aspartic acid has been researched along with Glioblastoma in 60 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma." | 9.12 | [Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007) |
| "To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)." | 7.72 | Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004) |
| "Thirteen patients with recurrent glioblastoma were enrolled in RTOG 0625/ACRIN 6677, a prospective multicenter trial in which bevacizumab was used in combination with either temozolomide or irinotecan." | 5.17 | Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. ( Barboriak, DP; Bokstein, F; Boxerman, JL; Gilbert, MR; McKinstry, RC; Ratai, EM; Safriel, Y; Snyder, BS; Sorensen, AG; Zhang, Z, 2013) |
| "The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma." | 5.12 | [Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| "Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volumes correlated with progression-free survival (PFS) and overall survival (OS) in patients with glioblastoma (GBM)." | 3.85 | Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. ( Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL, 2017) |
| "Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy." | 3.80 | 3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. ( Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC, 2014) |
| "Peritumoral N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, Cho/NAA and rCBV significantly differentiated glioblastomas from intracranial metastases." | 3.78 | Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. ( Fezoulidis, I; Fountas, K; Kapsalaki, E; Kousi, E; Svolos, P; Theodorou, K; Tsougos, I, 2012) |
| "In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)." | 3.73 | In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005) |
| "To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)." | 3.72 | Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004) |
| "Seven patients responded to tamoxifen therapy (three with glioblastomas multiforme; four with anaplastic astrocytomas), and nine did not (six with glioblastomas multiforme; three with anaplastic astrocytomas)." | 3.70 | Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy. ( Arnold, DL; Caramanos, Z; Langleben, A; LeBlanc, R; Preul, MC; Shenouda, G; Villemure, JG, 2000) |
| "Thirty-nine patients after the standard treatment of a glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence - median time to progression was 6." | 1.43 | Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging. ( Bulik, M; Jancalek, R; Kazda, T; Lakomy, R; Pospisil, P; Slampa, P; Smrcka, M, 2016) |
| "The differential diagnosis between brain abscesses and necrotic tumors such as glioblastomas is sometimes difficult to establish by conventional computed tomography and magnetic resonance imaging." | 1.31 | Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports. ( Harada, M; Kageji, T; Nagahiro, S; Nakaiso, M; Takimoto, O; Uno, M, 2002) |
