	1
Lancellotti, MI	1
Saindane, AM	1
Cha, S	3
Law, M	2
Xue, X	1
Knopp, EA	3
Zagzag, D	2
McKnight, TR	6
von dem Bussche, MH	1
Vigneron, DB	4
Berger, MS	2
McDermott, MW	1
Dillon, WP	4
Graves, EE	2
Pirzkall, A	3
Bulakbasi, N	1
Kocaoglu, M	1
Ors, F	1
Tayfun, C	1
Uçöz, T	1
Galanaud, D	1
Nicoli, F	1
Le Fur, Y	1
Roche, P	1
Confort-Gouny, S	1
Dufour, H	1
Ranjeva, JP	1
Peragut, JC	1
Viout, P	1
Cozzone, PJ	1
Simonetti, AW	1
Melssen, WJ	1
van der Graaf, M	1
Postma, GJ	1
Heerschap, A	1
Buydens, LM	1
Owusu, A	1
Lehnert, S	1
Lee, MC	1
Tong, Z	2
Yamaki, T	2
Harada, K	2
Houkin, K	2
Chiang, IC	1
Kuo, YT	1
Lu, CY	1
Yeung, KW	1
Lin, WC	1
Sheu, FO	1
Liu, GC	1
Moser, E	3
Gruber, S	3
Buslei, R	4
Nimsky, C	4
Fahlbusch, R	3
Magalhaes, A	1
Godfrey, W	1
Shen, Y	1
Hu, J	1
Smith, W	1
Izumiyama, H	1
Abe, T	1
Tanioka, D	1
Fukuda, A	1
Kunii, N	1
Floeth, FW	1
Pauleit, D	1
Wittsack, HJ	1
Langen, KJ	1
Reifenberger, G	1
Hamacher, K	1
Messing-Jünger, M	1
Zilles, K	1
Weber, F	1
Stummer, W	1
Steiger, HJ	1
Woebker, G	1
Müller, HW	1
Coenen, H	1
Sabel, M	1
Chernov, MF	1
Muragaki, Y	1
Ochiai, T	1
Maruyama, T	1
Izawa, M	1
Hayashi, M	1
Ono, Y	2
Kubo, O	1
Hori, T	1
Kamada, K	1
Blumcke, I	1
Laprie, A	1
Haas-Kogan, DA	1
Banerjee, A	1
Le, TP	1
Nelson, S	1
Tong, ZY	1
Toshiaki, Y	1
Wang, YJ	1
Balmaceda, C	1
Critchell, D	1
Mao, X	1
Cheung, K	1
Pannullo, S	1
DeLaPaz, RL	1
Shungu, DC	1
Cohen, BA	1
Rusinek, H	1
Babb, JS	1
Gonen, O	1
Pulkkinen, J	1
Häkkinen, AM	1
Lundbom, N	2
Paetau, A	1
Kauppinen, RA	1
Hiltunen, Y	1
Likavcanová, K	1
Dobrota, D	1
Liptaj, T	1
Prónayová, N	1
Mlynárik, V	1
Belan, V	1
Galanda, M	1
Béres, A	1
De Riggo, J	1
Tomandl, B	1
Di Costanzo, A	1
Scarabino, T	1
Trojsi, F	1
Giannatempo, GM	1
Popolizio, T	1
Catapano, D	1
Bonavita, S	2
Maggialetti, N	1
Tosetti, M	1
Salvolini, U	1
d'Angelo, VA	1
Tedeschi, G	2
Kim, JH	1
Chang, KH	1
Na, DG	1
Song, IC	1
Kwon, BJ	1
Han, MH	1
Kim, K	1
Goebell, E	1
Fiehler, J	1
Ding, XQ	1
Paustenbach, S	1
Nietz, S	1
Heese, O	1
Kucinski, T	1
Hagel, C	1
Westphal, M	1
Zeumer, H	1
Matulewicz, Ł	1
Michnik, A	1
Wydmański, J	1
Fan, G	1
Porto, L	1
Pilatus, U	2
Kieslich, M	1
Yan, B	1
Schwabe, D	1
Zanella, FE	2
Lanfermann, H	2
Li, CF	2
Zhen, JH	2
Feng, DC	1
Pinker, K	1
Lamborn, KR	1
Love, TD	1
Chang, S	2
Bollen, A	1
Kang, XS	1
Zonari, P	1
Baraldi, P	1
Crisi, G	1
Alimenti, A	1
Delavelle, J	1
Lazeyras, F	1
Yilmaz, H	1
Dietrich, PY	1
de Tribolet, N	1
Lövblad, KO	1
Bianchi, MG	1
Gazzola, GC	1
Tognazzi, L	1
Bussolati, O	1
Bartha, R	1
Megyesi, JF	1
Watling, CJ	1
Hagberg, G	1
Burlina, AP	1
Mader, I	1
Roser, W	1
Radue, EW	1
Seelig, J	1
Poptani, H	1
Gupta, RK	1
Roy, R	1