| "We examined 120 patients with brain tumors using a 1." | 1.31 | In vivo proton magnetic resonance spectroscopy of brain tumors. ( Fountas, KN; Gotsis, SD; Johnston, KW; Kapsalaki, EZ; Kapsalakis, JZ; Papadakis, N; Robinson, JS; Smisson , HF, 2000) |
| "Aspirated pus from one patient with brain abscess was examined using ex vivo proton MR spectroscopy." | 1.31 | Discrimination of brain abscess and cystic tumor by in vivo proton magnetic resonance spectroscopy. ( Kadota, O; Kikuchi, K; Kohno, K; Kumon, Y; Miki, H; Ohue, S; Sakaki, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.00) | 18.7374 |
| 1990's | 8 (13.33) | 18.2507 |
| 2000's | 22 (36.67) | 29.6817 |
| 2010's | 21 (35.00) | 24.3611 |
| 2020's | 6 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mekala, JR | 1 |
| Kurappalli, RK | 1 |
| Ramalingam, P | 1 |
| Moparthi, NR | 1 |
| Nakamura, Y | 1 |
| Inoue, A | 1 |
| Nishikawa, M | 1 |
| Ohnishi, T | 1 |
| Yano, H | 1 |
| Kanemura, Y | 1 |
| Ohtsuka, Y | 1 |
| Ozaki, S | 1 |
| Kusakabe, K | 1 |
| Suehiro, S | 1 |
| Yamashita, D | 1 |
| Shigekawa, S | 1 |
| Watanabe, H | 1 |
| Kitazawa, R | 1 |
| Tanaka, J | 1 |
| Kunieda, T | 1 |
| Tensaouti, F | 1 |
| Desmoulin, F | 1 |
| Gilhodes, J | 1 |
| Roques, M | 1 |
| Ken, S | 2 |
| Lotterie, JA | 1 |
| Noël, G | 1 |
| Truc, G | 1 |
| Sunyach, MP | 1 |
| Charissoux, M | 1 |
| Magné, N | 1 |
| Lubrano, V | 2 |
| Péran, P | 1 |
| Cohen-Jonathan Moyal, E | 2 |
| Laprie, A | 3 |
| Flores-Alvarez, E | 1 |
| Anselmo Rios Piedra, E | 1 |
| Cruz-Priego, GA | 1 |
| Durand-Muñoz, C | 1 |
| Moreno-Jimenez, S | 1 |
| Roldan-Valadez, E | 1 |
| Zhao, JP | 1 |
| Cui, CX | 1 |
| Wang, JC | 1 |
| Su, HW | 1 |
| Duan, CF | 1 |
| Liu, XJ | 1 |
| Mishkovsky, M | 1 |
| Gusyatiner, O | 1 |
| Lanz, B | 1 |
| Cudalbu, C | 1 |
| Vassallo, I | 1 |
| Hamou, MF | 1 |
| Bloch, J | 1 |
| Comment, A | 1 |
| Gruetter, R | 1 |
| Hegi, ME | 1 |
| Chen, F | 1 |
| Li, Z | 1 |
| Weng, C | 1 |
| Li, P | 1 |
| Tu, L | 1 |
| Chen, L | 1 |
| Xie, W | 1 |
| Li, L | 1 |
| Corbetta, C | 1 |
| Di Ianni, N | 1 |
| Bruzzone, MG | 1 |
| Patanè, M | 1 |
| Pollo, B | 1 |
| Cantini, G | 1 |
| Cominelli, M | 1 |
| Zucca, I | 1 |
| Pisati, F | 1 |
| Poliani, PL | 1 |
| Finocchiaro, G | 1 |
| Pellegatta, S | 1 |
| Gurbani, SS | 2 |
| Sheriff, S | 1 |
| Maudsley, AA | 2 |
| Shim, H | 2 |
| Cooper, LAD | 1 |
| Orza, A | 1 |
| Soriţău, O | 1 |
| Tomuleasa, C | 1 |
| Olenic, L | 1 |
| Florea, A | 1 |
| Pana, O | 1 |
| Bratu, I | 1 |
| Pall, E | 1 |
| Florian, S | 1 |
| Casciano, D | 1 |
| Biris, AS | 1 |
| Ratai, EM | 1 |
| Zhang, Z | 1 |
| Snyder, BS | 1 |
| Boxerman, JL | 1 |
| Safriel, Y | 1 |
| McKinstry, RC | 1 |
| Bokstein, F | 1 |
| Gilbert, MR | 1 |
| Sorensen, AG | 1 |
| Barboriak, DP | 1 |
| Muruganandham, M | 1 |
| Clerkin, PP | 1 |
| Smith, BJ | 1 |
| Anderson, CM | 1 |
| Morris, A | 1 |
| Capizzano, AA | 1 |
| Magnotta, V | 1 |
| McGuire, SM | 1 |
| Smith, MC | 1 |
| Bayouth, JE | 1 |
| Buatti, JM | 1 |
| Parra, NA | 1 |
| Gupta, RK | 1 |
| Ishkanian, F | 1 |
| Huang, K | 1 |
| Walker, GR | 1 |
| Padgett, K | 1 |
| Roy, B | 1 |
| Panoff, J | 1 |
| Markoe, A | 1 |
| Stoyanova, R | 1 |
| Deviers, A | 1 |
| Filleron, T | 1 |
| Rowland, B | 1 |
| Laruelo, A | 1 |
| Catalaa, I | 3 |
| Celsis, P | 1 |
| Berry, I | 2 |
| Mogicato, G | 1 |
| Stadlbauer, A | 1 |
| Pichler, P | 1 |
| Karl, M | 1 |
| Brandner, S | 1 |
| Lerch, C | 1 |
| Renner, B | 1 |
| Heinz, G | 1 |
| Tang, C | 1 |
| Guo, J | 1 |
| Chen, H | 1 |
| Yao, CJ | 1 |
| Zhuang, DX | 1 |
| Wang, Y | 1 |
| Tang, WJ | 1 |
| Ren, G | 1 |
| Yao, Y | 1 |
| Wu, JS | 1 |
| Mao, Y | 1 |
| Zhou, LF | 1 |
| Cordova, JS | 1 |
| Shu, HK | 1 |
| Liang, Z | 1 |
| Cooper, LA | 1 |
| Holder, CA | 1 |
| Olson, JJ | 1 |
| Kairdolf, B | 1 |
| Schreibmann, E | 1 |
| Neill, SG | 1 |
| Hadjipanayis, CG | 1 |
| Kazda, T | 1 |
| Bulik, M | 1 |
| Pospisil, P | 1 |
| Lakomy, R | 1 |
| Smrcka, M | 1 |
| Slampa, P | 1 |
| Jancalek, R | 1 |
| Heiland, DH | 1 |
| Mader, I | 2 |
| Schlosser, P | 1 |
| Pfeifer, D | 1 |
| Carro, MS | 1 |
| Lange, T | 1 |
| Schwarzwald, R | 1 |
| Vasilikos, I | 1 |
| Urbach, H | 1 |
| Weyerbrock, A | 1 |
| Nelson, SJ | 6 |
| Li, Y | 1 |
| Lupo, JM | 1 |
| Olson, M | 1 |
| Crane, JC | 1 |
| Molinaro, A | 1 |
| Roy, R | 1 |
| Clarke, J | 1 |
| Butowski, N | 1 |
| Prados, M | 1 |
| Cha, S | 2 |
| Chang, SM | 3 |
| Boonzaier, NR | 1 |
| Larkin, TJ | 1 |
| Matys, T | 1 |
| van der Hoorn, A | 1 |
| Yan, JL | 1 |
| Price, SJ | 1 |
| Crawford, FW | 1 |
| Khayal, IS | 1 |
| McGue, C | 1 |
| Saraswathy, S | 1 |
| Pirzkall, A | 3 |
| Lamborn, KR | 1 |
| Berger, MS | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Eloqayli, H | 1 |
| Melø, TM | 1 |
| Haukvik, A | 1 |
| Sonnewald, U | 1 |
| Einstein, DB | 1 |
| Wessels, B | 1 |
| Bangert, B | 1 |
| Fu, P | 1 |
| Nelson, AD | 1 |
| Cohen, M | 1 |
| Sagar, S | 1 |
| Lewin, J | 1 |
| Sloan, A | 1 |
| Zheng, Y | 1 |
| Williams, J | 1 |
| Colussi, V | 1 |
| Vinkler, R | 1 |
| Maciunas, R | 1 |
| Jeon, JY | 1 |
| Kovanlikaya, I | 1 |
| Boockvar, JA | 1 |
| Mao, X | 1 |
| Shin, B | 1 |
| K Burkhardt, J | 1 |
| Kesavabhotla, K | 1 |
| Christos, P | 1 |
| Riina, H | 1 |
| Shungu, DC | 1 |
| Tsiouris, AJ | 1 |
| Donmez, FY | 1 |
| Aslan, H | 1 |
| Coban, G | 1 |
| Ozen, O | 1 |
| Agildere, M | 1 |
| Tsougos, I | 1 |
| Svolos, P | 1 |
| Kousi, E | 1 |
| Fountas, K | 1 |
| Theodorou, K | 1 |
| Fezoulidis, I | 1 |
| Kapsalaki, E | 1 |
| Gmeiner, M | 1 |
| Sonnberger, M | 1 |
| Wurm, G | 1 |
| Weis, S | 1 |
| Nakaiso, M | 1 |
| Uno, M | 1 |
| Harada, M | 1 |
| Kageji, T | 1 |
| Takimoto, O | 1 |
| Nagahiro, S | 1 |
| Howe, FA | 1 |
| Barton, SJ | 1 |
| Cudlip, SA | 1 |
| Stubbs, M | 1 |
| Saunders, DE | 1 |
| Murphy, M | 1 |
| Wilkins, P | 1 |
| Opstad, KS | 1 |
| Doyle, VL | 1 |
| McLean, MA | 1 |
| Bell, BA | 1 |
| Griffiths, JR | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Ors, F | 1 |
| Tayfun, C | 1 |
| Uçöz, T | 1 |
| Oh, J | 1 |
| Henry, RG | 2 |
| Lu, Y | 1 |
| Li, X | 1 |
| Chang, S | 3 |
| Dillon, WP | 4 |
| Chan, AA | 1 |
| Lau, A | 1 |
| Verhey, LJ | 1 |
| Larson, D | 2 |