Pandey, R	1
Jain, VK	1
Chhabra, DK	1
Shinno, H	1
Mikuni, M	1
Saitoh, K	1
Tomita, U	1
Yamawaki, S	1
Takahashi, K	1
de Graaf, RA	1
Luo, Y	1
Terpstra, M	1
Garwood, M	2
Go, KG	2
Kamman, RL	2
Mooyaart, EL	2
Heesters, MA	2
Pruim, J	1
Vaalburg, W	1
Paans, AM	1
Harada, M	1
Tanouchi, M	1
Nishitani, H	1
Miyoshi, H	1
Bandou, K	1
Kannuki, S	1
Castillo, M	1
Green, C	1
Kwock, L	1
Smith, K	1
Wilson, D	1
Schiro, S	1
Greenwood, R	1
Portais, JC	1
Schuster, R	1
Merle, M	2
Canioni, P	2
Green, AR	1
Cross, AJ	1
Cazzaniga, S	1
Schold, SC	1
Sostman, HD	1
Charles, HC	1
Gyngell, ML	2
Els, T	1
Hoehn-Berlage, M	1
Hossmann, KA	1
Barker, PB	1
Blackband, SJ	1
Chatham, JC	1
Soher, BJ	1
Samphilipo, MA	1
Magee, CA	1
Hilton, JD	1
Strandberg, JD	1
Anderson, JH	1
Felber, SR	1
Shimizu, H	1
Kumabe, T	1
Tominaga, T	1
Kayama, T	1
Hara, K	1
Sato, K	1
Arai, N	1
Fujiwara, S	1
Yoshimoto, T	1
Dowd, LA	1
Robinson, MB	1
Falini, A	1
Calabrese, G	1
Origgi, D	1
Lipari, S	1
Triulzi, F	1
Losa, M	1
Scotti, G	1
Broniscer, A	1
Gajjar, A	1
Bhargava, R	1
Langston, JW	1
Heideman, R	1
Jones, D	1
Kun, LE	1
Taylor, J	1
Furuya, S	1
Naruse, S	2
Ide, M	1
Morishita, H	1
Kizu, O	1
Ueda, S	1
Maeda, T	1
Raman, R	1
Duyn, JH	1
Alger, JR	1
Di Chiro, G	1
Burtscher, IM	1
Ståhlberg, F	1
Holtås, S	1
Kort, JJ	1
Bouzier, AK	1
Quesson, B	1
Valeins, H	1
Henry, RG	1
Fischbein, NJ	1
Grant, PE	1
Day, MR	1
Noworolski, SM	2
Star-Lack, JM	1
Wald, LL	1
Shinohara, H	1
Yagita, H	1
Ikawa, Y	1
Oyaizu, N	1
Wilken, B	1
Dechent, P	1
Herms, J	1
Maxton, C	1
Markakis, E	1
Hanefeld, F	1
Frahm, J	2
Nelson , SJ	1
Hsu, L	1
Rockenstein, E	1
Mallory, M	1
Hashimoto, M	1
Masliah, E	1
Verhey, L	1
McDermott, M	1
Larson, D	1
Prados, MD	1
Son, BC	1
Kim, MC	1
Choi, BG	1
Kim, EN	1
Baik, HM	1
Choe, BY	1
Kang, JK	1
Ziegler, A	2
von Kienlin , M	1
Décorps, M	1
Rémy, C	2
García-Martín, ML	1
Hérigault, G	1
Farion, R	1
Ballesteros, P	1
Coles, JA	1
Cerdán, S	1
Croteau, D	1
Scarpace, L	1
Hearshen, D	1
Gutierrez, J	1
Fisher, JL	1
Rock, JP	1
Mikkelsen, T	1
Sabatier, J	1
Ibarrola, D	1
Malet-Martino, M	1
Berry, I	1
Johnson, G	1
Arnett, J	1
Litt, AW	1
Möller-Hartmann, W	1
Herminghaus, S	1
Krings, T	1
Marquardt, G	1
Johnson, RK	1
Swyryd, EA	1
Stark, GR	1
Deas, J	2
Silver, IA	2
Erecińska, M	2
Matthews, PM	1
Francis, GS	1
O'Connor, J	1
Antel, JP	1
Chuang, DM	1
Lin, WW	1
Lee, CY	1
Ross, BD	1
Merkle, H	1
Hendrich, K	1
Staewen, RS	1
Segebarth, CM	1
Balériaux, DF	1
Luyten, PR	1
den Hollander, JA	1
Bruhn, H	1
Merboldt, KD	1
Hänicke, W	1
Sauter, R	1
Hamburger, C	1
Lacoste, L	1
Hertz, L	1
Lapointe, J	1
Hannuniemi, R	1
Pajari-Backas, M	1
Oja, OS	1
Oja, SS	1
Nadler, JV	1
Cooper, JR	1