| McDermott, MW | 1 |
| Magalhaes, A | 1 |
| Godfrey, W | 1 |
| Shen, Y | 1 |
| Hu, J | 1 |
| Smith, W | 1 |
| Pulkkinen, J | 1 |
| Häkkinen, AM | 1 |
| Lundbom, N | 1 |
| Paetau, A | 1 |
| Kauppinen, RA | 1 |
| Hiltunen, Y | 1 |
| Likavcanová, K | 1 |
| Dobrota, D | 1 |
| Liptaj, T | 1 |
| Prónayová, N | 1 |
| Mlynárik, V | 1 |
| Belan, V | 1 |
| Galanda, M | 1 |
| Béres, A | 1 |
| De Riggo, J | 1 |
| Lichy, MP | 1 |
| Bachert, P | 1 |
| Hamprecht, F | 1 |
| Weber, MA | 1 |
| Debus, J | 1 |
| Schulz-Ertner, D | 1 |
| Schlemmer, HP | 1 |
| Kauczor, HU | 1 |
| Aragão, Mde F | 1 |
| Otaduy, MC | 1 |
| Melo, RV | 1 |
| Azevedo Filho, HR | 1 |
| Victor, EG | 1 |
| Silva, JL | 1 |
| Araújo, N | 1 |
| Leite, Cda C | 1 |
| Valença, MM | 1 |
| Cassol, E | 1 |
| McKnight, TR | 1 |
| Berchery, D | 1 |
| Marre, D | 1 |
| Bachaud, JM | 1 |
| Moyal, EC | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| McBride, DQ | 1 |
| Miller, BL | 1 |
| Nikas, DL | 1 |
| Buchthal, S | 1 |
| Chang, L | 1 |
| Chiang, F | 1 |
| Booth, RA | 1 |
| Tien, RD | 1 |
| Lai, PH | 1 |
| Smith, JS | 1 |
| Lazeyras, F | 1 |
| Wald, LL | 1 |
| Day, MR | 1 |
| Noworolski, SE | 1 |
| Huhn, SL | 1 |
| Prados, MD | 2 |
| Sneed, PK | 2 |
| Larson, DA | 1 |
| Wara, WM | 1 |
| McDermott, M | 2 |
| Gutin, PH | 1 |
| Vigneron, DB | 2 |
| Kinoshita, K | 1 |
| Tada, E | 1 |
| Matsumoto, K | 1 |
| Asari, S | 1 |
| Ohmoto, T | 1 |
| Itoh, T | 1 |
| Baunach, S | 1 |
| Meixensberger, J | 1 |
| Gerlach, M | 1 |
| Lan, J | 1 |
| Roosen, K | 1 |
| Meyerand, ME | 1 |
| Pipas, JM | 1 |
| Mamourian, A | 1 |
| Tosteson, TD | 1 |
| Dunn, JF | 1 |
| Preul, MC | 1 |
| Caramanos, Z | 1 |
| Villemure, JG | 1 |
| Shenouda, G | 1 |
| LeBlanc, R | 1 |
| Langleben, A | 1 |
| Arnold, DL | 1 |
| Graves, EE | 1 |
| Chin, C | 1 |
| Verhey, L | 1 |
| Lamborn, K | 1 |
| Ricci, PE | 1 |
| Pitt, A | 1 |
| Keller, PJ | 1 |
| Coons, SW | 1 |
| Heiserman, JE | 1 |
| Castillo, M | 1 |
| Smith, JK | 1 |
| Kwock, L | 1 |
| Fountas, KN | 1 |
| Kapsalaki, EZ | 1 |
| Gotsis, SD | 1 |
| Kapsalakis, JZ | 1 |
| Smisson , HF | 1 |
| Johnston, KW | 1 |
| Robinson, JS | 1 |
| Papadakis, N | 1 |
| Son, BC | 1 |
| Kim, MC | 1 |
| Choi, BG | 1 |
| Kim, EN | 1 |
| Baik, HM | 1 |
| Choe, BY | 1 |
| Naruse, S | 1 |
| Kang, JK | 1 |
| Kadota, O | 1 |
| Kohno, K | 1 |
| Ohue, S | 1 |
| Kumon, Y | 1 |
| Sakaki, S | 1 |
| Kikuchi, K | 1 |
| Miki, H | 1 |
| Liu, H | 1 |
| Hall, WA | 1 |
| Martin, AJ | 1 |
| Truwit, CL | 1 |
| Ishimaru, H | 1 |
| Morikawa, M | 1 |
| Iwanaga, S | 1 |
| Kaminogo, M | 1 |
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| Cooper, JR | 1 |
| Fischer, W | 1 |
| Müller, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Phase II Trial of Conventional Radiotherapy With Stereotactic Radiosurgery to High Risk Tumor Regions as Determined by Functional Imaging in Patients With Glioblastoma Multiforme[NCT00253448] | Phase 2 | 35 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| Ependymomics: Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents[NCT05151718] | 370 participants (Anticipated) | Observational | 2021-09-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Followed every 3 months for 2 years, every 6 months for 3 years, and annually thereafter for at least 5 years (NCT00253448)
Timeframe: Minimum of 5 years.
| Intervention | months (Median) | ||||||
|---|---|---|---|---|---|---|---|
| Entire Cohort | RTOG Glioma Recursive Partitioning Class 3 n=4 | RTOG Glioma Recursive Partitioning Class 4 n=13 | RTOG Glioma Recursive Partitioning Class 5 n=16 | RTOG Glioma Recursive Partitioning Class 6 n=2 | Patients receiving concurrent chemotherapy | Patients who were not candidates for chemotherapy | |
| Stereotactic Radiosurgery Plus Conventional Radiotherapy | 15.8 | 22 | 18.7 | 12.5 | 3.9 | 20.8 | 11 |
4 reviews available for aspartic acid and Glioblastoma
| Article | Year |
|---|---|
Progressive multifocal exophytic pontine glioblastoma: a case report with literature review.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child, Preschool; Choline; Diagnosis, Differential; Fatal Outco | 2017 |
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
Glioblastoma with the appearance of arteriovenous malformation: pitfalls in diagnosis.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Choline; Diagnosis, | 2013 |
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates; | 1992 |
6 trials available for aspartic acid and Glioblastoma
| Article | Year |
|---|---|
Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Be | 2013 |
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea | 2014 |
Phase II trial of radiosurgery to magnetic resonance spectroscopy-defined high-risk tumor volumes in patients with glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Combined Modality Therapy; | 2012 |
Metabolic response of glioblastoma to superselective intra-arterial cerebral infusion of bevacizumab: a proton MR spectroscopic imaging study.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Aspartic Acid; Bevacizumab; Brain; | 2012 |
[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Chol | 2007 |
Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Magnetic Resonance Ima | 2008 |
50 other studies available for aspartic acid and Glioblastoma
| Article | Year |
|---|---|
N-acetyl l-aspartate and Triacetin modulate tumor suppressor MicroRNA and class I and II HDAC gene expression induce apoptosis in Glioblastoma cancer cells in vitro.
Topics: Apoptosis; Aspartic Acid; Brain Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression | 2021 |
Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.
Topics: Aspartic Acid; Creatine; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Glioblastoma; Glutamic Ac | 2022 |
Is pre-radiotherapy metabolic heterogeneity of glioblastoma predictive of progression-free survival?
Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magnetic Resonance Imaging; | 2023 |
Correlations between DTI-derived metrics and MRS metabolites in tumour regions of glioblastoma: a pilot study.
Topics: Anisotropy; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Contrast Media; Creatine; Di | 2020 |
Multimodal MR Features of 8 Cases of Epithelioid Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Diffusi | 2020 |
Hyperpolarized
Topics: Aerobiosis; Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Glioblastoma | 2021 |
Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma.
Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Aspartic Acid; Astrocytes; Benzopyrans; Cell L | 2019 |
Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting.
Topics: Algorithms; Artifacts; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Computer Graphics; Cr | 2019 |
Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles.
Topics: Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptos | 2013 |
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; C | 2014 |
Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Brain Mapping; Brain Neoplasms; Choline; Creatine; F | 2014 |
Quantification of serial changes in cerebral blood volume and metabolism in patients with recurrent glioblastoma undergoing antiangiogenic therapy.
Topics: Angiogenesis Inhibitors; Aspartic Acid; Bevacizumab; Blood Volume; Brain; Brain Mapping; Brain Neopl | 2015 |
Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Codon, Nonsense; DNA | 2015 |
Whole-brain spectroscopic MRI biomarkers identify infiltrating margins in glioblastoma patients.
Topics: Aminolevulinic Acid; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Count; Choline; Disease | 2016 |
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Cohort Studies; Diffusion Magnetic Resonance I | 2016 |
Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Computational Biology; Creatine; Fem | 2016 |
Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab.
Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Chol | 2016 |
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor I | 2017 |
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM.
Topics: Adult; Aged; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti | 2009 |
[2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Astrocytes; Brain Neoplasms; Citric Acid Cycle; Diet, | 2011 |
Multimodal MR imaging findings of a congenital glioblastoma multiforme.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Female; Glioblastoma; Humans; Infant; Magnetic Resonance Imag | 2012 |
Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, D | 2012 |
Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports.
Topics: Acetates; Adult; Amino Acids; Aspartic Acid; Brain Abscess; Brain Neoplasms; Diagnosis, Differential | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Blood Volume; Brain Neoplasms; Choline; Glioblastoma; Humans | 2004 |
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor | 2004 |
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin | 2005 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla | 2005 |
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors].
Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined | 2006 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Analysis of brain tumors using 1H magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magneti | 1995 |
Single-voxel proton brain spectroscopy exam (PROBE/SV) in patients with primary brain tumors.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Crea | 1996 |
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.
Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Pro | 1997 |
Proton MR spectroscopy of delayed cerebral radiation in monkeys and humans after brachytherapy.
Topics: Adult; Animals; Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Cranial Irradiation; | 1997 |
Intraoperative microdialysis and tissue-pO2 measurement in human glioma.
Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Cell Death; Female; Frontal Lobe; Glioblastoma; Glutami | 1998 |
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms; | 1999 |
Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Astro | 2000 |
A preliminary study of the prognostic value of proton magnetic resonance spectroscopic imaging in gamma knife radiosurgery of recurrent malignant gliomas.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Choline; Creatine; Female; Glioblastoma; Humans; Lactic Aci | 2000 |
Effect of voxel position on single-voxel MR spectroscopy findings.
Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio | 2000 |
Correlation of myo-inositol levels and grading of cerebral astrocytomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil | 2000 |
In vivo proton magnetic resonance spectroscopy of brain tumors.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Brain; Brain Abscess; Brain Neoplasms; Choline | 2000 |
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene | 2001 |
Discrimination of brain abscess and cystic tumor by in vivo proton magnetic resonance spectroscopy.
Topics: Acetates; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Bacteria; Biomarkers; Brain Abscess; Child; | 2001 |
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop | 2001 |
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil | 2001 |
Some biochemical characteristics of neuroglia as deduced by glial tumor biochemical analysis.
Topics: Aminobutyrates; Aspartic Acid; Astrocytoma; Brain; Brain Chemistry; Brain Neoplasms; Carboxy-Lyases; | 1971 |
N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Cattle; Cerebral Cortex; Craniopharyngioma; Glioblastoma; G | 1972 |
[Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors].
Topics: Adenoma; Aspartate Aminotransferases; Aspartic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Craniopha | 1972 |